Homo sapiens (human): 1128
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Entry
1128 CDS
T01001
Symbol
CHRM1, HM1, M1, M1R
Name
(RefSeq) cholinergic receptor muscarinic 1
KO
K04129
muscarinic acetylcholine receptor M1
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04024
cAMP signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04151
PI3K-Akt signaling pathway
hsa04725
Cholinergic synapse
hsa04810
Regulation of actin cytoskeleton
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06528
Calcium signaling
nt06530
PI3K signaling
Element
N01000
mAChR-Ca2+ -apoptotic pathway
N01001
Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway
N01640
GPCR-PLCB-ITPR signaling pathway
N01657
GPCR-PI3K signaling pathway
Drug target
Aceclidine:
D02750
Acetylcholine (
DG01133
):
D00999
<JP/US>
Aclatonium (
DG01291
):
D01955
Aclidinium bromide:
D08837
<JP/US>
Alvameline maleate:
D02876
Anisotropine methylbromide:
D00232
Atropine (
DG00052
):
D00113
D02069
<JP/US>
Atropine oxide (
DG01243
):
D03011
D07477
Batefenterol (
DG01627
):
D10545
D10546
Benapryzine hydrochloride:
D03076
Benzatropine (
DG00859
):
D00778
<US>
D07511
Benzetimide (
DG01301
):
D03087
D07513
Benzilone:
D03088
Bethanechol (
DG00991
):
D01000
<JP/US>
Bevonium:
D01532
Biperiden (
DG00852
):
D00779
D02246
<JP>
D02247
<JP>
Blarcamesine (
DG03048
):
D11383
D11549
Bornaprine:
D07302
Butropium bromide:
D01491
<JP>
Butylscopolamine:
D01451
<JP>
Carbachol:
D00524
<US>
Carpronium (
DG01289
):
D01175
<JP>
D09752
<JP>
Chlorpromazine (
DG00867
):
D00270
D00789
<JP/US>
D03274
D04034
<JP>
D09819
Choline alfoscerate:
D07349
Cimetropium bromide:
D07099
Clidinium bromide:
D00716
Cyclopentolate (
DG01141
):
D01002
<JP/US>
D07759
Darotropium bromide:
D09402
Dexetimide (
DG00856
):
D03711
D07804
Dicycloverine (
DG00032
):
D00717
<US>
D07820
Diethazine (
DG01921
):
D02603
D07823
Difemerine:
D07079
Dihexyverine (
DG00033
):
D03824
D07821
Diphenidol (
DG02880
):
D01318
<JP>
D03858
D03859
Diphenylpiperidinomethyldioxolan iodide:
D01600
Diponium bromide:
D01463
Elantrine:
D03970
Elucaine:
D03979
Esoxybutynin chloride:
D04057
Etomidoline:
D01359
Etybenzatropine:
D04087
Eucatropine hydrochloride:
D04116
Fenpiverinium:
D07070
Fentonium:
D07951
Flutropium bromide:
D02417
Glycopyrronium (
DG02467
):
D10939
<JP/US>
Heteronium bromide:
D04434
Homatropine (
DG01142
):
D01004
Homatropine methylbromide:
D02070
Hyoscyamine (
DG00053
):
D00147
D00719
D01648
D04479
Imidafenacin:
D06273
<JP>
Ipratropium bromide:
D02212
<JP/US>
Mazaticol (
DG00857
):
D03264
D08157
Mebeverine (
DG00030
):
D04868
D08160
Mepenzolate (
DG00040
):
D00720
<JP>
Methacholine:
D04970
<JP/US>
Methantheline (
DG00036
):
D00721
Methscopolamine bromide:
D00715
<US>
Methylatropine (
DG01242
):
D01077
D03814
Methylbenactyzium bromide:
D01315
Methylscopolamine:
D01976
<JP>
Metixene (
DG00853
):
D01871
D08209
Metoquizine:
D05012
Milameline hydrochloride:
D05035
Otilonium bromide:
D07083
Oxapium iodide:
D01815
Oxitropium bromide:
D01946
Oxybutynin (
DG00478
):
D00465
<US>
D00722
<JP/US>
Oxyphencyclimine (
DG00029
):
D01006
D08325
Oxyphenonium:
D06877
Parapenzolate bromide:
D05360
Pentapiperium methylsulfate:
D05418
Penthienate:
D07081
Phencarbamide:
D05452
Phenglutarimide:
D07301
Pipenzolate:
D07084
Piperidolate (
DG00034
):
D01165
<JP>
D08382
Pipethanate (
DG01255
):
D01521
D08384
Pipethanate ethobromide:
D01987
Pirenzepine (
DG00026
):
D01297
D05276
<JP>
D08389
Piroheptine (
DG01272
):
D01231
<JP>
D08395
Poldine:
D05535
Pridinol (
DG00774
):
D02064
<JP>
D08418
D08419
Prifinium bromide:
D01377
Procyclidine (
DG00854
):
D00782
D08425
Profenamine (
DG00855
):
D01118
D03276
D08426
Propantheline (
DG00035
):
D00481
<JP>
Propenzolate hydrochloride:
D05628
Propiverine (
DG00479
):
D01007
<JP>
D08441
Rapacuronium bromide:
D05703
Rocuronium bromide:
D00765
<JP/US>
Sabcomeline hydrochloride:
D05779
Scopolamine (
DG00065
):
D00138
<US>
D02071
<JP>
Talsaclidine fumarate:
D06000
Tazomeline citrate:
D06015
Telenzepine hydrochloride hydrate:
D11098
Tematropium methylsulfate:
D06061
Tiemonium (
DG01254
):
D08595
Tiemonium iodide:
D01201
Timepidium bromide (
DG00041
):
D02535
<JP>
Tofenacin hydrochloride:
D06175
Toquizine:
D06192
Triampyzine sulfate:
D06217
Tridihexethyl (
DG00037
):
D00723
Trihexyphenidyl (
DG00851
):
D00787
<JP/US>
D08638
Tropatepine (
DG00858
):
D07303
D08653
Tropicamide:
D00397
<JP/US>
Umeclidinium (
DG01253
):
D10180
Umeclidinium bromide:
D10181
<JP/US>
Valethamate:
D01538
Xanomeline (
DG01300
):
D06330
D06331
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
1128 (CHRM1)
04024 cAMP signaling pathway
1128 (CHRM1)
04151 PI3K-Akt signaling pathway
1128 (CHRM1)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
1128 (CHRM1)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
1128 (CHRM1)
09150 Organismal Systems
09156 Nervous system
04725 Cholinergic synapse
1128 (CHRM1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
1128 (CHRM1)
05022 Pathways of neurodegeneration - multiple diseases
1128 (CHRM1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
1128 (CHRM1)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Biogenic amine
Acetylcholine (muscarinic)
1128 (CHRM1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7tm_4
7TM_GPCR_Srbc
7TM_GPCR_Srx
Motif
Other DBs
NCBI-GeneID:
1128
NCBI-ProteinID:
NP_000729
OMIM:
118510
HGNC:
1950
Ensembl:
ENSG00000168539
UniProt:
P11229
Q53XZ3
Structure
PDB
LinkDB
All DBs
Position
11:complement(62908679..62921878)
Genome browser
AA seq
460 aa
AA seq
DB search
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
NT seq
1383 nt
NT seq
+upstream
nt +downstream
nt
atgaacacttcagccccacctgctgtcagccccaacatcaccgtcctggcaccaggaaag
ggtccctggcaagtggccttcattgggatcaccacgggcctcctgtcgctagccacagtg
acaggcaacctgctggtactcatctctttcaaggtcaacacggagctcaagacagtcaat
aactacttcctgctgagcctggcctgtgctgacctcatcatcggtaccttctccatgaac
ctctataccacgtacctgctcatgggccactgggctctgggcacgctggcttgtgacctc
tggctggccctggactatgtggccagcaatgcctccgtcatgaatctgctgctcatcagc
tttgaccgctacttctccgtgactcggcccctgagctaccgtgccaagcgcacaccccgc
cgggcagctctgatgatcggcctggcctggctggtttcctttgtgctctgggccccagcc
atcctcttctggcagtacctggtaggggagcggacagtgctagctgggcagtgctacatc
cagttcctctcccagcccatcatcacctttggcacagccatggctgccttctacctccct
gtcacagtcatgtgcacgctctactggcgcatctaccgggagacagagaaccgagcacgg
gagctggcagcccttcagggctccgagacgccaggcaaagggggtggcagcagcagcagc
tcagagaggtctcagccaggggctgagggctcaccagagactcctccaggccgctgctgt
cgctgctgccgggcccccaggctgctgcaggcctacagctggaaggaagaagaggaagag
gacgaaggctccatggagtccctcacatcctcagagggagaggagcctggctccgaagtg
gtgatcaagatgccaatggtggaccccgaggcacaggcccccaccaagcagcccccacgg
agctccccaaatacagtcaagaggccgactaagaaagggcgtgatcgagctggcaagggc
cagaagccccgtggaaaggagcagctggccaagcggaagaccttctcgctggtcaaggag
aagaaggcggctcggaccctgagtgccatcctcctggccttcatcctcacctggacaccg
tacaacatcatggtgctggtgtccaccttctgcaaggactgtgttcccgagaccctgtgg
gagctgggctactggctgtgctacgtcaacagcaccatcaaccccatgtgctacgcactc
tgcaacaaagccttccgggacacctttcgcctgctgctgctttgccgctgggacaagaga
cgctggcgcaagatccccaagcgccctggctccgtgcaccgcactccctcccgccaatgc
tga
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integrated database retrieval system