Entry |
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Gene name |
RIPK1, AIEFL, IMD57, RIP, RIP-1, RIP1
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Definition |
(RefSeq) receptor interacting serine/threonine kinase 1
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KO |
K02861 | receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1] |
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Organism |
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Pathway |
hsa04620 | Toll-like receptor signaling pathway |
hsa04621 | NOD-like receptor signaling pathway |
hsa04622 | RIG-I-like receptor signaling pathway |
hsa05130 | Pathogenic Escherichia coli infection |
hsa05163 | Human cytomegalovirus infection |
hsa05170 | Human immunodeficiency virus 1 infection |
|
Network |
nt06123 TNF signaling (viruses and bacteria) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06161 Human immunodeficiency virus type 1 (HIV-1) nt06163 Hepatitis C virus (HCV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06167 Human cytomegalovirus (HCMV) nt06223 TNF signaling nt06263 Hepatocellular carcinoma nt06416 TNF signaling nt06461 Huntington disease |
Element |
N00151 | TNF-NFKB signaling pathway |
N00441 | HIV gp120 to TNF-NFKB signaling pathway |
N00442 | HIV Nef to TNF-NFKB signaling pathway |
N00444 | TNF-p38 signaling pathway |
N00446 | TNF-JNK signaling pathway |
N00928 | Escherichia NleB to TNF-NFKB signaling pathway |
N00945 | Shigella IpaH1.4/2.5 to TNF-NFKB signaling pathway |
N01113 | Salmonella SseK1 to TNF-NFKB signaling pathway |
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Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04064 NF-kappa B signaling pathway
8737 (RIPK1)
04668 TNF signaling pathway
8737 (RIPK1)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
8737 (RIPK1)
04217 Necroptosis
8737 (RIPK1)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
8737 (RIPK1)
04621 NOD-like receptor signaling pathway
8737 (RIPK1)
04622 RIG-I-like receptor signaling pathway
8737 (RIPK1)
04623 Cytosolic DNA-sensing pathway
8737 (RIPK1)
09160 Human Diseases
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
8737 (RIPK1)
05160 Hepatitis C
8737 (RIPK1)
05163 Human cytomegalovirus infection
8737 (RIPK1)
05169 Epstein-Barr virus infection
8737 (RIPK1)
09171 Infectious disease: bacterial
05130 Pathogenic Escherichia coli infection
8737 (RIPK1)
05132 Salmonella infection
8737 (RIPK1)
05131 Shigellosis
8737 (RIPK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
8737 (RIPK1)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
8737 (RIPK1)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: TKL group
RIPK family [OT]
8737 (RIPK1)
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SSDB |
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Motif |
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Other DBs |
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LinkDB |
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Structure |
PDB: |
Position |
6p25.2
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AA seq |
671 aa
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN |
NT seq |
2016 nt +upstreamnt +downstreamnt
atgcaaccagacatgtccttgaatgtcattaagatgaaatccagtgacttcctggagagt
gcagaactggacagcggaggctttgggaaggtgtctctgtgtttccacagaacccaggga
ctcatgatcatgaaaacagtgtacaaggggcccaactgcattgagcacaacgaggccctc
ttggaggaggcgaagatgatgaacagactgagacacagccgggtggtgaagctcctgggc
gtcatcatagaggaagggaagtactccctggtgatggagtacatggagaagggcaacctg
atgcacgtgctgaaagccgagatgagtactccgctttctgtaaaaggaaggataattttg
gaaatcattgaaggaatgtgctacttacatggaaaaggcgtgatacacaaggacctgaag
cctgaaaatatccttgttgataatgacttccacattaagatcgcagacctcggccttgcc
tcctttaagatgtggagcaaactgaataatgaagagcacaatgagctgagggaagtggac
ggcaccgctaagaagaatggcggcaccctctactacatggcgcccgagcacctgaatgac
gtcaacgcaaagcccacagagaagtcggatgtgtacagctttgctgtagtactctgggcg
atatttgcaaataaggagccatatgaaaatgctatctgtgagcagcagttgataatgtgc
ataaaatctgggaacaggccagatgtggatgacatcactgagtactgcccaagagaaatt
atcagtctcatgaagctctgctgggaagcgaatccggaagctcggccgacatttcctggc
attgaagaaaaatttaggcctttttatttaagtcaattagaagaaagtgtagaagaggac
gtgaagagtttaaagaaagagtattcaaacgaaaatgcagttgtgaagagaatgcagtct
cttcaacttgattgtgtggcagtaccttcaagccggtcaaattcagccacagaacagcct
ggttcactgcacagttcccagggacttgggatgggtcctgtggaggagtcctggtttgct
ccttccctggagcacccacaagaagagaatgagcccagcctgcagagtaaactccaagac
gaagccaactaccatctttatggcagccgcatggacaggcagacgaaacagcagcccaga
cagaatgtggcttacaacagagaggaggaaaggagacgcagggtctcccatgaccctttt
gcacagcaaagaccttacgagaattttcagaatacagagggaaaaggcactgcttattcc
agtgcagccagtcatggtaatgcagtgcaccagccctcagggctcaccagccaacctcaa
gtactgtatcagaacaatggattatatagctcacatggctttggaacaagaccactggat
ccaggaacagcaggtcccagagtttggtacaggccaattccaagtcatatgcctagtctg
cataatatcccagtgcctgagaccaactatctaggaaatacacccaccatgccattcagc
tccttgccaccaacagatgaatctataaaatataccatatacaatagtactggcattcag
attggagcctacaattatatggagattggtgggacgagttcatcactactagacagcaca
aatacgaacttcaaagaagagccagctgctaagtaccaagctatctttgataataccact
agtctgacggataaacacctggacccaatcagggaaaatctgggaaagcactggaaaaac
tgtgcccgtaaactgggcttcacacagtctcagattgatgaaattgaccatgactatgag
cgagatggactgaaagaaaaggtttaccagatgctccaaaagtgggtgatgagggaaggc
ataaagggagccacggtggggaagctggcccaggcgctccaccagtgttccaggatcgac
cttctgagcagcttgatttacgtcagccagaactaa |