| PI3K signaling |
| N00582 |
IGF1 | → | IGF1R | → | PI3K | → | PIP3 | → | AKT | ⊣ | (TSC1+TSC2) | ⊣ | RHEB | → | MTOR | ⊣ | EIF4EBP1 |
| N00583 |
| | VP11/12 | → | PI3K |
| N00584 |
| | | | | | | | US3 | ⊣ | (TSC1+TSC2) |
| TLR signaling |
| N00435 |
| | (TLR1,TLR2,TLR4) | → | (TIRAP+MYD88) | → | (IRAK4+IRAK1) | → | (TRAF6+TAK1+TAB2) | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (TNF,IL6,IL12A,IL1.. |
| N00561 |
| | ICP0 | ⊣ | MYD88 |
| N00562 |
| | | | | | US3 | ⊣ | (TRAF6+TAK1+TAB2) |
| N00563 |
| | TLR3 | → | TICAM1 | → | TRAF6 | → | TAK1 | → | IKK | → | NFKBIA | → | NFKB |
| N00564 |
US3 | ⊣ | TLR3 |
| RLR signaling |
| N00469 |
RNA | → | RIGI | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
| N00565 |
US11 | ⊣ | (RIGI,MDA5) |
| N00566 |
| | | | UL36USP | ⊣ | TRAF3 |
| N00567 |
| | | | | | | | ICP34.5 | ⊣ | (TBK1+IKBKE) |
| N00568 |
| | | | | | | | | | US3 | ⊣ | IRF3 |
| CGAS-STING signaling |
| N00395 |
DNA | → | CGAS | → | cGAMP | → | STING1 | → | TBK1 | → | IRF3 | ⇒ | (IFNA,IFNB) |
| N00569 |
UL41 | ⊣ | CGAS |
| N00570 |
| | | | ICP0 | ⊣ | STING1 |
| NLR signaling |
| N00515 |
| | OAS | → | 2-5A | → | RNASEL |
| N00574 |
US11 | ⊣ | OAS |
| PKR-eIF2alpha signaling |
| N00571 |
| | EIF2AK2 | → | EIF2S1 | ⊣ | EIF2B |
| N00573 |
US11 | ⊣ | EIF2AK2 |
| N00572 |
ICP34.5 | = | PPP1C | ⊣ | EIF2S1 |
| Complement cascade |
| N01489 |
C3 | − | (C4b+C2a) | → | C3b | → | (C4b+C2a+C3b) |
| N00589 |
| | GC | ⊣ | C3b |
| IFN signaling |
| N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
| N00576 |
(UL41,UL13) | → | SOCS3 | ⊣ | JAK1 |
| N00577 |
| | UL41 | ⊣ | JAK1 |
| N00578 |
| | | | UL41 | ⊣ | (STAT1+STAT2+IRF9) |
| N00575 |
| | | | ICP27 | ⊣ | (STAT1+STAT2+IRF9) |
| TNF signaling |
| N00559 |
TNFSF14 | → | TNFRSF14 | → | TRAF2/5 | → | IKK | → | NFKBIA | → | NFKB |
| N00560 |
GD | → | TNFRSF14 | → | TRAF2/5 | → | IKK | → | NFKBIA | → | NFKB | ⇒ | (BIRC2,BIRC3,NFKB1.. |
| MHC presentation |
| N00363 |
| | TAP1/2 | = | TAPBP | = | (PDIA3+CALR) | → | (MHCI+B2M) |
| N00581 |
ICP47 | ⊣ | TAP1/2 |
| N00590 |
| | | | | | CD74 | → | MHCII |
| N00591 |
| | | | GB | ⊣ | CD74 |
| Apoptosis |
| N00145 |
TNF | → | TNFRSF1A | → | (RIPK1+TRADD+TRAF2.. | → | FADD | → | CASP8 | → | (CASP3,CASP7) |
| N00579 |
| | | | | | ICP6 | ⊣ | CASP8 |
| N00146 |
| | (FASLG,TNFSF10) | → | (FAS,TNFRSF10B) | → | FADD | → | (CASP8,CASP10) | → | BID | → | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
| N00580 |
| | | | | | | | | | | | | | | | | | ICP0 | → | CASP3 |
| N00098 |
| | | | | | | | (PMAIP1,BBC3,BAD,B.. | ⊣ | (BCL2,BCL2L1) | ⊣ | (BAX,BAK1) | → | CYCS | = | APAF1 | → | CASP9 | → | (CASP3,CASP7) |
| N00585 |
| | | | | | US3 | ⊣ | BAD |
| Nuclear export of mRNA |
| N00586 |
| | SRPK1 | → | SRSF1 | = | NXF1 |
| N00587 |
ICP27 | ⊣ | SRPK1 | → | SRSF1 | = | NXF1 |
| Transcription |
| N00592 |
ICP0 | ⊣ | TP53 |
| N00588 |
(VP16+HCF+POU2F1) | ⇒ | (ICP0,ICP4,ICP22,I.. |
|
Network variation - Herpes simplex virus 1 (HSV-1)