KEGG   PATHWAY: malb04115
malb04115                   Pathway                                

p53 signaling pathway - Monopterus albus (swamp eel)
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Cellular Processes; Cell growth and death
Pathway map
malb04115  p53 signaling pathway

Monopterus albus (swamp eel) [GN:malb]
109960285  atm; serine-protein kinase ATM [KO:K04728] [EC:]
109957388  serine/threonine-protein kinase Chk2-like isoform X1 [KO:K06641] [EC:]
109969614  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:]
109959175  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:]
109965272  gorab; RAB6-interacting golgin [KO:K19748]
109967598  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:]
109956058  mdm4; protein Mdm4 isoform X1 [KO:K10127]
109951400  tp53; cellular tumor antigen p53 [KO:K04451]
109967859  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109963107  G1/S-specific cyclin-D2-like [KO:K10151]
109961831  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
109969706  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
109964433  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109956190  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:]
109963185  cyclin-dependent kinase 6-like [KO:K02091] [EC:]
109968183  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:]
109963397  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
109958574  G1/S-specific cyclin-E2-like [KO:K06626]
109970056  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
109952674  mitogen-activated protein kinase HOG1-like [KO:K02206] [EC:]
109952750  mitogen-activated protein kinase HOG1-like [KO:K02206] [EC:]
109956212  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:]
109957142  rprm; protein reprimo [KO:K10128]
109964243  reprimo-like protein [KO:K10128]
109968695  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
109951260  G2/mitotic-specific cyclin-B2-like [KO:K21770]
109951232  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
109964351  cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:]
109956503  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109952067  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
109965191  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109954145  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109969313  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
109973653  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109973654  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
109965752  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
109956323  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
109960379  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
109951160  p53-induced death domain-containing protein 1-like [KO:K10130]
109959755  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109969775  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
109958094  caspase-8-like isoform X1 [KO:K04398] [EC:]
109961799  BH3-interacting domain death agonist-like [KO:K04726]
109964251  bax; apoptosis regulator BAX [KO:K02159]
109967870  apoptosis regulator BAX-like [KO:K02159]
109973692  apoptosis regulator BAX-like [KO:K02159]
109968325  siva1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
109956293  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
109974129  LOW QUALITY PROTEIN: bcl-2-like protein 1 [KO:K04570]
109957760  apoptosis regulator Bcl-2-like [KO:K02161]
109973370  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
109972861  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
109970848  protein shisa-5-like [KO:K10135]
109959574  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
109969876  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
109962566  siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:]
109954440  cytochrome c iso-1/iso-2-like [KO:K08738]
109952284  cytochrome c [KO:K08738]
109958102  cytochrome c-b [KO:K08738]
109959862  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109967174  casp9; caspase-9 [KO:K04399] [EC:]
109957512  casp3; caspase-3 isoform X1 [KO:K02187] [EC:]
109972113  caspase-3-like [KO:K02187] [EC:]
109961275  insulin-like growth factor-binding protein 3 [KO:K10138]
109957706  insulin-like growth factor-binding protein 3 isoform X1 [KO:K10138]
109971005  insulin-like growth factor I [KO:K05459]
109967822  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
109973963  adgrb1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
109951253  CD82 antigen-like [KO:K06509]
109972994  CD82 antigen-like [KO:K06509]
109970861  CD82 antigen-like [KO:K06509]
109962404  thrombospondin-1-like [KO:K16857]
109967980  thbs1; thrombospondin-1 [KO:K16857]
109971222  ddb2; DNA damage-binding protein 2 [KO:K10140]
109958595  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:]
109953831  ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:]
109974456  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:]
109953012  sesn1; sestrin-1 isoform X1 [KO:K10141]
109957995  sestrin-3-like isoform X1 [KO:K10141]
109963978  sestrin-2-like isoform X1 [KO:K20394]
109960336  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:]
109969673  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:]
109957851  tsc2; tuberin isoform X1 [KO:K07207]
109955738  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109967641  rfwd2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:]
109954756  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:]
109971158  ccng1; cyclin-G1 [KO:K10145]
109953039  cyclin-G2-like [KO:K10146]
109960783  cyclin-G2-like [KO:K10146]
109959603  protein phosphatase 1D-like isoform X1 [KO:K10147] [EC:]
109969731  ppm1d; protein phosphatase 1D [KO:K10147] [EC:]
109970537  tp73; tumor protein p73 isoform X1 [KO:K10148]
Levine AJ, Hu W, Feng Z.
The P53 pathway: what questions remain to be explored?
Cell Death Differ 13:1027-36 (2006)
Harris SL, Levine AJ.
The p53 pathway: positive and negative feedback loops.
Oncogene 24:2899-908 (2005)
Balint E E, Vousden KH.
Activation and activities of the p53 tumour suppressor protein.
Br J Cancer 85:1813-23 (2001)
Taylor WR, Stark GR.
Regulation of the G2/M transition by p53.
Oncogene 20:1803-15 (2001)
Hofseth LJ, Hussain SP, Harris CC.
p53: 25 years after its discovery.
Trends Pharmacol Sci 25:177-81 (2004)
Pietenpol JA, Stewart ZA.
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
Toxicology 181-182:475-81 (2002)
Tokino T, Nakamura Y.
The role of p53-target genes in human cancer.
Crit Rev Oncol Hematol 33:1-6 (2000)
Hermeking H, Benzinger A.
14-3-3 proteins in cell cycle regulation.
Semin Cancer Biol 16:183-92 (2006)
Sherr CJ.
Divorcing ARF and p53: an unsettled case.
Nat Rev Cancer 6:663-73 (2006)
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
Cancer Res 67:3043-53 (2007)
Resnick-Silverman L, Manfredi JJ
Two Faces of SIVA.
Cancer Discov 5:581-3 (2015)
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
J Cell Sci 122:2651-61 (2009)
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
J Carcinog 8:2 (2009)
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
FEBS Lett 524:163-71 (2002)
malb04110  Cell cycle
malb04210  Apoptosis
malb04218  Cellular senescence
KO pathway

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