KEGG   PATHWAY: malb04115
Entry
malb04115                   Pathway                                
Name
p53 signaling pathway - Monopterus albus (swamp eel)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
malb04115  p53 signaling pathway
malb04115

Organism
Monopterus albus (swamp eel) [GN:malb]
Gene
109951160  [KO:K10130]
109951232  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
109951253  [KO:K06509]
109951260  [KO:K21770]
109951400  tp53; cellular tumor antigen p53 [KO:K04451]
109952067  [KO:K04402]
109952284  [KO:K08738]
109953012  sesn1; sestrin-1 isoform X1 [KO:K10141]
109953039  [KO:K10146]
109953831  [KO:K10808] [EC:1.17.4.1]
109954145  [KO:K04402]
109954440  [KO:K08738]
109954756  rchy1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
109955738  steap3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
109956058  mdm4; protein Mdm4 isoform X1 [KO:K10127]
109956135  [KO:K26543]
109956190  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109956212  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
109956293  [KO:K04570]
109956323  gtse1; G2 and S phase-expressed protein 1 [KO:K10129]
109956503  [KO:K04402]
109957142  rprm; protein reprimo [KO:K10128]
109957388  [KO:K06641] [EC:2.7.11.1]
109957512  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
109957706  [KO:K10138]
109957760  [KO:K02161]
109957851  tsc2; tuberin isoform X1 [KO:K07207]
109957995  [KO:K10141]
109958094  [KO:K04398] [EC:3.4.22.61]
109958102  [KO:K08738]
109958574  [KO:K06626]
109958595  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
109959175  chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
109959574  perp; p53 apoptosis effector related to PMP-22 [KO:K10136]
109959603  [KO:K10147] [EC:3.1.3.16]
109959755  [KO:K04722]
109959862  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
109960285  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
109960336  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109960379  [KO:K04390]
109960384  cntd2; cyclin N-terminal domain-containing protein 2 isoform X1 [KO:K21770]
109960783  [KO:K10146]
109961275  [KO:K10138]
109961799  [KO:K04726]
109961831  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
109962404  [KO:K16857]
109962566  siah1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
109963107  [KO:K10151]
109963185  [KO:K02091] [EC:2.7.11.22]
109963222  ppp1r13l; LOW QUALITY PROTEIN: relA-associated inhibitor [KO:K27356]
109963397  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
109963978  [KO:K20394]
109964243  [KO:K10128]
109964251  bax; apoptosis regulator BAX [KO:K02159]
109964351  cdk1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
109964433  ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109965191  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
109965272  gorab; RAB6-interacting golgin [KO:K19748]
109965752  [KO:K04402]
109967174  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109967598  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109967641  rfwd2; E3 ubiquitin-protein ligase RFWD2 [KO:K10143] [EC:2.3.2.27]
109967822  igf1; insulin-like growth factor I isoform X1 [KO:K05459]
109967859  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
109967870  [KO:K02159]
109967980  thbs1; thrombospondin-1 [KO:K16857]
109968183  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
109968325  siva1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
109968695  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
109969313  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
109969614  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
109969673  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109969706  [KO:K10151]
109969731  ppm1d; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
109969775  [KO:K04722]
109969876  zmat3; zinc finger matrin-type protein 3 isoform X1 [KO:K10137]
109970056  [KO:K06626]
109970537  tp73; tumor protein p73 isoform X1 [KO:K10148]
109970848  [KO:K10135]
109970861  [KO:K06509]
109971005  [KO:K05459]
109971122  [KO:K06625]
109971158  ccng1; cyclin-G1 [KO:K10145]
109971222  ddb2; DNA damage-binding protein 2 [KO:K10140]
109972113  [KO:K02187] [EC:3.4.22.56]
109972861  ei24; etoposide-induced protein 2.4 homolog [KO:K10134]
109972994  [KO:K06509]
109973370  tp53i3; quinone oxidoreductase PIG3 isoform X1 [KO:K10133] [EC:1.-.-.-]
109973653  [KO:K04402]
109973654  [KO:K04402]
109973692  [KO:K02159]
109973963  adgrb1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
109974129  [KO:K04570]
109974456  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
Reference
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
malb04110  Cell cycle
malb04210  Apoptosis
malb04218  Cellular senescence
KO pathway
ko04115   

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