KEGG ORTHOLOGY: K06279

ORTHOLOGY: K06279

Entry

K06279                      KO

Symbol

SHC1

Name

SHC-transforming protein 1

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05206

MicroRNAs in cancer

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K06279  SHC1; SHC-transforming protein 1
   04012 ErbB signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04014 Ras signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04072 Phospholipase D signaling pathway
    K06279  SHC1; SHC-transforming protein 1
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06279  SHC1; SHC-transforming protein 1
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06279  SHC1; SHC-transforming protein 1
   04062 Chemokine signaling pathway
    K06279  SHC1; SHC-transforming protein 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04915 Estrogen signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04917 Prolactin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04926 Relaxin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04935 Growth hormone synthesis, secretion and action
    K06279  SHC1; SHC-transforming protein 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06279  SHC1; SHC-transforming protein 1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K06279  SHC1; SHC-transforming protein 1
   05226 Gastric cancer
    K06279  SHC1; SHC-transforming protein 1
   05214 Glioma
    K06279  SHC1; SHC-transforming protein 1
   05220 Chronic myeloid leukemia
    K06279  SHC1; SHC-transforming protein 1
   05224 Breast cancer
    K06279  SHC1; SHC-transforming protein 1
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K06279  SHC1; SHC-transforming protein 1
  09165 Substance dependence
   05034 Alcoholism
    K06279  SHC1; SHC-transforming protein 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K06279  SHC1; SHC-transforming protein 1
   01522 Endocrine resistance
    K06279  SHC1; SHC-transforming protein 1

Genes

HSA:	6464(SHC1)

PTR:	457351(SHC1)

PPS:	100993361(SHC1)

GGO:	101136424(SHC1)

PON:	100173225(SHC1)

PPYG:

129018416(SHC1)

NLE:	100606068(SHC1)

HMH:	116469345(SHC1)

SSYN:

134734366(SHC1)

MCC:	718982(SHC1)

MCF:	102142777(SHC1)

MTHB:

126933571

MNI:	105497981(SHC1)

CSAB:

103223899(SHC1)

CATY:

105585292 105585293 105593504(SHC1)

PANU:

101001939(SHC1)

TGE:	112628791(SHC1)

MLEU:

105544828(SHC1)

RRO:	104663483(SHC1)

RBB:	108526812(SHC1)

TFN:	117075160(SHC1)

PTEH:

111543732(SHC1)

CANG:

105502016(SHC1)

CJC:	100390337(SHC1)

SBQ:	101038895(SHC1) 101047748

CIMI:

108292463(SHC1)

ANAN:

105733700(SHC1)

CSYR:

103249998(SHC1)

MMUR:

105873192(SHC1)

LCAT:

123634038(SHC1)

PCOQ:

105821872(SHC1)

OGA:	100966694(SHC1)

MMU:	20416(Shc1)

MCAL:

110290710(Shc1)

MPAH:

110320247(Shc1)

RNO:	85385(Shc1)

MCOC:

116093178(Shc1)

ANU:	117706686(Shc1)

MUN:	110551574(Shc1)

CGE:	100758936(Shc1)

MAUA:

101841290(Shc1)

PROB:

127233113(Shc1)

PLEU:

114707889(Shc1)

MORG:

121445583 121450478(Shc1)

MFOT:

126516104

AAMP:

119800744(Shc1)

NGI:	103751254(Shc1)

HGL:	101717434(Shc1)

CPOC:

100734561(Shc1)

CCAN:

109688030(Shc1)

DORD:

105984949(Shc1)

DSP:	122109169(Shc1)

PLOP:

125360001(Shc1)

NCAR:

124982298

MMMA:

107146439 107156736(Shc1)

OCU:

100342812

OPI:	101529134(SHC1)

TUP:	102481002(SHC1)

GVR:	103608197(SHC1)

CFA:	490439(SHC1)

CLUD:

112648956(SHC1)

VVP:	112918897(SHC1)

VLG:	121485053(SHC1)

NPO:	129508769(SHC1)

AML:	100480856(SHC1)

UMR:	103668383(SHC1)

UAH:	113245295(SHC1)

UAR:	123783413(SHC1)

ELK:

111138866

LLV:

125086356

MPUF:

101680880(SHC1)

MNP:	132025921(SHC1)

MLK:	131814353(SHC1)

ORO:	101373821(SHC1)

EJU:	114198628(SHC1)

ZCA:	113933024(SHC1)

MLX:	118013864(SHC1)

NSU:	110573574(SHC1)

LWW:	102738885(SHC1)

FCA:	101092911(SHC1)

PYU:	121015654(SHC1)

PCOO:

112851716(SHC1)

PBG:	122476583(SHC1)

PVIV:

125155101(SHC1)

LRUF:

124521760

PTG:	102949026(SHC1)

PPAD:

109256269(SHC1)

PUC:

125925730

AJU:

106988382

HHV:	120244661(SHC1)

BTA:	507196(SHC1)

BOM:	102265814(SHC1)

BIU:	109553931(SHC1)

BBUB:

102409515(SHC1)

BBIS:

104987424(SHC1)

CHX:	102170926(SHC1)

OAS:	101113548(SHC1)

BTAX:

128044445(SHC1)

ODA:	120855734(SHC1)

CCAD:

122432839(SHC1)

MBEZ:

129541489(SHC1)

SSC:	100156321(SHC1)

CFR:	102524489(SHC1)

CBAI:

105068173(SHC1)

CDK:	105089005(SHC1)

VPC:	102526482(SHC1)

BACU:

103015382(SHC1)

BMUS:

118893636(SHC1)

LVE:	103074885(SHC1)

OOR:	101276908(SHC1)

DLE:	111167062(SHC1)

PCAD:

102991486(SHC1)

PSIU:

116740554(SHC1)

NASI:

112401764(SHC1)

ECB:	100063053(SHC1)

EPZ:	103552865(SHC1)

EAI:	106828516(SHC1)

MYB:	102245916(SHC1)

MYD:	102755241(SHC1)

MMYO:

118669819 118672782(SHC1)

MLF:	102430334(SHC1)

MDT:	132220603(SHC1)

PKL:	118721351(SHC1)

EFUS:

103298913(SHC1)

MNA:	107543890(SHC1)

DRO:	112316734(SHC1)

SHON:

118990179(SHC1)

AJM:	119061761(SHC1)

PDIC:

114488773(SHC1)

PHAS:

123804815(SHC1)

MMF:	118637475(SHC1)

PPAM:

129062405(SHC1)

HAI:	109393422(SHC1)

RFQ:	117014851(SHC1)

PALE:

102894443(SHC1)

PGIG:

120592211(SHC1)

PVP:	105296379(SHC1)

RAY:	107505474(SHC1) 107512423

MJV:	108407280 118972101

TOD:	119235491(SHC1)

SARA:

101553821(SHC1)

SETR:

126020709(SHC1)

LAV:	100653766(SHC1)

TMU:

101358105

ETF:	101638643(SHC1)

DNM:	101438260(SHC1)

MDO:	100016090(SHC1)

GAS:	123244440(SHC1)

SHR:	100926921(SHC1)

AFZ:

127559844

PCW:	110198538 110211965(SHC1)

TVP:	118833102 118844020 118846389(SHC1)

OAA:	114808180(SHC1)

GGA:	395934(SHC1)

PCOC:

116237337(SHC1)

MGP:	100540048(SHC1)

CJO:	107324486(SHC1)

TPAI:

128078804(SHC1)

LMUT:

125685714(SHC1)

NMEL:

110391258(SHC1)

APLA:

101791792(SHC1)

ACYG:

106048510(SHC1)

CATA:

118258448(SHC1)

AFUL:

116499756(SHC1)

TGU:	100229782(SHC1)

LSR:	110471528(SHC1)

SCAN:

103823958(SHC1)

PMOA:

120498883(SHC1)

OTC:	121332174(SHC1)

PRUF:

121352206(SHC1)

GFR:	102039503(SHC1)

FAB:	101807411(SHC1)

OMA:	130263184(SHC1)

PHI:	102106714(SHC1)

PMAJ:

107214540(SHC1)

CCAE:

111939466(SHC1)

CBRC:

103611255(SHC1)

ETL:	114068431(SHC1)

ZAB:	102064958(SHC1)

ZLE:	135457930(SHC1)

ACHL:

103808487(SHC1)

SVG:	106863386(SHC1)

MMEA:

130583217(SHC1)

HRT:	120764204(SHC1)

SATI:

136373009(SHC1)

FPG:	101919976(SHC1)

FCH:	102048929(SHC1)

CCRI:

104169019(SHC1)

SHAB:

115602564(SHC1)

ACUN:

113488759(SHC1)

TALA:

104368486(SHC1)

ACHC:

115345778(SHC1)

HLE:	104829653(SHC1)

AGEN:

126040820

CSTI:

104557197(SHC1)

LDI:	104345663(SHC1)

DPUB:

104310257(SHC1)

EGZ:	104127244(SHC1)

NNI:	104012052(SHC1)

PCRI:

104030563(SHC1)

PADL:

103922288(SHC1)

AFOR:

103905525(SHC1)

CLV:	102093713(SHC1)

PLET:

104618885(SHC1)

CUCA:

104065074(SHC1)

TEO:	104382695(SHC1)

CPEA:

104387520(SHC1)

CVF:	104286744(SHC1)

RTD:	128900875(SHC1)

AAM:

106483710

AROW:

112973269(SHC1)

NPD:	112955215(SHC1)

DNE:	112995804(SHC1)

SCAM:

104147743(SHC1)

ASN:	102376721(SHC1)

AMJ:	106737253(SHC1)

CPOO:

109324765(SHC1)

GGN:	109303877(SHC1)

PSS:	102457971(SHC1)

CMY:	102941809(SHC1)

CCAY:

125625917(SHC1)

DCC:	119847945(SHC1)

CPIC:

101952789(SHC1)

TST:	117888534(SHC1)

CABI:

116830123(SHC1)

MRV:	120390163(SHC1)

ACS:	100566335(shc1)

ASAO:

132764085(SHC1)

PVT:	110081020(SHC1)

SUND:

121915058(SHC1)

PBI:	103049298(SHC1)

PMUR:

107296691(SHC1)

CTIG:

120317081(SHC1)

TSR:	106537474(SHC1)

PGUT:

117658844(SHC1)

APRI:

131186587(SHC1)

PTEX:

113446695(SHC1)

VKO:	123032556(SHC1)

PMUA:

114586090(SHC1)

PRAF:

128404474(SHC1)

ZVI:	118075732(SHC1)

HCG:	128337514(SHC1)

GJA:	107117081(SHC1)

STOW:

125440647(SHC1)

EMC:	129339940(SHC1)

XLA:	108700442(shc1.S) 399198(shc1.L)

XTR:	116406911(shc1)

NPR:	108795195(SHC1)

RTEM:

120920621(SHC1)

BBUF:

120982018(SHC1)

MUO:	115458394(SHC1)

GSH:	117350024(SHC1)

DRE:	323818(shc1)

SRX:	107714692 107723450

SANH:

107673667(shc1) 107677023

SGH:	107582132 107594952(shc1)

CCAR:

109108120

CAUA:

113060226 113116470

CGIB:

127975200 128030709

PTET:

122361104(shc1)

LROH:

127178036(shc1)

OMC:	131522592(shc1)

PPRM:

120484361(shc1)

RKG:	130101945(shc1)

MAMB:

125244114(shc1)

CIDE:

127497924

CERY:

137035868(shc1)

MASI:

127452900 127453838

TROS:

130557460(shc1)

TDW:	130432343(shc1)

MANU:

129447953(shc1)

IPU:

108265869

IFU:	128607170(shc1)

PHYP:

113542402(shc1)

SMEO:

124384218(shc1)

TFD:	113646702(shc1)

TVC:	132846174(shc1)

TRN:	134310985(shc1)

AMEX:

103030808(shc1)

CMAO:

118823294(shc1)

EEE:	113590613(shc1)

CHAR:

105891930(shc1)

TRU:	101071954(shc1)

TFS:	130532015(shc1)

TNG:	GSTEN00033961G001

LCO:	104918187(shc1)

NCC:	104962177(shc1)

TBEN:

117480192(shc1)

CGOB:

115020898(shc1)

PGEO:

117460302(shc1)

GACU:

117553868(shc1)

EMAC:

134861829(shc1)

ELY:	117265729(shc1)

EFO:	125892594(shc1)

PLEP:

121945480(shc1)

SLUC:

116049544(shc1)

ECRA:

117946714(shc1)

ESP:	116691703(shc1)

PFLV:

114556600(shc1)

GAT:	120810662(shc1)

PPUG:

119197382(shc1)

AFB:	129109232(shc1)

CLUM:

117745760(shc1)

PSWI:

130212740(shc1)

MSAM:

119897594(shc1)

SCHU:

122882185(shc1)

CUD:	121513974(shc1)

ALAT:

119005783(shc1)

MZE:	101480827(shc1)

ONL:	100704980(shc1)

OAU:	116315698(shc1)

OLA:	101154895(shc1)

OML:	112143897(shc1)

CSAI:

133432211(shc1)

XMA:	102228847(shc1)

XCO:	114140972(shc1)

XHE:	116716789(shc1)

PRET:

103478162(shc1)

PFOR:

103140804(shc1)

PLAI:

106964507(shc1)

PMEI:

106916259(shc1)

GAF:	122830934(shc1)

PPRL:

129358025 129371203(shc1)

CVG:	107088415(shc1)

CTUL:

119786725(shc1)

GMU:	124865598(shc1)

NFU:	107379732(shc1)

KMR:	108241071(shc1)

ALIM:

106529899(shc1)

NWH:	119409401(shc1)

AOCE:

111566077(shc1)

MCEP:

125016060(shc1)

CSEM:

103388227(shc1)

POV:	109633454(shc1)

SSEN:

122774494(shc1)

HHIP:

117776519(shc1)

HSP:	118113543(shc1)

PPLT:

128449372(shc1)

SMAU:

118309118(shc1)

LCF:

108885949

SDU:	111230117(shc1)

SLAL:

111656972(shc1)

XGL:	120783842(shc1)

HCQ:	109521038(shc1)

SSCV:

125975384

SBIA:

133500406(shc1)

PEE:	133401243(shc1)

PTAO:

133479091(shc1)

BPEC:

110162980(shc1) 110173049(shc4)

MALB:

109964107(shc1)

BSPL:

114843588(shc1)

SJO:	128367075(shc1)

SASA:

106575570 106593005

STRU:

115176818 115186485

OTW:	112222667(shc1) 121841079

OMY:	110520788 110536161

OGO:

123998235

ONE:	115122691 115125349

OKI:	109888011 109901647

OKE:	118374980 118382829(shc1)

SALP:

111959065(shc1)

SNH:	120048816 120048880

CCLU:

121542715 121543201

ELS:	105024470(shc1)

SFM:	108925486(shc1)

PKI:	111848307(shc1)

AANG:

118222288(shc1) 118232709

LOC:	102684095(shc1)

PSPA:

121307017(shc1)

ARUT:

117395410(shc1)

PSEX:

120528097(shc1)

LCM:	102356771(SHC1)

HOC:

132808907

LERI:

129715661

PMRN:

116950676 116953603(SHC1)

LRJ:	133354191 133355129(SHC1)

BBEL:

109463526

CIN:

100181792

SCLV:

120342172

SPU:	100892028 578929

APLC:

110990360

SKO:

102802005

DME:	Dmel_CG3715(Shc)

DER:

6545643

DSE:

6605028

DSI:	Dsimw501_GD14181(Dsim_GD14181)

DYA:	Dyak_GE20839

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12075

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108360081 108377307 108383230

AOQ:

129244594

TDA:	119679180 119679182

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

109413081 115253778 115257693

ASUA:

134224847

CQU:	CpipJ_CPIJ006219

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105677602(Shc)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_201490

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106683317(Shc)

NLU:

111050810

HVI:

124354718

MQU:	128996482 128997003

PHU:	Phum_PHUM387540

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

PVM:	113812518 113830556

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

EAF:

LSM:

TCF:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

CSCU:

CVS:	136976403 136990101

PTEP:

107436767 107451463

ABRU:

129961852 129989406

UDV:	129224423 129227377

SDM:	118200363 118201766

LPOL:

106460297 106464620 106465580

PMEO:

129586995

CEL:	CELE_F54A5.3(shc-1)

CBR:	CBG_05128(Cbr-shc-1)

CRQ:	GCK72_001372

NAI:	NECAME_05438

LOA:	LOAG_17991

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CANU:

CVN:	111130165 111130271

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ADF:	107330508 107345345

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HSY:

SRE:	PTSG_05060 PTSG_07105

» show all

Reference

PMID:14665640

Authors

Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F

Title

Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.

Journal

J Biol Chem 279:13224-33 (2004)
DOI:10.1074/jbc.M307456200

Sequence

[hsa:6464]

Reference

PMID:1623525

Authors

Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG

Title

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.

Journal

Cell 70:93-104 (1992)
DOI:10.1016/0092-8674(92)90536-L

Sequence

[hsa:6464]

LinkDB

ORTHOLOGY: K17447

Entry

K17447                      KO

Symbol

SHC2

Name

SHC-transforming protein 2

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04370

VEGF signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04014 Ras signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04370 VEGF signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04072 Phospholipase D signaling pathway
    K17447  SHC2; SHC-transforming protein 2
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17447  SHC2; SHC-transforming protein 2
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17447  SHC2; SHC-transforming protein 2
   04062 Chemokine signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04915 Estrogen signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04917 Prolactin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04926 Relaxin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04935 Growth hormone synthesis, secretion and action
    K17447  SHC2; SHC-transforming protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17447  SHC2; SHC-transforming protein 2
   05226 Gastric cancer
    K17447  SHC2; SHC-transforming protein 2
   05214 Glioma
    K17447  SHC2; SHC-transforming protein 2
   05220 Chronic myeloid leukemia
    K17447  SHC2; SHC-transforming protein 2
   05224 Breast cancer
    K17447  SHC2; SHC-transforming protein 2
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17447  SHC2; SHC-transforming protein 2
  09165 Substance dependence
   05034 Alcoholism
    K17447  SHC2; SHC-transforming protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17447  SHC2; SHC-transforming protein 2
   01522 Endocrine resistance
    K17447  SHC2; SHC-transforming protein 2

Genes

HSA:	25759(SHC2)

PTR:	749831(SHC2)

PPS:	100974798(SHC2)

GGO:	101129046(SHC2)

PON:	100445042(SHC2)

PPYG:

129026077(SHC2)

NLE:	100591489(SHC2)

HMH:

116464630

SSYN:

129465500(SHC2)

MCC:	721021(SHC2)

MCF:	102125325(SHC2)

MTHB:

126942949

MNI:	105486618(SHC2)

CSAB:

103233559(SHC2)

CATY:

105591876(SHC2)

PANU:

101006054

TGE:	112612298(SHC2)

MLEU:

105548833(SHC2)

RBB:	108531776(SHC2) 108533994

TFN:	117074894(SHC2)

PTEH:

111528883(SHC2)

CANG:

105527663(SHC2)

CJC:	100415083(SHC2)

SBQ:	101048523(SHC2)

CIMI:

108297501(SHC2)

ANAN:

105706187(SHC2)

MMUR:

105860825(SHC2)

LCAT:

123632067(SHC2)

PCOQ:

105811228(SHC2)

OGA:	100957623(SHC2)

MMU:	216148(Shc2)

MCAL:

110303444(Shc2)

MPAH:

110326457(Shc2)

RNO:	314612(Shc2)

MCOC:

116076241(Shc2)

ANU:	117696653(Shc2)

MUN:	110551355(Shc2)

CGE:	100761269(Shc2)

MAUA:

101843435(Shc2)

PROB:

127216670(Shc2)

PLEU:

114684102(Shc2)

MORG:

121459499(Shc2)

MFOT:

126489227

AAMP:

119825434(Shc2)

NGI:	103737407(Shc2)

HGL:	101723930(Shc2)

CPOC:

100723025

CCAN:

109686083(Shc2)

DORD:

105990314(Shc2)

DSP:	122122823(Shc2)

PLOP:

125347922(Shc2)

NCAR:

124975378

MMMA:

107157391(Shc2)

OPI:	101522080(SHC2)

TUP:	102481863(SHC2)

GVR:	103600233(SHC2)

CFA:	611955(SHC2)

CLUD:

112666141(SHC2)

VVP:	112935467(SHC2)

VLG:	121494261(SHC2)

NPO:	129522289(SHC2)

AML:	100480694(SHC2)

UMR:	103681753(SHC2)

UAH:	113242690(SHC2)

UAR:

123794070

ELK:

111161808

LLV:

125087478

MPUF:

101692343(SHC2)

MNP:	132010667(SHC2)

MLK:	131823143(SHC2)

NVS:	122909991(SHC2)

ORO:	101384118(SHC2)

EJU:	114226321(SHC2)

ZCA:	113917867(SHC2)

MLX:	118004996(SHC2)

NSU:	110594105(SHC2)

LWW:	102727078(SHC2)

FCA:	101083489(SHC2)

PYU:	121021890(SHC2)

PCOO:

112852752(SHC2)

PBG:	122486600(SHC2)

PVIV:

125159758(SHC2)

LRUF:

124527699

PTG:	102954336(SHC2)

PPAD:

109257730(SHC2)

PUC:

125928763

AJU:

106978092

HHV:	120242345(SHC2)

BTA:	533455(SHC2)

BOM:	102281047(SHC2)

BIU:	109561056(SHC2)

BBUB:

102389953(SHC2)

BBIS:

104991966(SHC2)

CHX:	102169956(SHC2)

OAS:	101113847(SHC2)

BTAX:

128051196(SHC2)

ODA:	120864498(SHC2)

MBEZ:

129558379(SHC2)

SSC:	110259382(SHC2)

CFR:	102506382(SHC2)

CBAI:

105078342(SHC2)

CDK:	105093416(SHC2)

VPC:	102526634(SHC2)

BACU:

103006868(SHC2)

BMUS:

118893410(SHC2)

LVE:	103088833(SHC2)

OOR:	101275665(SHC2)

DLE:	111170483(SHC2)

PCAD:

102974315(SHC2)

PSIU:

116751918(SHC2)

NASI:

112396342(SHC2)

ECB:	100146209(SHC2)

EPZ:	103542441(SHC2)

EAI:	106834253(SHC2)

MYB:	102251506(SHC2)

MYD:	102752087(SHC2)

MMYO:

118659254(SHC2)

MDT:	132235316(SHC2)

PKL:	118711420(SHC2)

EFUS:

103294446(SHC2)

MNA:	107538554(SHC2)

DRO:	112312297(SHC2)

SHON:

118984370(SHC2)

AJM:	119044619(SHC2)

PDIC:

114504166(SHC2)

PHAS:

123813838(SHC2)

MMF:	118615745(SHC2)

PPAM:

129072430(SHC2)

HAI:	109390676(SHC2)

RFQ:	117037962(SHC2)

PALE:

102885958(SHC2)

PGIG:

120589513(SHC2)

PVP:	105302278(SHC2)

RAY:	107500961(SHC2)

MJV:	108391745(SHC2)

TOD:	119240463(SHC2)

SARA:

101550526(SHC2)

SETR:

126030826(SHC2)

TMU:

101359726

ETF:	101644867(SHC2)

DNM:	101447321(SHC2)

GAS:	123256803(SHC2)

SHR:	100917745(SHC2)

AFZ:

127545256

PCW:	110223483(SHC2)

TVP:	118858308(SHC2)

OAA:	100081397(SHC2)

GGA:	770341(SHC2)

PCOC:

116235831(SHC2)

MGP:	100538500(SHC2)

CJO:	107325668(SHC2)

TPAI:

128090392(SHC2)

LMUT:

125684893(SHC2)

NMEL:

110389019(SHC2)

APLA:

101803969(SHC2)

ACYG:

106049094(SHC2)

CATA:

118260038(SHC2)

AFUL:

116499186(SHC2)

TGU:	100217581(SHC2)

LSR:	110475781(SHC2)

SCAN:

103822026(SHC2)

PMOA:

120496007(SHC2)

OTC:	121341581(SHC2)

PRUF:

121361768(SHC2)

GFR:	102034643(SHC2)

FAB:	101815242(SHC2)

OMA:	130264447(SHC2)

PHI:	102100749(SHC2)

PMAJ:

107215430(SHC2)

CCAE:

111940286(SHC2)

CCW:	104697005(SHC2)

CBRC:

103622163(SHC2)

ETL:	114066416(SHC2)

ZAB:

102072622

ZLE:	135458912(SHC2)

SVG:	106857053(SHC2)

MMEA:

130580224(SHC2)

HRT:	120763362(SHC2)

SATI:

136371857(SHC2)

FPG:	101924524(SHC2)

FCH:	102049085(SHC2)

SHAB:

115618057(SHC2)

TALA:

116961635(SHC2)

ACHC:

115349526(SHC2)

HLE:	104829150(SHC2)

AGEN:

126041747

GCL:

127025457

CSTI:

104553408(SHC2)

MNB:	103767954(SHC2)

DPUB:

104300737(SHC2)

EGZ:	104124436(SHC2)

NNI:	104016320(SHC2)

PADL:

103923470(SHC2)

AFOR:

103899434(SHC2)

CLV:	102088882(SHC2)

CUCA:

104067731(SHC2)

TEO:	104376503(SHC2)

CPEA:

104392436(SHC2)

CVF:	104294391(SHC2)

RTD:	128900700(SHC2)

AAM:	106486386(SHC2)

AROW:

112973886(SHC2)

NPD:	112946874(SHC2)

DNE:	112988087(SHC2)

ASN:	102383911(SHC2)

AMJ:	102565747(SHC2)

GGN:	109294913(SHC2)

CMY:	102933759(SHC2)

CCAY:

125627065(SHC2)

DCC:	119848306(SHC2)

CPIC:

101944228(SHC2)

TST:	117868957(SHC2)

CABI:

116814882(SHC2)

MRV:	120391919(SHC2)

ACS:	100553545(shc2)

ASAO:

132781147(SHC2)

PVT:	110079278(SHC2)

SUND:

121937364(SHC2)

PBI:	103061599(SHC2)

PMUR:

107298759

CTIG:

120297060(SHC2)

PGUT:

117668639(SHC2)

APRI:

131188198(SHC2)

PTEX:

113434988(SHC2)

NSS:	113425094(SHC2)

VKO:	123036581(SHC2)

PMUA:

114588608(SHC2)

PRAF:

128405810(SHC2)

ZVI:	118087871(SHC2)

HCG:	128347884(SHC2)

GJA:	107110440(SHC2)

STOW:

125433261(SHC2)

EMC:	129329904(SHC2)

XLA:	108706896(shc2.S) 108713169(shc2.L)

XTR:	100487416(shc2)

NPR:	108790334(SHC2)

RTEM:

120910109(SHC2)

BBUF:

120991599(SHC2)

BGAR:

122930875(SHC2)

MUO:	115479981(SHC2)

GSH:	117365739(SHC2)

DRE:	562011(shc2)

SRX:	107719564 107729700

SANH:

107676975(shc2) 107699410

SGH:	107586398 107593314

CCAR:

109096032

CAUA:

113039600 113070302

CGIB:

127943197 127987888

PTET:

122327715(shc2)

LROH:

127153208(shc2)

OMC:	131530701(shc2)

PPRM:

120495450(shc2)

RKG:	130089176(shc2)

MAMB:

125263808(shc2)

CIDE:

127519729

CERY:

137027760(shc2)

MASI:

127438117 127439285

TROS:

130548718(shc2)

TDW:	130429330(shc2)

MANU:

129452610(shc2)

IPU:

108270761

IFU:	128613975(shc2)

PHYP:

113547084(shc2)

SMEO:

124391651(shc2)

TFD:	113646129(shc2)

TVC:	132841736(shc2)

TRN:	134331377(shc2)

AMEX:

103026451(shc2)

CMAO:

118819383(shc2)

EEE:	113587209(shc2)

CHAR:

105910744(shc2)

TRU:	101071160(shc2)

TFS:	130528532(shc2)

TNG:	GSTEN00028773G001

LCO:	104918475(shc2)

NCC:	104958981(shc2)

TBEN:

117495196(shc2)

CGOB:

115007109(shc2)

PGEO:

117445506(shc2)

GACU:

117550979(shc2)

EMAC:

134869118(shc2)

ELY:	117254016(shc2)

EFO:	125895735(shc2)

PLEP:

121938139(shc2)

SLUC:

116055201(shc2)

ECRA:

117950057(shc2)

ESP:

116696202

PFLV:

114561987(shc2)

GAT:	120823634(shc2)

PPUG:

119216728(shc2)

AFB:	129094479(shc2)

CLUM:

117729725(shc2)

MSAM:

119900775(shc2)

SCHU:

122877343(shc2)

CUD:	121512814(shc2)

ALAT:

119028931(shc2)

MZE:

101463941

ONL:

100696779

OAU:	116317325(shc2)

OLA:	101156242(shc2)

OML:	112150934(shc2)

CSAI:

133457791(shc2)

XMA:

102216631

XCO:

114150293

XHE:

116726316

PRET:

103463557(shc2)

PFOR:

103142600(shc2)

PLAI:

106947864(shc2)

PMEI:

106918340(shc2)

GAF:	122838868(shc2)

PPRL:

129372280(shc2)

CVG:	107085719(shc2)

CTUL:

119794273(shc2)

GMU:	124874121(shc2)

NFU:	107393200(shc2)

KMR:	108230757(shc2)

ALIM:

106530194(shc2)

NWH:	119407858(shc2)

AOCE:

111573492(shc2)

MCEP:

125009776(shc2)

CSEM:

103398231

POV:	109625730(shc2)

SSEN:

122780993(shc2)

HHIP:

117760743(shc2)

HSP:	118120944(shc2)

PPLT:

128447815(shc2)

SMAU:

118318508(shc2)

LCF:

108881424

SDU:

111232138

SLAL:

111654285

XGL:	120790651(shc2)

HCQ:

109532226

SSCV:

125971263

SBIA:

133503653(shc2)

PEE:	133406408(shc2)

PTAO:

133481173(shc2)

BPEC:

110167820(shc2)

MALB:

109964050

BSPL:

114854040(shc2)

SJO:	128361370(shc2)

SASA:

106584416 106613792

STRU:

115158273 115192606

OTW:	112235421 112250883

OMY:	110521457 110524319(shc2)

OGO:	123997551 124037680

ONE:	115108329 115144908

OKI:	109897869 109902523

OKE:	118359214 118389924

SALP:

111972117 111976010

SNH:	120052448(shc2) 120054467

CCLU:

121533510 121540343

ELS:	105011583(shc2)

SFM:	108919768(shc2)

PKI:	111860152(shc2)

AANG:

118226180(shc2)

LOC:

102690296

PSPA:

121301327(shc2)

ARUT:

117401420 117962910

PSEX:

120537706(shc2)

LCM:	102355047(SHC2)

CMK:

103182043

RTP:	109937865(shc2)

CPLA:

122565507(shc2)

HOC:	132828827(shc2)

LERI:

129711036(shc2)

ARUN:

IEL:

MCAF:

ATEN:

Reference

PMID:9507002

Authors

Nakamura T, Muraoka S, Sanokawa R, Mori N

Title

N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.

Journal

J Biol Chem 273:6960-7 (1998)
DOI:10.1074/jbc.273.12.6960

Sequence

[hsa:25759]

Reference

PMID:21658278

Authors

Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K

Title

Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.

Journal

Mol Brain 4:24 (2011)
DOI:10.1186/1756-6606-4-24

Sequence

[hsa:25759]

LinkDB

ORTHOLOGY: K17448

Entry

K17448                      KO

Symbol

SHC3

Name

SHC-transforming protein 3

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04014 Ras signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04072 Phospholipase D signaling pathway
    K17448  SHC3; SHC-transforming protein 3
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17448  SHC3; SHC-transforming protein 3
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17448  SHC3; SHC-transforming protein 3
   04062 Chemokine signaling pathway
    K17448  SHC3; SHC-transforming protein 3
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04915 Estrogen signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04917 Prolactin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04926 Relaxin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04935 Growth hormone synthesis, secretion and action
    K17448  SHC3; SHC-transforming protein 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17448  SHC3; SHC-transforming protein 3
   05226 Gastric cancer
    K17448  SHC3; SHC-transforming protein 3
   05214 Glioma
    K17448  SHC3; SHC-transforming protein 3
   05220 Chronic myeloid leukemia
    K17448  SHC3; SHC-transforming protein 3
   05224 Breast cancer
    K17448  SHC3; SHC-transforming protein 3
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17448  SHC3; SHC-transforming protein 3
  09165 Substance dependence
   05034 Alcoholism
    K17448  SHC3; SHC-transforming protein 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17448  SHC3; SHC-transforming protein 3
   01522 Endocrine resistance
    K17448  SHC3; SHC-transforming protein 3

Genes

HSA:	53358(SHC3)

PTR:	450176(SHC3)

PPS:	100972624(SHC3)

GGO:	101127418(SHC3)

PON:	100462011(SHC3)

PPYG:

129044343(SHC3)

NLE:	100589484(SHC3)

HMH:	116475219(SHC3)

SSYN:

129479239(SHC3)

MCC:	574275(SHC3)

MCF:	102130150(SHC3)

MTHB:

126937656

MNI:	105498803(SHC3)

CSAB:

103219725(SHC3)

CATY:

105584282(SHC3)

PANU:

101024393(SHC3)

TGE:	112608168(SHC3)

MLEU:

105535962(SHC3)

RRO:	104668515(SHC3)

RBB:	108532239(SHC3)

TFN:	117098366(SHC3)

PTEH:

111527961(SHC3)

CANG:

105516026(SHC3)

CJC:	100402406(SHC3)

SBQ:	101028764(SHC3)

CIMI:

108304324(SHC3)

ANAN:

105724608(SHC3)

CSYR:

103257751(SHC3)

MMUR:

105876163(SHC3)

LCAT:

123645857(SHC3)

PCOQ:

105817773(SHC3)

OGA:	100952749(SHC3)

MMU:	20418(Shc3)

MCAL:

110308134(Shc3)

MPAH:

110333751(Shc3)

RNO:	114858(Shc3)

MCOC:

116081462(Shc3)

ANU:	117713721(Shc3)

MUN:	110559069(Shc3)

CGE:	100760879(Shc3)

MAUA:

101832424(Shc3)

PROB:

127229241(Shc3)

PLEU:

114689488(Shc3)

MORG:

121445378 121453450

MFOT:

126502881

AAMP:

119817129(Shc3)

NGI:	103726215(Shc3)

HGL:	101715363(Shc3)

CPOC:

100732336(Shc3)

CCAN:

109675955(Shc3)

DORD:

105990929(Shc3)

DSP:	122113790(Shc3)

PLOP:

125355540(Shc3)

NCAR:

124965516

MMMA:

107157649(Shc3)

OCU:

100353992

OPI:	101522287(SHC3)

TUP:	102472295(SHC3)

GVR:	103608083(SHC3)

CFA:	476352(SHC3)

CLUD:

112644865(SHC3)

VVP:	112908627(SHC3)

VLG:	121485154(SHC3)

NPO:	129500459(SHC3)

AML:	100468080(SHC3)

UMR:	103663185(SHC3)

UAH:	113270120(SHC3)

UAR:	123776524(SHC3)

ELK:

111153623

LLV:

125083737

MPUF:

101676109(SHC3)

MNP:	132024896(SHC3)

MLK:	131812476(SHC3)

NVS:	122917799(SHC3)

ORO:	101375500(SHC3)

EJU:	114219804(SHC3)

ZCA:	113935041(SHC3)

MLX:	118026255(SHC3)

NSU:	110584374(SHC3)

LWW:	102739229(SHC3)

FCA:	101095865(SHC3)

PYU:	121013551(SHC3)

PCOO:

112868533(SHC3)

PBG:	122475305(SHC3)

PVIV:

125150616(SHC3)

LRUF:

124524856

PTG:	102965813(SHC3)

PPAD:

109275536(SHC3)

PUC:

125929330

AJU:

106987970

HHV:	120237954(SHC3)

BTA:	512696(SHC3)

BOM:	102268950(SHC3)

BIU:	109562580(SHC3)

BBUB:

102411865(SHC3)

BBIS:

104992086(SHC3)

CHX:	102189677(SHC3)

OAS:	101107936(SHC3)

BTAX:

128052614(SHC3)

ODA:	120861915(SHC3)

CCAD:

122431762(SHC3)

MBEZ:

129557186(SHC3)

SSC:	102164918(SHC3)

CFR:	102508169(SHC3)

CBAI:

105065419(SHC3)

CDK:	105086410(SHC3)

VPC:	102541852(SHC3)

BACU:

103017986(SHC3)

BMUS:

118896483(SHC3)

LVE:	103078122(SHC3)

OOR:	101280480(SHC3)

DLE:	111167641(SHC3)

PCAD:

102977456(SHC3)

PSIU:

116755660(SHC3)

NASI:

112390850(SHC3)

ECB:	100061926(SHC3)

EPZ:	103552516(SHC3)

EAI:	106841633(SHC3)

MYB:	102245983(SHC3)

MYD:	102772432(SHC3)

MMYO:

118652528(SHC3)

MLF:	102435382(SHC3)

MDT:	132211802(SHC3)

PKL:	118708684(SHC3)

EFUS:

103297925(SHC3)

MNA:	107529164(SHC3)

DRO:	112307260(SHC3)

SHON:

118993733(SHC3)

AJM:	119040940(SHC3)

PDIC:

114512532(SHC3)

PHAS:

123815569(SHC3)

MMF:	118629877(SHC3)

PPAM:

129082357(SHC3)

HAI:	109376923(SHC3)

RFQ:	117031898(SHC3)

PALE:

102879956(SHC3)

PGIG:

120594118(SHC3)

PVP:	105300265(SHC3)

RAY:	107504308(SHC3)

MJV:	108394387(SHC3)

TOD:	119231849(SHC3)

SARA:

101550468(SHC3)

SETR:

126003375(SHC3)

LAV:	100659669(SHC3)

TMU:

101360084

ETF:	101644193(SHC3)

DNM:	101417480(SHC3)

MDO:	100024603(SHC3)

GAS:	123231336(SHC3)

SHR:	100914800(SHC3)

AFZ:

127562429

PCW:	110223827(SHC3)

TVP:	118834894(SHC3)

GGA:	431265(SHC3)

PCOC:

116236693(SHC3)

CJO:	107306293(SHC3)

TPAI:

128089591(SHC3)

LMUT:

125687232(SHC3)

NMEL:

110390178(SHC3)

APLA:

101792705(SHC3)

ACYG:

106045108(SHC3)

CATA:

118259571(SHC3)

AFUL:

116500840(SHC3)

TGU:	100221851(SHC3)

LSR:	110470634(SHC3)

SCAN:

103821251(SHC3)

PMOA:

120509461(SHC3)

OTC:	121332732(SHC3)

PRUF:

121363937(SHC3)

GFR:	102039603(SHC3)

FAB:	101820104(SHC3)

OMA:	130265527(SHC3)

PHI:	102110162(SHC3)

PMAJ:

107216331(SHC3)

CCAE:

111941731(SHC3)

CCW:	104689719(SHC3)

CBRC:

103621374(SHC3)

ETL:	114061143(SHC3)

ZAB:	102068447(SHC3)

ZLE:	135459293(SHC3)

ACHL:

103808012(SHC3)

SVG:	106848871(SHC3)

MMEA:

130584683(SHC3)

HRT:	120765905(SHC3)

SATI:

136374400(SHC3)

FPG:	101913271(SHC3)

FCH:	102053453(SHC3)

CCRI:

104158850(SHC3)

NNT:	104401767(SHC3)

SHAB:

115600820(SHC3)

ACUN:

113490173(SHC3)

TALA:

104357645(SHC3)

ACHC:

115337159(SHC3)

HALD:

104319776(SHC3)

HLE:	104832480(SHC3)

AGEN:

126036635

GCL:

127027510

CSTI:

104561284(SHC3)

LDI:	104343238(SHC3)

MNB:	103777600(SHC3)

DPUB:

104296823(SHC3)

AVIT:

104274577(SHC3)

BRHI:

104495386(SHC3)

EGZ:	104126913(SHC3)

NNI:	104009737(SHC3)

PCRI:

104029588(SHC3)

PCAO:

104045338(SHC3)

PADL:

103921606(SHC3)

AFOR:

103900860(SHC3)

FGA:	104083819(SHC3)

GSTE:

104256868(SHC3)

CLV:	102091397(SHC3)

MUI:	104537582(SHC3)

PGUU:

104465733(SHC3)

PLET:

104619623(SHC3)

EHS:	104511251(SHC3)

CMAC:

104474491(SHC3)

CUCA:

104064071(SHC3)

TEO:	104382052(SHC3)

BREG:

104634670(SHC3)

OHA:	104331392(SHC3)

ACAR:

104528759(SHC3)

CPEA:

104387006(SHC3)

CVF:	104287014(SHC3)

RTD:	128902647(SHC3)

AAM:	106495478(SHC3)

AROW:

112965253(SHC3)

NPD:	112959236(SHC3)

TGT:	104580452(SHC3)

DNE:	112978778(SHC3)

SCAM:

104150288(SHC3)

ASN:	102374227(SHC3)

AMJ:	102574737(SHC3)

CPOO:

109323712(SHC3)

GGN:	109297521(SHC3)

PSS:	102449148(SHC3)

CMY:	102938973(SHC3)

CCAY:

125636728(SHC3)

DCC:	119856341(SHC3)

CPIC:

101943152(SHC3)

TST:	117879421(SHC3)

CABI:

116820123(SHC3)

MRV:	120407261(SHC3)

ACS:	100560033(shc3)

ASAO:

132767282(SHC3)

PVT:	110080566(SHC3)

SUND:

121923451(SHC3)

PBI:	103061531(SHC3)

PMUR:

107293823(SHC3)

CTIG:

120316152(SHC3)

TSR:	106543844(SHC3)

PGUT:

117661352(SHC3)

APRI:

131193358(SHC3)

PTEX:

113438512(SHC3)

NSS:	113414290(SHC3)

VKO:	123031493(SHC3)

PMUA:

114606494(SHC3)

PRAF:

128423236(SHC3)

ZVI:	118076970(SHC3)

HCG:	128346323(SHC3)

GJA:	107108634(SHC3)

STOW:

125436789(SHC3)

EMC:	129335216(SHC3)

XLA:	108706999 108714850

XTR:	100101768(shc3)

NPR:	108792509(SHC3)

RTEM:

120941594(SHC3)

BBUF:

120991487(SHC3)

BGAR:

122932862(SHC3)

MUO:	115463262(SHC3)

GSH:	117352322(SHC3)

DRE:	100332111(shc3)

SRX:	107713521(shc3) 107731079

SANH:

107653345 107675707

SGH:	107585661 107599382

CCAR:

109108077

CAUA:

113038997 113039148 113064459

CGIB:

127942206 127985828

PTET:

122332578(shc3)

LROH:

127152212(shc3)

OMC:	131528767(shc3)

PPRM:

120471251(shc3)

RKG:	130073035(shc3)

MAMB:

125252380(shc3)

CIDE:

127503996

CERY:

137012826(shc3)

MASI:

127429246 127430834

TROS:

130570122(shc3)

TDW:	130407777(shc3)

MANU:

129423808(shc3)

IPU:	108279345(shc3)

IFU:	128622479(shc3)

PHYP:

113535807

SMEO:

124398433(shc3)

TFD:	113646387(shc3)

TVC:	132859926(shc3)

TRN:	134330679(shc3)

AMEX:

103034159(shc3)

CMAO:

118820670(shc3)

EEE:

113573720

CHAR:

105911487(shc3)

TRU:

101074404

TFS:	130517765(shc3)

TNG:	GSTEN00034719G001

LCO:	104928532(shc3)

NCC:	104940972(shc3)

TBEN:

117476810(shc3)

CGOB:

115016959(shc3)

PGEO:

117456357(shc3)

GACU:

117538998(shc3)

EMAC:

134867979(shc3)

ELY:	117269992(shc3)

EFO:	125905484(shc3)

PLEP:

121960165(shc3)

SLUC:

116062835(shc3)

ECRA:

117959810(shc3)

ESP:	116704435(shc3)

PFLV:

114571470(shc3)

GAT:	120831599(shc3)

PPUG:

119226750(shc3)

AFB:	129102605(shc3)

CLUM:

117740595(shc3)

PSWI:

130205466(shc3)

MSAM:

119914153(shc3) 119915020

SCHU:

122865784(shc3)

CUD:	121525455(shc3)

ALAT:

119030496(shc3)

MZE:

101471658

ONL:

100703092

OAU:	116331844(shc3)

OLA:	101174847(shc3)

OML:	112163126(shc3)

CSAI:

133454532(shc3)

XMA:

102217649

XCO:	114149224(shc3)

XHE:	116724009(shc3)

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122819636(shc3)

PPRL:

129366485(shc3)

CVG:	107085834(shc3)

CTUL:

119789839(shc3)

GMU:	124872742(shc3)

NFU:	107374683(shc3)

KMR:	108231103(shc3)

ALIM:

106534007(shc3)

NWH:	119424705(shc3)

AOCE:

111585351(shc3)

MCEP:

124997099(shc3)

CSEM:

103390284(shc3)

POV:

109642612

SSEN:

122760760(shc3)

HHIP:

117771278(shc3)

HSP:	118098019(shc3)

PPLT:

128425391(shc3)

SMAU:

118284822(shc3)

LCF:

108874038

SDU:	111234683(shc3)

SLAL:

111664807(shc3)

XGL:	120806701(shc3)

HCQ:	109523621(shc3)

SSCV:

125979601

SBIA:

133490578(shc3)

PEE:	133414206(shc3)

PTAO:

133490346(shc3)

BPEC:

110160455

MALB:

109960608

BSPL:

114866659(shc3)

SJO:	128380306(shc3)

SASA:

106568489(shc3)

STRU:

115149458(shc3)

OTW:	112257355(shc3)

OMY:	110536941(shc3)

OGO:	124000022(shc3)

ONE:

115106013

OKI:	109893621(shc3)

OKE:	118372967(shc3)

SALP:

111980239

SNH:	120044764(shc3)

CCLU:

121573424 121582728

ELS:	105031363(shc3)

SFM:	108932838(shc3)

PKI:	111833617(shc3)

AANG:

118213341(shc3)

LOC:	102685302(shc3)

PSPA:

121302023 121315808

ARUT:

117409208 117962916

PSEX:

120532944(shc3)

LCM:	102362793(SHC3)

CMK:

103182842

RTP:	109919981(shc3)

CPLA:

122561732

HOC:	132825937(shc3)

LERI:

129695696(shc3)

AGIF:

122857946

» show all

Reference

PMID:8808684

Authors

Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N

Title

N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.

Journal

Oncogene 13:1111-21 (1996)

Sequence

[hsa:53358]

LinkDB

ORTHOLOGY: K17449

Entry

K17449                      KO

Symbol

SHC4

Name

SHC-transforming protein 4

Pathway

map01521

EGFR tyrosine kinase inhibitor resistance

map01522

Endocrine resistance

map04012

ErbB signaling pathway

map04014

Ras signaling pathway

map04062

Chemokine signaling pathway

map04072

Phospholipase D signaling pathway

map04510

Focal adhesion

map04650

Natural killer cell mediated cytotoxicity

map04722

Neurotrophin signaling pathway

map04910

Insulin signaling pathway

map04915

Estrogen signaling pathway

map04917

Prolactin signaling pathway

map04926

Relaxin signaling pathway

map04935

Growth hormone synthesis, secretion and action

map05034

Alcoholism

map05100

Bacterial invasion of epithelial cells

map05206

MicroRNAs in cancer

map05214

Glioma

map05220

Chronic myeloid leukemia

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04014 Ras signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04072 Phospholipase D signaling pathway
    K17449  SHC4; SHC-transforming protein 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17449  SHC4; SHC-transforming protein 4
09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17449  SHC4; SHC-transforming protein 4
   04062 Chemokine signaling pathway
    K17449  SHC4; SHC-transforming protein 4
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04915 Estrogen signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04917 Prolactin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04926 Relaxin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04935 Growth hormone synthesis, secretion and action
    K17449  SHC4; SHC-transforming protein 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K17449  SHC4; SHC-transforming protein 4
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17449  SHC4; SHC-transforming protein 4
   05226 Gastric cancer
    K17449  SHC4; SHC-transforming protein 4
   05214 Glioma
    K17449  SHC4; SHC-transforming protein 4
   05220 Chronic myeloid leukemia
    K17449  SHC4; SHC-transforming protein 4
   05224 Breast cancer
    K17449  SHC4; SHC-transforming protein 4
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17449  SHC4; SHC-transforming protein 4
  09165 Substance dependence
   05034 Alcoholism
    K17449  SHC4; SHC-transforming protein 4
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17449  SHC4; SHC-transforming protein 4
   01522 Endocrine resistance
    K17449  SHC4; SHC-transforming protein 4

Genes

HSA:	399694(SHC4)

PTR:	453414(SHC4)

PPS:	100991042(SHC4)

GGO:	101154420(SHC4)

PON:	100431574(SHC4)

PPYG:

129014141(SHC4)

NLE:	100591644(SHC4)

HMH:	116481523(SHC4)

SSYN:

129482743(SHC4)

MCC:	714611(SHC4)

MCF:	102130383(SHC4)

MTHB:

126958692

MNI:	105490670(SHC4)

CSAB:

103245659(SHC4)

CATY:

105588205(SHC4)

PANU:

101014651 116272720 116272724 116272729 116272733 116272789

TGE:	112627393(SHC4)

MLEU:

105529990(SHC4)

RRO:	104657941(SHC4)

RBB:	108530104(SHC4)

TFN:	117070688(SHC4)

PTEH:

111552722(SHC4)

CANG:

105502189(SHC4)

CJC:	100392220(SHC4)

SBQ:	101032627(SHC4)

CIMI:

108315604(SHC4)

ANAN:

105710105(SHC4)

CSYR:

103272388(SHC4)

MMUR:

105870730(SHC4)

LCAT:

123622389(SHC4)

PCOQ:

105814299(SHC4)

OGA:	100945538(SHC4)

MMU:	271849(Shc4)

MCAL:

110289726(Shc4)

MPAH:

110318126(Shc4)

RNO:	679845(Shc4)

MCOC:

116090849(Shc4)

ANU:	117704137(Shc4)

MUN:	110550937(Shc4)

CGE:	100763505(Shc4)

MAUA:

101841602(Shc4)

PROB:

127221520(Shc4)

PLEU:

114683897(Shc4)

MORG:

121465649(Shc4)

MFOT:

126496689

AAMP:

119815646(Shc4)

NGI:	103733036(Shc4)

HGL:	101717788(Shc4)

CPOC:

100717842(Shc4)

CCAN:

109684252(Shc4)

DORD:

105980977(Shc4)

DSP:	122114464(Shc4)

PLOP:

125340436(Shc4)

NCAR:

124978227

MMMA:

107138120(Shc4)

OCU:

100350676

OPI:	101535980(SHC4)

TUP:	102479734(SHC4)

GVR:	103587215(SHC4)

CFA:	487546(SHC4)

CLUD:

112675960(SHC4)

VVP:	112920045(SHC4)

VLG:	121485135(SHC4)

NPO:	129506392(SHC4)

AML:	100475137(SHC4)

UMR:	103676722(SHC4)

UAH:	113269597(SHC4)

UAR:	123801854(SHC4)

ELK:

111162137

LLV:

125105042

MPUF:

101689202(SHC4)

MNP:	131999737(SHC4)

MLK:	131836254(SHC4)

NVS:	122893234(SHC4)

ORO:	101375729(SHC4)

EJU:	114206514(SHC4)

ZCA:	113909494(SHC4)

MLX:	118002971(SHC4)

NSU:	110584023(SHC4)

LWW:	102732584(SHC4)

FCA:	101099050(SHC4)

PYU:	121041673(SHC4)

PCOO:

112856265(SHC4)

PBG:	122468671(SHC4)

PVIV:

125168731(SHC4)

LRUF:

124508608

PTG:	102955115(SHC4)

PPAD:

109263016(SHC4)

PUC:

125909988

AJU:

106967221

HHV:	120220858(SHC4)

BTA:	524734(SHC4)

BOM:	102284488(SHC4)

BIU:	109565147(SHC4)

BBUB:

102406154(SHC4)

BBIS:

104988263(SHC4)

CHX:	102179773(SHC4)

OAS:	101110241(SHC4)

BTAX:

128054009(SHC4)

ODA:	120852962(SHC4)

CCAD:

122443633(SHC4)

MBEZ:

129562932(SHC4)

SSC:	100526147(SHC4)

CFR:	102517753(SHC4)

CBAI:

105077007(SHC4)

CDK:	105104832(SHC4)

VPC:	102528702(SHC4)

BACU:

102999132(SHC4)

BMUS:

118890587(SHC4)

LVE:	103088900(SHC4)

OOR:	101289594(SHC4)

DLE:	111181617(SHC4)

PCAD:

102988652(SHC4)

PSIU:

116749591(SHC4)

NASI:

112402165(SHC4)

ECB:	100055699(SHC4)

EPZ:	103551857(SHC4)

EAI:	106838625(SHC4)

MYB:	102239285(SHC4)

MYD:	102762219(SHC4)

MMYO:

118651538(SHC4)

MLF:	102431548(SHC4)

MDT:	132237519(SHC4)

PKL:	118721624(SHC4)

EFUS:

103287410(SHC4)

MNA:	107535558(SHC4)

DRO:	112311774(SHC4)

SHON:

118992600(SHC4)

AJM:	119057612(SHC4)

PDIC:

114492960(SHC4)

PHAS:

123808639(SHC4)

MMF:	118631532(SHC4)

PPAM:

129064266(SHC4)

HAI:	109394486(SHC4)

RFQ:	117023566(SHC4)

PALE:

102888926(SHC4)

PGIG:

120622672(SHC4)

PVP:	105288811(SHC4)

RAY:	107519965(SHC4)

MJV:	108402352(SHC4)

TOD:	119238599(SHC4)

SARA:

101537303(SHC4)

SETR:

126020007(SHC4)

LAV:	100654827(SHC4)

TMU:

101355900

ETF:	101654517(SHC4)

DNM:	101422617(SHC4)

MDO:	100031128(SHC4)

GAS:	123234105(SHC4)

SHR:	100927458(SHC4)

AFZ:

127551137

PCW:	110201503(SHC4)

TVP:	118828960(SHC4)

GGA:	426482(SHC4)

PCOC:

116225316(SHC4)

MGP:	100541111(SHC4)

CJO:	107318783(SHC4)

TPAI:

128075375(SHC4)

LMUT:

125698401(SHC4)

NMEL:

110403695(SHC4)

APLA:

101797165(SHC4)

ACYG:

106033799(SHC4)

CATA:

118251605(SHC4)

AFUL:

116493314(SHC4)

TGU:	100226451(SHC4)

LSR:	110474245(SHC4)

SCAN:

103816021(SHC4)

PMOA:

120509194(SHC4)

OTC:	121343474(SHC4)

PRUF:

121354436(SHC4)

GFR:	102037367(SHC4)

FAB:	101809679(SHC4)

OMA:	130257341(SHC4)

PHI:	102103363(SHC4)

PMAJ:

107209575(SHC4)

CCAE:

111934113(SHC4)

CCW:	104683990(SHC4)

CBRC:

103621260(SHC4)

ETL:	114059944(SHC4)

ZAB:	102067308(SHC4)

ZLE:	135452305(SHC4)

ACHL:

103798302(SHC4)

SVG:	106860078(SHC4)

MMEA:

130575771(SHC4)

HRT:	120758926(SHC4)

SATI:

136367052(SHC4)

FPG:	101914295(SHC4)

FCH:	102053624(SHC4)

CCRI:

104161587(SHC4)

NNT:	104411986(SHC4)

SHAB:

115613139(SHC4)

ACUN:

113484090(SHC4)

TALA:

104357518(SHC4)

ACHC:

115341918(SHC4)

HALD:

104315604(SHC4)

HLE:	104834500(SHC4)

AGEN:

126043703

GCL:

127020528

CSTI:

104556641(SHC4)

LDI:	104346282(SHC4)

MNB:	103776604(SHC4)

DPUB:

104297382(SHC4)

AVIT:

104274922(SHC4)

BRHI:

104500250(SHC4)

EGZ:	104130918(SHC4)

NNI:	104017130(SHC4)

PCRI:

104035380

PADL:

103922748(SHC4)

AFOR:

103896621(SHC4)

FGA:	104082118(SHC4)

GSTE:

104264988(SHC4)

CLV:	102088829(SHC4)

MUI:	104546219(SHC4)

PGUU:

104464437(SHC4)

PLET:

104614810(SHC4)

EHS:	104516719(SHC4)

CMAC:

104487484(SHC4)

CUCA:

104055747(SHC4)

TEO:	104382566(SHC4)

BREG:

104637341(SHC4)

OHA:	104334595(SHC4)

ACAR:

104522621(SHC4)

CPEA:

104386019(SHC4)

CVF:	104287431(SHC4)

RTD:	128915243(SHC4)

AAM:	106496580(SHC4)

AROW:

112963474(SHC4)

NPD:	112952858(SHC4)

TGT:	104569525(SHC4)

DNE:	112981447(SHC4)

SCAM:

104148257(SHC4)

ASN:	102383468(SHC4)

AMJ:	102568049(SHC4)

CPOO:

109309042(SHC4)

GGN:	109288589(SHC4)

PSS:	102455357(SHC4)

CMY:	102934651(SHC4)

CCAY:

125644095(SHC4)

DCC:	119862189(SHC4)

CPIC:

101946426(SHC4)

TST:	117884252(SHC4)

CABI:

116814983(SHC4)

MRV:	120372994(SHC4)

ACS:	100560740(shc4)

ASAO:

132762381(SHC4)

PVT:	110077281(SHC4)

SUND:

121933468(SHC4)

PBI:	103055438(SHC4)

PMUR:

107287682(SHC4)

CTIG:

120315185(SHC4)

PGUT:

117675742(SHC4)

APRI:

131184796(SHC4)

PTEX:

113442312(SHC4)

NSS:	113418294(SHC4)

VKO:	123027782(SHC4)

PMUA:

114584523(SHC4)

PRAF:

128401621(SHC4)

ZVI:	118092793(SHC4)

HCG:	128335158(SHC4)

GJA:	107124453(SHC4)

EMC:	129345563(SHC4)

XLA:	108711398(shc4.L) 108712318(shc4.S)

XTR:	100490718(shc4)

NPR:	108792188(SHC4)

RTEM:

120931328(SHC4)

BBUF:

120985832(SHC4)

BGAR:

122927622(SHC4)

MUO:	115460653(SHC4)

GSH:	117348271(SHC4)

CHAR:

105889012

TRU:	105417270(shc4)

TFS:

130516637

LCO:	109136640(shc4)

TBEN:

117471585

CGOB:

115023683(shc4)

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116703619(shc4)

PFLV:

114556819(shc4)

GAT:

PPUG:

AFB:

CLUM:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101474172(shc4)

ONL:	100701320(shc4)

OAU:

116311729

OLA:	101170912(shc4)

OML:

112160361

CSAI:

133420018

XMA:	102222349(shc4)

XCO:	114142814(shc4)

XHE:	116719254(shc4)

PRET:

103462081(shc4)

PFOR:

103146152(shc4)

PLAI:

106935451(shc4)

PMEI:

106904493(shc4)

GAF:

122841451

PPRL:

129369591

CVG:	107085339(shc4)

CTUL:

119782435

GMU:

124867254

NFU:	107381724(shc4)

AOCE:

111565759(shc4)

MCEP:

125005205

CSEM:

103379110(shc4)

POV:	109637245(shc4)

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:	111238681(shc4)

SLAL:

111661140(shc4)

XGL:

120792101

HCQ:	109525729(shc4)

SSCV:

SBIA:

PEE:

PTAO:

SJO:

SFM:

PKI:	111844965(shc4)

AANG:

118227959

LOC:	102684593(shc4)

PSPA:

121294465 121298902

ARUT:

117428494 117429071

PSEX:

120539955

LCM:	102354432(SHC4)

CMK:

CPLA:

HOC:

LERI:

MMER:

Reference

PMID:17409413

Authors

Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L

Title

RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.

Journal

Cancer Res 67:3064-73 (2007)
DOI:10.1158/0008-5472.CAN-06-2301

Sequence

[hsa:399694]

Reference

PMID:17452444

Authors

Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T

Title

Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.

Journal

Mol Cell Biol 27:4759-73 (2007)
DOI:10.1128/MCB.00184-07

Sequence

[hsa:399694]

LinkDB

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