KEGG ORTHOLOGY: K24496

ORTHOLOGY: K24496

Entry

K24496                      KO

Symbol

NPHS1

Name

nephrin

Disease

H01657

Nephrotic syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K24496  NPHS1; nephrin
Domain-containing proteins not elsewhere classified [BR:ko04990]
Fibronectin (FN) domain-containing proteins
  Fibronectin type III domain-containing proteins
   K24496  NPHS1; nephrin

Genes

HSA:	4868(NPHS1)

PTR:	468841(NPHS1)

PPS:	100982087(NPHS1)

GGO:	101123744(NPHS1)

PON:	100449007(NPHS1)

PPYG:

129019527(NPHS1)

NLE:	100583583(NPHS1)

HMH:	116479636(NPHS1)

SSYN:

129459905(NPHS1)

MCC:	106996059 114670312 114675763 718929(NPHS1)

MCF:	102120468 107127882(NPHS1) 135965560

MTHB:

126929262 126941946

MNI:	105495497(NPHS1)

CSAB:

103234542(NPHS1)

CATY:

105578195(NPHS1)

PANU:

101017014 101021992(NPHS1)

MLEU:

105543102(NPHS1)

RRO:	104666694(NPHS1) 104666999

TFN:	117087158 117092380(NPHS1) 117093538

PTEH:

113222610(NPHS1)

CANG:

105516229(NPHS1)

CJC:	100392294(NPHS1)

SBQ:	101052075(NPHS1)

CIMI:

108298521(NPHS1)

ANAN:

105706981(NPHS1)

CSYR:

103249684(NPHS1)

MMUR:

105876904(NPHS1)

LCAT:

123624453(NPHS1)

ERUF:

138374759(NPHS1)

PCOQ:

105816166(NPHS1)

OGA:	105887613(NPHS1)

MMU:	54631(Nphs1)

MCAL:

110297673(Nphs1)

MPAH:

110327198(Nphs1)

RNO:	64563(Nphs1)

MCOC:

116100440(Nphs1)

ANU:	117717874(Nphs1)

ASYL:

127671649(Nphs1)

MUN:	110550893(Nphs1)

CGE:	100773617(Nphs1)

MAUA:

101839599(Nphs1)

PROB:

127238437(Nphs1)

PLEU:

114681669(Nphs1)

PMAV:

102917652(Nphs1)

MORG:

121449639(Nphs1)

MFOT:

126486733

AAMP:

119821106(Nphs1)

NGI:	103729942(Nphs1)

HGL:	101705086(Nphs1)

CPOC:

100713185(Nphs1)

CCAN:

109689282(Nphs1)

DORD:

105993124(Nphs1)

DSP:	122097465(Nphs1)

DMER:

138811095(Nphs1)

PLOP:

125368010(Nphs1)

NCAR:

124966336

MMMA:

107151748(Nphs1)

ITI:	101962020(Nphs1)

OCU:

100354996

OPI:	101536537(NPHS1)

OCZ:	121153885(NPHS1)

TUP:	102478645(NPHS1)

GVR:	103592817(NPHS1)

CFA:	484571(NPHS1)

CLUD:

112643524(NPHS1)

VVP:	112928471(NPHS1)

VLG:	121480173(NPHS1)

NPO:	129500428(NPHS1)

AML:	100466832(NPHS1)

UMR:	103682524(NPHS1)

UAH:	113244761(NPHS1)

UAR:	123793903(NPHS1)

ELK:

111161575

LLV:

125088369

MPUF:

101671776(NPHS1)

MNP:	132005317(NPHS1)

MLK:	131818541(NPHS1)

NVS:	122911570(NPHS1)

ORO:	101380280(NPHS1)

EJU:	114224362(NPHS1)

ZCA:	113935552(NPHS1)

MLX:	118022791(NPHS1)

NSU:	110590089(NPHS1)

LWW:	102733797(NPHS1)

FCA:	101101018(NPHS1)

PYU:	121011542(NPHS1)

PCOO:

112851007(NPHS1)

PBG:	122495066(NPHS1)

PVIV:

125153622(NPHS1)

LRUF:

124511942

LGF:	123578210(NPHS1)

AJU:

106974743

PTG:	102964217(NPHS1)

PPAD:

109251504(NPHS1)

PUC:

125915797

PLEZ:

122208269(NPHS1)

HHV:	120243514(NPHS1)

BTA:	519706(NPHS1)

BOM:	102279035(NPHS1)

BIU:	109572326(NPHS1)

BBUB:

102408360(NPHS1)

BBIS:

104995260(NPHS1)

CHX:	102173409(NPHS1)

OAS:	101115895(NPHS1)

BTAX:

128063628(NPHS1)

CSUM:

138096600(NPHS1)

ODA:	120872606(NPHS1)

CCAD:

122421380(NPHS1)

MREE:

136161183(NPHS1)

OVR:	110123623(NPHS1)

MBEZ:

129546061(NPHS1)

SSC:	100622946(NPHS1)

CFR:	102519807(NPHS1)

CBAI:

105065104(NPHS1)

CDK:	105088062(NPHS1)

VPC:	102539309(NPHS1)

BACU:

103020804(NPHS1)

BMUS:

118884799(NPHS1)

LVE:	103076086(NPHS1)

OOR:	101287446(NPHS1)

LALB:

132510279(NPHS1)

GMF:	115862570(NPHS1)

DDP:	132416030(NPHS1)

DLE:	111180548(NPHS1)

PCAD:

102989131(NPHS1)

PSIU:

116744555(NPHS1)

PPHC:

136140265(NPHS1)

NASI:

112392226(NPHS1)

ECB:	100147013(NPHS1)

EPZ:	103566805(NPHS1)

EAI:	106829153(NPHS1)

MYB:	102242721(NPHS1)

MYD:	102760743(NPHS1)

MMYO:

118674816(NPHS1)

MLF:	102420476(NPHS1)

MDT:	132216364(NPHS1)

MYUM:

138996729(NPHS1)

PKL:	118720610(NPHS1)

EFUS:

103284520(NPHS1)

MNA:	107543370(NPHS1)

DRO:	112320159(NPHS1)

SHON:

118982560(NPHS1)

AJM:	119044200(NPHS1)

PDIC:

114511709(NPHS1)

PHAS:

123823773(NPHS1)

MMF:	118638955(NPHS1)

PPAM:

129083103(NPHS1)

HAI:	109372013(NPHS1)

RFQ:	117034920(NPHS1)

PALE:

102896148(NPHS1)

PGIG:

120592439(NPHS1)

PVP:	105306656(NPHS1)

RAY:	107497663(NPHS1)

MJV:	108401531(NPHS1)

TOD:	119250255(NPHS1)

SARA:

101538761(NPHS1)

SFUM:

130044017(NPHS1)

SETR:

126028492(NPHS1)

LAV:	100665179(NPHS1)

TMU:

101345161

ETF:	101660203(NPHS1)

DNM:	101430106(NPHS1)

MDO:	100016152(NPHS1)

GAS:	123240076(NPHS1)

SHR:	100927411(NPHS1)

AFZ:

127556063

PCW:	110201361(NPHS1)

TVP:	118839021(NPHS1)

PBRV:

138154159(NPHS1)

MLAO:

141509372(NPHS1)

OAA:	103168942(NPHS1)

TACU:

119945723(NPHS1)

PRUF:

121364113

OMA:	130262705(NPHS1)

ACOE:

138101526(NPHS1)

ZLE:

135441582

CCIC:

134055862

HHAR:

128138395(NPHS1)

BBUT:

142026001(NPHS1)

CBOR:

142074372 142077452

CBOY:

140644984(NPHS1)

MAME:

142403307(NPHS1)

CNIC:

136000656(NPHS1)

RTD:	128903915(NPHS1)

ASN:	102381936(NPHS1)

AMJ:	102572209(NPHS1)

PSS:	102455361(NPHS1)

CIZ:	142003739(NPHS1)

CMY:	102930154(NPHS1)

LKP:	140902470(NPHS1)

NDS:	141977467(NPHS1)

DCC:	119847614(NPHS1)

CPIC:

101948649(NPHS1)

TST:	117869828(NPHS1)

CABI:

116818447(NPHS1)

MRV:	120390612(NPHS1)

ACS:	100555423(nphs1)

ASAO:

132780663(NPHS1)

PVT:	110070504(NPHS1)

SUND:

121915498(NPHS1)

PBI:	103068118(NPHS1)

PMUR:

107288354(NPHS1)

CTIG:

120300153(NPHS1)

TSR:	106555575(NPHS1)

PGUT:

117669318(NPHS1)

PCAE:

139321092(NPHS1)

APRI:

131204718(NPHS1)

PTEX:

113437674(NPHS1)

NSS:	113427305(NPHS1)

VKO:	123026028(NPHS1)

PMUA:

114602891 114602892(NPHS1)

PRAF:

128418573(NPHS1)

ZVI:	118086747(NPHS1)

HCG:	128333075(NPHS1)

GJA:	107108173(NPHS1)

STOW:

125435440(NPHS1)

EMC:	129342934(NPHS1)

XLA:	734213(nphs1.S)

XTR:	100494620(nphs1)

NPR:	108798923(NPHS1)

RTEM:

120916228(NPHS1)

ACAT:

141110308(NPHS1)

PADS:

140340413(NPHS1)

BBUF:

120993721(NPHS1)

BGAR:

122927083(NPHS1)

DTC:	141085208(NPHS1)

PWL:	138246481(NPHS1)

MUO:	115476625(NPHS1)

GSH:	117345796(NPHS1)

DRE:	692352(nphs1)

SRX:

107755383

SANH:

107694805 107704689

SGH:

107582260

CCAR:

109068035(nphs1)

CAUA:

113085420 113099206

CGIB:

128028566

PTET:

122359595(nphs1)

LROH:

127176997(nphs1)

OMC:	131520417(nphs1)

PPRM:

120478714(nphs1)

RKG:	130077930(nphs1)

MAMB:

125249535(nphs1)

CIDE:

127495664

CERY:

137004904(nphs1)

MASI:

127429843

TROS:

130564941(nphs1)

TDW:	130429251(nphs1)

MANU:

129438367(nphs1)

PDAB:

135770823(nphs1)

IPU:

108278108

IFU:	128621512(nphs1)

PHYP:

113539257(nphs1)

SMEO:

124394122(nphs1)

TFD:	113642327(nphs1)

TVC:	132858373(nphs1)

CGAR:

128533487(nphs1)

NGRA:

132864312(nphs1)

TRN:	134334216(nphs1)

AMEX:

103038279(nphs1)

CMAO:

118804681(nphs1)

EEE:	113588822(nphs1)

CHAR:

105901271(nphs1)

SPIL:

134083483

TRU:	101074785(nphs1)

TFS:	130532257(nphs1)

TNG:	GSTEN00034184G001

LCO:	104925516(nphs1)

NCC:	104961402(nphs1)

TBEN:

117480687(nphs1)

CGOB:

115021056(nphs1)

PGEO:

117460423(nphs1)

GACU:

117554006(nphs1)

EMAC:

134861422(nphs1)

ELY:	117265501(nphs1)

EFO:	125893720(nphs1)

PLEP:

121945398(nphs1)

SLUC:

116049353(nphs1)

ECRA:

117946585(nphs1)

ESP:	116691004(nphs1)

PFLV:

114556964(nphs1)

GAT:	120810315(nphs1)

PPUG:

119198047(nphs1)

AFB:	129110176(nphs1)

CLUM:

117745602(nphs1)

PSWI:

130213234(nphs1)

CANA:

137781133(nphs1)

CVE:	137891065(nphs1)

MSAM:

119897796(nphs1)

SCHU:

122881422(nphs1)

CUD:	121513527(nphs1)

SPUL:

138584695(nphs1)

LMIX:

132984067(nphs1)

HTC:	141800592(nphs1)

ALAT:

119006537(nphs1)

ASTR:

137601454(nphs1)

MZE:	101478627(nphs1)

ONL:	100701764(nphs1)

OAU:	116319812(nphs1)

OLA:	101155460(nphs1)

OML:	112143574(nphs1)

CSAI:

133440607(nphs1)

XMA:	102228961(nphs1)

XCO:	114139282(nphs1)

XHE:	116715222(nphs1)

PRET:

103478528(nphs1)

PFOR:

103143095(nphs1)

PLAI:

106945865(nphs1)

PMEI:

106927182(nphs1)

GAF:	122831098(nphs1)

PPRL:

129371341(nphs1)

CVG:	107086093(nphs1)

CTUL:

119771537(nphs1)

GMU:	124863568(nphs1)

NFU:	107378623(nphs1)

KMR:	108241976(nphs1)

ALIM:

106517710(nphs1)

AOCE:

111577065(nphs1)

EJA:	138192422(nphs1)

BFRE:

138619260(nphs1)

MCEP:

125015857(nphs1)

CSEM:

103388504(nphs1)

POV:	109633030(nphs1)

SSEN:

122775190(nphs1)

SSOE:

131470782(nphs1)

HHIP:

117776215(nphs1)

HSP:	118113856(nphs1)

PPLT:

128449264(nphs1)

SMAU:

118312825(nphs1)

LCF:

108890767

SDU:	111234037(nphs1)

SLAL:

111664918(nphs1)

XGL:	120784504(nphs1)

BPEC:

110171498(nphs1)

ENY:	140374540(nphs1)

MALB:

109971696(nphs1)

BSPL:

114843411(nphs1)

SJO:	128366816(nphs1)

SSCO:

133983400(nphs1)

TTY:	137191602(nphs1)

GMH:	115553260(nphs1)

SASA:

106605624

STRU:

115182907

OTW:	112245877(nphs1)

OMY:	110538442(nphs1)

OGO:	123996968(nphs1)

ONE:

115140880

OKI:	109901663(nphs1)

OKE:	118364086(nphs1)

OMM:	135523069(nphs1)

OCLA:

139380022

SALP:

112067951

SNH:	120047219(nphs1)

SFON:

129857294

CCLU:

121562834 123492837

ELS:	105019153(nphs1)

OEP:

134024170

SFM:	108930312(nphs1)

PKI:

111841096

AANG:

118219770(nphs1)

AROT:

135238377(nphs1)

CCOG:

133136202(nphs1)

LOC:	102690772(nphs1)

PSPA:

121299234(nphs1) 121320771

ARUT:

117433768 117962692

LCM:	102357007(NPHS1)

SCAU:

119974241(nphs1)

PMRN:

BFO:

BBEL:

CIN:

SCLV:

SPU:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

DME:	Dmel_CG33141(sns)

DER:

6542389

DSE:

6608236

DSI:	Dsimw501_GD10605(Dsim_GD10605)

DYA:	Dyak_GE19230

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI18925

DAZ:

108616349

DNV:

108653386

DHE:

111598029

DVI:	6635375(sns)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135959784(sns)

GFS:

ECOE:

CLON:

HIS:

AGA:	1272555 4397681

ACOZ:

120956221 120956222 120956355

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ADAR:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001305

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108723532(sns)

CCOA:

TCZ:

TSEP:

PBAR:

COBS:

139110176(Sns)

TLN:	139815792(Sns)

HST:

DQU:

CFO:

FEX:

PMEC:

138942883(Sns)

LHU:	105674585(sns)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141525050(Sns)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124219147(sns)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138126730(sns)

DPA:

125504162

ESIM:

136416579(sns)

EFOR:

136347688(sns)

SOY:

115880775

RFG:	143198340(sns)

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

DCOR:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137924921(sns)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PGW:

LGLY:

CSTB:

CFUM:

141444140(sns)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

LDA:	142320252(sns)

HVI:

124364541

MQU:	129000363 129004623

PHU:	Phum_PHUM068980

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138690974(sns)

SGRE:

BROR:

IEL:

HAMR:

FCD:

DPX:	DAPPUDRAFT_305049

DMK:

116915605

DPZ:

124314606

AFRA:

136028879

PVM:	113802662 113805085 113813958 138863215

PJA:	122249449 122251254 122252771 122254215 122254589 122256064 122259817 122260242 122262065 122262562 122267895

PCHN:

125033351 125045353 125045717 125047951

PMOO:

119577630 119595157 119597122

HAME:

121854498 121863150 121863387 121865842 121867769 121874860 121879722

PCLA:

123755806 123762750 123766211 123769483 123770509 123771721 123774448 123774449 138369290

CQD:	128688793 128689665 128693143 128693160 128696637

PTRU:

123501671 123502034 123505024 123506073 123507096 123512239 123520665 123520757 123520837

ESN:	126994337 127004947 127008756

MNZ:	135196169 135198010 135198097 135201267 135209819 135212176 135214186 135226583 135227091

MRJ:	136826017 136831526 136832246 136836270 136851414 136851599 136854721 136855098

PORN:

139746457 139749905 139755108 139757556 139757573 139757760 139758291 139758626 139758780 139766101 139766102

HAZT:

108664788 108679880 108682113

OOT:	143036592 143037814

EAF:	111704569 111711354

LSM:	121117533 121117756

TCF:	131883444 131883887

PPOI:

119093960 119102923 119102940 119105439

ISC:

8042097

DSV:	119455428 119457078

DALB:

135895979 135902456

RSAN:

119376741 119393097 119394371

RMP:	119171604 119172902

OTI:

135386084

VDE:	111249008 111251006

VJA:	111259907 111264601

GOE:	100903448 100905568

TUT:

107371656

DPTE:

113788944

DFR:	124490925 124500389

CSCU:

111619060 111634112 111635045 111637098 111642161

CVS:	136975640 136977513 136979468 136979552 136979553 136985031

PTEP:

107441037 107443592 107449764 107454481

ABRU:

129958649 129966056 129966074 129968147 129968766 129976732 129989305

UDV:	129218240 129228432 129228493 129228672 129229565

SDM:	118184280 118186316 118191999 118195504 118197468

LPOL:

106457250 106457828 106457838 106460984 106461973 106466744 106470423 106476276 111084557 111086920

CEL:	CELE_C26G2.1(syg-2)

CBR:	CBG_07568(Cbr-syg-2)

CRQ:	GCK72_025659

NAI:	NECAME_07285

BMY:	BM_BM2413(Bma-syg-2)

LOA:	LOAG_01148

TSP:

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:	124116188 124119607 124125796 124126441

HRJ:	124255657 124267484 124274412

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

132732983 132736976 132754476

DPOL:

127860780 127873643

MAEA:

128234398

OBI:

106873723

OSN:	115212345 115220440

LJP:

135462001

LAK:

106151486

SMM:	Smp_130070

OVI:	T265_02206

EGL:

EGR_09148

LLON:

135502200

» show all

Reference

PMID:9660941

Authors

Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K

Title

Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome.

Journal

Mol Cell 1:575-82 (1998)
DOI:10.1016/s1097-2765(00)80057-x

Sequence

[hsa:4868]

LinkDB

DBGET integrated database retrieval system