KEGG   REACTION: R08141
Entry
R08141                      Reaction                               
Definition
3-Dehydroecdysone + NADH + H+ <=> Ecdysone + NAD+
Equation
C02513 + C00004 + C00080 <=> C00477 + C00003
Comment
3-dehydroecdysone 3beta-reductase
Reaction class
RC00001  C00003_C00004
RC00154  C00477_C02513
Enzyme
1.1.1.-
Pathway
rn00981  Insect hormone biosynthesis
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-
     R08141  3-Dehydroecdysone + NADH + H+ <=> Ecdysone + NAD+
Reference
1  [PMID:15813704]
  Authors
Takeuchi H, Rigden DJ, Ebrahimi B, Turner PC, Rees HH
  Title
Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration.
  Journal
Biochem J 389:637-45 (2005)
DOI:10.1042/BJ20050498
LinkDB

KEGG   RCLASS: RC00154
Entry
RC00154                     RClass                                 
Definition
C1y-C5x:*-*:C1x+C1y+O1a-C1x+C1y+O5x
Reactant pair
C00296_C00944    C00400_C00843    C00477_C02513
C00553_C00843    C00584_C00639    C00639_C00696
C00695_C04643    C00696_C05959    C00735_C00762
C01147_C03739    C01147_C12313    C01788_C04297
C01881_C02956    C02140_C05490    C02141_C22121
C02513_C16496    C03037_C03448    C03598_C04297
C04453_C08825    C04670_C04687    C05103_C15816
C05284_C05285    C05476_C05478    C05961_C05962
C06485_C07326    C06485_C16538    C09812_C09813
C09824_C09825    C11396_C11398    C11397_C11398
C11399_C11401    C11400_C11401    C11410_C11412
C11411_C11412    C11413_C11415    C11415_C11416
C11934_C11935    C12448_C20371    C15788_C15789
C15794_C15803    C17326_C17327    C17580_C17581
C17693_C21204    C18017_C18018    C18637_C18638
C20260_C20261    C20400_C20403    C20612_C20613
C20838_C23003    C20940_C20941    C21258_C21259
C21826_C21829    C21929_C22610
 » show all
Related class
Reaction
R01872 R01873 R02177 R02373 R02548 R02581 R02684 R02792
R02799 R02834 R02836 R03279 R03753 R03847 R03848 R04265
R04758 R04840 R05059 R05315 R05582 R05583 R05682 R05691
R06370 R06376 R06377 R06378 R06379 R06382 R06383 R06384
R06385 R06621 R06846 R07451 R07468 R07495 R08140 R08141
R08194 R08709 R08710 R08711 R08892 R08893 R08918 R09322
R09334 R09986 R09987 R10021 R10114 R10130 R10156 R10420
R10421 R10917 R11243 R11277 R11986 R12399 R13093 R13475
Enzyme
1.1.1.24        1.1.1.146       1.1.1.159       1.1.1.166       
1.1.1.174       1.1.1.184       1.1.1.188       1.1.1.189       
1.1.1.201       1.1.1.207       1.1.1.208       1.1.1.263       
1.1.1.270       1.1.1.282       1.1.1.292       1.1.1.296       
1.1.1.323       1.1.1.327       1.1.1.329       1.1.1.334       
1.1.1.340       1.1.1.341       1.1.1.342       1.1.1.356       
1.1.1.385       1.1.1.-         1.1.3.16        1.1.3.45        
1.1.5.8         1.1.99.38       1.1.-.-         1.14.14.69      
1.14.14.179     4.2.1.-
Pathway
rn00100  Steroid biosynthesis
rn00140  Steroid hormone biosynthesis
rn00362  Benzoate degradation
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn00590  Arachidonic acid metabolism
rn00902  Monoterpenoid biosynthesis
rn00903  Limonene degradation
rn00905  Brassinosteroid biosynthesis
rn00907  Pinene, camphor and geraniol degradation
rn00930  Caprolactam degradation
rn00960  Tropane, piperidine and pyridine alkaloid biosynthesis
rn00981  Insect hormone biosynthesis
rn00984  Steroid degradation
rn00998  Biosynthesis of various antibiotics
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
rn01250  Biosynthesis of nucleotide sugars
RModule
RM016  Ring cleavage via beta oxidation, anaerobic
RM017  Ring cleavage via Baeyer-Villiger oxidation
Orthology
K00071  corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-]
K00079  carbonyl reductase 1 [EC:1.1.1.184 1.1.1.189 1.1.1.197]
K00081  carbonyl reductase 2 [EC:1.1.1.184]
K00084  carbonyl reductase 3 [EC:1.1.1.184]
K04119  aldo-keto reductase family 1 member C3 [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
K05358  quinate dehydrogenase (quinone) [EC:1.1.5.8]
K05887  quinate/shikimate dehydrogenase [EC:1.1.1.282]
K07535  2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]
K09484  quinate dehydrogenase [EC:1.1.1.24]
K09590  brassinosteroid 6-oxygenase [EC:1.14.14.179]
K09827  3-keto steroid reductase [EC:1.1.1.270]
K10724  ecdysone oxidase [EC:1.1.3.16]
K12453  CDP-paratose synthetase [EC:1.1.1.342]
K12455  CDP-abequose synthase [EC:1.1.1.341]
K12640  brassinosteroid 6-oxygenase / brassinolide synthase [EC:1.14.14.179 1.14.14.180]
K13373  17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]
K13548  2-deoxy-scyllo-inosamine dehydrogenase [EC:1.1.1.329]
K13549  2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) [EC:1.1.99.38]
K15094  (-)-menthol dehydrogenase [EC:1.1.1.207]
K15095  (+)-neomenthol dehydrogenase [EC:1.1.1.208]
K15680  corticosteroid 11-beta-dehydrogenase isozyme 1 [EC:1.1.1.146]
K15858  CDP-3, 6-dideoxy-D-glycero-L-glycero-4-hexulose-4-reductase [EC:1.1.1.-]
K15949  aclacinomycin-N/aclacinomycin-A oxidase [EC:1.1.3.45 1.3.3.14]
K17747  1-deoxy-11beta-hydroxypentalenate dehydrogenase [EC:1.1.1.340]
K19548  dihydroanticapsin dehydrogenase [EC:1.1.1.385]
K19632  CDP-abequose synthase [EC:1.1.1.341]
K19649  5-exo-hydroxycamphor dehydrogenase [EC:1.1.1.327]
K19651  methylecgonone reductase [EC:1.1.1.334]
K20424  2-epi-valiolone-7-phosphate 1-reductase [EC:1.1.1.-]
K20576  NADP-dependent dehydrogenase [EC:1.1.1.-]
K21130  GDP-L-colitose synthase [EC:1.1.1.356]
K25901  quinate/shikimate dehydrogenase (NAD+) [EC:1.1.1.24]
K25959  brassinosteroid 6-oxygenase / brassinolide synthase [EC:1.14.14.179 1.14.14.180]
K28220  hydroxylacyl dehydrogenase [EC:1.1.-.-]

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