KEGG   PATHWAY: btax04310
Entry
btax04310                   Pathway                                
Name
Wnt signaling pathway - Budorcas taxicolor (takin)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04310  Wnt signaling pathway
btax04310

Other DBs
GO: 0016055
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128069966  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
128062889  protein-serine O-palmitoleoyltransferase porcupine-like [KO:K00181] [EC:2.3.1.250]
128048884  WNT1; proto-oncogene Wnt-1 [KO:K03209]
128044967  WNT2B; protein Wnt-2b [KO:K00182]
128046758  WNT2; protein Wnt-2 [KO:K00182]
128051398  WNT3A; protein Wnt-3a [KO:K00312]
128065491  WNT3; proto-oncogene Wnt-3 [KO:K00312]
128064929  WNT4; protein Wnt-4 [KO:K00408]
128051429  WNT5A; protein Wnt-5a [KO:K00444]
128047274  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
128043631  WNT6; protein Wnt-6 [KO:K00445]
128054243  WNT7A; protein Wnt-7a [KO:K00572]
128048826  WNT7B; protein Wnt-7b [KO:K00572]
128051617  WNT8A; protein Wnt-8a [KO:K00714]
128067661  WNT8B; protein Wnt-8b [KO:K00714]
128051174  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
128065456  WNT9B; protein Wnt-9b [KO:K01064]
128043684  WNT10A; protein Wnt-10a [KO:K01357]
128048628  WNT10B; protein Wnt-10b [KO:K01357]
128060249  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
128046389  WNT16; protein Wnt-16 [KO:K01558]
128052817  CER1; cerberus [KO:K01645]
128065527  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
128048523  WIF1; wnt inhibitory factor 1 [KO:K01691]
128065449  SOST; sclerostin [KO:K16834]
128049941  DKK2; dickkopf-related protein 2 [KO:K02165]
128067978  DKK1; dickkopf-related protein 1 [KO:K02165]
128068175  dickkopf-related protein 4-like [KO:K02165]
128068218  dickkopf-related protein 4-like [KO:K02165]
128065140  SERPINF1; pigment epithelium-derived factor [KO:K19614]
128068241  SFRP1; secreted frizzled-related protein 1 [KO:K02166]
128062438  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
128043479  FRZB; secreted frizzled-related protein 3 [KO:K25481]
128046630  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
128067911  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
128045505  RSPO1; R-spondin-1 [KO:K19471]
128059507  RSPO2; R-spondin-2 [KO:K23097]
128053123  RSPO3; R-spondin-3 isoform X1 [KO:K23098]
128058075  RSPO4; R-spondin-4 [KO:K23099]
128060446  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
128048368  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
128061571  LGR6; leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
128065490  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
128062422  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 isoform X1 [KO:K16273] [EC:2.3.2.27]
128070496  FZD7; frizzled-7 [KO:K02432]
128046799  FZD1; frizzled-1 [KO:K02432]
128065200  FZD2; frizzled-2 [KO:K02235]
128052483  FZD3; frizzled-3 [KO:K02329]
128068654  FZD4; frizzled-4 [KO:K02354]
128071105  frizzled-5 [KO:K02375]
128058547  FZD8; frizzled-8 [KO:K02375]
128065941  FZD5; frizzled-5 [KO:K02375]
128059374  FZD6; frizzled-6 [KO:K02376]
128043337  FZD9; frizzled-9 [KO:K02842]
128062458  FZD10; frizzled-10 [KO:K02842]
128069156  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
128048011  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
128058736  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
128058855  APCDD1L; protein APCDD1-like [KO:K25812]
128067302  APCDD1; protein APCDD1 [KO:K25812]
128048902  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
128066631  CCDC88C; protein Daple [KO:K25811]
128064845  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
128045751  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
128061181  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
128067878  FRAT1; proto-oncogene FRAT1 [KO:K03069]
128067855  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
128063252  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
128058293  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
128056158  CSNK2B; casein kinase II subunit beta [KO:K03115]
128063764  NKD1; protein naked cuticle homolog 1 [KO:K03213]
128066213  NKD2; protein naked cuticle homolog 2 [KO:K03213]
128050015  CXXC4; CXXC-type zinc finger protein 4 [KO:K03344]
128067865  SENP2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128058237  CTNNB1; catenin beta-1 [KO:K02105]
128061865  AXIN1; axin-1 isoform X1 [KO:K02157]
128065073  AXIN2; axin-2 [KO:K04385]
128050459  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
128053813  APC; adenomatous polyposis coli protein [KO:K02085]
128050290  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
128069547  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
128070116  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
128070471  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
128070472  casein kinase I [KO:K08957] [EC:2.7.11.1]
128070473  casein kinase I [KO:K08957] [EC:2.7.11.1]
128070474  casein kinase I [KO:K08957] [EC:2.7.11.1]
128050871  TCF7; transcription factor 7 [KO:K02620]
128056483  TCF7L1; transcription factor 7-like 1 [KO:K04490]
128067999  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
128049642  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
128067732  LZTS2; leucine zipper putative tumor suppressor 2 isoform X1 [KO:K26471]
128061508  CTNNBIP1; beta-catenin-interacting protein 1 [KO:K04493]
128048407  CBY1; protein chibby homolog 1 [KO:K23402]
128071351  chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
128053776  CHD8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
128054240  MCC; colorectal mutant cancer protein [KO:K26734]
128052321  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
128048381  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
128059435  SOX17; transcription factor SOX-17 [KO:K04495]
128044788  LOW QUALITY PROTEIN: C-terminal-binding protein 2-like [KO:K04496] [EC:1.1.1.428]
128067691  CTBP2; C-terminal-binding protein 2 [KO:K04496] [EC:1.1.1.428]
128049442  CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
128050957  TLE6; transducin-like enhancer protein 6 [KO:K04497]
128064180  TLE7; transducin-like enhancer protein 7 [KO:K04497]
128051489  TLE2; transducin-like enhancer protein 2 isoform X1 [KO:K04497]
128052524  transducin-like enhancer protein 1 isoform X1 [KO:K04497]
128052853  TLE4; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
128054305  TLE3; transducin-like enhancer protein 3 isoform X1 [KO:K04497]
128065977  CTNND2; catenin delta-2 [KO:K23491]
128043638  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
128047516  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
128064861  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
128067298  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
128054493  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
128053252  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
128065136  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128044447  JUN; transcription factor Jun [KO:K04448]
128068636  FOSL1; fos-related antigen 1 [KO:K04502]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128059645  CCN4; CCN family member 4 [KO:K22471]
128056646  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
128060945  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
128053976  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128062992  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
128070008  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
128070009  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
128070077  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
128061552  CACYBP; calcyclin-binding protein [KO:K04507]
128050765  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
128058336  S-phase kinase-associated protein 1-like [KO:K03094]
128046705  S-phase kinase-associated protein 1-like [KO:K03094]
128066272  S-phase kinase-associated protein 1-like [KO:K03094]
128069765  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
128071005  F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
128046416  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 isoform X1 [KO:K04508]
128065993  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
128067734  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
128046241  CUL1; cullin-1 [KO:K03347]
128046932  cullin-1-like [KO:K03347]
128047495  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
128067535  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
128069761  GPC4; glypican-4 [KO:K08110]
128045586  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
128052591  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
128045556  RYK; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
128045170  VANGL1; vang-like protein 1 [KO:K04510]
128045345  VANGL2; vang-like protein 2 [KO:K04510]
128069741  PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511]
128056712  PRICKLE4; prickle-like protein 4 [KO:K04511]
128053484  PRICKLE2; prickle-like protein 2 [KO:K04511]
128048206  PRICKLE1; prickle-like protein 1 [KO:K04511]
128052289  INVS; inversin [KO:K19626]
128053834  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
128055884  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128055373  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128065663  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128058011  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128058303  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
128054050  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128068545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
128050399  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
128047085  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
128047602  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
128049625  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128058335  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128054080  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
btax04010  MAPK signaling pathway
btax04110  Cell cycle
btax04115  p53 signaling pathway
btax04120  Ubiquitin mediated proteolysis
btax04350  TGF-beta signaling pathway
btax04510  Focal adhesion
btax04520  Adherens junction
btax05010  Alzheimer disease
KO pathway
ko04310   
LinkDB

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