KEGG   PATHWAY: btax04010
Entry
btax04010                   Pathway                                
Name
MAPK signaling pathway - Budorcas taxicolor (takin)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
btax04010  MAPK signaling pathway
btax04010

Other DBs
GO: 0000165
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128050795  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
128055241  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
128048945  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
128052044  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
128061226  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
128070004  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
128065152  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
128043484  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
128048649  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
128061188  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128046666  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
128054644  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
128047111  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
128048256  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
128065237  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
128058156  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
128048899  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
128064089  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
128064592  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
128048584  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
128043545  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
128065398  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
128065383  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
128063025  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
128063783  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
128063702  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128064366  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128066726  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
128051143  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
128054167  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
128068739  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
128055903  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
128063466  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
128062012  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
128065548  NF1; neurofibromin [KO:K08052]
128051785  RASA1; ras GTPase-activating protein 1 [KO:K04352]
128048762  RASA2; ras GTPase-activating protein 2 [KO:K08053]
128044450  RAP1A; ras-related protein Rap-1A [KO:K04353]
128061218  LOW QUALITY PROTEIN: ras-related protein Rap-1A-like [KO:K04353]
128047462  RAP1B; ras-related protein Rap-1b [KO:K07836]
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128055664  TGFA; protransforming growth factor alpha [KO:K08774]
128049547  EREG; proepiregulin [KO:K09784]
128050080  AREG; amphiregulin [KO:K09782]
128050845  FGF1; fibroblast growth factor 1 [KO:K18496]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128049947  FGF5; fibroblast growth factor 5 [KO:K04358]
128069166  FGF4; fibroblast growth factor 4 [KO:K04358]
128069196  FGF3; fibroblast growth factor 3 [KO:K04358]
128070322  FGF16; fibroblast growth factor 16 [KO:K04358]
128057718  FGF9; fibroblast growth factor 9 [KO:K04358]
128051703  FGF22; fibroblast growth factor 22 [KO:K04358]
128052704  FGF17; fibroblast growth factor 17 [KO:K04358]
128065968  FGF10; fibroblast growth factor 10 [KO:K04358]
128066262  FGF18; fibroblast growth factor 18 [KO:K04358]
128053785  FGF7; fibroblast growth factor 7 [KO:K04358]
128048008  FGF6; fibroblast growth factor 6 [KO:K04358]
128067938  FGF8; fibroblast growth factor 8 [KO:K04358]
128068355  FGF20; fibroblast growth factor 20 [KO:K04358]
128069264  FGF19; fibroblast growth factor 19 [KO:K22603]
128064178  FGF21; fibroblast growth factor 21 [KO:K22429]
128048959  FGF23; fibroblast growth factor 23 [KO:K22428]
128045179  NGF; beta-nerve growth factor [KO:K02582]
128060339  BDNF; brain-derived neurotrophic factor [KO:K04355]
128048554  NTF3; neurotrophin-3 [KO:K04356]
128063771  NTF4; neurotrophin-4 isoform X1 [KO:K12457]
128069208  INS; insulin [KO:K04526]
128048032  IGF1; insulin-like growth factor I [KO:K05459]
128068647  IGF2; insulin-like growth factor II [KO:K13769]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128060743  PDGFD; platelet-derived growth factor D [KO:K05450]
128062428  PDGFC; platelet-derived growth factor C [KO:K05450]
128044745  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
128048430  KITLG; kit ligand [KO:K05461]
128063479  FLT3LG; fms-related tyrosine kinase 3 ligand [KO:K05454]
128055613  VEGFA; vascular endothelial growth factor A [KO:K05448]
128068711  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
128054318  PGF; placenta growth factor [KO:K16859]
128070311  VEGFD; vascular endothelial growth factor D [KO:K05449]
128068325  VEGFC; vascular endothelial growth factor C [KO:K05449]
128046678  HGF; hepatocyte growth factor [KO:K05460]
128059324  ANGPT1; angiopoietin-1 [KO:K05465]
128068156  ANGPT2; angiopoietin-2 [KO:K05466]
128058453  ANGPT4; angiopoietin-4 [KO:K05467]
128044606  EFNA1; ephrin-A1 [KO:K05462]
128045080  EFNA3; ephrin-A3 [KO:K05462]
128045081  EFNA4; ephrin-A4 [KO:K05462]
128051506  EFNA5; ephrin-A5 [KO:K05462]
128051746  EFNA2; ephrin-A2 [KO:K05462]
128066098  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
128051433  NRTN; neurturin [KO:K25414]
128045697  ARTN; artemin [KO:K25415]
128051720  PSPN; LOW QUALITY PROTEIN: persephin [KO:K25416]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128064538  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
128047384  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
128061017  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
128068375  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128067669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
128049397  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
128050311  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
128065569  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128044483  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
128052378  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
128050313  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
128066571  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128050693  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
128049641  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
128057569  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
128057485  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
128050341  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
128049477  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
128046469  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
128052138  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
128043849  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
128048891  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
128064562  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128063078  RRAS; ras-related protein R-Ras [KO:K07829]
128060054  RRAS2; ras-related protein R-Ras2 [KO:K07830]
128044902  MRAS; ras-related protein M-Ras [KO:K07831]
128070468  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
128046969  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128049714  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128044486  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
128051524  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
128063260  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
128069871  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
128070615  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
128053046  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
128047885  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
128048350  LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
128070470  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
128061610  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128055386  SRF; serum response factor [KO:K04378]
128053951  FOS; protein c-Fos [KO:K04379]
128064960  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
128071507  STMN1; stathmin [KO:K04381]
128046214  stathmin-like [KO:K04381]
128053914  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
128053916  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
128053917  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
128054024  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
128061302  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
128056772  TNF; tumor necrosis factor [KO:K03156]
128056679  IL1A; interleukin-1 alpha [KO:K04383]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128053888  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128056062  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
128054017  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
128051987  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128048354  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128050920  CD14; monocyte differentiation antigen CD14 [KO:K04391]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128065663  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128066401  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128063092  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
128068336  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
128055475  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
128055526  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
128049046  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
128069805  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
128048533  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
128060227  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
128050874  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
128044871  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
128052323  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
128049014  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
128053126  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
128050397  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
128056991  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
128055154  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
128063138  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
128068496  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128057235  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128058469  STK4; serine/threonine-protein kinase 4 [KO:K04411]
128059540  STK3; serine/threonine-protein kinase 3 [KO:K04412]
128068484  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
128058726  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
128065982  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
128069202  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
128071523  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
128064421  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
128053937  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
128063002  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
128047964  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
128047920  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
128050640  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
128070371  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13-like [KO:K04422] [EC:2.7.11.25]
128061362  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
128067403  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
128053214  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
128053252  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
128053073  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
128063017  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
128064628  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
128062645  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
128064467  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
128050697  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128064641  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
128065178  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128060730  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
128048000  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
128043876  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
128070229  FLNA; filamin-A isoform X1 [KO:K04437]
128064843  CRK; adapter molecule crk isoform X1 [KO:K04438]
128062501  CRKL; crk-like protein [KO:K04438]
128064406  ARRB2; beta-arrestin-2 [KO:K04439]
128059802  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128062190  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
128061864  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
128049452  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
128054614  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
128068508  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
128057998  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
128054373  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128044447  JUN; transcription factor Jun [KO:K04448]
128051098  JUND; transcription factor JunD [KO:K04449]
128065610  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128047285  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
128054008  MAX; protein max isoform X1 [KO:K04453]
128051474  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
128064766  HSPB1; heat shock protein beta-1 [KO:K04455]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128053779  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
128047823  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
128069107  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
128061708  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
128065956  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
128046209  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128048012  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128067925  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128068345  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128068742  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128055791  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
128047953  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
128070333  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
128061430  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
128065308  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
128063108  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
128055226  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
128044370  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
128061031  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
128055080  heat shock 70 kDa protein 1A [KO:K03283]
128055295  heat shock 70 kDa protein 1-like [KO:K03283]
128045496  MECOM; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
128053773  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
128064484  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
128047279  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
128065013  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
128067677  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
128068238  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
128069947  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
128065136  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128067674  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
128068546  RELA; transcription factor p65 [KO:K04735]
128063412  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
btax04070  Phosphatidylinositol signaling system
btax04110  Cell cycle
btax04115  p53 signaling pathway
btax04210  Apoptosis
btax04310  Wnt signaling pathway
btax04668  TNF signaling pathway
KO pathway
ko04010   
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