KEGG   PATHWAY: btax04110
Entry
btax04110                   Pathway                                
Name
Cell cycle - Budorcas taxicolor (takin)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
btax04110  Cell cycle
btax04110

Other DBs
GO: 0000278
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128047322  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128046639  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
128057539  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
128058150  RBL1; retinoblastoma-like protein 1 [KO:K04681]
128062924  RBL2; retinoblastoma-like protein 2 [KO:K16332]
128056857  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
128053221  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
128066557  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
128058399  E2F1; transcription factor E2F1 [KO:K17454]
128043619  E2F2; transcription factor E2F2 [KO:K09389]
128056580  E2F3; transcription factor E2F3 [KO:K06620]
128063191  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
128059232  E2F5; transcription factor E2F5 [KO:K04682]
128057522  TFDP1; transcription factor Dp-1 [KO:K04683]
128056463  TFDP2; transcription factor Dp-2 isoform X1 [KO:K09392]
128043889  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128053888  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128067292  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
128054493  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
128067298  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128061352  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
128052529  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
128052514  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
128044912  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
128051399  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
128047650  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
128068901  CDKN1C; cyclin-dependent kinase inhibitor 1C [KO:K09993]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128063478  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
128059332  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
128047622  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
128050765  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
128058336  S-phase kinase-associated protein 1-like [KO:K03094]
128046705  S-phase kinase-associated protein 1-like [KO:K03094]
128066272  S-phase kinase-associated protein 1-like [KO:K03094]
128046241  CUL1; cullin-1 [KO:K03347]
128046932  cullin-1-like [KO:K03347]
128047495  RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 [KO:K03868] [EC:2.3.2.32]
128067535  E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
128059172  S-phase kinase-associated protein 2-like [KO:K03875]
128066055  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
128049924  CCNA2; cyclin-A2 [KO:K06627]
128057751  CCNA1; cyclin-A1 [KO:K06627]
128065526  CDC6; cell division control protein 6 homolog [KO:K02213]
128063690  CDT1; DNA replication factor Cdt1 [KO:K10727]
128045285  ORC1; origin recognition complex subunit 1 [KO:K02603]
128043422  ORC2; origin recognition complex subunit 2 [KO:K02604]
128053341  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
128068818  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
128046701  ORC5; origin recognition complex subunit 5 [KO:K02607]
128063659  ORC6; origin recognition complex subunit 6 [KO:K02608]
128045312  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
128055494  MCM3; LOW QUALITY PROTEIN: DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
128059349  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
128047936  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
128071518  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
128064551  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
128062486  CDC45; LOW QUALITY PROTEIN: cell division control protein 45 homolog [KO:K06628]
128066871  TICRR; treslin [KO:K26117]
128059312  MTBP; mdm2-binding protein [KO:K26116]
128045278  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
128065452  DBF4B; LOW QUALITY PROTEIN: protein DBF4 homolog B [KO:K06629]
128046941  DBF4; protein DBF4 homolog A [KO:K06629]
128048047  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
128066149  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
128066902  G2/mitotic-specific cyclin-B1-like [KO:K05868]
128054390  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
128070382  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
128057998  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
128054373  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
128051380  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
128058124  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
128058395  14-3-3 protein theta-like [KO:K16197]
128059098  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
128054333  14-3-3 protein zeta/delta-like [KO:K16197]
128055931  YWHAQ; 14-3-3 protein theta [KO:K16197]
128064436  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
128049733  14-3-3 protein epsilon-like [KO:K06630]
128062632  YWHAH; 14-3-3 protein eta [KO:K16198]
128062952  YWHAG; 14-3-3 protein gamma [KO:K16198]
128062494  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
128046943  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
128060398  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
128064176  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
128051786  CCNH; cyclin-H isoform X1 [KO:K06634]
128066118  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
128055163  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
128055109  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
128064760  CDC27; cell division cycle protein 27 homolog [KO:K03350]
128049612  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
128062231  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
128057556  CDC16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
128062568  ANAPC7; anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
128050894  CDC23; cell division cycle protein 23 homolog [KO:K03355]
128070329  anaphase-promoting complex subunit 10-like [KO:K03357]
128062340  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
128069039  anaphase-promoting complex subunit 10-like [KO:K03357]
128064532  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
128052686  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
128050778  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
128060036  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
128048135  anaphase-promoting complex subunit 15-like [KO:K25228]
128047354  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
128045153  CDC20; cell division cycle protein 20 homolog [KO:K03363]
128051529  PTTG1; securin [KO:K06635]
128048511  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
128070486  SMC1A; structural maintenance of chromosomes protein 1A isoform X1 [KO:K06636]
128047582  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
128067745  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
128059161  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
128050596  STAG1; cohesin subunit SA-1 [KO:K06671]
128069715  STAG2; cohesin subunit SA-2 [KO:K06671]
128069837  ATRX; transcriptional regulator ATRX [KO:K10779]
128047535  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
128065928  NIPBL; nipped-B-like protein [KO:K06672]
128051725  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
128069880  HDAC8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
128052790  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
128067516  ESCO1; N-acetyltransferase ESCO1 [KO:K11268] [EC:2.3.1.-]
128057665  PDS5B; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
128049604  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
128047395  WAPL; wings apart-like protein homolog [KO:K25163]
128069224  CDCA5; sororin [KO:K17390]
128065150  AURKB; aurora kinase B [KO:K11479] [EC:2.7.11.1]
128054071  SGO1; shugoshin 1 [KO:K11580]
128051757  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
128068193  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
128063523  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
128070222  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
128070224  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
128060694  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
128056208  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
128066367  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
128053851  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
128061157  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
128068474  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
128067545  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
128054420  KNL1; kinetochore scaffold 1 [KO:K11542]
128053450  TTK; dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
128063517  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
128049881  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A isoform X1 [KO:K02537]
128061551  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
128054489  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
128067813  BUB3; mitotic checkpoint protein BUB3 isoform X1 [KO:K02180]
128056349  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
128066157  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
128056982  MAD2L1BP; MAD2L1-binding protein [KO:K26093]
128050579  FZR1; fizzy-related protein homolog isoform X1 [KO:K03364]
128053528  FBXO5; F-box only protein 5 [KO:K10292]
128044766  CDC14A; dual specificity protein phosphatase CDC14A [KO:K06639] [EC:3.1.3.16 3.1.3.48]
128052480  CDC14B; dual specificity protein phosphatase CDC14B [KO:K06639] [EC:3.1.3.16 3.1.3.48]
128043638  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
128047516  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
128059433  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
128053092  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
128060504  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
128047314  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
128049822  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128050874  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
128044871  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
128052323  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
128058522  PCNA; proliferating cell nuclear antigen [KO:K04802]
128043433  SFN; 14-3-3 protein sigma [KO:K06644]
128068939  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
128071171  serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
128062388  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
128054910  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
btax03030  DNA replication
btax04010  MAPK signaling pathway
btax04120  Ubiquitin mediated proteolysis
btax04210  Apoptosis
KO pathway
ko04110   
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