Entry Name C-type lectin receptor signaling pathway - Corvus brachyrhynchos (American crow)
Description C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map cbrc04625 C-type lectin receptor signaling pathway
Organism Corvus brachyrhynchos (American crow) [GN:
cbrc ]
Gene 103611985 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
103612443 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
103615008 PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
103615287 CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467 ] [EC:2.7.11.10 ]
103616302 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958 ]
103617377 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
103618139 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
103618578 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
103618702 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
103619521 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369 ] [EC:3.4.22.-]
103620109 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859 ] [EC:3.1.4.11 ]
103620183 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
103621908 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
103622106 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
103622243 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
103623121 CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794 ]
103623356 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959 ]
103624307 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
103624456 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6 [KO:K04348 ] [EC:3.1.3.16 ]
103625098 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
103625304 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C21790 Mycobacterial trehalose dimycolate
G13115 Mannose-capped lipoarabinomannan
Reference Authors Geijtenbeek TB, Gringhuis SI
Title C-type lectin receptors in the control of T helper cell differentiation.
Journal Reference Authors Hajishengallis G, Lambris JD
Title Microbial manipulation of receptor crosstalk in innate immunity.
Journal Reference Authors Iliev ID, Leonardi I
Title Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal Reference Authors Richardson MB, Williams SJ
Title MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal Reference Authors Vautier S, MacCallum DM, Brown GD
Title C-type lectin receptors and cytokines in fungal immunity.
Journal Reference Authors Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal Reference Authors Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title DAMP signaling in fungal infections and diseases.
Journal Reference Authors Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal Reference Authors Mayer S, Raulf MK, Lepenies B
Title C-type lectins: their network and roles in pathogen recognition and immunity.
Journal Reference Authors Plato A, Willment JA, Brown GD
Title C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal Reference Authors Dupaul-Chicoine J, Saleh M
Title A new path to IL-1beta production controlled by caspase-8.
Journal Reference Authors Batbayar S, Lee DH, Kim HW
Title Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal Reference Authors Bendickova K, Tidu F, Fric J
Title Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal Reference Authors den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal Reference Authors Marakalala MJ, Ndlovu H
Title Signaling C-type lectin receptors in antimycobacterial immunity.
Journal Reference Authors Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal Reference Authors Geijtenbeek TB, Gringhuis SI
Title Signalling through C-type lectin receptors: shaping immune responses.
Journal Reference Authors Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal KO pathway
