Entry Name C-type lectin receptor signaling pathway
Description C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map ko04625 C-type lectin receptor signaling pathway
Orthology K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153 ]
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K03156 TNF, TNFA; tumor necrosis factor superfamily, member 2
K04348 PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16 ]
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1 ]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1 ]
K04446 NFATC1, NFAT2, NFATC; nuclear factor of activated T-cells, cytoplasmic 1
K04448 JUN; transcription factor AP-1
K04466 MAP3K14, NIK; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25 ]
K04467 IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10 ]
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K04513 RHOA; Ras homolog gene family, member A
K04519 IL1B; interleukin 1 beta
K04693 IRF9, ISGF3G, P48; interferon regulatory factor 9
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K04735 RELA; transcription factor p65
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K05426 IL23A; interleukin 23 subunit alpha
K05443 IL10, CSIF; interleukin 10
K05492 IL17D, IL27; interleukin 17D
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11 ]
K06268 PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06563 CLEC4L_M, DC-SIGN, CD209, CD299; C-type lectin domain family 4 member L/M
K07209 IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10 ]
K07210 IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07211 IKBKE, IKKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [EC:2.7.11.10 ]
K07293 PTPN11, SHP2; tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48 ]
K07368 BCL10; B-cell CLL/lymphoma 10
K07369 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K07532 ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
K07827 KRAS, KRAS2; GTPase KRas
K07829 RRAS; Ras-related protein R-Ras
K07830 RRAS2, TC21; Ras-related protein R-Ras2
K07831 MRAS; Ras-related protein M-Ras
K07983 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma
K08601 CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12 ]
K09253 RELB; transcription factor RelB
K09258 BCL3; B-cell CLL/lymphoma 3 protein
K09444 IRF1; interferon regulatory factor 1
K10058 CLEC4D, MCL, CD368; C-type lectin domain family 4 member D
K10059 CLEC4E, MINCLE; C-type lectin domain family 4 member E
K10070 CLEC1B; C-type lectin domain family 1 member B
K10074 CLEC7A, DECTIN1, CD369; C-type lectin domain family 7 member A
K11220 STAT1; signal transducer and activator of transcription 1
K11221 STAT2; signal transducer and activator of transcription 2
K12496 EGR2; early growth response protein 2
K12497 EGR3; early growth response protein 3
K12794 CARD9; caspase recruitment domain-containing protein 9
K12799 PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
K12800 NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
K14957 LSP1; lymphocyte-specific protein 1
K14958 KSR1; kinase suppressor of Ras 1
K17332 NFATC2, NFAT1, NFATP; nuclear factor of activated T-cells, cytoplasmic 2
K17333 NFATC3, NFAT4; nuclear factor of activated T-cells, cytoplasmic 3
K17334 NFATC4, NFAT3; nuclear factor of activated T-cells, cytoplasmic 4
K17514 CLEC6A, DECTIN2; C-type lectin domain family 6 member A
K21083 CCL17; C-C motif chemokine 17
K21095 CCL22; C-C motif chemokine 22
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C21790 Mycobacterial trehalose dimycolate
G13115 Mannose-capped lipoarabinomannan
Reference Authors Geijtenbeek TB, Gringhuis SI
Title C-type lectin receptors in the control of T helper cell differentiation.
Journal Reference Authors Hajishengallis G, Lambris JD
Title Microbial manipulation of receptor crosstalk in innate immunity.
Journal Reference Authors Iliev ID, Leonardi I
Title Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal Reference Authors Richardson MB, Williams SJ
Title MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal Reference Authors Vautier S, MacCallum DM, Brown GD
Title C-type lectin receptors and cytokines in fungal immunity.
Journal Reference Authors Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal Reference Authors Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title DAMP signaling in fungal infections and diseases.
Journal Reference Authors Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal Reference Authors Mayer S, Raulf MK, Lepenies B
Title C-type lectins: their network and roles in pathogen recognition and immunity.
Journal Reference Authors Plato A, Willment JA, Brown GD
Title C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal Reference Authors Dupaul-Chicoine J, Saleh M
Title A new path to IL-1beta production controlled by caspase-8.
Journal Reference Authors Batbayar S, Lee DH, Kim HW
Title Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal Reference Authors Bendickova K, Tidu F, Fric J
Title Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal Reference Authors den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal Reference Authors Marakalala MJ, Ndlovu H
Title Signaling C-type lectin receptors in antimycobacterial immunity.
Journal Reference Authors Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal Reference Authors Geijtenbeek TB, Gringhuis SI
Title Signalling through C-type lectin receptors: shaping immune responses.
Journal Reference Authors Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal Related ko00571 Lipoarabinomannan (LAM) biosynthesis
ko04658 Th1 and Th2 cell differentiation
