KEGG   PATHWAY: char03460
Entry
char03460                   Pathway                                
Name
Fanconi anemia pathway - Clupea harengus (Atlantic herring)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
char03460  Fanconi anemia pathway
char03460

Other DBs
GO: 0043240
Organism
Clupea harengus (Atlantic herring) [GN:char]
Gene
105889851  ube2t; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
105890039  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
105890421  ercc1; DNA excision repair protein ERCC-1 [KO:K10849]
105890918  mlh1; DNA mismatch repair protein Mlh1 [KO:K08734]
105892762  faap100; LOW QUALITY PROTEIN: Fanconi anemia core complex-associated protein 100 [KO:K10993]
105893444  fancl; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
105893508  [KO:K10905]
105893622  fance; Fanconi anemia group E protein [KO:K10892]
105893782  atr; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
105894151  [KO:K10890]
105894376  rmi1; recQ-mediated genome instability protein 1 [KO:K10990]
105894523  polh; DNA polymerase eta isoform X2 [KO:K03509] [EC:2.7.7.7]
105894789  [KO:K15361]
105894849  rev3l; LOW QUALITY PROTEIN: DNA polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
105895465  mus81; crossover junction endonuclease MUS81 isoform X1 [KO:K08991] [EC:3.1.22.-]
105897148  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
105898220  rpa1; replication protein A 70 kDa DNA-binding subunit isoform X1 [KO:K07466]
105899068  her9; hairy-related 9 isoform X1 [KO:K06054]
105899134  [KO:K06054]
105899457  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
105899805  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
105900753  faap24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
105900944  her6; hairy-related 6 isoform X1 [KO:K06054]
105901093  polk; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
105901174  fancg; Fanconi anemia group G protein isoform X1 [KO:K10894]
105901872  cenps; centromere protein S [KO:K11511]
105902900  poli; DNA polymerase iota isoform X1 [KO:K03510] [EC:2.7.7.7]
105903331  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
105903626  [KO:K10739]
105904662  fancd2; Fanconi anemia group D2 protein [KO:K10891]
105904666  fanci; Fanconi anemia group I protein [KO:K10895]
105905124  fancf; Fanconi anemia group F protein [KO:K10893]
105905552  blm; Bloom syndrome protein homolog [KO:K10901] [EC:5.6.2.4]
105906984  wdr48b; WD repeat-containing protein 48 isoform X1 [KO:K15361]
105907192  slx1b; structure-specific endonuclease subunit SLX1 [KO:K15078] [EC:3.6.1.-]
105908171  fancm; Fanconi anemia group M protein isoform X1 [KO:K10896]
105908957  cenpx; centromere protein X [KO:K15360]
105909785  [KO:K10870]
105910112  rpa2; replication protein A 32 kDa subunit [KO:K10739]
105910258  ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
105910342  [KO:K10888]
105912620  rpa3; replication protein A 14 kDa subunit [KO:K10740]
105913187  usp1; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1 [KO:K11832] [EC:3.4.19.12]
105913294  rev1; DNA repair protein REV1 isoform X2 [KO:K03515] [EC:2.7.7.-]
116224734  fancc; Fanconi anemia group C protein [KO:K10890]
122129265  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
122129803  [KO:K10870]
122129936  [KO:K10905]
122131860  pms2; mismatch repair endonuclease PMS2 [KO:K10858]
122131965  rmi2; recQ-mediated genome instability protein 2 [KO:K15365]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
char03430  Mismatch repair
char03440  Homologous recombination
KO pathway
ko03460   

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