KEGG   PATHWAY: cro00540Help
Entry
cro00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Citrobacter rodentium
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
cro00540  Lipopolysaccharide biosynthesis
cro00540

Ortholog table
Module
cro_M00060  Lipopolysaccharide biosynthesis, KDO2-lipid A [PATH:cro00540]
cro_M00063  CMP-KDO biosynthesis [PATH:cro00540]
cro_M00064  ADP-L-glycero-D-manno-heptose biosynthesis [PATH:cro00540]
Other DBs
BSID: 133594
GO: 0009103
Organism
Citrobacter rodentium [GN:cro]
Gene
ROD_01841  lpxA; acyl-[acyl-carrier-protein]--UDP-N-acetylglucos amine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
ROD_01021  lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
ROD_01821  lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
ROD_05561  lpxH; UDP-2,3-diacylglucosamine hydrolase [KO:K03269] [EC:3.6.1.54]
ROD_01851  lpxB; lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
ROD_09831  lpxK; tetraacyldisaccharide 4'-kinase (lipid A 4'-kinase) [KO:K00912] [EC:2.7.1.130]
ROD_46231  kdsD; arabinose 5-phosphate isomerase [KO:K06041] [EC:5.3.1.13]
ROD_17981  kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
ROD_46221  kdsC; 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase [KO:K03270] [EC:3.1.3.45]
ROD_09861  kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
ROD_41831  kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
ROD_11131  htrB; lipid A biosynthesis lauroyl acyltransferase [KO:K02517] [EC:2.3.1.241]
ROD_18961  msbB; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase [KO:K02560] [EC:2.3.1.243]
ROD_02231  gmhA; phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
ROD_35951  hldE; bifunctional protein HldE [includes: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 1-phosphate adenosyltransferase] [KO:K03272] [EC:2.7.7.70 2.7.1.167]
ROD_02101  gmhB; D,D-heptose 1,7-bisphosphate phosphatase [KO:K03273] [EC:3.1.3.83 3.1.3.82]
ROD_41981  rfaD; ADP-L-glycero-D-manno-heptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
ROD_41931  rfaZ; lipopolysaccharide core biosynthesis protein RfaZ [KO:K12981] [EC:2.4.99.-]
ROD_41961  rfaC; lipopolysaccharide heptosyltransferase 1 [KO:K02841] [EC:2.4.-.-]
ROD_41971  rfaF; ADP-heptose-LPS heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
ROD_41861  rfaG; UDP-glucose:(heptosyl) LPS alpha-1,3-glucosyltransferase [KO:K02844] [EC:2.4.1.-]
ROD_41921  rfaY; lipopolysaccharide core biosynthesis protein [KO:K02850] [EC:2.7.1.-]
ROD_41871  rfaP; heptosyl-I-kinase [KO:K02848] [EC:2.7.1.-]
ROD_41851  rfaQ; heptosyl-III-transferase [KO:K02849] [EC:2.4.-.-]
ROD_41891  rfaB; lipopolysaccharide 1,6-galactosyltransferase [KO:K02840] [EC:2.4.1.-]
ROD_42621  eptb; phosphoethanolamine transferase [KO:K12975] [EC:2.7.8.42]
ROD_37901  putative membrane protein [KO:K19353] [EC:2.7.8.-]
ROD_41901  rfaI; UDP-galactose:(glucosyl) LPS alpha-1,3-galactosyltransferase [KO:K03275] [EC:2.4.1.-]
ROD_41911  rfaJ; UDP-glucose:(galactosyl) LPS alpha-1,2-glucosyltransferase [KO:K03276] [EC:2.4.1.-]
ROD_41941  rfaK; lipopolysaccharide 1,2-N-acetylglucosaminetransferase [KO:K03280] [EC:2.4.1.56]
ROD_41951  rfaL; lipid A-core:O-antigen ligase [KO:K02847] [EC:2.4.1.-]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  Di[3-deoxy-D-manno-octulosonyl]-lipid IV(A)
C06026  Di[3-deoxy-D-manno-octulosonyl]-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
KO pathway
ko00540   
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