Entry
Name
Wnt signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Other DBs
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene
101411225 DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353 ]
101412787 LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308 ]
101413575 TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508 ]
101413654 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101414656 CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816 ]
101414700 BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162 ]
101416179 LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068 ]
101416677 PPARD; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta [KO:K04504 ]
101417008 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
101419567 TLE3; LOW QUALITY PROTEIN: transducin-like enhancer protein 3 [KO:K04497 ]
101419692 CHD8; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 8 [KO:K04494 ] [EC:5.6.2.-]
101419878 PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
101420075 PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
101420315 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101421086 RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
101421842 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
101423227 LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068 ]
101424450 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333 ]
101427179 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101427527 DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512 ]
101427629 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101427882 NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446 ]
101429879 LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309 ]
101430728 SFRP1; secreted frizzled-related protein 1 isoform X1 [KO:K02166 ]
101433286 TCF7L2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491 ]
101435196 DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353 ]
101435854 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
101438745 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515 ] [EC:2.7.11.17 ]
101439692 DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353 ]
101441891 BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362 ]
101442429 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515 ] [EC:2.7.11.17 ]
101443825 DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512 ]
101445510 LGR6; LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399 ]
101445683 CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
101447050 SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605 ]
Compound
Reference
Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
Title
Beta-catenin and Tcfs in mammary development and cancer.
Journal
Reference
Authors
Yang Y.
Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
Journal
Reference
Authors
Kalderon D.
Title
Similarities between the Hedgehog and Wnt signaling pathways.
Journal
Reference
Authors
Nusse R.
Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
Journal
Reference
Authors
Jope RS, Johnson GV.
Title
The glamour and gloom of glycogen synthase kinase-3.
Journal
Reference
Authors
Veeman MT, Axelrod JD, Moon RT.
Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
Journal
Reference
Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
Journal
Reference
Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
Title
The way Wnt works: Components and mechanism.
Journal
Reference
Authors
Carethers JM
Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
Journal
Reference
Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
Journal
Reference
Authors
Niehrs C
Title
The complex world of WNT receptor signalling.
Journal
Reference
Authors
Abou Ziki MD, Mani A
Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
Journal
Reference
Authors
He Y, Ki H, Kim H, Kim K
Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
Journal
Reference
Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
Journal
Reference
Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
Journal
Related pathway
KO pathway