KEGG   PATHWAY: dnm04310
Entry
dnm04310                    Pathway                                
Name
Wnt signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
dnm04310  Wnt signaling pathway
dnm04310

Other DBs
GO: 0016055
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410832  MMP7; matrilysin [KO:K01397] [EC:3.4.24.23]
101411225  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101411312  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
101411457  TCF7; LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101411463  AXIN1; axin-1 [KO:K02157]
101411621  DKK1; dickkopf-related protein 1 [KO:K02165]
101411787  [KO:K04508]
101411899  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101412070  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101412391  WNT9A; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
101412476  AXIN2; axin-2 isoform X1 [KO:K04385]
101412686  DKK4; dickkopf-related protein 4 [KO:K02165]
101412787  LGR5; leucine-rich repeat-containing G-protein coupled receptor 5 [KO:K04308]
101412959  GPC4; glypican-4 [KO:K08110]
101413275  SOST; sclerostin [KO:K16834]
101413304  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101413366  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101413575  TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1 [KO:K04508]
101413654  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101413809  [KO:K04345] [EC:2.7.11.11]
101413976  RSPO4; R-spondin-4 [KO:K23099]
101414043  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101414453  RSPO3; R-spondin-3 [KO:K23098]
101414535  MCC; colorectal mutant cancer protein [KO:K26734]
101414656  CCAR2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
101414700  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101415111  WNT16; protein Wnt-16 [KO:K01558]
101415205  CUL1; LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
101415427  APC; adenomatous polyposis coli protein [KO:K02085]
101415471  WNT6; protein Wnt-6 [KO:K00445]
101416017  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
101416090  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416179  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101416565  RNF43; E3 ubiquitin-protein ligase RNF43 [KO:K15694] [EC:2.3.2.27]
101416677  PPARD; LOW QUALITY PROTEIN: peroxisome proliferator-activated receptor delta [KO:K04504]
101417008  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101417060  CACYBP; calcyclin-binding protein [KO:K04507]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101417363  SERPINF1; pigment epithelium-derived factor [KO:K19614]
101417902  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101417966  FZD3; frizzled-3 [KO:K02329]
101418404  SFRP4; secreted frizzled-related protein 4 [KO:K02185]
101418767  CTNNB1; catenin beta-1 [KO:K02105]
101419186  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101419396  WNT8A; protein Wnt-8a [KO:K00714]
101419456  SENP2; sentrin-specific protease 2 isoform X1 [KO:K03345] [EC:3.4.22.68]
101419567  TLE3; LOW QUALITY PROTEIN: transducin-like enhancer protein 3 [KO:K04497]
101419692  CHD8; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 8 [KO:K04494] [EC:5.6.2.-]
101419878  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101420075  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101420315  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101420545  PRICKLE3; prickle planar cell polarity protein 3 [KO:K04511]
101420648  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101420847  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101421288  PRICKLE1; prickle-like protein 1 [KO:K04511]
101421301  WIF1; wnt inhibitory factor 1 [KO:K01691]
101421680  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101421842  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101422116  FZD7; frizzled-7 [KO:K02432]
101422302  SIAH1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
101422457  CBY1; protein chibby homolog 1 isoform X2 [KO:K23402]
101423227  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101423293  CCDC88C; protein Daple [KO:K25811]
101423354  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101423566  SFRP5; secreted frizzled-related protein 5 [KO:K02222]
101423668  APCDD1; protein APCDD1 [KO:K25812]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101424120  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
101424450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101425368  FOSL1; LOW QUALITY PROTEIN: fos-related antigen 1 [KO:K04502]
101425823  WNT4; protein Wnt-4 [KO:K00408]
101426088  FZD6; frizzled-6 [KO:K02376]
101426543  FZD1; frizzled-1 [KO:K02432]
101427179  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
101427403  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101427420  WNT8B; protein Wnt-8b [KO:K00714]
101427527  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
101427629  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101427751  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101427870  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101427882  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101428006  LEF1; lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
101428161  [KO:K17388] [EC:2.7.11.1]
101428728  [KO:K00572]
101428846  SFRP2; secreted frizzled-related protein 2 [KO:K02176]
101429184  FZD10; frizzled-10 [KO:K02842]
101429650  FBXW11; F-box/WD repeat-containing protein 11 [KO:K03362]
101429879  LGR4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
101430209  TLE6; transducin-like enhancer protein 6 [KO:K04497]
101430645  TLE2; transducin-like enhancer protein 2 [KO:K04497]
101430685  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
101430689  CTBP1; C-terminal-binding protein 1 [KO:K04496] [EC:1.1.1.428]
101430728  SFRP1; secreted frizzled-related protein 1 isoform X1 [KO:K02166]
101431018  ROR1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
101431024  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
101431125  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101431405  PRICKLE4; prickle-like protein 4 isoform X1 [KO:K04511]
101431536  DKK2; dickkopf-related protein 2 [KO:K02165]
101432213  WNT2; protein Wnt-2 precursor [KO:K00182]
101432459  PRICKLE2; prickle-like protein 2 [KO:K04511]
101433286  TCF7L2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
101434005  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
101434851  [KO:K03096]
101434905  CTBP2; C-terminal-binding protein 2 isoform X1 [KO:K04496] [EC:1.1.1.428]
101435050  CER1; cerberus [KO:K01645]
101435131  PORCN; protein-serine O-palmitoleoyltransferase porcupine isoform X1 [KO:K00181] [EC:2.3.1.250]
101435196  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101435464  ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [KO:K16273] [EC:2.3.2.27]
101435527  WNT10A; protein Wnt-10a [KO:K01357]
101435854  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101436426  FZD5; frizzled-5 [KO:K02375]
101436827  WNT2B; protein Wnt-2b [KO:K00182]
101437182  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101437683  [KO:K03094]
101437790  FZD9; frizzled-9 [KO:K02842]
101437955  RUVBL1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
101438034  VANGL2; vang-like protein 2 isoform X2 [KO:K04510]
101438038  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101438650  CSNK2B; casein kinase II subunit beta [KO:K03115]
101438745  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101439209  CSNK1A1; casein kinase I [KO:K08957] [EC:2.7.11.1]
101439692  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101440970  [KO:K06268]
101441088  ROR2; tyrosine-protein kinase transmembrane receptor ROR2 [KO:K05123] [EC:2.7.10.1]
101441152  WNT5B; protein Wnt-5b [KO:K00444]
101441452  TLE1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]
101441891  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
101441913  VANGL1; vang-like protein 1 [KO:K04510]
101441952  [KO:K08957] [EC:2.7.11.1]
101442004  RSPO1; R-spondin-1 [KO:K19471]
101442429  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
101442817  TBL1X; F-box-like/WD repeat-containing protein TBL1X [KO:K04508]
101443001  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
101443141  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101443248  [KO:K07860]
101443396  [KO:K04513]
101443432  WISP1; WNT1-inducible-signaling pathway protein 1 [KO:K22471]
101443494  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101443559  NOTUM; palmitoleoyl-protein carboxylesterase NOTUM [KO:K19882] [EC:3.1.1.98]
101443643  LZTS2; leucine zipper putative tumor suppressor 2 [KO:K26471]
101443748  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
101443825  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
101444027  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101444123  WNT9B; protein Wnt-9b [KO:K01064]
101444571  FRZB; secreted frizzled-related protein 3 [KO:K25481]
101445025  TLE4; transducin-like enhancer protein 4 isoform X1 [KO:K04497]
101445510  LGR6; LOW QUALITY PROTEIN: leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
101445596  [KO:K04345] [EC:2.7.11.11]
101445683  CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101446055  RSPO2; R-spondin-2 [KO:K23097]
101446117  [KO:K23491]
101446600  NKD1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
101446676  RYK; tyrosine-protein kinase RYK [KO:K05128] [EC:2.7.10.1]
101447050  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101447222  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101447314  WNT3A; protein Wnt-3a [KO:K00312]
101447351  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111764971  INVS; inversin [KO:K19626]
Compound
C00076  Calcium cation
Reference
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
Related
pathway
dnm04010  MAPK signaling pathway
dnm04110  Cell cycle
dnm04115  p53 signaling pathway
dnm04120  Ubiquitin mediated proteolysis
dnm04350  TGF-beta signaling pathway
dnm04510  Focal adhesion
dnm04520  Adherens junction
dnm05010  Alzheimer disease
KO pathway
ko04310   

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