KEGG   PATHWAY: dnm04350
Entry
dnm04350                    Pathway                                
Name
TGF-beta signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
dnm04350  TGF-beta signaling pathway
dnm04350

Other DBs
GO: 0007179
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410694  [KO:K03456]
101410737  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
101411009  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101411312  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
101411588  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101411899  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101412267  TFDP1; transcription factor Dp-1 [KO:K04683]
101413185  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
101413382  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101413828  FBN1; fibrillin-1 [KO:K06825]
101414279  ID3; DNA-binding protein inhibitor ID-3 [KO:K17694]
101414494  NBL1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
101414564  TF; serotransferrin [KO:K14736]
101414700  BAMBI; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
101415205  CUL1; LOW QUALITY PROTEIN: cullin-1 [KO:K03347]
101418449  RGMB; RGM domain family member B [KO:K06847]
101419110  [KO:K04668]
101419186  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101419409  EMP3; epithelial membrane protein 3 [KO:K26257]
101420273  RBL1; retinoblastoma-like protein 1 isoform X2 [KO:K04681]
101420445  TNF; tumor necrosis factor [KO:K03156]
101420561  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
101421322  BMP7; bone morphogenetic protein 7 [KO:K16621]
101422574  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
101422825  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101422877  IFNG; interferon gamma [KO:K04687]
101423043  BMP6; bone morphogenetic protein 6 [KO:K16620]
101423411  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
101423691  BMP2; bone morphogenetic protein 2 [KO:K21283]
101423870  FMOD; fibromodulin [KO:K08121]
101424204  THBS1; thrombospondin-1 [KO:K16857]
101424233  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
101424622  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
101425169  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101426734  ID1; LOW QUALITY PROTEIN: DNA-binding protein inhibitor ID-1 [KO:K04680]
101427402  SKI; ski oncogene [KO:K26503]
101427466  CHRD; chordin [KO:K04657]
101427782  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101427870  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101428036  SF3A2; splicing factor 3A subunit 2 [KO:K04665]
101428586  [KO:K16620]
101428991  BMP5; bone morphogenetic protein 5 [KO:K04663]
101429066  HFE; hereditary hemochromatosis protein [KO:K26535]
101429090  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
101429319  TFR2; transferrin receptor protein 2 [KO:K23910]
101429388  INHBC; inhibin beta C chain isoform X1 [KO:K22688]
101429828  TFRC; transferrin receptor protein 1 [KO:K06503]
101430016  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430914  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
101430981  SKIL; LOW QUALITY PROTEIN: ski-like protein [KO:K18499]
101431096  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
101431294  SMAD7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
101431300  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101431771  SMAD6; mothers against decapentaplegic homolog 6 isoform X1 [KO:K04677]
101431773  NODAL; nodal homolog [KO:K04666]
101432493  [KO:K19559]
101433515  RGMA; repulsive guidance molecule A [KO:K23096]
101433564  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101433978  TGIF2; homeobox protein TGIF2 [KO:K19553]
101434210  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101434549  TGFB3; transforming growth factor beta-3 [KO:K13377]
101434858  E2F5; transcription factor E2F5 isoform X1 [KO:K04682]
101435000  GDF6; growth/differentiation factor 6 [KO:K20012]
101435208  INHBE; LOW QUALITY PROTEIN: inhibin beta E chain [KO:K22689]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435965  SMAD9; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 9 [KO:K04676]
101435993  GREM2; gremlin-2 isoform X1 [KO:K23318]
101436331  HFE2; LOW QUALITY PROTEIN: hemojuvelin [KO:K23100]
101436627  HAMP; hepcidin [KO:K23106]
101437683  [KO:K03094]
101437737  TGFB1; transforming growth factor beta-1 [KO:K13375]
101438319  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
101438535  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
101438630  NRROS; negative regulator of reactive oxygen species isoform X1 [KO:K26317]
101439051  GDF5; growth/differentiation factor 5 [KO:K04664]
101439052  NOG; noggin [KO:K04658]
101439242  GREM1; gremlin-1 [KO:K23318]
101439255  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101439273  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
101439506  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
101439640  LRRC32; leucine-rich repeat-containing protein 32 [KO:K26316]
101439641  THSD4; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
101439956  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
101440373  [KO:K20013]
101440444  NCOR1; LOW QUALITY PROTEIN: nuclear receptor corepressor 1 [KO:K04650]
101440547  TGIF1; homeobox protein TGIF1 [KO:K19383]
101440572  ZFYVE9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
101440707  SIN3A; LOW QUALITY PROTEIN: paired amphipathic helix protein Sin3a [KO:K11644]
101441212  IGSF1; LOW QUALITY PROTEIN: immunoglobulin superfamily member 1 [KO:K26168]
101441960  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
101442678  AMHR2; LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
101443080  GDF7; growth/differentiation factor 7 [KO:K20013]
101443141  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101443396  [KO:K04513]
101444027  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101444331  [KO:K16622]
101444880  NEO1; neogenin isoform X1 [KO:K06766]
101444912  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101445012  DCN; decorin [KO:K04660]
101446043  ZFYVE16; LOW QUALITY PROTEIN: zinc finger FYVE domain-containing protein 16 [KO:K04679]
101446946  FST; follistatin isoform X1 [KO:K04661]
101447050  SMAD3; mothers against decapentaplegic homolog 3 isoform X2 [KO:K23605]
101447477  SMAD5; mothers against decapentaplegic homolog 5 [KO:K16790]
101447896  PITX2; pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Related
pathway
dnm04010  MAPK signaling pathway
dnm04110  Cell cycle
dnm04120  Ubiquitin mediated proteolysis
dnm04210  Apoptosis
KO pathway
ko04350   

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