KEGG   PATHWAY: dnm04510
Entry
dnm04510                    Pathway                                
Name
Focal adhesion - Dasypus novemcinctus (nine-banded armadillo)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
dnm04510  Focal adhesion
dnm04510

Other DBs
GO: 0005925
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
100913180  VWF; von Willebrand factor precursor [KO:K03900]
101411552  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101411761  [KO:K05692]
101411989  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101412224  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
101412315  TLN1; talin-1 [KO:K06271]
101412472  [KO:K04353]
101412724  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
101413147  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101413723  SPP1; osteopontin [KO:K06250]
101413834  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101414002  TNR; tenascin-R isoform X1 [KO:K06252]
101414043  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101414193  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
101414233  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101414245  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101414417  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101414592  PARVA; alpha-parvin [KO:K06275]
101415120  EMP2; epithelial membrane protein 2 [KO:K26256]
101415497  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101415610  FLNA; filamin-A [KO:K04437]
101415906  TNN; tenascin-N [KO:K06252]
101416079  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416334  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101416459  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101416622  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
101416767  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101416957  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
101417003  [KO:K06238]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101417480  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
101417744  CHAD; chondroadherin [KO:K06248]
101418095  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101418722  VEGFA; vascular endothelial growth factor A [KO:K05448]
101418748  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
101418767  CTNNB1; catenin beta-1 [KO:K02105]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419023  [KO:K05692]
101419124  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419695  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
101419952  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101419977  LAMA2; laminin subunit alpha-2 [KO:K05637]
101420015  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
101420045  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101420176  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101420406  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101420422  ITGA7; integrin alpha-7 [KO:K06583]
101420455  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101420537  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101420590  LAMB2; LOW QUALITY PROTEIN: laminin subunit beta-2 [KO:K06243]
101420624  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
101420648  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101420980  PIP5K1C; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
101421000  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101421103  RAP1B; ras-related protein Rap-1b [KO:K07836]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421444  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
101421478  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101421534  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101421680  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101421870  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101422146  ITGA5; integrin alpha-5 [KO:K06484]
101422156  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101422200  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101422617  SHC4; SHC-transforming protein 4 [KO:K17449]
101423380  ITGA8; integrin alpha-8 [KO:K06584]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101423744  [KO:K02649]
101423956  LAMC1; laminin subunit gamma-1 [KO:K05635]
101424138  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
101424204  THBS1; thrombospondin-1 [KO:K16857]
101424389  ITGA11; integrin alpha-11 [KO:K06587]
101424493  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101424609  EMP1; epithelial membrane protein 1 [KO:K26255]
101424691  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
101424943  IBSP; bone sialoprotein 2 [KO:K06253]
101424990  CRK; adapter molecule crk isoform X1 [KO:K04438]
101425091  ITGA3; integrin alpha-3 [KO:K06482]
101425135  FLNB; filamin-B isoform X1 [KO:K27392]
101425286  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101425321  [KO:K00889] [EC:2.7.1.68]
101425577  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101425815  ITGA4; integrin alpha-4 [KO:K06483]
101425835  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101426371  PGF; placenta growth factor isoform X2 [KO:K16859]
101426457  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101426465  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101426854  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101426900  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101427017  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
101427147  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
101427751  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101427801  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101428161  [KO:K17388] [EC:2.7.11.1]
101428234  [KO:K16060]
101428297  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101428656  ITGB1; integrin beta-1 [KO:K05719]
101428761  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428967  [KO:K05692]
101429575  VCL; vinculin isoform X1 [KO:K05700]
101429660  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101429999  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
101430321  ITGA9; integrin alpha-9 [KO:K06585]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430574  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
101430613  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101430628  CAV3; caveolin-3 [KO:K12959]
101431053  COL4A3; collagen alpha-3(IV) chain isoform X2 [KO:K06237]
101431477  [KO:K07836]
101431654  RAP1A; ras-related protein Rap-1A [KO:K04353]
101431717  [KO:K05735] [EC:2.7.11.1]
101431880  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101432371  THBS4; thrombospondin-4 [KO:K04659]
101432391  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101432586  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
101432628  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
101433020  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101433054  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101433098  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
101433224  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433497  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101433544  SOS2; son of sevenless homolog 2 [KO:K03099]
101433858  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101434926  CRKL; crk-like protein isoform X1 [KO:K04438]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435491  PXN; paxillin isoform X1 [KO:K05760]
101435623  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101435652  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435770  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101435788  CAV2; caveolin-2 [KO:K12958]
101436211  CAV1; caveolin-1 [KO:K06278]
101436341  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101436471  ITGB3; integrin beta-3 [KO:K06493]
101436527  TLN2; talin-2 isoform X2 [KO:K06271]
101436598  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
101437013  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
101437077  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
101437323  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
101438244  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101438260  SHC1; SHC-transforming protein 1 [KO:K06279]
101438715  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101438860  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
101439384  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
101439506  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
101439685  ZYX; zyxin [KO:K06273]
101439742  ITGA10; integrin alpha-10 isoform X2 [KO:K06586]
101439821  LAMB3; laminin subunit beta-3 [KO:K06244]
101440357  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101440502  LAMC2; laminin subunit gamma-2 [KO:K06246]
101440550  [KO:K05692]
101440768  THBS2; thrombospondin-2 [KO:K04659]
101440782  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
101440893  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101441006  LAMB1; laminin subunit beta-1 [KO:K05636]
101441254  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101441490  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101441500  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101441570  [KO:K12757]
101441616  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
101441649  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
101441801  VTN; vitronectin [KO:K06251]
101442163  [KO:K05692]
101442193  PARVG; gamma-parvin isoform X1 [KO:K06275]
101442198  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
101442307  [KO:K12757]
101443086  PARVB; beta-parvin isoform X3 [KO:K06275]
101443248  [KO:K07860]
101443257  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
101443396  [KO:K04513]
101443494  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101443644  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101443919  LAMA4; LOW QUALITY PROTEIN: laminin subunit alpha-4 [KO:K06241]
101444214  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444399  [KO:K05097] [EC:2.7.10.1]
101444762  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101445147  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101445333  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101445493  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101446901  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
101446965  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101447321  SHC2; SHC-transforming protein 2 [KO:K17447]
101447351  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101447727  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101447857  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
105746538  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
dnm04010  MAPK signaling pathway
dnm04060  Cytokine-cytokine receptor interaction
dnm04070  Phosphatidylinositol signaling system
dnm04110  Cell cycle
dnm04151  PI3K-Akt signaling pathway
dnm04310  Wnt signaling pathway
dnm04512  ECM-receptor interaction
dnm04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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