KEGG   PATHWAY: dnm05010
Entry
dnm05010                    Pathway                                
Name
Alzheimer disease - Dasypus novemcinctus (nine-banded armadillo)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
dnm05010  Alzheimer disease
dnm05010

Disease
H00056  Alzheimer disease
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410879  [KO:K04374]
101410933  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101411043  PSMB6; LOW QUALITY PROTEIN: proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
101411083  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101411225  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
101411295  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
101411311  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
101411463  AXIN1; axin-1 [KO:K02157]
101411485  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
101411493  [KO:K04522] [EC:3.4.23.-]
101411540  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
101411610  [KO:K04634]
101411621  DKK1; dickkopf-related protein 1 [KO:K02165]
101411659  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
101411989  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101412040  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
101412070  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
101412100  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101412104  [KO:K02264]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101412335  SLC39A14; zinc transporter ZIP14 isoform X1 [KO:K14720]
101412391  WNT9A; LOW QUALITY PROTEIN: protein Wnt-9a [KO:K01064]
101412476  AXIN2; axin-2 isoform X1 [KO:K04385]
101412632  [KO:K07374]
101412686  DKK4; dickkopf-related protein 4 [KO:K02165]
101412746  [KO:K00418]
101412843  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
101413064  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101413106  [KO:K08738]
101413116  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
101413207  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
101413233  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101413237  [KO:K02270]
101413241  KLC3; kinesin light chain 3 [KO:K10407]
101413270  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
101413304  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101413339  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101413355  SLC39A10; zinc transporter ZIP10 [KO:K14716]
101413363  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X4 [KO:K02136]
101413366  CSNK2A1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
101413442  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
101413565  APOE; apolipoprotein E [KO:K04524]
101413566  ADRM1; LOW QUALITY PROTEIN: proteasomal ubiquitin receptor ADRM1 [KO:K06691]
101413574  APP; amyloid-beta A4 protein isoform X1 [KO:K04520]
101413654  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101413908  [KO:K08738]
101414072  ATG101; autophagy-related protein 101 [KO:K19730]
101414080  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
101414240  [KO:K07828]
101414255  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
101414351  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X3 [KO:K08860] [EC:2.7.11.1]
101414361  [KO:K07375]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101414488  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
101414536  [KO:K02270]
101414612  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
101414631  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
101414657  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
101414723  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101414828  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
101414865  TUBB4B; tubulin beta-4B chain [KO:K07375]
101415022  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
101415111  WNT16; protein Wnt-16 [KO:K01558]
101415427  APC; adenomatous polyposis coli protein [KO:K02085]
101415471  WNT6; protein Wnt-6 [KO:K00445]
101415478  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
101415588  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
101415689  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
101415698  FADD; FAS-associated death domain protein [KO:K02373]
101415994  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
101416017  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416149  [KO:K08738]
101416179  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
101416233  IRS4; insulin receptor substrate 4 [KO:K17446]
101416247  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101416405  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
101416570  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
101416595  CALM2; calmodulin-2 [KO:K02183]
101416657  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
101416667  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
101416831  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101416948  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
101416998  [KO:K00419]
101417009  [KO:K02266]
101417090  [KO:K04741] [EC:3.4.22.-]
101417330  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101417423  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
101417556  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101417745  [KO:K02735] [EC:3.4.25.1]
101417865  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X3 [KO:K17908]
101417885  RELA; transcription factor p65 [KO:K04735]
101417950  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
101417966  FZD3; frizzled-3 [KO:K02329]
101417995  CALM1; calmodulin-1 [KO:K02183]
101418297  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
101418484  [KO:K04851]
101418610  RTN3; reticulon-3 [KO:K20723]
101418655  NCSTN; nicastrin [KO:K06171]
101418734  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
101418767  CTNNB1; catenin beta-1 [KO:K02105]
101418796  [KO:K02270]
101418803  [KO:K03947]
101418816  [KO:K07375]
101418910  [KO:K00416]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419153  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101419155  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
101419167  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101419371  MAPT; microtubule-associated protein tau [KO:K04380]
101419396  WNT8A; protein Wnt-8a [KO:K00714]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419528  [KO:K07374]
101419806  [KO:K02268]
101419878  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101420075  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101420315  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101420359  [KO:K03949]
101420428  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
101420436  PSMD12; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
101420445  TNF; tumor necrosis factor [KO:K03156]
101420451  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101420460  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
101420466  [KO:K15040]
101420546  [KO:K04369] [EC:2.7.12.2]
101420660  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101420685  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
101421174  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421250  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101421409  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
101421427  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101421632  [KO:K02264]
101421930  [KO:K03934] [EC:7.1.1.2]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101421948  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101422116  FZD7; frizzled-7 [KO:K02432]
101422727  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
101422946  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
101423206  PSMA5; LOW QUALITY PROTEIN: proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
101423227  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
101423259  [KO:K00413]
101423325  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101423354  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
101423375  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101423721  [KO:K02271]
101423744  [KO:K02649]
101423975  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
101423988  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
101423999  [KO:K03949]
101424047  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
101424109  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
101424213  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
101424472  [KO:K00236]
101424495  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
101424547  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
101424680  APBB1; amyloid-beta A4 precursor protein-binding family B member 1 [KO:K04529]
101424691  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
101425113  GAPDH; LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
101425165  IRS2; LOW QUALITY PROTEIN: insulin receptor substrate 2 [KO:K07187]
101425303  [KO:K02265]
101425711  SLC39A5; zinc transporter ZIP5 [KO:K14711]
101425810  TUBB1; tubulin beta-1 chain [KO:K07375]
101425823  WNT4; protein Wnt-4 [KO:K00408]
101425978  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
101425999  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101426088  FZD6; frizzled-6 [KO:K02376]
101426121  [KO:K07374]
101426202  [KO:K02727] [EC:3.4.25.1]
101426319  BACE2; LOW QUALITY PROTEIN: beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
101426373  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
101426543  FZD1; frizzled-1 [KO:K02432]
101426868  KIF5C; kinesin heavy chain [KO:K10396]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101426960  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
101426965  CALM3; calmodulin-3 [KO:K02183]
101426987  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
101427164  [KO:K02263]
101427179  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
101427222  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
101427420  WNT8B; protein Wnt-8b [KO:K00714]
101427474  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101427480  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
101427484  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101427610  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101427629  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101427723  [KO:K00417]
101427814  BACE1; beta-secretase 1 isoform X2 [KO:K04521] [EC:3.4.23.46]
101427919  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
101428068  [KO:K07375]
101428131  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
101428335  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
101428360  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
101428530  [KO:K20723]
101428566  [KO:K02739] [EC:3.4.25.1]
101428674  KLC4; kinesin light chain 4 [KO:K10407]
101428713  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
101428728  [KO:K00572]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101429135  TUBB6; tubulin beta-6 chain isoform X2 [KO:K07375]
101429170  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
101429184  FZD10; frizzled-10 [KO:K02842]
101429392  SLC39A8; zinc transporter ZIP8 [KO:K14714]
101429481  [KO:K05405]
101429543  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101430299  [KO:K02183]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430606  APH1B; LOW QUALITY PROTEIN: gamma-secretase subunit APH-1B [KO:K06172]
101430685  WNT10B; protein Wnt-10b isoform X2 [KO:K01357]
101430720  [KO:K07374]
101430732  [KO:K00414]
101430817  NRAS; GTPase NRas [KO:K07828]
101430818  [KO:K03962]
101431001  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
101431024  FZD4; LOW QUALITY PROTEIN: frizzled-4 [KO:K02354]
101431125  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101431165  TUBA4A; tubulin alpha-4A chain [KO:K07374]
101431198  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
101431251  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101431301  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
101431307  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
101431325  ATP5F1A; LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial [KO:K02132]
101431536  DKK2; dickkopf-related protein 2 [KO:K02165]
101431660  [KO:K00134] [EC:1.2.1.12]
101431862  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101431882  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
101431970  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101432149  [KO:K02271]
101432213  WNT2; protein Wnt-2 precursor [KO:K00182]
101432441  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
101432519  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101432667  TUBB; tubulin beta chain [KO:K07375]
101432723  [KO:K05863]
101432735  APAF1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
101432853  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101433033  [KO:K02266]
101433110  [KO:K08738]
101433135  [KO:K05863]
101433276  [KO:K02264]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433348  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
101433349  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101434005  FZD8; LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
101434069  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101434103  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101434296  NAE1; NEDD8-activating enzyme E1 regulatory subunit isoform X1 [KO:K04532]
101434544  [KO:K02267]
101434572  [KO:K00417]
101434740  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
101434771  KIF5A; kinesin heavy chain [KO:K10396]
101434817  BECN1; beclin-1 [KO:K08334]
101434834  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
101434851  [KO:K03096]
101434986  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101435194  SLC39A6; zinc transporter ZIP6 [KO:K14712]
101435196  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435311  [KO:K05210]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435396  [KO:K21421] [EC:1.-.-.-]
101435433  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
101435527  WNT10A; protein Wnt-10a [KO:K01357]
101435577  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
101435630  [KO:K00237]
101435656  LRRC74B; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 74B [KO:K07374]
101435697  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435760  [KO:K02273]
101435822  KIF5B; kinesin-1 heavy chain [KO:K10396]
101435833  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101435854  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101436006  CDK5; cyclin-dependent-like kinase 5 isoform X1 [KO:K02090] [EC:2.7.11.22]
101436325  [KO:K07374]
101436332  [KO:K00415]
101436426  FZD5; frizzled-5 [KO:K02375]
101436562  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
101436746  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
101436815  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
101436827  WNT2B; protein Wnt-2b [KO:K00182]
101436834  PSMC3; 26S proteasome regulatory subunit 6A isoform X1 [KO:K03065]
101436979  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
101437023  [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101437182  CSNK1E; casein kinase I isoform X1 [KO:K08960] [EC:2.7.11.1]
101437295  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X2 [KO:K17589]
101437300  [KO:K07374]
101437313  SLC39A3; zinc transporter ZIP3 [KO:K14709]
101437367  IRS1; insulin receptor substrate 1 [KO:K16172]
101437415  [KO:K02183]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437672  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101437676  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101437740  [KO:K07374]
101437750  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
101437790  FZD9; frizzled-9 [KO:K02842]
101437836  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
101438038  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
101438039  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
101438266  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
101438337  [KO:K00420]
101438376  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
101438629  [KO:K07374]
101438650  CSNK2B; casein kinase II subunit beta [KO:K03115]
101438727  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
101438902  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
101438934  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101438960  RTN4; reticulon-4 isoform X1 [KO:K20720]
101439172  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
101439203  TUBB4A; tubulin beta-4A chain [KO:K07375]
101439209  CSNK1A1; casein kinase I [KO:K08957] [EC:2.7.11.1]
101439386  PSMD11; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101439692  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101439815  CDK5R1; cyclin-dependent kinase 5 activator 1 [KO:K11716]
101439844  NDUFS3; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
101440057  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
101440177  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
101440596  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
101440824  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 [KO:K17908]
101440970  [KO:K06268]
101441152  WNT5B; protein Wnt-5b [KO:K00444]
101441300  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101441413  PSMA1; LOW QUALITY PROTEIN: proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
101441434  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101441481  SNCA; alpha-synuclein [KO:K04528]
101441607  [KO:K02267]
101441702  SLC39A4; zinc transporter ZIP4 [KO:K14710]
101441936  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101441952  [KO:K08957] [EC:2.7.11.1]
101442089  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
101442217  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
101442474  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
101442884  [KO:K08738]
101443001  WNT11; protein Wnt-11 isoform X3 [KO:K01384]
101443113  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
101443144  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
101443250  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
101443291  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
101443369  SLC39A9; zinc transporter ZIP9 [KO:K14715]
101443638  SLC39A1; zinc transporter ZIP1 [KO:K14709]
101443695  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
101443748  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101443963  IL6; interleukin-6 [KO:K05405]
101444123  WNT9B; protein Wnt-9b [KO:K01064]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444678  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
101445087  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
101445167  IL1B; interleukin-1 beta [KO:K04519]
101445299  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
101445594  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101445631  [KO:K00411] [EC:7.1.1.8]
101445645  [KO:K02267]
101445731  RYR3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101445825  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
101445839  [KO:K02267]
101445858  KLC2; kinesin light chain 2 [KO:K10407]
101445869  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
101445958  SLC39A12; LOW QUALITY PROTEIN: zinc transporter ZIP12 [KO:K14718]
101446035  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
101446230  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
101446249  [KO:K02263]
101446294  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
101446378  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
101446420  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
101446493  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
101446663  CHRNA7; CHRNA7-FAM7A fusion protein [KO:K04809]
101446691  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
101446824  [KO:K03940] [EC:7.1.1.2]
101446876  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
101447000  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
101447222  FRAT1; proto-oncogene FRAT1 [KO:K03069]
101447262  [KO:K03940] [EC:7.1.1.2]
101447272  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
101447314  WNT3A; protein Wnt-3a [KO:K00312]
101447422  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
105744587  [KO:K02183]
111759679  [KO:K02271]
111759729  [KO:K08738]
111763660  [KO:K08738]
111763815  [KO:K02268]
111764174  [KO:K02271]
111764248  [KO:K02267]
111764544  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
111764560  [KO:K08738]
111765510  [KO:K02135]
111765858  [KO:K04634]
111765918  [KO:K02135]
111766325  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
111767097  [KO:K02272]
808124  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808125  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
808126  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808127  CYTB; cytochrome b [KO:K00412]
808128  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808129  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808130  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
808131  COX3; cytochrome c oxidase subunit III [KO:K02262]
808132  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
808133  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808134  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808135  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808136  COX2; cytochrome c oxidase subunit II [KO:K02261]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Related
pathway
dnm00190  Oxidative phosphorylation
dnm03050  Proteasome
dnm04020  Calcium signaling pathway
dnm04140  Autophagy - animal
dnm04141  Protein processing in endoplasmic reticulum
dnm04210  Apoptosis
dnm04310  Wnt signaling pathway
dnm04910  Insulin signaling pathway
dnm04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   

DBGET integrated database retrieval system