KEGG   PATHWAY: dnm04010
Entry
dnm04010                    Pathway                                
Name
MAPK signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
dnm04010  MAPK signaling pathway
dnm04010

Other DBs
GO: 0000165
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410635  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101410864  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
101410879  [KO:K04374]
101410933  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101411083  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101411149  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101411204  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101411312  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
101411552  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101411588  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101411653  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101411655  EREG; proepiregulin [KO:K09784]
101411685  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101411989  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101412034  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101412042  NTF3; LOW QUALITY PROTEIN: neurotrophin-3 [KO:K04356]
101412100  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101412233  KRAS; GTPase KRas isoform X4 [KO:K07827]
101412269  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101412293  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
101412330  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101412472  [KO:K04353]
101412731  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
101412781  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101412865  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101412966  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
101413043  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
101413067  KITLG; kit ligand isoform X1 [KO:K05461]
101413233  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101413415  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
101413705  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101413809  [KO:K04345] [EC:2.7.11.11]
101413963  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
101413986  [KO:K16342] [EC:3.1.1.4]
101414043  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101414225  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101414240  [KO:K07828]
101414417  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101414542  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101414850  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101414859  ANGPT4; angiopoietin-4 [KO:K05467]
101415110  FGF23; fibroblast growth factor 23 [KO:K22428]
101415186  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
101415355  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
101415496  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101415497  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101415609  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101415610  FLNA; filamin-A [KO:K04437]
101415616  FGF9; fibroblast growth factor 9 [KO:K04358]
101415624  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
101415898  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
101416000  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101416042  EFNA1; ephrin-A1 [KO:K05462]
101416069  TP53; cellular tumor antigen p53 [KO:K04451]
101416090  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416217  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101416245  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
101416658  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
101416709  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101416767  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101416934  STK4; serine/threonine-protein kinase 4 [KO:K04411]
101417157  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101417353  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
101417885  RELA; transcription factor p65 [KO:K04735]
101417906  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101418130  [KO:K04871]
101418484  [KO:K04851]
101418565  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101418598  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
101418675  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
101418722  VEGFA; vascular endothelial growth factor A [KO:K05448]
101418748  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
101418819  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101418890  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
101418944  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419116  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
101419167  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101419178  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
101419371  MAPT; microtubule-associated protein tau [KO:K04380]
101419458  STK3; serine/threonine-protein kinase 3 [KO:K04412]
101419480  HRAS; GTPase HRas isoform X1 [KO:K02833]
101419752  [KO:K03283]
101419849  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101420025  [KO:K03283]
101420045  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101420075  PPP3CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101420105  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101420406  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101420445  TNF; tumor necrosis factor [KO:K03156]
101420451  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101420455  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
101420537  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101420546  [KO:K04369] [EC:2.7.12.2]
101420847  NLK; LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101421083  FGF19; fibroblast growth factor 19 [KO:K22603]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101421103  RAP1B; ras-related protein Rap-1b [KO:K07836]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421427  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101421519  FGF4; fibroblast growth factor 4 [KO:K04358]
101421534  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101421680  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101421964  FGF3; fibroblast growth factor 3 [KO:K04358]
101422036  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101422047  FGF21; fibroblast growth factor 21 [KO:K22429]
101422096  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
101422156  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101422236  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
101422310  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101422418  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101422478  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
101422899  HSPB1; heat shock protein beta-1 [KO:K04455]
101423520  RELB; transcription factor RelB [KO:K09253]
101423570  FGF2; fibroblast growth factor 2 [KO:K18497]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101423756  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
101424026  MAX; protein max isoform X2 [KO:K04453]
101424130  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
101424173  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101424235  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101424427  [KO:K04344]
101424442  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101424450  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
101424505  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101424677  [KO:K04360] [EC:2.7.10.1]
101424874  RRAS; ras-related protein R-Ras [KO:K07829]
101424990  CRK; adapter molecule crk isoform X1 [KO:K04438]
101425133  STMN1; stathmin [KO:K04381]
101425522  [KO:K04391]
101425577  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
101425751  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101425772  PPP5C; serine/threonine-protein phosphatase 5 isoform X2 [KO:K04460] [EC:3.1.3.16]
101425795  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101425824  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
101425856  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101425884  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
101426146  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101426197  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
101426221  CACNA2D1; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
101426371  PGF; placenta growth factor isoform X2 [KO:K16859]
101426561  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101426829  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101426841  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101426854  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101426900  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101427165  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
101427189  [KO:K13769]
101427287  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101427474  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101427617  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
101427629  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101427669  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
101427698  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101427882  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101428001  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
101428020  [KO:K04391]
101428055  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
101428113  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101428297  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101428552  BDNF; brain-derived neurotrophic factor [KO:K04355]
101428693  ARRB1; beta-arrestin-1 isoform X5 [KO:K04439]
101428737  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101428775  FGF16; fibroblast growth factor 16 [KO:K04358]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101428889  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101429084  NTF4; neurotrophin-4 [KO:K12457]
101429151  FGF18; fibroblast growth factor 18 [KO:K04358]
101429662  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
101429730  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
101429772  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101430010  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101430016  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101430180  MRAS; ras-related protein M-Ras [KO:K07831]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430817  NRAS; GTPase NRas [KO:K07828]
101430930  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
101430983  PLA2G4D; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
101431251  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101431289  [KO:K04373] [EC:2.7.11.1]
101431301  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
101431376  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
101431430  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
101431477  [KO:K07836]
101431630  MYD88; LOW QUALITY PROTEIN: myeloid differentiation primary response protein MyD88 [KO:K04729]
101431654  RAP1A; ras-related protein Rap-1A [KO:K04353]
101431782  FOS; proto-oncogene c-Fos [KO:K04379]
101431862  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101431970  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
101431978  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101432008  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
101432181  NF1; neurofibromin [KO:K08052]
101432336  SRF; serum response factor [KO:K04378]
101433067  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101433158  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101433349  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101433544  SOS2; son of sevenless homolog 2 [KO:K03099]
101433632  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101433644  ARTN; artemin isoform X1 [KO:K25415]
101433683  FGF5; fibroblast growth factor 5 [KO:K04358]
101433858  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101433878  MAP4K2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
101433953  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
101434542  TAOK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
101434549  TGFB3; transforming growth factor beta-3 [KO:K13377]
101434699  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
101434926  CRKL; crk-like protein isoform X1 [KO:K04438]
101435256  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435283  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
101435286  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
101435652  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101435792  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X2 [KO:K04428] [EC:2.7.11.25]
101435854  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101436324  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101436647  [KO:K04453]
101436951  FGF7; fibroblast growth factor 7 [KO:K04358]
101437007  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
101437144  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101437323  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437737  TGFB1; transforming growth factor beta-1 [KO:K13375]
101438500  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101438899  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X2 [KO:K04462] [EC:2.1.1.367]
101439000  RASA2; ras GTPase-activating protein 2 [KO:K08053]
101439142  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
101439228  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101439353  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101439368  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101439489  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101439549  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101439571  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
101440435  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101440611  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
101440696  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
101440893  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101440970  [KO:K06268]
101441399  [KO:K05085] [EC:2.7.10.1]
101441434  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
101441490  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101441585  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101441784  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101441820  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101441858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101441936  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101442177  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101442244  PSPN; persephin [KO:K25416]
101442552  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
101442636  NGF; beta-nerve growth factor [KO:K02582]
101442775  IL1RAP; interleukin-1 receptor accessory protein isoform X3 [KO:K04723]
101443033  FGF10; fibroblast growth factor 10 [KO:K04358]
101443248  [KO:K07860]
101443460  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
101443644  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101443875  MAP3K12; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
101444378  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101444399  [KO:K05097] [EC:2.7.10.1]
101444493  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
101444714  FGF6; fibroblast growth factor 6 [KO:K04358]
101444912  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101445091  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
101445147  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101445167  IL1B; interleukin-1 beta [KO:K04519]
101445307  [KO:K04434]
101445359  [KO:K04370]
101445389  NRTN; neurturin isoform X2 [KO:K25414]
101445596  [KO:K04345] [EC:2.7.11.11]
101445661  AREG; amphiregulin isoform X1 [KO:K09782]
101445739  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101445868  RASA1; ras GTPase-activating protein 1 [KO:K04352]
101445964  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
101446221  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101446468  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101446968  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101447218  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101447351  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101447376  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101447415  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101447530  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
101447774  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101447924  FGF20; fibroblast growth factor 20 [KO:K04358]
105746538  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111761346  [KO:K04453]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
dnm04070  Phosphatidylinositol signaling system
dnm04110  Cell cycle
dnm04115  p53 signaling pathway
dnm04210  Apoptosis
dnm04310  Wnt signaling pathway
dnm04668  TNF signaling pathway
KO pathway
ko04010   

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