KEGG PATHWAY: ecb00590

PATHWAY: ecb00590

Entry

ecb00590                    Pathway

Name

Arachidonic acid metabolism - Equus caballus (horse)

Class

Metabolism; Lipid metabolism

Pathway map

ecb00590

Arachidonic acid metabolism

Other DBs

GO:

0019369

Organism

Equus caballus (horse) [GN:ecb]

Gene

100009687

HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]

100033889

PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]

100034087

PTGS1; prostaglandin G/H synthase 1 precursor [KO:K00509] [EC:1.14.99.1]

100034143

PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]

100037401

PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]

100049811

[KO:K16817] [EC:3.1.1.32 3.1.1.4]

100050188

GGT1; glutathione hydrolase 1 proenzyme isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

100050259

GGT5; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]

100050467

PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100050600

PTGR2; prostaglandin reductase 2 isoform X1 [KO:K13949] [EC:1.3.1.48]

100052257

LTA4H; leukotriene A-4 hydrolase isoform X1 [KO:K01254] [EC:3.3.2.6]

100053460

HPGDS; hematopoietic prostaglandin D synthase isoform X2 [KO:K04097] [EC:5.3.99.2 2.5.1.18]

100053834

[KO:K16817] [EC:3.1.1.32 3.1.1.4]

100053989

[KO:K16817] [EC:3.1.1.32 3.1.1.4]

100054324

PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100054405

FAM213B; LOW QUALITY PROTEIN: prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]

100055064

PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]

100057212

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

100058059

PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]

100058509

PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100058536

PLA2G5; calcium-dependent phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100059858

PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]

100060414

EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]

100061367

[KO:K07413] [EC:1.14.14.1]

100061400

[KO:K07413] [EC:1.14.14.1]

100061440

CYP2C92; cytochrome P450 2C92 precursor [KO:K07413] [EC:1.14.14.1]

100061454

[KO:K00084] [EC:1.1.1.184]

100061470

[KO:K07413] [EC:1.14.14.1]

100061502

[KO:K07413] [EC:1.14.14.1]

100061579

CYP2C113; cytochrome P450 2C19-like precursor [KO:K07413] [EC:1.14.14.1]

100061592

[KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

100061609

[KO:K07413] [EC:1.14.14.1]

100061622

[KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

100061690

[KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

100061787

[KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

100061958

ZADH2; prostaglandin reductase 3 isoform X1 [KO:K07119] [EC:1.3.1.48]

100062042

ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]

100062323

ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]

100062351

ALOXE3; hydroperoxide isomerase ALOXE3 isoform X1 [KO:K18684] [EC:4.2.1.152 5.4.4.7]

100063726

PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]

100064020

[KO:K07425] [EC:1.14.14.80]

100064092

[KO:K07425] [EC:1.14.14.80]

100066198

TBXAS1; thromboxane-A synthase [KO:K01832] [EC:5.3.99.5]

100066422

CYP2E1; cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]

100067247

[KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]

100067282

LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]

100067921

PTGDS; prostaglandin-H2 D-isomerase precursor [KO:K01830] [EC:5.3.99.2]

100068569

[KO:K07412] [EC:1.14.14.1]

100068603

[KO:K07412] [EC:1.14.14.1]

100070332

PTGES2; prostaglandin E synthase 2 isoform X1 [KO:K05309] [EC:5.3.99.3]

100070400

[KO:K07413] [EC:1.14.14.1]

100070491

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

100070501

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

100070509

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

100070616

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

100071016

PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]

100071025

PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]

100071038

PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]

100071062

PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]

100071076

PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]

100071214

[KO:K01047] [EC:3.1.1.4]

100071412

PTGIS; LOW QUALITY PROTEIN: prostacyclin synthase [KO:K01831] [EC:5.3.99.4]

100071826

PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]

100071833

PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100071838

PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100071870

PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100072858

PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]

100072900

ALOX15; LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]

100072916

[KO:K00458] [EC:1.13.11.31]

100072967

CYP2U1; cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]

100073039

ALOX15B; arachidonate 15-lipoxygenase B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]

100146938

[KO:K00081] [EC:1.1.1.184]

100630657

[KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]

102147383

GPX4; phospholipid hydroperoxide glutathione peroxidase, mitochondrial isoform X1 [KO:K05361] [EC:1.11.1.12]

111771771

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

111771772

[KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]

791253

PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]

Compound

C00157

Phosphatidylcholine

C00219

Arachidonate

C00427

Prostaglandin H2

C00584

Prostaglandin E2

C00639

Prostaglandin F2alpha

C00696

Prostaglandin D2

C00909

Leukotriene A4

C01312

Prostaglandin I2

C02165

Leukotriene B4

C02166

Leukotriene C4

C02198

Thromboxane A2

C03577

20-Hydroxyleukotriene E4

C04577

15-OxoETE

C04671

(5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate

C04707

(5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate

C04742

(15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate

C04758

(5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate

C04805

5(S)-HETE

C04822

8(R)-HPETE

C04835

(5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate

C04853

20-OH-Leukotriene B4

C05356

5(S)-HPETE

C05949

12-Keto-leukotriene B4

C05950

20-COOH-Leukotriene B4

C05951

Leukotriene D4

C05952

Leukotriene E4

C05953

Prostaglandin A2

C05954

Prostaglandin B2

C05955

Prostaglandin C2

C05956

Prostaglandin G2

C05957

Prostaglandin J2

C05958

Delta-12-Prostaglandin J2

C05959

11-epi-Prostaglandin F2alpha

C05960

15-Keto-prostaglandin F2alpha

C05961

6-Keto-prostaglandin F1alpha

C05962

6-Keto-prostaglandin E1

C05963

Thromboxane B2

C05964

11-Dehydro-thromboxane B2

C05965

12(S)-HPETE

C05966

15(S)-HPETE

C06314

Lipoxin A4

C06315

Lipoxin B4

C06462

Leukotriene F4

C13809

9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid

C14717

15-Deoxy-Delta12,14-PGJ2

C14732

5-OxoETE

C14748

20-HETE

C14749

19(S)-HETE

C14768

5,6-EET

C14769

8,9-EET

C14770

11,12-EET

C14771

14,15-EET

C14772

5,6-DHET

C14773

8,9-DHET

C14774

11,12-DHET

C14775

14,15-DHET

C14776

8(S)-HETE

C14777

12(S)-HETE

C14778

16(R)-HETE

C14779

9(S)-HETE

C14780

11(R)-HETE

C14781

15H-11,12-EETA

C14782

11,12,15-THETA

C14794

2,3-Dinor-8-iso prostaglandin F2alpha

C14795

2,3-Dinor-8-iso prostaglandin F1alpha

C14807

12-OxoETE

C14808

Hepoxilin A3

C14809

Trioxilin A3

C14810

Hepoxilin B3

C14811

Trioxilin B3

C14812

12(R)-HPETE

C14813

11H-14,15-EETA

C14814

11,14,15-THETA

C14815

5,6-Epoxytetraene

C14820

11(R)-HPETE

C14821

9(S)-HPETE

C14822

12(R)-HETE

C14823

8(S)-HPETE

C14824

8(R)-HETE

Reference

PMID:14636671

Authors

Spector AA, Fang X, Snyder GD, Weintraub NL.

Title

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.

Journal

Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3

Reference

PMID:15292194

Authors

Harman CA, Rieke CJ, Garavito RM, Smith WL.

Title

Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.

Journal

J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200

Reference

PMID:15205388

Authors

Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.

Title

The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.

Journal

Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727

Reference

PMID:14660610

Authors

Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.

Title

CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.

Journal

J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200

Reference

PMID:14626496

Authors

Sacerdoti D, Gatta A, McGiff JC.

Title

Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.

Journal

Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7

Reference

PMID:14622984

Authors

Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.

Title

Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.

Journal

Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026

Reference

PMID:11679404

Authors

Fleming I.

Title

Cytochrome p450 and vascular homeostasis.

Journal

Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268

Reference

PMID:11328810

Authors

Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.

Title

Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.

Journal

J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200

Reference

PMID:10908295

Authors

Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.

Title

CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.

Journal

Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279

Reference

PMID:9812980

Authors

Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.

Title

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.

Journal

J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879

Related
pathway

ecb00591

Linoleic acid metabolism

KO pathway

ko00590

DBGET integrated database retrieval system