KEGG   PATHWAY: eju04145
Entry
eju04145                    Pathway                                
Name
Phagosome - Eumetopias jubatus (Steller sea lion)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
eju04145  Phagosome
eju04145

Other DBs
GO: 0045335
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114196420  COMP; cartilage oligomeric matrix protein [KO:K04659]
114196599  LAMP1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
114196720  ITGB3; integrin beta-3 [KO:K06493]
114196746  MRC2; C-type mannose receptor 2 [KO:K06560]
114196836  STX18; syntaxin-18 [KO:K08492]
114196947  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
114197270  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
114197301  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
114197462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114197483  ACTB; actin, cytoplasmic 1 [KO:K05692]
114197769  CALR; calreticulin [KO:K08057]
114197933  TUBB1; tubulin beta-1 chain [KO:K07375]
114198063  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
114198631  THBS3; thrombospondin-3 [KO:K04659]
114199238  [KO:K06751]
114199266  TUBB; tubulin beta chain [KO:K07375]
114199406  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
114199499  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
114200150  [KO:K07374]
114200338  [KO:K07375]
114200378  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
114200487  CANX; calnexin [KO:K08057]
114200795  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
114200838  [KO:K08009]
114200839  CD209; CD209 antigen isoform X1 [KO:K06563]
114201211  [KO:K06751]
114201352  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114201386  RAB5C; ras-related protein Rab-5C [KO:K07889]
114201596  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
114201738  TUBB4B; tubulin beta-4B chain [KO:K07375]
114201934  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
114201953  [KO:K07374]
114201963  [KO:K07374]
114202063  FCAR; LOW QUALITY PROTEIN: immunoglobulin alpha Fc receptor [KO:K06513]
114202662  [KO:K10062]
114202666  [KO:K10062]
114203023  [KO:K06481]
114203024  [KO:K06481]
114203066  [KO:K08054]
114203068  [KO:K08054]
114203088  [KO:K13885]
114203089  [KO:K13885]
114203280  [KO:K02153]
114203282  [KO:K02153]
114203962  [KO:K04392]
114204214  [KO:K06751]
114204266  [KO:K07374]
114205075  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
114205639  RAB5A; ras-related protein Rab-5A [KO:K07887]
114205867  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
114205941  COLEC11; collectin-11 isoform X1 [KO:K10066]
114206133  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
114206153  MSR1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558]
114206968  TFRC; transferrin receptor protein 1 isoform X1 [KO:K06503]
114207342  MARCO; macrophage receptor MARCO [KO:K13884]
114207668  RAB7A; ras-related protein Rab-7a [KO:K07897]
114207678  SEC61A1; protein transport protein Sec61 subunit alpha [KO:K10956]
114207947  SEC22B; vesicle-trafficking protein SEC22b [KO:K08517]
114208485  [KO:K02155]
114208646  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
114208888  [KO:K07374]
114209136  [KO:K02152]
114209289  THBS2; thrombospondin-2 [KO:K04659]
114209490  CD14; LOW QUALITY PROTEIN: monocyte differentiation antigen CD14 [KO:K04391]
114209667  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
114209729  [KO:K07375]
114210089  TLR2; toll-like receptor 2 [KO:K10159]
114210095  [KO:K04392]
114210408  [KO:K06463]
114210517  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
114210618  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
114211037  EEA1; early endosome antigen 1 [KO:K12478]
114211397  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
114211692  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
114211706  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
114212234  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
114212737  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
114212779  ATP6V1G1; V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
114213296  VAMP3; vesicle-associated membrane protein 3 isoform X1 [KO:K13505]
114213581  SEC61B; protein transport protein Sec61 subunit beta [KO:K09481]
114213708  SEC61G; protein transport protein Sec61 subunit gamma [KO:K07342]
114213918  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
114213925  RILP; rab-interacting lysosomal protein [KO:K13883]
114214066  [KO:K10067]
114214069  MBL2; LOW QUALITY PROTEIN: mannose-binding protein C [KO:K03991]
114214085  SFTPD; pulmonary surfactant-associated protein D [KO:K10068]
114214310  CORO1A; coronin-1A [KO:K13882]
114214337  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
114214363  NCF1; neutrophil cytosol factor 1 [KO:K08011]
114214765  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
114214936  RAB5B; ras-related protein Rab-5B [KO:K07888]
114215007  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
114215563  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
114215966  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
114216053  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114216172  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
114216207  [KO:K02150]
114216467  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
114216507  PLA2R1; secretory phospholipase A2 receptor [KO:K06560]
114216715  [KO:K21421] [EC:1.-.-.-]
114216837  [KO:K07374]
114217158  STX12; syntaxin-12 [KO:K13813]
114217307  MRC1; macrophage mannose receptor 1 [KO:K06560]
114217613  THBS4; thrombospondin-4 [KO:K04659]
114217714  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
114217747  SEC61A2; protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
114217773  [KO:K07374]
114218355  NCF4; neutrophil cytosol factor 4 [KO:K08012]
114218399  [KO:K07374]
114218956  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
114219124  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
114220227  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
114220661  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
114220883  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
114221286  THBS1; thrombospondin-1 [KO:K16857]
114221439  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
114221604  OLR1; oxidized low-density lipoprotein receptor 1 [KO:K08763]
114221633  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
114221733  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
114221839  CD36; platelet glycoprotein 4 [KO:K06259]
114221886  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
114222003  [KO:K07374]
114222005  RAB7B; ras-related protein Rab-7b [KO:K07898]
114222068  [KO:K06751]
114222080  [KO:K06752]
114222082  [KO:K06752]
114222085  [KO:K06752]
114222086  [KO:K06752]
114222121  [KO:K06752]
114222122  [KO:K06752]
114222136  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
114222137  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
114222164  [KO:K06751]
114222182  [KO:K06752]
114222184  [KO:K06752]
114222220  [KO:K06752]
114222222  [KO:K06752]
114222228  [KO:K06752]
114222244  ATP6V1G2; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 2 [KO:K02152]
114222281  [KO:K06752]
114222402  ITGB1; integrin beta-1 [KO:K05719]
114222483  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
114222545  C1R; complement C1r subcomponent isoform X1 [KO:K01330] [EC:3.4.21.41]
114222582  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
114222825  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
114223349  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
114223369  [KO:K01365] [EC:3.4.22.15]
114223380  [KO:K01365] [EC:3.4.22.15]
114223381  [KO:K01365] [EC:3.4.22.15]
114223385  [KO:K01365] [EC:3.4.22.15]
114223458  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
114223638  [KO:K02150]
114223868  [KO:K07375]
114223871  TUBB2B; tubulin beta-2B chain [KO:K07375]
114223906  [KO:K07375]
114224059  [KO:K02152]
114224275  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
114224976  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
114225284  [KO:K02152]
114225614  STX7; syntaxin-7 isoform X1 [KO:K08488]
114225742  [KO:K07374]
114225746  ITGA5; integrin alpha-5 [KO:K06484]
114225882  TUBA1A; tubulin alpha-1A chain [KO:K07374]
114225883  TUBA1C; tubulin alpha-1C chain [KO:K07374]
114226149  C3; complement C3 [KO:K03990]
114226326  TUBB4A; tubulin beta-4A chain [KO:K07375]
114226448  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
114226472  [KO:K02150]
114226556  TLR6; toll-like receptor 6 [KO:K10169]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
eju04142  Lysosome
eju04144  Endocytosis
eju04610  Complement and coagulation cascades
eju04612  Antigen processing and presentation
eju04620  Toll-like receptor signaling pathway
eju04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04145   

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