KEGG   PATHWAY: ely04070
Entry
ely04070                    Pathway                                
Name
Phosphatidylinositol signaling system - Epinephelus lanceolatus (giant grouper)
Class
Environmental Information Processing; Signal transduction
Pathway map
ely04070  Phosphatidylinositol signaling system
ely04070

Organism
Epinephelus lanceolatus (giant grouper) [GN:ely]
Gene
117245777  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117245782  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117245927  itpkca; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
117245953  [KO:K13084] [EC:3.1.3.78]
117246316  [KO:K01109] [EC:3.1.3.66]
117246404  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117246838  mtmr2; myotubularin-related protein 2 isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117246921  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117247072  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
117247302  [KO:K05858] [EC:3.1.4.11]
117247374  ipmkb; inositol polyphosphate multikinase [KO:K00915] [EC:2.7.1.140 2.7.1.151]
117247633  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
117248054  [KO:K01106] [EC:3.1.3.56]
117248328  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
117248395  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117248423  inpp5f; phosphatidylinositide phosphatase SAC2 [KO:K21798] [EC:3.1.3.-]
117249429  dgki; diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
117249896  [KO:K00901] [EC:2.7.1.107]
117249907  [KO:K01109] [EC:3.1.3.66]
117249910  plcd4a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
117250832  [KO:K02183]
117250944  [KO:K05859] [EC:3.1.4.11]
117251250  dgkh; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
117251327  pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
117251396  inpp4aa; inositol polyphosphate-4-phosphatase type I A [KO:K01109] [EC:3.1.3.66]
117251683  [KO:K00901] [EC:2.7.1.107]
117251734  plcd4b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
117251861  [KO:K02183]
117251900  pi4kab; phosphatidylinositol 4-kinase, catalytic, alpha b isoform X1 [KO:K00888] [EC:2.7.1.67]
117252041  inpp5e; phosphatidylinositol polyphosphate 5-phosphatase type IV [KO:K20278] [EC:3.1.3.36]
117252094  inpp5l; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
117252217  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
117252529  [KO:K02649]
117252676  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117252749  mtmr3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117252798  cds1; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
117253448  [KO:K00922] [EC:2.7.1.153]
117253479  [KO:K01116] [EC:3.1.4.11]
117253836  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117253851  inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
117254143  [KO:K02649]
117254148  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117254945  [KO:K19662] [EC:2.7.11.13]
117255181  [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117255356  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
117255390  pi4k2a; phosphatidylinositol 4-kinase type 2-alpha [KO:K13711] [EC:2.7.1.67]
117255414  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117255421  pi4k2b; phosphatidylinositol 4-kinase type 2-beta isoform X1 [KO:K13711] [EC:2.7.1.67]
117255506  [KO:K00920] [EC:2.7.1.149]
117255563  inpp4b; type II inositol 3,4-bisphosphate 4-phosphatase isoform X1 [KO:K01109] [EC:3.1.3.66]
117256214  [KO:K04958]
117256232  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
117256325  inpp1; inositol polyphosphate 1-phosphatase [KO:K01107] [EC:3.1.3.57]
117256403  ippk; inositol-pentakisphosphate 2-kinase [KO:K10572] [EC:2.7.1.158]
117256444  [KO:K07756] [EC:2.7.4.21]
117256586  [KO:K00920] [EC:2.7.1.149]
117256637  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X1 [KO:K00923] [EC:2.7.1.154]
117256821  ip6k1; inositol hexakisphosphate kinase 1 [KO:K07756] [EC:2.7.4.21]
117256973  ip6k2b; inositol hexakisphosphate kinase 2b [KO:K07756] [EC:2.7.4.21]
117256979  [KO:K02183]
117257186  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
117257450  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
117257969  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
117258364  ppip5k1a; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X1 [KO:K13024] [EC:2.7.4.24]
117258443  pip4k2ca; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
117258561  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
117258562  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117258827  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117259423  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
117259631  [KO:K00901] [EC:2.7.1.107]
117259781  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
117259817  [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117259836  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117259974  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [KO:K15909] [EC:3.1.3.86]
117260061  si:ch73-22a13.3; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
117260928  ocrl; inositol polyphosphate 5-phosphatase OCRL isoform X1 [KO:K01099] [EC:3.1.3.36]
117260935  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
117261231  [KO:K00901] [EC:2.7.1.107]
117261499  mtmr7a; myotubularin-related protein 7a [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117261747  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
117261975  calml4b; calmodulin-like protein 4 [KO:K02183]
117262184  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
117262289  ppip5k1b; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 isoform X1 [KO:K13024] [EC:2.7.4.24]
117262419  pik3c2g; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
117262420  [KO:K05861] [EC:3.1.4.11]
117262473  dgkzb; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
117262733  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117263385  [KO:K00889] [EC:2.7.1.68]
117263527  synj1; synaptojanin-1 isoform X1 [KO:K20279] [EC:3.1.3.36]
117263714  [KO:K19801] [EC:2.7.1.67]
117263720  sacm1la; phosphatidylinositide phosphatase SAC1-A isoform X1 [KO:K21797] [EC:3.1.3.-]
117263899  pip4p2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform X1 [KO:K13084] [EC:3.1.3.78]
117264411  sacm1lb; phosphatidylinositide phosphatase SAC1-B [KO:K21797] [EC:3.1.3.-]
117264418  [KO:K01092] [EC:3.1.3.25]
117264479  [KO:K01092] [EC:3.1.3.25]
117264573  plcd1a; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a [KO:K05857] [EC:3.1.4.11]
117264839  pip4k2aa; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
117265122  mtmr6; myotubularin-related protein 6 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
117265709  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117265803  [KO:K00889] [EC:2.7.1.68]
117266251  pi4kb; phosphatidylinositol 4-kinase beta isoform X1 [KO:K19801] [EC:2.7.1.67]
117266446  inpp5b; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [KO:K01099] [EC:3.1.3.36]
117266449  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
117266757  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117266794  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
117267012  itpk1b; inositol-tetrakisphosphate 1-kinase [KO:K00913] [EC:2.7.1.159 2.7.1.134]
117267056  calm1a; calmodulin-1a [KO:K02183]
117268140  [KO:K19662] [EC:2.7.11.13]
117268354  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117268902  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
117269042  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
117269552  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117269633  pi4kaa; phosphatidylinositol 4-kinase alpha isoform X1 [KO:K00888] [EC:2.7.1.67]
117269864  mtmr4; myotubularin-related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
117270226  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
117270599  [KO:K02183]
117270835  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
117270860  [KO:K05858] [EC:3.1.4.11]
117271061  [KO:K05858] [EC:3.1.4.11]
117271502  [KO:K02649]
117271508  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117271648  pip4p1a; type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A [KO:K13084] [EC:3.1.3.78]
117271943  [KO:K00922] [EC:2.7.1.153]
117271953  impa1; inositol monophosphatase 1 [KO:K01092] [EC:3.1.3.25]
117272109  bpnt2; inositol monophosphatase 3 [KO:K15759] [EC:3.1.3.7]
117272289  [KO:K01092] [EC:3.1.3.25]
117272413  [KO:K05857] [EC:3.1.4.11]
117272483  [KO:K00889] [EC:2.7.1.68]
117272623  mtmr1a; myotubularin-related protein 1a isoform X1 [KO:K18081] [EC:3.1.3.64 3.1.3.95]
117272901  mtm1; myotubularin isoform X1 [KO:K01108] [EC:3.1.3.64 3.1.3.95]
Compound
C00076  Calcium cation
C00137  myo-Inositol
C00269  CDP-diacylglycerol
C00416  Phosphatidate
C00641  1,2-Diacyl-sn-glycerol
C01177  Inositol 1-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01204  Phytic acid
C01220  1D-myo-Inositol 1,4-bisphosphate
C01243  1D-myo-Inositol 1,3,4-trisphosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01272  1D-myo-Inositol 1,3,4,5-tetrakisphosphate
C01277  1-Phosphatidyl-1D-myo-inositol 4-phosphate
C01284  1D-myo-Inositol 1,3,4,5,6-pentakisphosphate
C03546  myo-Inositol 4-phosphate
C04006  1D-myo-Inositol 3-phosphate
C04062  D-myo-Inositol 1,3-bisphosphate
C04063  D-myo-Inositol 3,4-bisphosphate
C04477  1D-myo-Inositol 1,3,4,6-tetrakisphosphate
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11174  1-Diphosinositol pentakisphosphate
C11526  5-PP-InsP5
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
C11555  1D-myo-Inositol 1,4,5,6-tetrakisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C11557  1-Phosphatidyl-1D-myo-inositol 5-phosphate
C20690  1D-myo-Inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
Reference
PMID:19580826
  Authors
Sasaki T, Takasuga S, Sasaki J, Kofuji S, Eguchi S, Yamazaki M, Suzuki A
  Title
Mammalian phosphoinositide kinases and phosphatases.
  Journal
Prog Lipid Res 48:307-43 (2009)
DOI:10.1016/j.plipres.2009.06.001
Reference
PMID:19439500
  Authors
Shears SB
  Title
Diphosphoinositol polyphosphates: metabolic messengers?
  Journal
Mol Pharmacol 76:236-52 (2009)
DOI:10.1124/mol.109.055897
Related
pathway
ely04020  Calcium signaling pathway
ely04144  Endocytosis
ely04510  Focal adhesion
KO pathway
ko04070   

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