KEGG   PATHWAY: etf04115
Entry
etf04115                    Pathway                                
Name
p53 signaling pathway - Echinops telfairi (small Madagascar hedgehog)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
etf04115  p53 signaling pathway
etf04115

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101649302  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101654360  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101647559  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
101640005  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101645530  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
123521593  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101642422  MDM4; protein Mdm4 isoform X1 [KO:K10127]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101648693  PPP1R13L; relA-associated inhibitor [KO:K27356]
101660587  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101654378  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101645619  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101651720  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101649401  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101642843  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101650855  SFN; 14-3-3 protein sigma [KO:K06644]
101660772  RPRM; protein reprimo [KO:K10128]
101659025  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
101654399  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
101641440  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101649161  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101650390  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101660000  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101641486  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101661067  GTSE1; G2 and S phase-expressed protein 1 [KO:K10129]
101639932  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
101649262  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101659226  BID; BH3-interacting domain death agonist [KO:K04726]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101657818  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 isoform X2 [KO:K10131]
101659338  BBC3; bcl-2-binding component 3 [KO:K10132]
101642729  SIVA1; apoptosis regulatory protein Siva isoform X1 [KO:K22744]
101644838  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101659262  bcl-2-like protein 1 [KO:K04570]
101659722  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101643969  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
101648580  etoposide-induced protein 2.4 homolog [KO:K10134]
101657157  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
101639957  SHISA5; protein shisa-5 [KO:K10135]
101651562  p53 apoptosis effector related to PMP-22 [KO:K10136]
101641539  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
101639413  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
101657957  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
101638398  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
105979230  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101649850  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101660484  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101641235  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101661288  cytochrome c, testis-specific [KO:K08738]
101650600  cytochrome c-like [KO:K08738]
101656765  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
101659735  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101661703  AIFM2; ferroptosis suppressor protein 1 [KO:K22745]
101660698  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
101644114  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101651774  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
101640224  ADGRB1; adhesion G protein-coupled receptor B1 [KO:K04596]
101655142  CD82; CD82 antigen [KO:K06509]
101656527  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
101638154  SERPINB5; serpin B5 [KO:K10139]
101659849  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101642597  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101646624  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101661525  SESN3; sestrin-3 [KO:K10141]
101655528  SESN1; sestrin-1 [KO:K10141]
101651465  SESN2; sestrin-2 [KO:K20394]
101663717  TSC2; tuberin isoform X1 [KO:K07207]
101664268  STEAP3; metalloreductase STEAP3 isoform X1 [KO:K10142] [EC:1.16.1.-]
101663526  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
101639309  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
101654443  CCNG1; cyclin-G1 [KO:K10145]
101643175  CCNG2; cyclin-G2 [KO:K10146]
101651367  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
101647737  TP73; tumor protein p73 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
etf04110  Cell cycle
etf04210  Apoptosis
etf04218  Cellular senescence
KO pathway
ko04115   
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