KEGG   PATHWAY: etf04110
Entry
etf04110                    Pathway                                
Name
Cell cycle - Echinops telfairi (small Madagascar hedgehog)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
etf04110  Cell cycle
etf04110

Other DBs
GO: 0000278
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101654378  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101645619  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101646101  RB1; retinoblastoma-associated protein isoform X5 [KO:K06618]
101644403  RBL1; retinoblastoma-like protein 1 [KO:K04681]
101658150  RBL2; retinoblastoma-like protein 2 [KO:K16332]
101659985  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
101664320  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101664236  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101660509  E2F1; transcription factor E2F1 [KO:K17454]
101661819  E2F2; transcription factor E2F2 [KO:K09389]
101646404  E2F3; transcription factor E2F3 [KO:K06620]
101640899  E2F4; transcription factor E2F4 isoform X3 [KO:K04682]
101645519  TFDP1; transcription factor Dp-1 [KO:K04683]
101648398  TFDP2; transcription factor Dp-2 isoform X2 [KO:K09392]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101650988  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
101639819  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
101642513  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
101642964  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
105979476  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
101648760  SMAD4; mothers against decapentaplegic homolog 4 [KO:K04501]
101649029  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101658794  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
123521593  cyclin-dependent kinase 4 inhibitor B-like [KO:K06621]
101653356  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
101647907  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101649259  CDKN2D; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
101641071  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101660587  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101651720  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101649401  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101642843  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101648514  S-phase kinase-associated protein 1-like [KO:K03094]
105978575  S-phase kinase-associated protein 1 [KO:K03094]
101663453  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101648516  CUL1; cullin-1 isoform X3 [KO:K03347]
101662489  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
101646762  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101646103  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
101657266  CCNA1; cyclin-A1 [KO:K06627]
101642639  CCNA2; cyclin-A2 [KO:K06627]
101650669  CDC6; cell division control protein 6 homolog [KO:K02213]
101656591  CDT1; DNA replication factor Cdt1 [KO:K10727]
101660017  ORC1; origin recognition complex subunit 1 [KO:K02603]
101663287  ORC2; origin recognition complex subunit 2 [KO:K02604]
101663859  ORC3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
101641102  ORC4; origin recognition complex subunit 4 isoform X1 [KO:K02606]
101638056  ORC5; origin recognition complex subunit 5 [KO:K02607]
101643812  ORC6; origin recognition complex subunit 6 isoform X1 [KO:K02608]
101640044  MCM2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
101643646  MCM3; DNA replication licensing factor MCM3 [KO:K02541] [EC:5.6.2.3]
101661676  MCM4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
101661156  MCM5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
101659609  MCM6; DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
101655059  DNA replication licensing factor MCM6 [KO:K02542] [EC:5.6.2.3]
101642770  MCM7; DNA replication licensing factor MCM7 isoform X1 [KO:K02210] [EC:5.6.2.3]
101658037  LOW QUALITY PROTEIN: cell division control protein 45 homolog [KO:K06628]
101654074  CDC45; cell division control protein 45 homolog [KO:K06628]
101639761  TICRR; treslin [KO:K26117]
101657156  mdm2-binding protein [KO:K26116]
101639811  CDC7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
101646248  DBF4; protein DBF4 homolog A [KO:K06629]
101649161  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
101659025  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B1-like [KO:K05868]
101654399  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
101641440  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
101664078  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
101645781  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
101650912  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
101641454  YWHAQ; 14-3-3 protein theta [KO:K16197]
101647575  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
101652654  14-3-3 protein theta-like [KO:K16197]
101644365  YWHAE; 14-3-3 protein epsilon [KO:K06630]
101655441  YWHAG; 14-3-3 protein gamma [KO:K16198]
101644426  YWHAH; 14-3-3 protein eta [KO:K16198]
101657618  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
101650888  WEE1; wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
101655491  WEE2; wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
101662444  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
101661927  CCNH; cyclin-H isoform X1 [KO:K06634]
101663818  CDK7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
101638079  ANAPC1; anaphase-promoting complex subunit 1 isoform X3 [KO:K03348]
101650083  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
101651985  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
101652403  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
101660578  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
101646468  CDC16; cell division cycle protein 16 homolog [KO:K03353]
101659639  ANAPC7; anaphase-promoting complex subunit 7 isoform X2 [KO:K03354]
101638001  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101664573  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
101646282  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
101641766  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
115870563  anaphase-promoting complex subunit 13-like [KO:K12456]
105979806  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101652249  anaphase-promoting complex subunit 13 [KO:K12456]
101656706  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
101658135  anaphase-promoting complex subunit 15-like [KO:K25228]
101658016  anaphase-promoting complex subunit 15 [KO:K25228]
101646928  anaphase-promoting complex subunit 15-like [KO:K25228]
101663033  anaphase-promoting complex subunit 15-like [KO:K25228]
101638137  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
101643999  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101640845  PTTG1; securin isoform X2 [KO:K06635]
101653299  securin-like [KO:K06635]
101651389  ESPL1; separin [KO:K02365] [EC:3.4.22.49]
101662953  SMC1B; structural maintenance of chromosomes protein 1B [KO:K06636]
101654853  SMC1A; structural maintenance of chromosomes protein 1A [KO:K06636]
101661285  SMC3; structural maintenance of chromosomes protein 3 [KO:K06669]
101662498  RAD21; double-strand-break repair protein rad21 homolog [KO:K06670]
101663244  STAG2; cohesin subunit SA-2 isoform X1 [KO:K06671]
101646610  STAG1; cohesin subunit SA-1 [KO:K06671]
101645479  ATRX; transcriptional regulator ATRX [KO:K10779]
101662270  DDX11; ATP-dependent DNA helicase DDX11 [KO:K11273] [EC:5.6.2.7]
101645258  NIPBL; nipped-B-like protein isoform X1 [KO:K06672]
101657407  MAU2; MAU2 chromatid cohesion factor homolog isoform X1 [KO:K11266]
101648828  HDAC8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
101642963  ESCO1; N-acetyltransferase ESCO1 isoform X1 [KO:K11268] [EC:2.3.1.-]
101662995  ESCO2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
101642631  PDS5B; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
101651051  PDS5A; sister chromatid cohesion protein PDS5 homolog A [KO:K11267]
101654114  WAPL; wings apart-like protein homolog isoform X1 [KO:K25163]
101657873  CDCA5; sororin [KO:K17390]
101661966  AURKB; aurora kinase B isoform X1 [KO:K11479] [EC:2.7.11.1]
101662880  SGO1; shugoshin 1 [KO:K11580]
101644319  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
101644179  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101657344  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101645417  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101647744  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
101663474  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101655698  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101642174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101641890  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101639916  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101657070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101638894  NDC80; kinetochore protein NDC80 homolog [KO:K11547]
101651815  KNL1; kinetochore scaffold 1 [KO:K11542]
101648501  TTK; dual specificity protein kinase TTK isoform X1 [KO:K08866] [EC:2.7.12.1]
101661634  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
101641075  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
101662567  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B isoform X2 [KO:K13728]
101650270  BUB1B; mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1 [KO:K06637] [EC:2.7.11.1]
101655325  BUB3; mitotic checkpoint protein BUB3 [KO:K02180]
101662353  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
101641578  TRIP13; pachytene checkpoint protein 2 homolog [KO:K22399]
101647652  MAD2L1-binding protein [KO:K26093]
101646522  FZR1; fizzy-related protein homolog [KO:K03364]
101663501  FBXO5; F-box only protein 5 [KO:K10292]
101660309  CDC14B; dual specificity protein phosphatase CDC14B [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101652470  CDC14A; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
101641939  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101647070  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101661361  PRKDC; DNA-dependent protein kinase catalytic subunit [KO:K06642] [EC:2.7.11.1]
101647559  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
101649302  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101650390  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101660000  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101641486  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101646339  LOW QUALITY PROTEIN: proliferating cell nuclear antigen-like [KO:K04802]
105979800  proliferating cell nuclear antigen-like [KO:K04802]
101651523  PCNA; proliferating cell nuclear antigen [KO:K04802]
101642141  proliferating cell nuclear antigen-like [KO:K04802]
101650855  SFN; 14-3-3 protein sigma [KO:K06644]
101640005  CHEK1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
101654360  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
101640269  CDC25A; M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
Reference
PMID:7908906
  Authors
Matsuoka S, Yamaguchi M, Matsukage A
  Title
D-type cyclin-binding regions of proliferating cell nuclear antigen.
  Journal
J Biol Chem 269:11030-6 (1994)
Reference
PMID:8242749
  Authors
Welch PJ, Wang JY
  Title
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle.
  Journal
Cell 75:779-90 (1993)
DOI:10.1016/0092-8674(93)90497-E
Reference
PMID:16936746
  Authors
Macaluso M, Montanari M, Giordano A
  Title
Rb family proteins as modulators of gene expression and new aspects regarding the interaction with chromatin remodeling enzymes.
  Journal
Oncogene 25:5263-7 (2006)
DOI:10.1038/sj.onc.1209680
Reference
PMID:15838516
  Authors
Cobrinik D
  Title
Pocket proteins and cell cycle control.
  Journal
Oncogene 24:2796-809 (2005)
DOI:10.1038/sj.onc.1208619
Reference
PMID:17568790
  Authors
Boutros R, Lobjois V, Ducommun B
  Title
CDC25 phosphatases in cancer cells: key players? Good targets?
  Journal
Nat Rev Cancer 7:495-507 (2007)
DOI:10.1038/nrc2169
Reference
PMID:9832503
  Authors
Diehl JA, Cheng M, Roussel MF, Sherr CJ
  Title
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
  Journal
Genes Dev 12:3499-511 (1998)
DOI:10.1101/gad.12.22.3499
Reference
PMID:19020303
  Authors
Klein EA, Assoian RK
  Title
Transcriptional regulation of the cyclin D1 gene at a glance.
  Journal
J Cell Sci 121:3853-7 (2008)
DOI:10.1242/jcs.039131
Reference
PMID:10385618
  Authors
Sherr CJ, Roberts JM
  Title
CDK inhibitors: positive and negative regulators of G1-phase progression.
  Journal
Genes Dev 13:1501-12 (1999)
DOI:10.1101/gad.13.12.1501
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:12925736
  Authors
Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
  Title
Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
  Journal
Proc Natl Acad Sci U S A 100:10231-6 (2003)
DOI:10.1073/pnas.1831009100
Reference
PMID:16212951
  Authors
Bond M, Sala-Newby GB, Wu YJ, Newby AC
  Title
Biphasic effect of p21Cip1 on smooth muscle cell proliferation: role of PI 3-kinase and Skp2-mediated degradation.
  Journal
Cardiovasc Res 69:198-206 (2006)
DOI:10.1016/j.cardiores.2005.08.020
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11099028
  Authors
Vogelstein B, Lane D, Levine AJ
  Title
Surfing the p53 network.
  Journal
Nature 408:307-10 (2000)
DOI:10.1038/35042675
Reference
PMID:7973727
  Authors
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ Jr
  Title
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
  Journal
Science 266:1376-80 (1994)
DOI:10.1126/science.7973727
Reference
PMID:9889196
  Authors
Petersen BO, Lukas J, Sorensen CS, Bartek J, Helin K
  Title
Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
  Journal
EMBO J 18:396-410 (1999)
DOI:10.1093/emboj/18.2.396
Reference
PMID:17018296
  Authors
Sheu YJ, Stillman B
  Title
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
  Journal
Mol Cell 24:101-13 (2006)
DOI:10.1016/j.molcel.2006.07.033
Reference
PMID:9029154
  Authors
Martinez AM, Afshar M, Martin F, Cavadore JC, Labbe JC, Doree M
  Title
Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
  Journal
EMBO J 16:343-54 (1997)
DOI:10.1093/emboj/16.2.343
Reference
PMID:15876871
  Authors
Lolli G, Johnson LN
  Title
CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
  Journal
Cell Cycle 4:572-7 (2005)
DOI:10.4161/cc.4.4.1607
Reference
PMID:17426725
  Authors
Musacchio A, Salmon ED
  Title
The spindle-assembly checkpoint in space and time.
  Journal
Nat Rev Mol Cell Biol 8:379-93 (2007)
DOI:10.1038/nrm2163
Reference
PMID:12573239
  Authors
Uhlmann F
  Title
Chromosome cohesion and separation: from men and molecules.
  Journal
Curr Biol 13:R104-14 (2003)
DOI:10.1016/S0960-9822(03)00039-3
Reference
PMID:15568976
  Authors
Stegmeier F, Amon A
  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
  Journal
Annu Rev Genet 38:203-32 (2004)
DOI:10.1146/annurev.genet.38.072902.093051
Reference
PMID:9618481
  Authors
Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
  Journal
Proc Natl Acad Sci U S A 95:6733-8 (1998)
DOI:10.1073/pnas.95.12.6733
Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
etf03030  DNA replication
etf04010  MAPK signaling pathway
etf04120  Ubiquitin mediated proteolysis
etf04210  Apoptosis
KO pathway
ko04110   
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