KEGG   PATHWAY: etf04120
Entry
etf04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Echinops telfairi (small Madagascar hedgehog)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
etf04120  Ubiquitin mediated proteolysis
etf04120

Other DBs
GO: 0016567
Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101664603  ubiquitin-like [KO:K02927]
101656761  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
101661818  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
101649312  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
101647008  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
101650859  ubiquitin-40S ribosomal protein S27a [KO:K02977]
101654147  ubiquitin-like [KO:K02977]
101645780  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
101639765  SAE1; SUMO-activating enzyme subunit 1 [KO:K10684] [EC:6.2.1.45]
101641487  UBA2; SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
101659412  UBA3; NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
101660514  UBA7; ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
101642981  UBA6; ubiquitin-like modifier-activating enzyme 6 isoform X1 [KO:K10699] [EC:6.2.1.45]
101657423  ubiquitin-conjugating enzyme E2 A-like [KO:K10573] [EC:2.3.2.23]
101639028  UBE2A; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
101657965  UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 [KO:K10574] [EC:2.3.2.23]
101650034  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
101650426  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
101657032  ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
101645377  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
101655581  ubiquitin-conjugating enzyme E2 C-like isoform X1 [KO:K06688] [EC:2.3.2.23]
101645332  ubiquitin-conjugating enzyme E2 C-like [KO:K06688] [EC:2.3.2.23]
101661364  UBE2C; ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
101658935  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
101657657  ubiquitin-conjugating enzyme E2 D2-like [KO:K06689] [EC:2.3.2.23]
101646552  UBE2D1; ubiquitin-conjugating enzyme E2 D1 [KO:K06689] [EC:2.3.2.23]
101662972  UBE2D3; ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
101638777  ubiquitin-conjugating enzyme E2 D3 [KO:K06689] [EC:2.3.2.23]
101643973  UBE2D2; ubiquitin-conjugating enzyme E2 D2 isoform X1 [KO:K06689] [EC:2.3.2.23]
101654717  ubiquitin-conjugating enzyme E2 E1 [KO:K20217] [EC:2.3.2.23]
101639836  UBE2E3; ubiquitin-conjugating enzyme E2 E3 [KO:K20217] [EC:2.3.2.23]
101647478  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 E3-like [KO:K20217] [EC:2.3.2.23]
101638902  UBE2E2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
101662011  UBE2F; NEDD8-conjugating enzyme UBE2F [KO:K10687] [EC:2.3.2.34]
101643914  NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
101656394  LOW QUALITY PROTEIN: NEDD8-conjugating enzyme UBE2F-like [KO:K10687] [EC:2.3.2.34]
101660112  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
101642914  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
101639109  UBE2H; ubiquitin-conjugating enzyme E2 H [KO:K10576] [EC:2.3.2.23]
101654925  UBE2I; SUMO-conjugating enzyme UBC9 [KO:K10577]
101660284  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
101654291  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
101651353  UBE2K; ubiquitin-conjugating enzyme E2 K isoform X2 [KO:K04649] [EC:2.3.2.23]
101646650  UBE2L3; ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
101664556  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
101651117  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
101644737  UBE2M; NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
101663384  UBE2N; ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
101640479  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101657659  ubiquitin-conjugating enzyme E2 N [KO:K10580] [EC:2.3.2.23]
105979993  ubiquitin-conjugating enzyme E2 N-like [KO:K10580] [EC:2.3.2.23]
101653684  UBE2O; (E3-independent) E2 ubiquitin-conjugating enzyme [KO:K10581] [EC:2.3.2.24]
101658844  UBE2Q1; ubiquitin-conjugating enzyme E2 Q1 [KO:K10582] [EC:2.3.2.23]
101652793  UBE2Q2; ubiquitin-conjugating enzyme E2 Q2 [KO:K10582] [EC:2.3.2.23]
101639776  UBE2R2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
101657998  CDC34; ubiquitin-conjugating enzyme E2 R1 [KO:K02207] [EC:2.3.2.23]
101652677  UBE2S; ubiquitin-conjugating enzyme E2 S [KO:K10583] [EC:2.3.2.23]
101645992  UBE2W; ubiquitin-conjugating enzyme E2 W [KO:K10688] [EC:2.3.2.23 2.3.2.25]
101653986  UBE2Z; ubiquitin-conjugating enzyme E2 Z [KO:K10585] [EC:2.3.2.23]
101662909  BIRC6; baculoviral IAP repeat-containing protein 6 [KO:K10586] [EC:2.3.2.23]
101657114  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
101649840  UBE3B; ubiquitin-protein ligase E3B [KO:K10588] [EC:2.3.2.26]
101641192  UBE3C; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
101660885  SMURF2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
101649606  SMURF1; E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
101654665  ITCH; E3 ubiquitin-protein ligase Itchy homolog [KO:K05632] [EC:2.3.2.26]
101662385  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
101654605  WWP2; NEDD4-like E3 ubiquitin-protein ligase WWP2 [KO:K05630] [EC:2.3.2.26]
101653443  TRIP12; E3 ubiquitin-protein ligase TRIP12 isoform X12 [KO:K10590] [EC:2.3.2.26]
101663106  NEDD4; E3 ubiquitin-protein ligase NEDD4 [KO:K10591] [EC:2.3.2.26]
101654710  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X8 [KO:K13305] [EC:2.3.2.26]
101655596  HUWE1; E3 ubiquitin-protein ligase HUWE1 [KO:K10592] [EC:2.3.2.26]
101641363  UBR5; E3 ubiquitin-protein ligase UBR5 [KO:K10593] [EC:2.3.2.26]
101644644  HERC1; probable E3 ubiquitin-protein ligase HERC1 [KO:K10594] [EC:2.3.2.26]
101658438  HERC2; E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
101657701  HERC3; probable E3 ubiquitin-protein ligase HERC3 [KO:K10614] [EC:2.3.2.26]
101656047  HERC4; probable E3 ubiquitin-protein ligase HERC4 [KO:K10615] [EC:2.3.2.26]
101656218  UBE4A; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
101639738  UBE4B; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
101650969  STUB1; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
101661475  PPIL2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
101658619  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
101659253  UBOX5; RING finger protein 37 isoform X1 [KO:K10600]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101649648  CBL; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
101641844  CBLB; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
101641756  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
101639304  PRKN; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
101639413  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
101657957  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1A-like [KO:K04506] [EC:2.3.2.27]
101638398  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
105979230  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101649850  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101660484  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101641235  E3 ubiquitin-protein ligase SIAH1-like [KO:K04506] [EC:2.3.2.27]
101659033  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
101658809  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
101645836  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101663526  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
101639309  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
101655890  baculoviral IAP repeat-containing protein 3 [KO:K16060]
101659133  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
115869468  baculoviral IAP repeat-containing protein 2 [KO:K16060]
101662600  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
115870648  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 7-like [KO:K16061]
101642525  BIRC7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
101652320  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
101641513  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X5 [KO:K16063] [EC:2.3.2.-]
101653948  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X2 [KO:K16064] [EC:2.3.2.-]
101655298  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
101664492  SYVN1; E3 ubiquitin-protein ligase synoviolin isoform X3 [KO:K10601] [EC:2.3.2.27]
101656310  NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [KO:K10602] [EC:2.3.2.27]
101641777  AIRE; autoimmune regulator [KO:K10603]
101645211  MGRN1; E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
101639869  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
101646813  FANCL; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
101639027  MID1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
101647562  TRIM32; E3 ubiquitin-protein ligase TRIM32 [KO:K10607] [EC:2.3.2.27]
101658677  TRIM37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
101662489  E3 ubiquitin-protein ligase RBX1-like [KO:K03868] [EC:2.3.2.32]
101646762  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
101648516  CUL1; cullin-1 isoform X3 [KO:K03347]
101648514  S-phase kinase-associated protein 1-like [KO:K03094]
105978575  S-phase kinase-associated protein 1 [KO:K03094]
101663453  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
101644874  BTRC; F-box/WD repeat-containing protein 1A [KO:K03362]
101660400  FBXW11; F-box/WD repeat-containing protein 11 isoform X3 [KO:K03362]
101646103  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
101641540  FBXW7; F-box/WD repeat-containing protein 7 isoform X1 [KO:K10260]
101639322  FBXO2; F-box only protein 2 [KO:K10099]
101656565  FBXO4; F-box only protein 4 [KO:K10291]
101654589  CUL2; cullin-2 isoform X2 [KO:K03870]
101648670  ELOC; elongin-C [KO:K03872]
101649233  elongin-C-like [KO:K03872]
101644459  ELOB; elongin-B [KO:K03873]
101651152  VHL; von Hippel-Lindau disease tumor suppressor [KO:K03871]
101647827  CUL3; cullin-3 isoform X2 [KO:K03869]
101663172  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
101642270  KLHL13; kelch-like protein 13 isoform X2 [KO:K10447]
101647226  KLHL9; kelch-like protein 9 [KO:K10447]
101655767  RHOBTB2; rho-related BTB domain-containing protein 2 [KO:K07868]
101649690  RHOBTB1; rho-related BTB domain-containing protein 1 [KO:K07868]
101646469  CUL4A; cullin-4A isoform X1 [KO:K10609]
101659243  CUL4B; cullin-4B isoform X2 [KO:K10609]
101647685  DDB1; DNA damage-binding protein 1 [KO:K10610]
101659849  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
101638898  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
101648688  DET1; DET1 homolog isoform X1 [KO:K10571]
101649009  RNF7; RING-box protein 2 isoform X1 [KO:K10611]
101650244  CUL5; cullin-5 [KO:K10612]
101650439  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
101653170  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
101643739  CUL7; cullin-7 [KO:K10613]
101648992  FBXW8; F-box/WD repeat-containing protein 8 isoform X1 [KO:K10264]
101646282  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
101650083  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
101643999  CDC20; cell division cycle protein 20 homolog [KO:K03363]
101646522  FZR1; fizzy-related protein homolog [KO:K03364]
101638079  ANAPC1; anaphase-promoting complex subunit 1 isoform X3 [KO:K03348]
101651985  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
101652403  ANAPC4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
101660578  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
101646468  CDC16; cell division cycle protein 16 homolog [KO:K03353]
101659639  ANAPC7; anaphase-promoting complex subunit 7 isoform X2 [KO:K03354]
101638001  CDC23; cell division cycle protein 23 homolog [KO:K03355]
101664573  ANAPC10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
101641766  CDC26; anaphase-promoting complex subunit CDC26 isoform X1 [KO:K03359]
115870563  anaphase-promoting complex subunit 13-like [KO:K12456]
105979806  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
101652249  anaphase-promoting complex subunit 13 [KO:K12456]
101656706  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
101658135  anaphase-promoting complex subunit 15-like [KO:K25228]
101658016  anaphase-promoting complex subunit 15 [KO:K25228]
101646928  anaphase-promoting complex subunit 15-like [KO:K25228]
101663033  anaphase-promoting complex subunit 15-like [KO:K25228]
101638137  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
etf03050  Proteasome
KO pathway
ko04120   
LinkDB

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