KEGG   PATHWAY: fca00230
Entry
fca00230                    Pathway                                
Name
Purine metabolism - Felis catus (domestic cat)
Class
Metabolism; Nucleotide metabolism
Pathway map
fca00230  Purine metabolism
fca00230

Module
fca_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:fca00230]
fca_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:fca00230]
fca_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:fca00230]
fca_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:fca00230]
fca_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:fca00230]
fca_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:fca00230]
fca_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:fca00230]
Other DBs
GO: 0006163 0042278
Organism
Felis catus (domestic cat) [GN:fca]
Gene
100533976  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
101080290  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
101080682  NPR1; atrial natriuretic peptide receptor 1 isoform X3 [KO:K12323] [EC:4.6.1.2]
101080693  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
101081226  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
101081288  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
101081316  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101081398  AK2; adenylate kinase 2, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
101081485  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101081508  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
101081554  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
101081886  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
101082099  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
101082117  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
101082731  FHIT; bis(5'-adenosyl)-triphosphatase isoform X8 [KO:K01522] [EC:3.6.1.29]
101082824  AK9; adenylate kinase 9 isoform X3 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101083101  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4 [KO:K13755] [EC:3.1.4.17]
101083164  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
101083353  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
101083366  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 [KO:K18283] [EC:3.1.4.17]
101083622  NT5C2; cytosolic purine 5'-nucleotidase isoform X4 [KO:K01081] [EC:3.1.3.5]
101083652  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
101083845  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101084274  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
101084635  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101084638  AK4; adenylate kinase 4, mitochondrial isoform X3 [KO:K00939] [EC:2.7.4.3]
101084705  PAICS; multifunctional protein ADE2 isoform X4 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101084957  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
101085100  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
101085117  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
101085161  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101085582  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X3 [KO:K01510] [EC:3.6.1.5]
101085644  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
101086030  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101086044  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
101086123  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X4 [KO:K13293] [EC:3.1.4.53]
101086313  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
101086786  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
101086883  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
101087346  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
101087555  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101087673  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X2 [KO:K01939] [EC:6.3.4.4]
101087744  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
101087772  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101087987  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X7 [KO:K10808] [EC:1.17.4.1]
101088157  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101088196  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101088281  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
101088443  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
101088586  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
101088776  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
101088837  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101088956  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
101089435  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
101089682  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101089863  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
101089896  ADK; adenosine kinase isoform X4 [KO:K00856] [EC:2.7.1.20]
101089902  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
101090105  [KO:K11265] [EC:4.6.1.1]
101090242  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101090270  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
101090360  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X1 [KO:K07023] [EC:3.1.3.89]
101090414  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
101090683  ADA; adenosine deaminase isoform X3 [KO:K01488] [EC:3.5.4.4]
101090852  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
101090958  AMPD2; AMP deaminase 2 isoform X2 [KO:K01490] [EC:3.5.4.6]
101091207  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
101091211  ADCY6; adenylate cyclase type 6 isoform X2 [KO:K08046] [EC:4.6.1.1]
101092038  AK5; adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
101092076  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X2 [KO:K01939] [EC:6.3.4.4]
101092763  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
101092826  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9 [KO:K13293] [EC:3.1.4.53]
101093014  [KO:K01081] [EC:3.1.3.5]
101093538  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
101093653  AK1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
101093975  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
101094103  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101094148  ADCY7; adenylate cyclase type 7 isoform X2 [KO:K08047] [EC:4.6.1.1]
101094301  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
101094327  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
101094350  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101094498  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
101094608  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101094627  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X2 [KO:K13757] [EC:3.1.4.35]
101094858  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
101094877  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101094947  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101095012  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
101095109  GUCY2C; heat-stable enterotoxin receptor isoform X3 [KO:K12320] [EC:4.6.1.2]
101095116  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
101095235  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
101095541  NME4; LOW QUALITY PROTEIN: nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
101095577  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101095942  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101095997  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
101096356  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X3 [KO:K01510] [EC:3.6.1.5]
101096750  [KO:K00365] [EC:1.7.3.3]
101096755  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
101096963  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101097233  ALLC; probable allantoicase isoform X1 [KO:K01477] [EC:3.5.3.4]
101097343  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101097496  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
101097735  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
101097918  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101098083  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
101098377  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
101098715  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X6 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101098913  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
101099099  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
101099336  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
101099458  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
101099494  GUCY1A2; guanylate cyclase soluble subunit alpha-2 isoform X1 [KO:K12318] [EC:4.6.1.2]
101099523  GUK1; guanylate kinase isoform X3 [KO:K00942] [EC:2.7.4.8]
101099582  [KO:K12321] [EC:4.6.1.2]
101099777  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
101100071  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X2 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101100392  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X4 [KO:K18436] [EC:3.1.4.53]
101100604  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
101100749  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101101009  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
101101087  [KO:K22600] [EC:4.6.1.2]
101101262  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
101101375  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102899897  [KO:K07127] [EC:3.5.2.17]
102900269  [KO:K00939] [EC:2.7.4.3]
105261186  [KO:K00940] [EC:2.7.4.6]
109491348  AK6; adenylate kinase isoenzyme 6 isoform X3 [KO:K18532] [EC:2.7.4.3]
109496736  [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111558223  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
111559490  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
123378925  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
493692  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
751107  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X5 [KO:K13293] [EC:3.1.4.53]
768284  [KO:K00760] [EC:2.4.2.8]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
fca00030  Pentose phosphate pathway
fca00220  Arginine biosynthesis
fca00250  Alanine, aspartate and glutamate metabolism
fca00260  Glycine, serine and threonine metabolism
fca00340  Histidine metabolism
fca00630  Glyoxylate and dicarboxylate metabolism
fca00730  Thiamine metabolism
fca00740  Riboflavin metabolism
fca00790  Folate biosynthesis
KO pathway
ko00230   

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