KEGG   PATHWAY: gvr04723
Entry
gvr04723                    Pathway                                
Name
Retrograde endocannabinoid signaling - Galeopterus variegatus (Sunda flying lemur)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
gvr04723  Retrograde endocannabinoid signaling
gvr04723

Other DBs
GO: 0071926
Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103581319  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
103582610  [KO:K04440] [EC:2.7.11.24]
103583202  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
103583204  [KO:K08047] [EC:4.6.1.1]
103583388  [KO:K19663] [EC:2.7.11.13]
103584460  [KO:K03960]
103584995  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103585135  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103585136  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
103585144  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103585473  FAAH; fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
103585483  [KO:K15528] [EC:3.5.1.99]
103585515  KCNJ5; G protein-activated inward rectifier potassium channel 4 isoform X1 [KO:K04999]
103585560  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
103585627  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
103586085  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
103586228  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
103586407  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
103586711  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103586777  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
103586779  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
103586913  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103587083  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
103587098  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
103587107  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
103587451  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
103587477  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587478  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103587675  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
103587952  KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X1 [KO:K05002]
103588127  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
103588331  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
103588545  [KO:K05858] [EC:3.1.4.11]
103588664  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
103588774  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
103588815  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103588863  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
103588939  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
103589588  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
103589593  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
103589599  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
103589935  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
103590144  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103590972  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
103591088  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
103591300  [KO:K05858] [EC:3.1.4.11]
103591384  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103591492  [KO:K05181]
103591833  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103591872  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103591966  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
103592075  NDUFA4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [KO:K03948]
103592192  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103592255  [KO:K04603]
103592332  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
103592478  [KO:K03967]
103592516  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
103592574  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
103592610  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
103592642  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
103592767  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
103592909  DAGLA; sn1-specific diacylglycerol lipase alpha [KO:K13806] [EC:3.1.1.116]
103592984  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
103593557  ABHD6; monoacylglycerol lipase ABHD6 [KO:K13700] [EC:3.1.1.23]
103593617  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103593713  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
103594052  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
103594053  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
103594081  DAGLB; sn1-specific diacylglycerol lipase beta [KO:K13806] [EC:3.1.1.116]
103594734  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103594947  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103595029  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
103595679  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
103595819  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
103596084  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
103596097  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103596179  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103596263  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103596484  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
103596534  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
103596554  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
103596930  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
103597123  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
103597229  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
103597330  [KO:K03938]
103597404  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
103597698  [KO:K04960]
103597760  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103597918  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
103597992  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
103597995  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
103598152  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103598637  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103599611  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103599653  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
103599669  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
103599715  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
103599762  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
103599786  CNR1; cannabinoid receptor 1 [KO:K04277]
103599847  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
103600150  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
103600324  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103600566  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
103600926  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103601439  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103601724  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
103601791  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
103602496  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103602700  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
103602798  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
103603077  [KO:K04851]
103603406  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
103603478  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103603521  [KO:K04440] [EC:2.7.11.24]
103604296  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
103604574  [KO:K04849]
103605247  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
103605455  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
103605647  GABRP; gamma-aminobutyric acid receptor subunit pi isoform X1 [KO:K05189]
103606169  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
103606234  [KO:K05200]
103606378  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
103606393  [KO:K05186]
103606578  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103606635  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103606746  GRIA2; glutamate receptor 2 [KO:K05198]
103606874  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103607103  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
103607131  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
103607428  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607442  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103607466  [KO:K03943] [EC:7.1.1.2]
103607843  NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D [KO:K13985] [EC:3.1.4.54]
103608283  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103609465  [KO:K05175]
103609893  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103610927  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
804968  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
804970  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
804971  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
804972  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
804978  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
804979  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
804980  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
gvr00190  Oxidative phosphorylation
gvr04020  Calcium signaling pathway
gvr04721  Synaptic vesicle cycle
gvr04724  Glutamatergic synapse
gvr04727  GABAergic synapse
KO pathway
ko04723   

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