KEGG   PATHWAY: hgl00230
Entry
hgl00230                    Pathway                                
Name
Purine metabolism - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Nucleotide metabolism
Pathway map
hgl00230  Purine metabolism
hgl00230

Module
hgl_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:hgl00230]
hgl_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:hgl00230]
hgl_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:hgl00230]
hgl_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:hgl00230]
hgl_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:hgl00230]
hgl_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:hgl00230]
hgl_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:hgl00230]
Other DBs
GO: 0006163 0042278
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101723004  Nudt9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
101700336  Adprm; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101722031  Nudt5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101711743  Pgm1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
101712721  Pgm2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101707653  Prps1l1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
101725109  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
101696750  Prps2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
101720775  Ppat; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
101697318  Gart; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101715643  Pfas; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
101721606  Paics; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101719217  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
101721008  Atic; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101713665  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
101719663  Nt5c1b; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
101714870  Nt5c1a; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
101710390  Nt5c; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
101701244  Nt5c2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
101708532  Nt5m; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
101724629  Nt5dc4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
101707419  Nt5e; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
101708512  Pnp; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
101722043  Lacc1; laccase domain containing 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101714108  Hprt1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
101701391  Impdh2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
101720344  Impdh1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
101714526  inosine-5'-monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
101696650  Nme6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
101699234  Nme4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
101723023  Nme3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
101723532  Nme1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
106007568  Nme2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
101717407  Nme7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
101713299  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101715301  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
101696417  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
101708535  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
101708374  Cant1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
101700645  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
101703881  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
101717001  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
101717221  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101709761  Nudt16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101724609  Itpa; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
101708017  Xdh; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101699878  Nudt2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
101719752  Gmps; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
101712019  Gmpr; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
101698819  Gmpr2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
101713028  Gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
101718827  Guk1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
101708047  Rrm1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
101700655  Rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
101718446  Rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
101717485  Hddc2; HD domain containing 2 [KO:K07023] [EC:3.1.3.89]
101709356  Dguok; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
101722212  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101716057  Hddc3; HD domain containing 3 [KO:K21138] [EC:3.1.7.2]
101712283  Prune1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
101711366  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
101718304  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
101713887  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
101719464  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
101702436  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
101698189  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
101712483  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
101698293  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
101714605  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
101725888  Adcy10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
101702803  Gucy1a2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
101712487  Gucy1a3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
101726611  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
101724888  Gucy1b3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
101720874  Gucy2c; guanylate cyclase 2C [KO:K12320] [EC:4.6.1.2]
101697777  Gucy2d; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
101717731  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
101707903  Gucy2f; guanylate cyclase 2F, retinal [KO:K12322] [EC:4.6.1.2]
101713282  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
101714641  Npr1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101712380  Npr2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
101718122  Pde1b; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
101717015  Pde1c; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
101712147  Pde1a; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
101696343  Pde2a; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
101704787  Pde3a; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
101724440  Pde3b; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
101696421  Pde5a; phosphodiesterase 5A [KO:K13762] [EC:3.1.4.35]
101718823  Pde6a; phosphodiesterase 6A [KO:K08718] [EC:3.1.4.35]
101705017  Pde6b; phosphodiesterase 6B [KO:K13756] [EC:3.1.4.35]
101702814  Pde6c; phosphodiesterase 6C [KO:K13757] [EC:3.1.4.35]
101702746  Pde6d; phosphodiesterase 6D [KO:K13758]
101705352  Pde6g; phosphodiesterase 6G [KO:K13759]
101717519  Pde6h; phosphodiesterase 6H [KO:K13760]
101707431  Pde9a; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
101711466  Pde10a; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101700959  Pde11a; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101702121  Adssl1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]
101697507  Adss; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
101706263  Ampd3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
101704709  Ampd2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
101718930  Ampd1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
101719125  Adk; adenosine kinase [KO:K00856] [EC:2.7.1.20]
101707051  Ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
101704143  Cecr1; cat eye syndrome chromosome region, candidate 1 [KO:K19572] [EC:3.5.4.4]
101709339  Ak4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
101706938  Ak5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
101715028  Ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
101704809  Ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
101718797  Ak1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
101697619  Ak2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
101702543  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
101702578  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
102288482  Ak6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
106010804  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
106007688  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
101698558  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
101716319  Ak3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
101726023  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
101704716  Ntpcr; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
101706464  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101705137  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101715566  cAMP-specific 3',5'-cyclic phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
101717168  Pde4a; phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
101703441  Pde4b; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
101703048  Pde4c; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
101719453  Pde7a; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
101716394  Pde7b; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
101712263  Pde8b; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
101697131  Pde8a; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
101720165  Fhit; fragile histidine triad [KO:K01522] [EC:3.6.1.29]
101721340  Enpp4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) [KO:K18424] [EC:3.6.1.29]
101712205  Papss2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101714839  Papss1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101719675  uricase [KO:K00365] [EC:1.7.3.3]
101722738  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
101714307  Urad; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [KO:K13485] [EC:4.1.1.97]
101706738  Allc; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
hgl00030  Pentose phosphate pathway
hgl00220  Arginine biosynthesis
hgl00250  Alanine, aspartate and glutamate metabolism
hgl00260  Glycine, serine and threonine metabolism
hgl00340  Histidine metabolism
hgl00630  Glyoxylate and dicarboxylate metabolism
hgl00730  Thiamine metabolism
hgl00740  Riboflavin metabolism
hgl00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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