KEGG   PATHWAY: hgl00600
Entry
hgl00600                    Pathway                                
Name
Sphingolipid metabolism - Heterocephalus glaber (naked mole-rat)
Class
Metabolism; Lipid metabolism
Pathway map
hgl00600  Sphingolipid metabolism
hgl00600

Module
hgl_M00066  Lactosylceramide biosynthesis [PATH:hgl00600]
hgl_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:hgl00600]
hgl_M00094  Ceramide biosynthesis [PATH:hgl00600]
hgl_M00099  Sphingosine biosynthesis [PATH:hgl00600]
hgl_M00100  Sphingosine degradation [PATH:hgl00600]
Other DBs
GO: 0006665
Organism
Heterocephalus glaber (naked mole-rat) [GN:hgl]
Gene
101702482  Sptlc3; serine palmitoyltransferase long chain base subunit 3 [KO:K00654] [EC:2.3.1.50]
101702355  Sptlc2; serine palmitoyltransferase long chain base subunit 2 [KO:K00654] [EC:2.3.1.50]
101716616  Sptlc1; serine palmitoyltransferase long chain base subunit 1 [KO:K00654] [EC:2.3.1.50]
101702019  Kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
101705418  Cers1; ceramide synthase 1 [KO:K04710] [EC:2.3.1.299]
101716285  Cers2; ceramide synthase 2 [KO:K24621] [EC:2.3.1.297]
101715336  Cers4; ceramide synthase 4 [KO:K24621] [EC:2.3.1.297]
101702770  Cers3; ceramide synthase 3 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
101713278  Cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
101701089  Cers5; ceramide synthase 5 [KO:K23727] [EC:2.3.1.291]
101724913  Asah1; N-acylsphingosine amidohydrolase 1 [KO:K12348] [EC:3.5.1.23]
101709668  Asah2; N-acylsphingosine amidohydrolase 2 [KO:K12349] [EC:3.5.1.23]
101723877  Acer2; alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
101702052  Acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
106007497  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
101714598  Acer3; alkaline ceramidase 3 [KO:K04711] [EC:3.5.1.-]
101706415  Degs2; delta 4-desaturase, sphingolipid 2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
101722992  Degs1; delta 4-desaturase, sphingolipid 1 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
101710267  Sgms1; sphingomyelin synthase 1 [KO:K04714] [EC:2.7.8.27]
101712715  Sgms2; sphingomyelin synthase 2 [KO:K04714] [EC:2.7.8.27]
101699079  Smpd1; sphingomyelin phosphodiesterase 1 [KO:K12350] [EC:3.1.4.12]
101702568  Smpd2; sphingomyelin phosphodiesterase 2 [KO:K12351] [EC:3.1.4.12]
101722154  Smpd3; sphingomyelin phosphodiesterase 3 [KO:K12352] [EC:3.1.4.12]
101699020  Smpd4; sphingomyelin phosphodiesterase 4 [KO:K12353] [EC:3.1.4.12]
101723307  Enpp7; ectonucleotide pyrophosphatase/phosphodiesterase 7 [KO:K12354] [EC:3.1.4.12]
101720871  Cerk; ceramide kinase [KO:K04715] [EC:2.7.1.138]
101724889  Plpp1; phospholipid phosphatase 1 [KO:K01080] [EC:3.1.3.4]
101725640  Plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
101699454  Plpp3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
101710628  Sgpp1; sphingosine-1-phosphate phosphatase 1 [KO:K04716] [EC:3.1.3.-]
101698443  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
101697333  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
101701693  Sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
101711606  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
101720879  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
101719478  Sgpl1; sphingosine-1-phosphate lyase 1 [KO:K01634] [EC:4.1.2.27]
101700996  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
101716042  Ugcg; UDP-glucose ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
101704109  Gba; glucosylceramidase beta [KO:K01201] [EC:3.2.1.45]
101719027  Gba2; glucosylceramidase beta 2 [KO:K17108] [EC:3.2.1.45]
101726172  B4galt6; beta-1,4-galactosyltransferase 6 [KO:K07553] [EC:2.4.1.274]
101699877  B4galt5; beta-1,4-galactosyltransferase 5 [KO:K09905] [EC:2.4.1.274 2.4.1.-]
101712908  Glb1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]
101702896  Ugt8; UDP glycosyltransferase 8 [KO:K04628] [EC:2.4.1.47]
101721890  Galc; galactosylceramidase [KO:K01202] [EC:3.2.1.46]
101706903  Gal3st1; galactose-3-O-sulfotransferase 1 [KO:K01019] [EC:2.8.2.11]
101722754  Arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
101699194  Neu1; neuraminidase 1 [KO:K01186] [EC:3.2.1.18]
101704883  Neu3; neuraminidase 3 [KO:K12357] [EC:3.2.1.18]
101698605  Neu2; neuraminidase 2 [KO:K12357] [EC:3.2.1.18]
101724302  Neu4; neuraminidase 4 [KO:K12357] [EC:3.2.1.18]
101713601  Gla; galactosidase alpha [KO:K01189] [EC:3.2.1.22]
101705101  B4galnt1; beta-1,4-N-acetyl-galactosaminyltransferase 1 [KO:K00725] [EC:2.4.1.92]
101713145  Hexb; hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
101718368  Hexa; hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
101706300  Gm2a; GM2 ganglioside activator [KO:K12383]
101722989  Psap; prosaposin [KO:K12382]
106009578  Psapl1; prosaposin-like 1 [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
hgl00260  Glycine, serine and threonine metabolism
hgl00601  Glycosphingolipid biosynthesis - lacto and neolacto series
hgl00603  Glycosphingolipid biosynthesis - globo and isoglobo series
hgl00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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