KEGG   Homo sapiens (human): 1869
Entry
1869              CDS       T01001                                 
Symbol
E2F1, E2F-1, RBAP1, RBBP3, RBP3
Name
(RefSeq) E2F transcription factor 1
  KO
K17454  transcription factor E2F1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04110  Cell cycle
hsa04137  Mitophagy - animal
hsa04218  Cellular senescence
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00073  Mutation-activated CDK4 to cell cycle G1/S
N00074  Loss of RB1 to cell cycle G1/S
N00075  Mutation-inactivated RB1 to cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00168  KSHV vCyclin to cell cycle G1/S
N00170  KSHV LANA to cell cycle G1/S
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00275  Amplified CCND1 to cell cycle G1/S
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00361  HPV E7 to cell cycle G1/S
N00422  HCMV IE2-86 to cell cycle G1/S
N00423  HCMV IE1-72 to cell cycle G1/S
N00424  HCMV pp71 to cell cycle G1/S
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00484  EBV EBNA3C to cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
N00537  HBV HBx to cell cycle G1/S
N01336  CHRNA7-E2F signaling pathway
N01337  NNK/NNN to CHRNA7-E2F signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    1869 (E2F1)
  09143 Cell growth and death
   04110 Cell cycle
    1869 (E2F1)
   04218 Cellular senescence
    1869 (E2F1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1869 (E2F1)
   05206 MicroRNAs in cancer
    1869 (E2F1)
   05207 Chemical carcinogenesis - receptor activation
    1869 (E2F1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1869 (E2F1)
   05225 Hepatocellular carcinoma
    1869 (E2F1)
   05226 Gastric cancer
    1869 (E2F1)
   05214 Glioma
    1869 (E2F1)
   05220 Chronic myeloid leukemia
    1869 (E2F1)
   05218 Melanoma
    1869 (E2F1)
   05219 Bladder cancer
    1869 (E2F1)
   05215 Prostate cancer
    1869 (E2F1)
   05224 Breast cancer
    1869 (E2F1)
   05222 Small cell lung cancer
    1869 (E2F1)
   05223 Non-small cell lung cancer
    1869 (E2F1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1869 (E2F1)
   05161 Hepatitis B
    1869 (E2F1)
   05160 Hepatitis C
    1869 (E2F1)
   05163 Human cytomegalovirus infection
    1869 (E2F1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1869 (E2F1)
   05169 Epstein-Barr virus infection
    1869 (E2F1)
   05165 Human papillomavirus infection
    1869 (E2F1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1869 (E2F1)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1869 (E2F1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1869 (E2F1)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1869 (E2F1)
SSDB
Motif
Pfam: E2F_CC-MB E2F_TDP TP1
Other DBs
NCBI-GeneID: 1869
NCBI-ProteinID: NP_005216
OMIM: 189971
HGNC: 3113
Ensembl: ENSG00000101412
Pharos: Q01094(Tbio)
UniProt: Q01094 Q9BSD8
Structure
LinkDB
Position
20:complement(33675477..33686385)
AA seq 437 aa
MALAGAPAGGPCAPALEALLGAGALRLLDSSQIVIISAAQDASAPPAPTGPAAPAAGPCD
PDLLLFATPQAPRPTPSAPRPALGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVK
SPGEKSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLI
AKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQLQESEQQLDHLMNICTTQLRLLSEDTDS
QRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSENFQISLKSKQGPIDVFLCPE
ETVGGISPGKTPSQEVTSEEENRATDSATIVSPPPSSPPSSLTTDPSQSLLSLEQEPLLS
RMGSLRAPVDEDRLSPLVAADSLLEHVREDFSGLLPEEFISLSPPHEALDYHFGLEEGEG
IRDLFDCDFGDLTPLDF
NT seq 1314 nt   +upstreamnt  +downstreamnt
atggccttggccggggcccctgcgggcggcccatgcgcgccggcgctggaggccctgctc
ggggccggcgcgctgcggctgctcgactcctcgcagatcgtcatcatctccgccgcgcag
gacgccagcgccccgccggctcccaccggccccgcggcgcccgccgccggcccctgcgac
cctgacctgctgctcttcgccacaccgcaggcgccccggcccacacccagtgcgccgcgg
cccgcgctcggccgcccgccggtgaagcggaggctggacctggaaactgaccatcagtac
ctggccgagagcagtgggccagctcggggcagaggccgccatccaggaaaaggtgtgaaa
tccccgggggagaagtcacgctatgagacctcactgaatctgaccaccaagcgcttcctg
gagctgctgagccactcggctgacggtgtcgtcgacctgaactgggctgccgaggtgctg
aaggtgcagaagcggcgcatctatgacatcaccaacgtccttgagggcatccagctcatt
gccaagaagtccaagaaccacatccagtggctgggcagccacaccacagtgggcgtcggc
ggacggcttgaggggttgacccaggacctccgacagctgcaggagagcgagcagcagctg
gaccacctgatgaatatctgtactacgcagctgcgcctgctctccgaggacactgacagc
cagcgcctggcctacgtgacgtgtcaggaccttcgtagcattgcagaccctgcagagcag
atggttatggtgatcaaagcccctcctgagacccagctccaagccgtggactcttcggag
aactttcagatctcccttaagagcaaacaaggcccgatcgatgttttcctgtgccctgag
gagaccgtaggtgggatcagccctgggaagaccccatcccaggaggtcacttctgaggag
gagaacagggccactgactctgccaccatagtgtcaccaccaccatcatctcccccctca
tccctcaccacagatcccagccagtctctactcagcctggagcaagaaccgctgttgtcc
cggatgggcagcctgcgggctcccgtggacgaggaccgcctgtccccgctggtggcggcc
gactcgctcctggagcatgtgcgggaggacttctccggcctcctccctgaggagttcatc
agcctttccccaccccacgaggccctcgactaccacttcggcctcgaggagggcgagggc
atcagagacctcttcgactgtgactttggggacctcacccccctggatttctga

KEGG   Homo sapiens (human): 1870
Entry
1870              CDS       T01001                                 
Symbol
E2F2, E2F-2
Name
(RefSeq) E2F transcription factor 2
  KO
K09389  transcription factor E2F2
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00073  Mutation-activated CDK4 to cell cycle G1/S
N00074  Loss of RB1 to cell cycle G1/S
N00075  Mutation-inactivated RB1 to cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00168  KSHV vCyclin to cell cycle G1/S
N00170  KSHV LANA to cell cycle G1/S
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00275  Amplified CCND1 to cell cycle G1/S
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00361  HPV E7 to cell cycle G1/S
N00422  HCMV IE2-86 to cell cycle G1/S
N00423  HCMV IE1-72 to cell cycle G1/S
N00424  HCMV pp71 to cell cycle G1/S
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00484  EBV EBNA3C to cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
N00537  HBV HBx to cell cycle G1/S
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1870 (E2F2)
   04218 Cellular senescence
    1870 (E2F2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1870 (E2F2)
   05206 MicroRNAs in cancer
    1870 (E2F2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1870 (E2F2)
   05225 Hepatocellular carcinoma
    1870 (E2F2)
   05226 Gastric cancer
    1870 (E2F2)
   05214 Glioma
    1870 (E2F2)
   05220 Chronic myeloid leukemia
    1870 (E2F2)
   05218 Melanoma
    1870 (E2F2)
   05219 Bladder cancer
    1870 (E2F2)
   05215 Prostate cancer
    1870 (E2F2)
   05224 Breast cancer
    1870 (E2F2)
   05222 Small cell lung cancer
    1870 (E2F2)
   05223 Non-small cell lung cancer
    1870 (E2F2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1870 (E2F2)
   05161 Hepatitis B
    1870 (E2F2)
   05160 Hepatitis C
    1870 (E2F2)
   05163 Human cytomegalovirus infection
    1870 (E2F2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1870 (E2F2)
   05169 Epstein-Barr virus infection
    1870 (E2F2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1870 (E2F2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1870 (E2F2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1870 (E2F2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1870 (E2F2)
SSDB
Motif
Pfam: E2F_CC-MB E2F_TDP
Other DBs
NCBI-GeneID: 1870
NCBI-ProteinID: NP_004082
OMIM: 600426
HGNC: 3114
Ensembl: ENSG00000007968
Pharos: Q14209(Tbio)
UniProt: Q14209
Structure
LinkDB
Position
1:complement(23505212..23531233)
AA seq 437 aa
MLQGPRALASAAGQTPKVVPAMSPTELWPSGLSSPQLCPATATYYTPLYPQTAPPAAAPG
TCLDATPHGPEGQVVRCLPAGRLPAKRKLDLEGIGRPVVPEFPTPKGKCIRVDGLPSPKT
PKSPGEKTRYDTSLGLLTKKFIYLLSESEDGVLDLNWAAEVLDVQKRRIYDITNVLEGIQ
LIRKKAKNNIQWVGRGMFEDPTRPGKQQQLGQELKELMNTEQALDQLIQSCSLSFKHLTE
DKANKRLAYVTYQDIRAVGNFKEQTVIAVKAPPQTRLEVPDRTEDNLQIYLKSTQGPIEV
YLCPEEVQEPDSPSEEPLPSTSTLCPSPDSAQPSSSTDPSIMEPTASSVPAPAPTPQQAP
PPPSLVPLEATDSLLELPHPLLQQTEDQFLSPTLACSSPLISFSPSLDQDDYLWGLEAGE
GISDLFDSYDLGDLLIN
NT seq 1314 nt   +upstreamnt  +downstreamnt
atgctgcaagggccccgggccttggcttcggccgctgggcagaccccgaaggtggtgccc
gcgatgagccccacagagctgtggccatccggcctcagcagcccccagctctgcccagct
actgctacctactacacaccgctgtacccgcagacggcgcctcccgcagcggcgccaggc
acctgcctcgacgccactccccacggacccgagggccaagttgtgcgatgcctgccggca
ggccggctgccggccaaaaggaagctggatctggaggggattgggaggcccgtcgtccct
gagttcccaacccccaaggggaagtgcatcagagtggatggcctccccagccccaaaacc
cccaaatcccccggggagaagactcggtatgacacttcgctggggctgctcaccaagaag
ttcatttacctcctgagcgagtcagaggatggggtcctggacctgaactgggccgctgag
gtgctggacgtgcagaagcggcgcatctatgacatcaccaacgtgctggaaggcatccag
ctcatccgcaagaaggccaagaacaacatccagtgggtaggcaggggaatgtttgaagac
cccaccagacctgggaagcagcaacagctggggcaggagctgaaggagctgatgaacacg
gagcaggccttggaccagctcatccagagctgctctctgagcttcaagcacctgactgag
gacaaggccaacaagaggctggcctatgtgacttaccaggatatccgtgctgttggcaac
tttaaggagcagacagtgattgccgtcaaggcccctccgcagacgagactggaagtgccc
gacaggactgaggacaacctgcagatatatctcaagagcacccaagggcccatcgaagtc
tacctgtgcccagaggaggtgcaggagccggacagtccttccgaggagcctctcccctct
acctccaccctctgccccagccctgactctgcccagcccagcagcagcaccgaccctagc
atcatggagcccacagcatcctcagtgccagcaccagcgccaaccccccagcaggcccca
ccgcctccatccctggtccccttggaggctactgacagcctgctggagctgccgcaccca
ctcctgcagcagactgaggaccagttcctgtccccgaccctggcgtgcagctcccctctg
atcagcttctccccatccttggaccaggacgactacctgtggggcttggaggcgggtgag
ggcatcagcgatctcttcgactcctacgaccttggggacctgttgattaattga

KEGG   Homo sapiens (human): 1871
Entry
1871              CDS       T01001                                 
Symbol
E2F3, E2F-3
Name
(RefSeq) E2F transcription factor 3
  KO
K06620  transcription factor E2F3
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04934  Cushing syndrome
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05163  Human cytomegalovirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05169  Epstein-Barr virus infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05212  Pancreatic cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05219  Bladder cancer
hsa05220  Chronic myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
Network
nt06130  Cell cycle (viruses)
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06230  Cell cycle
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06276  Chronic myeloid leukemia
nt06360  Cushing syndrome
  Element
N00066  MDM2-p21-Cell cycle G1/S
N00067  Deleted p14(ARF) to p21-cell cycle G1/S
N00068  Amplified MDM2 to p21-cell cycle G1/S
N00069  p16-Cell cycle G1/S
N00070  Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
N00071  Deleted p16(INK4a) to p16-cell cycle G1/S
N00072  Amplified CDK4 to cell cycle G1/S
N00073  Mutation-activated CDK4 to cell cycle G1/S
N00074  Loss of RB1 to cell cycle G1/S
N00075  Mutation-inactivated RB1 to cell cycle G1/S
N00076  Mutation-inactivated p14(ARF) to p21-cell cycle G1/S
N00088  Amplified MYC to p15-cell cycle G1/S
N00089  Amplified MYC to cell cycle G1/S
N00090  p15-Cell cycle G1/S
N00091  p27-Cell cycle G1/S
N00092  Amplified MYC to p27-cell cycle G1/S
N00093  Loss of CDKN1B to p27-cell cycle G1/S
N00168  KSHV vCyclin to cell cycle G1/S
N00170  KSHV LANA to cell cycle G1/S
N00254  CDKN1B-reduced expression to p27-cell cycle G1/S
N00255  Amplified CCNE to cell cycle G1/S
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00275  Amplified CCND1 to cell cycle G1/S
N00316  Mutation-inactivated CDKN1B to p27-cell cycle G1/S
N00347  p300-p21-Cell cycle G1/S
N00360  HPV E7 to p27-cell cycle G1/S
N00361  HPV E7 to cell cycle G1/S
N00422  HCMV IE2-86 to cell cycle G1/S
N00423  HCMV IE1-72 to cell cycle G1/S
N00424  HCMV pp71 to cell cycle G1/S
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00484  EBV EBNA3C to cell cycle G1/S
N00497  HTLV-1 Tax to p21-cell cycle G1/S
N00498  HTLV-1 Tax to p21-cell cycle G1/S
N00536  MDM2-p21-Cell cycle G1/S
N00537  HBV HBx to cell cycle G1/S
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1871 (E2F3)
   04218 Cellular senescence
    1871 (E2F3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    1871 (E2F3)
   05206 MicroRNAs in cancer
    1871 (E2F3)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    1871 (E2F3)
   05225 Hepatocellular carcinoma
    1871 (E2F3)
   05226 Gastric cancer
    1871 (E2F3)
   05214 Glioma
    1871 (E2F3)
   05220 Chronic myeloid leukemia
    1871 (E2F3)
   05218 Melanoma
    1871 (E2F3)
   05219 Bladder cancer
    1871 (E2F3)
   05215 Prostate cancer
    1871 (E2F3)
   05224 Breast cancer
    1871 (E2F3)
   05222 Small cell lung cancer
    1871 (E2F3)
   05223 Non-small cell lung cancer
    1871 (E2F3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    1871 (E2F3)
   05161 Hepatitis B
    1871 (E2F3)
   05160 Hepatitis C
    1871 (E2F3)
   05163 Human cytomegalovirus infection
    1871 (E2F3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    1871 (E2F3)
   05169 Epstein-Barr virus infection
    1871 (E2F3)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    1871 (E2F3)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    1871 (E2F3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1871 (E2F3)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1871 (E2F3)
SSDB
Motif
Pfam: E2F_CC-MB E2F_TDP
Other DBs
NCBI-GeneID: 1871
NCBI-ProteinID: NP_001940
OMIM: 600427
HGNC: 3115
Ensembl: ENSG00000112242
Pharos: O00716(Tbio)
UniProt: O00716
LinkDB
Position
6:20401879..20493714
AA seq 465 aa
MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQI
LTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALG
RGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYD
TSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQ
WMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVT
YQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSP
MKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEG
PFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
NT seq 1398 nt   +upstreamnt  +downstreamnt
atgagaaagggaatccagcccgctctggagcagtacctggtgaccgccgggggtggggag
ggggcggctgtcgtcgccgccgccgctgcagcctccatggacaaaagggcactgctagcc
agccccggcttcgccgccgccgccgccgctgccgccgccccgggcgcgtacatccagatc
ctcaccacgaacacttccaccacctcctgttcctcctccctccaaagcggcgccgtagcc
gccggccccctcctccccagtgcccccggcgcggagcagaccgccggcagcctcctctac
accacgccgcacggaccctccagcagagccgggctgctgcagcagccaccagcgctggga
cgcggcggcagcggcggcggcggcggccctccggcaaagcgaaggctggagctaggagaa
agcggtcatcagtacctctcagatggtttaaaaacccccaagggcaaaggaagagctgca
ctacgaagtccagatagtccaaaaactccaaaatctccctcagaaaaaacgcggtatgat
acgtctcttggtctgctcaccaagaagttcattcagctcctgagccagtcacccgatggg
gtattggatttgaacaaggcagcagaagtgctaaaagtgcaaaagagaaggatttatgat
atcaccaacgttctggaaggcatccacctcattaagaagaagtctaaaaacaacgtccaa
tggatgggctgcagtctgtctgaggatgggggcatgctggcccagtgtcaaggcctgtca
aaagaagtgaccgagctcagtcaggaagagaagaaattagatgaactgatccaaagctgc
accctggacctcaaactgttaaccgaggattcagagaatcaaaggttagcttatgttaca
tatcaagatattcgaaaaattagtggccttaaagaccaaactgttatagttgtgaaagcc
cctccagaaacaagacttgaagtgcctgactcaatagagagcctacaaatacatttggca
agtacccaagggcccattgaggtttacttatgtccagaagagactgaaacacacagtcca
atgaaaacaaacaaccaagaccacaatgggaatatccctaaacccgcttccaaagacttg
gcttcaaccaactcaggacatagcgattgctcagtttctatgggaaacctttctcctctg
gcctccccagccaacctcttacagcagactgaggaccaaattccttccaacctagaagga
ccgtttgtgaacttactgcctcccctgctgcaagaggactatctcctgagcctcggggag
gaggaaggcatcagcgatctcttcgatgcttacgatttggaaaagctcccactggtggaa
gacttcatgtgtagttga

KEGG   Homo sapiens (human): 1874
Entry
1874              CDS       T01001                                 
Symbol
E2F4, E2F-4
Name
(RefSeq) E2F transcription factor 4
  KO
K04682  transcription factor E2F4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04350  TGF-beta signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    1874 (E2F4)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1874 (E2F4)
   04218 Cellular senescence
    1874 (E2F4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1874 (E2F4)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1874 (E2F4)
SSDB
Motif
Pfam: E2F_CC-MB E2F_TDP DivIC
Other DBs
NCBI-GeneID: 1874
NCBI-ProteinID: NP_001941
OMIM: 600659
HGNC: 3118
Ensembl: ENSG00000205250
Pharos: Q16254(Tbio)
UniProt: Q16254
Structure
LinkDB
Position
16:67192155..67198918
AA seq 413 aa
MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYD
ITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVW
VQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQ
IHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEAS
RPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQ
SSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTR
ECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
NT seq 1242 nt   +upstreamnt  +downstreamnt
atggcggaggccgggccacaggcgccgccgcccccgggcactccaagccggcacgaaaag
agcctgggactgctcaccaccaagttcgtgtcccttctgcaggaggccaaggacggcgtg
cttgacctcaagctggcagctgacaccctagctgtacgccagaagcggcggatttacgac
attaccaatgttttggaaggtatcgggctaatcgagaaaaagtccaagaacagcatccag
tggaagggtgtggggcctggctgcaatacccgggagattgctgacaaactgattgagctc
aaggcagagatcgaggagctgcagcagcgggagcaagaactagaccagcacaaggtgtgg
gtgcagcagagcatccggaacgtcacagaggacgtgcagaacagctgtttggcctacgtc
actcatgaggacatctgcagatgctttgctggagataccctcttggccatccgggcccca
tcaggcaccagcctggaggtgcccatcccagagggtctcaatgggcagaagaagtaccag
attcacctgaagagtgtgagtggtcccattgaggttctgctggtgaacaaggaggcatgg
agctcaccccctgtggctgtgcctgtgccaccacctgaagatttgctccagagcccatct
gctgtttctacacctccacctctgcccaagcctgccctagcccagtcccaggaagcctca
cgtccaaatagtcctcagctcactcccactgctgtccctggcagtgcagaagtccaggga
atggctggcccagcagctgagatcacagtgagtggcggccctgggactgatagcaaggac
agtggtgagctcagttcactcccactgggcccaacaacactggacacccggccactgcag
tcttctgccctgctggacagcagcagcagcagcagcagcagcagcagcagcagcagcaac
agtaacagcagcagttcgtccggacccaacccttctacctcctttgagcccatcaaggca
gaccccacaggtgttttggaactccccaaagagctgtcagaaatctttgatcccacacga
gagtgcatgagctcggagctgctggaggagttgatgtcctcagaagtgtttgcccctctg
cttcgtctttctccacccccgggagaccacgattatatctacaacctggacgagagtgaa
ggtgtctgtgacctctttgatgtgcctgttctcaacctctga

KEGG   Homo sapiens (human): 1875
Entry
1875              CDS       T01001                                 
Symbol
E2F5, E2F-5
Name
(RefSeq) E2F transcription factor 5
  KO
K04682  transcription factor E2F4/5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
hsa04218  Cellular senescence
hsa04350  TGF-beta signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    1875 (E2F5)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    1875 (E2F5)
   04218 Cellular senescence
    1875 (E2F5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    1875 (E2F5)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    1875 (E2F5)
SSDB
Motif
Pfam: E2F_CC-MB E2F_TDP FAD_binding_5 TMEM171
Other DBs
NCBI-GeneID: 1875
NCBI-ProteinID: NP_001942
OMIM: 600967
HGNC: 3119
Ensembl: ENSG00000133740
Pharos: Q15329(Tbio)
UniProt: Q15329
Structure
LinkDB
Position
8:85177154..85214518
AA seq 346 aa
MAAAEPASSGQQAPAGQGQGQRPPPQPPQAQAPQPPPPPQLGGAGGGSSRHEKSLGLLTT
KFVSLLQEAKDGVLDLKAAADTLAVRQKRRIYDITNVLEGIDLIEKKSKNSIQWKGVGAG
CNTKEVIDRLRYLKAEIEDLELKERELDQQKLWLQQSIKNVMDDSINNRFSYVTHEDICN
CFNGDTLLAIQAPSGTQLEVPIPEMGQNGQKKYQINLKSHSGPIHVLLINKESSSSKPVV
FPVPPPDDLTQPSSQSLTPVTPQKSSMATQNLPEQHVSERSQALQQTSATDISSAGSISG
DIIDELMSSDVFPLLRLSPTPADDYNFNLDDNEGVCDLFDVQILNY
NT seq 1041 nt   +upstreamnt  +downstreamnt
atggcggcggcagagcccgcgagctcgggccagcaggcgccggcagggcaggggcagggc
cagcggccgccgccgcagcctccgcaggcgcaagccccgcagccgcccccgccgccgcag
ctcgggggcgccgggggcggcagcagcaggcacgagaagagcctggggctgctcactacc
aagttcgtgtcgctgctgcaggaggccaaggacggcgttctggatctcaaagcggctgct
gatactttggctgtgaggcaaaaaaggagaatttatgatatcaccaatgtcttagaggga
attgacttgattgaaaaaaagtcaaaaaacagtatccagtggaaaggtgtaggtgctggc
tgtaatactaaagaagtcatagatagattaagatatcttaaagctgaaattgaagatcta
gaactgaaggaaagagaacttgatcagcagaagttgtggctacagcaaagcatcaaaaat
gtgatggacgattccattaataatagattttcctatgtaactcatgaagacatctgtaat
tgctttaatggtgatacacttttggccattcaggcaccttctggtacacaactggaggta
cccattccagaaatgggtcagaatggacaaaagaaataccagatcaatctaaagagtcat
tcaggacctatccatgtgctgcttataaataaagagtcgagttcatctaagcccgtggtt
tttcctgttcccccacctgatgacctcacacagccttcctcccagtccttgactccagtg
actccacagaaatccagcatggcaactcaaaatctgcctgagcaacatgtctctgaaaga
agccaggctctgcagcagacatcagctacagatatatcttcagcaggatctattagtgga
gatatcattgatgagttaatgtcttctgacgtgtttcctctcttaaggctttctcctacc
ccggcagatgactacaactttaatttagatgataacgaaggagtttgtgatctgtttgat
gtccagatactaaattattag

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