| Entry |
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| Symbol |
STAT3, ADMIO, ADMIO1, APRF, HIES
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| Name |
(RefSeq) signal transducer and activator of transcription 3
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| KO |
| K04692 | signal transducer and activator of transcription 3 |
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| Organism |
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| Pathway |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
| hsa04920 | Adipocytokine signaling pathway |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications |
| hsa04935 | Growth hormone synthesis, secretion and action |
| hsa05163 | Human cytomegalovirus infection |
| hsa05167 | Kaposi sarcoma-associated herpesvirus infection |
| hsa05207 | Chemical carcinogenesis - receptor activation |
| hsa05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
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| Network |
nt06150 Cytokine-cytokine receptor interaction (viruses) nt06160 Human T-cell leukemia virus 1 (HTLV-1) nt06162 Hepatitis B virus (HBV) nt06164 Kaposi sarcoma-associated herpesvirus (KSHV) nt06165 Epstein-Barr virus (EBV) nt06167 Human cytomegalovirus (HCMV) nt06219 JAK-STAT signaling nt06262 Pancreatic cancer nt06263 Hepatocellular carcinoma nt06266 Non-small cell lung cancer nt06276 Chronic myeloid leukemia nt06518 JAK-STAT signaling |
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| Element |
| N00053 | Cytokine-Jak-STAT signaling pathway |
| N00094 | EGF-Jak-STAT signaling pathway |
| N00095 | ERBB2-overexpression to EGF-Jak-STAT signaling pathway |
| N00105 | EML4-ALK fusion kinase to Jak-STAT signaling pathway |
| N00181 | KSHV vIL-6 to Jak-STAT signaling pathway |
| N00415 | IL10 family to Jak-STAT signaling pathway |
| N00416 | HCMV vIL10 to IL10-JAK-STAT signaling pathway |
| N00486 | EBV LMP1 to Jak-STAT signaling pathway |
| N00548 | HBV HBx to Jak-STAT signaling pathway |
| N01340 | ACH-CHRN-JAK-STAT signaling pathway |
| N01341 | NNK/NNN to Jak-STAT signaling pathway |
| N01342 | Nicotine to Jak-STAT signaling pathway |
| N01554 | IL2 family to Jak-STAT signaling pathway |
| N01555 | Hormone-like-cytokine to Jak-STAT signaling pathway |
| N01556 | IL6 family to Jak-STAT signaling pathway |
| N01557 | IL12/23 to Jak-STAT signaling pathway |
| N01559 | Type II interferon to Jak-STAT signaling pathway |
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| Disease |
| H00107 | Other well-defined immunodeficiency syndromes |
| H02540 | Infantile-onset multisystem autoimmune disease |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
6774 (STAT3)
04066 HIF-1 signaling pathway
6774 (STAT3)
04068 FoxO signaling pathway
6774 (STAT3)
09140 Cellular Processes
09143 Cell growth and death
04217 Necroptosis
6774 (STAT3)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
6774 (STAT3)
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
6774 (STAT3)
04062 Chemokine signaling pathway
6774 (STAT3)
09152 Endocrine system
04920 Adipocytokine signaling pathway
6774 (STAT3)
04917 Prolactin signaling pathway
6774 (STAT3)
04935 Growth hormone synthesis, secretion and action
6774 (STAT3)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6774 (STAT3)
05206 MicroRNAs in cancer
6774 (STAT3)
05205 Proteoglycans in cancer
6774 (STAT3)
05207 Chemical carcinogenesis - receptor activation
6774 (STAT3)
05203 Viral carcinogenesis
6774 (STAT3)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
6774 (STAT3)
09162 Cancer: specific types
05212 Pancreatic cancer
6774 (STAT3)
05221 Acute myeloid leukemia
6774 (STAT3)
05223 Non-small cell lung cancer
6774 (STAT3)
09172 Infectious disease: viral
05161 Hepatitis B
6774 (STAT3)
05160 Hepatitis C
6774 (STAT3)
05171 Coronavirus disease - COVID-19
6774 (STAT3)
05162 Measles
6774 (STAT3)
05163 Human cytomegalovirus infection
6774 (STAT3)
05167 Kaposi sarcoma-associated herpesvirus infection
6774 (STAT3)
05169 Epstein-Barr virus infection
6774 (STAT3)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
6774 (STAT3)
09163 Immune disease
05321 Inflammatory bowel disease
6774 (STAT3)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6774 (STAT3)
09167 Endocrine and metabolic disease
04931 Insulin resistance
6774 (STAT3)
04933 AGE-RAGE signaling pathway in diabetic complications
6774 (STAT3)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
6774 (STAT3)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:hsa03000]
6774 (STAT3)
Transcription factors [BR:hsa03000]
Eukaryotic type
beta-Scaffold factors with minor groove contacts
STAT
6774 (STAT3)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| LinkDB |
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| Position |
17:complement(42313324..42388442)
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| AA seq |
770 aa
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM |
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| NT seq |
2313 nt +upstreamnt +downstreamnt
atggcccaatggaatcagctacagcagcttgacacacggtacctggagcagctccatcag
ctctacagtgacagcttcccaatggagctgcggcagtttctggccccttggattgagagt
caagattgggcatatgcggccagcaaagaatcacatgccactttggtgtttcataatctc
ctgggagagattgaccagcagtatagccgcttcctgcaagagtcgaatgttctctatcag
cacaatctacgaagaatcaagcagtttcttcagagcaggtatcttgagaagccaatggag
attgcccggattgtggcccggtgcctgtgggaagaatcacgccttctacagactgcagcc
actgcggcccagcaagggggccaggccaaccaccccacagcagccgtggtgacggagaag
cagcagatgctggagcagcaccttcaggatgtccggaagagagtgcaggatctagaacag
aaaatgaaagtggtagagaatctccaggatgactttgatttcaactataaaaccctcaag
agtcaaggagacatgcaagatctgaatggaaacaaccagtcagtgaccaggcagaagatg
cagcagctggaacagatgctcactgcgctggaccagatgcggagaagcatcgtgagtgag
ctggcggggcttttgtcagcgatggagtacgtgcagaaaactctcacggacgaggagctg
gctgactggaagaggcggcaacagattgcctgcattggaggcccgcccaacatctgccta
gatcggctagaaaactggataacgtcattagcagaatctcaacttcagacccgtcaacaa
attaagaaactggaggagttgcagcaaaaagtttcctacaaaggggaccccattgtacag
caccggccgatgctggaggagagaatcgtggagctgtttagaaacttaatgaaaagtgcc
tttgtggtggagcggcagccctgcatgcccatgcatcctgaccggcccctcgtcatcaag
accggcgtccagttcactactaaagtcaggttgctggtcaaattccctgagttgaattat
cagcttaaaattaaagtgtgcattgacaaagactctggggacgttgcagctctcagagga
tcccggaaatttaacattctgggcacaaacacaaaagtgatgaacatggaagaatccaac
aacggcagcctctctgcagaattcaaacacttgaccctgagggagcagagatgtgggaat
gggggccgagccaattgtgatgcttccctgattgtgactgaggagctgcacctgatcacc
tttgagaccgaggtgtatcaccaaggcctcaagattgacctagagacccactccttgcca
gttgtggtgatctccaacatctgtcagatgccaaatgcctgggcgtccatcctgtggtac
aacatgctgaccaacaatcccaagaatgtaaacttttttaccaagcccccaattggaacc
tgggatcaagtggccgaggtcctgagctggcagttctcctccaccaccaagcgaggactg
agcatcgagcagctgactacactggcagagaaactcttgggacctggtgtgaattattca
gggtgtcagatcacatgggctaaattttgcaaagaaaacatggctggcaagggcttctcc
ttctgggtctggctggacaatatcattgaccttgtgaaaaagtacatcctggccctttgg
aacgaagggtacatcatgggctttatcagtaaggagcgggagcgggccatcttgagcact
aagcctccaggcaccttcctgctaagattcagtgaaagcagcaaagaaggaggcgtcact
ttcacttgggtggagaaggacatcagcggtaagacccagatccagtccgtggaaccatac
acaaagcagcagctgaacaacatgtcatttgctgaaatcatcatgggctataagatcatg
gatgctaccaatatcctggtgtctccactggtctatctctatcctgacattcccaaggag
gaggcattcggaaagtattgtcggccagagagccaggagcatcctgaagctgacccaggt
agcgctgccccatacctgaagaccaagtttatctgtgtgacaccaacgacctgcagcaat
accattgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataat
ggtgaaggtgctgaaccctcagcaggagggcagtttgagtccctcacctttgacatggag
ttgacctcggagtgcgctacctcccccatgtga |
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