KEGG   Homo sapiens (human): 915
Entry
915               CDS       T01001                                 
Symbol
CD3D, CD3-DELTA, CD3DELTA, IMD19, T3D
Name
(RefSeq) CD3 delta subunit of T-cell receptor complex
  KO
K06450  T-cell surface glycoprotein CD3 delta chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00091  T-B+Severe combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Flotetuzumab: D11306
Muromonab-CD3: D05092
Otelixizumab: D08959
Tebentafusp: D12296<US>
Teplizumab: D09013<US>
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    915 (CD3D)
   04660 T cell receptor signaling pathway
    915 (CD3D)
   04658 Th1 and Th2 cell differentiation
    915 (CD3D)
   04659 Th17 cell differentiation
    915 (CD3D)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    915 (CD3D)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    915 (CD3D)
   05170 Human immunodeficiency virus 1 infection
    915 (CD3D)
   05162 Measles
    915 (CD3D)
   05169 Epstein-Barr virus infection
    915 (CD3D)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    915 (CD3D)
  09163 Immune disease
   05340 Primary immunodeficiency
    915 (CD3D)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    915 (CD3D)
CD molecules [BR:hsa04090]
 Proteins
  915 (CD3D)
SSDB
Motif
Pfam: Ig_4 ITAM Ig_5 DAP10
Other DBs
NCBI-GeneID: 915
NCBI-ProteinID: NP_000723
OMIM: 186790
HGNC: 1673
Ensembl: ENSG00000167286
UniProt: P04234 B0YIY4
Structure
LinkDB
Position
11:complement(118338954..118342705)
AA seq 171 aa
MEHSTFLSGLVLATLLSQVSPFKIPIEELEDRVFVNCNTSITWVEGTVGTLLSDITRLDL
GKRILDPRGIYRCNGTDIYKDKESTVQVHYRMCQSCVELDPATVAGIIVTDVIATLLLAL
GVFCFAGHETGRLSGAADTQALLRNDQVYQPLRDRDDAQYSHLGGNWARNK
NT seq 516 nt   +upstreamnt  +downstreamnt
atggaacatagcacgtttctctctggcctggtactggctacccttctctcgcaagtgagc
cccttcaagatacctatagaggaacttgaggacagagtgtttgtgaattgcaataccagc
atcacatgggtagagggaacggtgggaacactgctctcagacattacaagactggacctg
ggaaaacgcatcctggacccacgaggaatatataggtgtaatgggacagatatatacaag
gacaaagaatctaccgtgcaagttcattatcgaatgtgccagagctgtgtggagctggat
ccagccaccgtggctggcatcattgtcactgatgtcattgccactctgctccttgctttg
ggagtcttctgctttgctggacatgagactggaaggctgtctggggctgccgacacacaa
gctctgttgaggaatgaccaggtctatcagcccctccgagatcgagatgatgctcagtac
agccaccttggaggaaactgggctcggaacaagtga

KEGG   Homo sapiens (human): 916
Entry
916               CDS       T01001                                 
Symbol
CD3E, CD3epsilon, IMD18, T3E, TCRE
Name
(RefSeq) CD3 epsilon subunit of T-cell receptor complex
  KO
K06451  T-cell surface glycoprotein CD3 epsilon chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00091  T-B+Severe combined immunodeficiency
Drug target
Acapatamab: D12121
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Avitotamig: D12721
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Cevostamab: D11984
Cibisatamab: D11489
Duvortuxizumab: D11372
Elranatamab: D12058<JP/US>
Emirodatamab: D12641
Epcoritamab: D12368<JP/US>
Flotetuzumab: D11306
Forimtamig: D12724
Glofitamab: D11833<US>
Imvotamab: D12567
Mosunetuzumab: D11463<US>
Muromonab-CD3: D05092
Odronextamab: D11534
Otelixizumab: D08959
Pavurutamab: D11992
Plamotamab: D11686
Runimotamab: D12236
Talquetamab: D12180<US>
Tarlatamab: D12234
Tebentafusp: D12296<US>
Teclistamab: D12177<US>
Teplizumab: D09013<US>
Tidutamab: D11845
Ubamatamab: D12007
Vibecotamab: D11841
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    916 (CD3E)
   04660 T cell receptor signaling pathway
    916 (CD3E)
   04658 Th1 and Th2 cell differentiation
    916 (CD3E)
   04659 Th17 cell differentiation
    916 (CD3E)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    916 (CD3E)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    916 (CD3E)
   05170 Human immunodeficiency virus 1 infection
    916 (CD3E)
   05162 Measles
    916 (CD3E)
   05169 Epstein-Barr virus infection
    916 (CD3E)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    916 (CD3E)
  09163 Immune disease
   05340 Primary immunodeficiency
    916 (CD3E)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    916 (CD3E)
CD molecules [BR:hsa04090]
 Proteins
  916 (CD3E)
SSDB
Motif
Pfam: Ig_5 Ig_4 ITAM Ig_3 Ig_2
Other DBs
NCBI-GeneID: 916
NCBI-ProteinID: NP_000724
OMIM: 186830
HGNC: 1674
Ensembl: ENSG00000198851
UniProt: P07766
Structure
LinkDB
Position
11:118304730..118316173
AA seq 207 aa
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQ
HNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCE
NCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERP
PPVPNPDYEPIRKGQRDLYSGLNQRRI
NT seq 624 nt   +upstreamnt  +downstreamnt
atgcagtcgggcactcactggagagttctgggcctctgcctcttatcagttggcgtttgg
gggcaagatggtaatgaagaaatgggtggtattacacagacaccatataaagtctccatc
tctggaaccacagtaatattgacatgccctcagtatcctggatctgaaatactatggcaa
cacaatgataaaaacataggcggtgatgaggatgataaaaacataggcagtgatgaggat
cacctgtcactgaaggaattttcagaattggagcaaagtggttattatgtctgctacccc
agaggaagcaaaccagaagatgcgaacttttatctctacctgagggcaagagtgtgtgag
aactgcatggagatggatgtgatgtcggtggccacaattgtcatagtggacatctgcatc
actgggggcttgctgctgctggtttactactggagcaagaatagaaaggccaaggccaag
cctgtgacacgaggagcgggtgctggcggcaggcaaaggggacaaaacaaggagaggcca
ccacctgttcccaacccagactatgagcccatccggaaaggccagcgggacctgtattct
ggcctgaatcagagacgcatctga

KEGG   Homo sapiens (human): 917
Entry
917               CDS       T01001                                 
Symbol
CD3G, CD3-GAMMA, CD3GAMMA, IMD17, T3G
Name
(RefSeq) CD3 gamma subunit of T-cell receptor complex
  KO
K06452  T-cell surface glycoprotein CD3 gamma chain
Organism
hsa  Homo sapiens (human)
Pathway
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05162  Measles
hsa05166  Human T-cell leukemia virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00093  Combined immunodeficiency
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Blinatumomab: D09325<JP/US>
Catumaxomab: D09207
Flotetuzumab: D11306
Muromonab-CD3: D05092
Otelixizumab: D08959
Tebentafusp: D12296<US>
Teplizumab: D09013<US>
Visilizumab: D06314
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    917 (CD3G)
   04660 T cell receptor signaling pathway
    917 (CD3G)
   04658 Th1 and Th2 cell differentiation
    917 (CD3G)
   04659 Th17 cell differentiation
    917 (CD3G)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    917 (CD3G)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    917 (CD3G)
   05170 Human immunodeficiency virus 1 infection
    917 (CD3G)
   05162 Measles
    917 (CD3G)
   05169 Epstein-Barr virus infection
    917 (CD3G)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    917 (CD3G)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    917 (CD3G)
CD molecules [BR:hsa04090]
 Proteins
  917 (CD3G)
SSDB
Motif
Pfam: Ig_4 Ig_5 ITAM Ig_3 Ig_2
Other DBs
NCBI-GeneID: 917
NCBI-ProteinID: NP_000064
OMIM: 186740
HGNC: 1675
Ensembl: ENSG00000160654
UniProt: P09693 B0YIY5
Structure
LinkDB
Position
11:118344344..118355161
AA seq 182 aa
MEQGKGLAVLILAIILLQGTLAQSIKGNHLVKVYDYQEDGSVLLTCDAEAKNITWFKDGK
MIGFLTEDKKKWNLGSNAKDPRGMYQCKGSQNKSKPLQVYYRMCQNCIELNAATISGFLF
AEIVSIFVLAVGVYFIAGQDGVRQSRASDKQTLLPNDQLYQPLKDREDDQYSHLQGNQLR
RN
NT seq 549 nt   +upstreamnt  +downstreamnt
atggaacaggggaagggcctggctgtcctcatcctggctatcattcttcttcaaggtact
ttggcccagtcaatcaaaggaaaccacttggttaaggtgtatgactatcaagaagatggt
tcggtacttctgacttgtgatgcagaagccaaaaatatcacatggtttaaagatgggaag
atgatcggcttcctaactgaagataaaaaaaaatggaatctgggaagtaatgccaaggac
cctcgagggatgtatcagtgtaaaggatcacagaacaagtcaaaaccactccaagtgtat
tacagaatgtgtcagaactgcattgaactaaatgcagccaccatatctggctttctcttt
gctgaaatcgtcagcattttcgtccttgctgttggggtctacttcattgctggacaggat
ggagttcgccagtcgagagcttcagacaagcagactctgttgcccaatgaccagctctac
cagcccctcaaggatcgagaagatgaccagtacagccaccttcaaggaaaccagttgagg
aggaattga

KEGG   Homo sapiens (human): 919
Entry
919               CDS       T01001                                 
Symbol
CD247, CD3-ZETA, CD3H, CD3Q, CD3Z, CD3ZETA, IMD25, T3Z, TCRZ
Name
(RefSeq) CD247 molecule
  KO
K06453  CD3Z antigen, zeta polypeptide
Organism
hsa  Homo sapiens (human)
Pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05142  Chagas disease
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    919 (CD247)
   04660 T cell receptor signaling pathway
    919 (CD247)
   04658 Th1 and Th2 cell differentiation
    919 (CD247)
   04659 Th17 cell differentiation
    919 (CD247)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    919 (CD247)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    919 (CD247)
   05169 Epstein-Barr virus infection
    919 (CD247)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    919 (CD247)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    919 (CD247)
   04090 CD molecules [BR:hsa04090]
    919 (CD247)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   919 (CD247)
CD molecules [BR:hsa04090]
 Proteins
  919 (CD247)
SSDB
Motif
Pfam: ITAM TCR_zetazeta
Other DBs
NCBI-GeneID: 919
NCBI-ProteinID: NP_932170
OMIM: 186780
HGNC: 1677
Ensembl: ENSG00000198821
UniProt: P20963
Structure
LinkDB
Position
1:complement(167430640..167518529)
AA seq 164 aa
MKWKALFTAAILQAQLPITEAQSFGLLDPKLCYLLDGILFIYGVILTALFLRVKFSRSAD
APAYQQGQNQLYNELNLGRREEYDVLDKRRGRDPEMGGKPQRRKNPQEGLYNELQKDKMA
EAYSEIGMKGERRRGKGHDGLYQGLSTATKDTYDALHMQALPPR
NT seq 495 nt   +upstreamnt  +downstreamnt
atgaagtggaaggcgcttttcaccgcggccatcctgcaggcacagttgccgattacagag
gcacagagctttggcctgctggatcccaaactctgctacctgctggatggaatcctcttc
atctatggtgtcattctcactgccttgttcctgagagtgaagttcagcaggagcgcagac
gcccccgcgtaccagcagggccagaaccagctctataacgagctcaatctaggacgaaga
gaggagtacgatgttttggacaagagacgtggccgggaccctgagatggggggaaagccg
cagagaaggaagaaccctcaggaaggcctgtacaatgaactgcagaaagataagatggcg
gaggcctacagtgagattgggatgaaaggcgagcgccggaggggcaaggggcacgatggc
ctttaccagggtctcagtacagccaccaaggacacctacgacgcccttcacatgcaggcc
ctgccccctcgctaa

KEGG   Homo sapiens (human): 920
Entry
920               CDS       T01001                                 
Symbol
CD4, CD4mut, IMD79, Leu-3, OKT4D, T4
Name
(RefSeq) CD4 molecule
  KO
K06454  T-cell surface glycoprotein CD4
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa03260  Virion - Human immunodeficiency virus
hsa04060  Cytokine-cytokine receptor interaction
hsa04514  Cell adhesion molecules
hsa04612  Antigen processing and presentation
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
hsa05135  Yersinia infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05340  Primary immunodeficiency
Network
nt06183  Yersinia
nt06537  TCR/BCR signaling
  Element
N01106  TCR-PLCG-ITPR signaling pathway
Disease
H02526  Disorders of adaptive immunity
Drug target
Antithymocyte immunoglobulin (rabbit): D09190<JP/US>
Cedelizumab: D03420
Ibalizumab: D09575<US>
Lifileucel: D12833<US>
Priliximab: D05610
Zanolimumab: D06356
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    920 (CD4)
   03260 Virion - Human immunodeficiency virus
    920 (CD4)
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    920 (CD4)
   04514 Cell adhesion molecules
    920 (CD4)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    920 (CD4)
   04612 Antigen processing and presentation
    920 (CD4)
   04660 T cell receptor signaling pathway
    920 (CD4)
   04658 Th1 and Th2 cell differentiation
    920 (CD4)
   04659 Th17 cell differentiation
    920 (CD4)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    920 (CD4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    920 (CD4)
   05170 Human immunodeficiency virus 1 infection
    920 (CD4)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    920 (CD4)
  09163 Immune disease
   05340 Primary immunodeficiency
    920 (CD4)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    920 (CD4)
CD molecules [BR:hsa04090]
 Proteins
  920 (CD4)
SSDB
Motif
Pfam: CD4-extracel C2-set ig Tcell_CD4_C V-set I-set Ig_3 Ig_2 Receptor_2B4
Other DBs
NCBI-GeneID: 920
NCBI-ProteinID: NP_000607
OMIM: 186940
HGNC: 1678
Ensembl: ENSG00000010610
UniProt: P01730 B4DT49 A0A4Y5UGE4
Structure
LinkDB
Position
12:6789528..6820799
AA seq 458 aa
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIK
ILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQL
LVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSG
TWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWW
QAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLA
LEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWV
LNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCV
RCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
NT seq 1377 nt   +upstreamnt  +downstreamnt
atgaaccggggagtcccttttaggcacttgcttctggtgctgcaactggcgctcctccca
gcagccactcagggaaagaaagtggtgctgggcaaaaaaggggatacagtggaactgacc
tgtacagcttcccagaagaagagcatacaattccactggaaaaactccaaccagataaag
attctgggaaatcagggctccttcttaactaaaggtccatccaagctgaatgatcgcgct
gactcaagaagaagcctttgggaccaaggaaactttcccctgatcatcaagaatcttaag
atagaagactcagatacttacatctgtgaagtggaggaccagaaggaggaggtgcaattg
ctagtgttcggattgactgccaactctgacacccacctgcttcaggggcagagcctgacc
ctgaccttggagagcccccctggtagtagcccctcagtgcaatgtaggagtccaaggggt
aaaaacatacagggggggaagaccctctccgtgtctcagctggagctccaggatagtggc
acctggacatgcactgtcttgcagaaccagaagaaggtggagttcaaaatagacatcgtg
gtgctagctttccagaaggcctccagcatagtctataagaaagagggggaacaggtggag
ttctccttcccactcgcctttacagttgaaaagctgacgggcagtggcgagctgtggtgg
caggcggagagggcttcctcctccaagtcttggatcacctttgacctgaagaacaaggaa
gtgtctgtaaaacgggttacccaggaccctaagctccagatgggcaagaagctcccgctc
cacctcaccctgccccaggccttgcctcagtatgctggctctggaaacctcaccctggcc
cttgaagcgaaaacaggaaagttgcatcaggaagtgaacctggtggtgatgagagccact
cagctccagaaaaatttgacctgtgaggtgtggggacccacctcccctaagctgatgctg
agtttgaaactggagaacaaggaggcaaaggtctcgaagcgggagaaggcggtgtgggtg
ctgaaccctgaggcggggatgtggcagtgtctgctgagtgactcgggacaggtcctgctg
gaatccaacatcaaggttctgcccacatggtccaccccggtgcagccaatggccctgatt
gtgctggggggcgtcgccggcctcctgcttttcattgggctaggcatcttcttctgtgtc
aggtgccggcaccgaaggcgccaagcagagcggatgtctcagatcaagagactcctcagt
gagaagaagacctgccagtgtcctcaccggtttcagaagacatgtagccccatttga

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