Homo sapiens (human): 3717
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Entry
3717 CDS
T01001
Symbol
JAK2, JTK10
Name
(RefSeq) Janus kinase 2
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa01521
EGFR tyrosine kinase inhibitor resistance
hsa04062
Chemokine signaling pathway
hsa04148
Efferocytosis
hsa04151
PI3K-Akt signaling pathway
hsa04217
Necroptosis
hsa04550
Signaling pathways regulating pluripotency of stem cells
hsa04630
JAK-STAT signaling pathway
hsa04658
Th1 and Th2 cell differentiation
hsa04659
Th17 cell differentiation
hsa04725
Cholinergic synapse
hsa04917
Prolactin signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04933
AGE-RAGE signaling pathway in diabetic complications
hsa04935
Growth hormone synthesis, secretion and action
hsa05140
Leishmaniasis
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05161
Hepatitis B
hsa05164
Influenza A
hsa05167
Kaposi sarcoma-associated herpesvirus infection
hsa05168
Herpes simplex virus 1 infection
hsa05200
Pathways in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05417
Lipid and atherosclerosis
Network
nt06160
Human T-cell leukemia virus 1 (HTLV-1)
nt06162
Hepatitis B virus (HBV)
nt06164
Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165
Epstein-Barr virus (EBV)
nt06219
JAK-STAT signaling (cancer)
nt06263
Hepatocellular carcinoma
nt06266
Non-small cell lung cancer
nt06276
Chronic myeloid leukemia
nt06324
GHRH-GH-IGF signaling
nt06325
Hormone/cytokine signaling
nt06518
JAK-STAT signaling
nt06527
Necroptosis
nt06535
Efferocytosis
Element
N00053
Cytokine-Jak-STAT signaling pathway
N00181
KSHV vIL-6 to Jak-STAT signaling pathway
N00907
GH-Jak-STAT signaling pathway
N00920
PRL-JAK-STAT signaling pathway
N01340
ACH-CHRN-JAK-STAT signaling pathway
N01341
NNK/NNN to Jak-STAT signaling pathway
N01342
Nicotine to Jak-STAT signaling pathway
N01555
Hormone-like-cytokine to Jak-STAT signaling pathway
N01556
IL6 family to Jak-STAT signaling pathway
N01557
IL12/23 to Jak-STAT signaling pathway
N01559
Type II interferon to Jak-STAT signaling pathway
N01662
IFN-RIPK1/3 signaling pathway
N01751
Macrophage EPO signaling
N01800
LEP-LEPR signaling pathway
N01804
IL3 family to Jak-STAT signaling pathway
Disease
H00003
Acute myeloid leukemia
H00012
Polycythemia vera
H00236
Congenital polycythemia
H01433
Budd-Chiari syndrome
H01605
Myelofibrosis
H01612
Essential thrombocythemia
H02410
Myelodysplastic/myeloproliferative neoplasms
H02411
Chronic myelomonocytic leukemia
H02412
Atypical chronic myeloid leukemia
Drug target
Baricitinib:
D10308
<JP/US>
Delgocitinib:
D11046
<JP>
Deuruxolitinib (
DG03114
):
D11866
D11867
Fedratinib (
DG02968
):
D10630
D11296
<US>
Filgotinib (
DG01991
):
D11106
<JP>
Frevecitinib:
D12993
Gandotinib:
D10365
Gusacitinib (
DG03080
):
D11676
D11677
Momelotinib (
DG01366
):
D10315
D10358
D10889
<JP/US>
D10889
<JP/US>
Nezulcitinib:
D12118
Pacritinib:
D11768
<US>
Peficitinib (
DG01853
):
D10653
D10721
<JP>
Ruxolitinib (
DG00719
):
D09959
D09960
<JP/US>
Tinengotinib:
D12545
Tofacitinib (
DG00742
):
D09783
<JP/US>
D09970
Tuspetinib:
D12476
Zotiraciclib (
DG03058
):
D11599
D11600
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
3717 (JAK2)
04151 PI3K-Akt signaling pathway
3717 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
3717 (JAK2)
09143 Cell growth and death
04217 Necroptosis
3717 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
3717 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
3717 (JAK2)
04659 Th17 cell differentiation
3717 (JAK2)
04062 Chemokine signaling pathway
3717 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
3717 (JAK2)
04917 Prolactin signaling pathway
3717 (JAK2)
04935 Growth hormone synthesis, secretion and action
3717 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
3717 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
3717 (JAK2)
05207 Chemical carcinogenesis - receptor activation
3717 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
3717 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
3717 (JAK2)
05164 Influenza A
3717 (JAK2)
05168 Herpes simplex virus 1 infection
3717 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
3717 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
3717 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
3717 (JAK2)
05140 Leishmaniasis
3717 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
3717 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
3717 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
3717 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
3717 (JAK2)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
3717 (JAK2)
Protein kinases [BR:
hsa01001
]
Non-receptor tyrosine kinases
JAK family [OT]
3717 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
SH2
FERM_C_FAK1
ABC1
Kinase-like
RIO1
FERM_M
Motif
Other DBs
NCBI-GeneID:
3717
NCBI-ProteinID:
NP_001309123
OMIM:
147796
HGNC:
6192
Ensembl:
ENSG00000096968
UniProt:
O60674
Structure
PDB
PDBj
LinkDB
All DBs
Position
9:4984390..5129948
Genome browser
AA seq
1132 aa
AA seq
DB search
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG
EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF
PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG
MAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQF
SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC
YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI
RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA
MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq
3399 nt
NT seq
+upstream
nt +downstream
nt
atgggaatggcctgccttacgatgacagaaatggagggaacatccacctcttctatatat
cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagttcttcag
gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg
gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg
tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat
gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt
cctcgttggtattgcagtggcagcaacagagcctatcggcatggaatatctcgaggtgct
gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat
tttgtgcacggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg
atggcagtgttagatatgatgagaatagccaaagaaaacgatcaaaccccactggccatc
tataactctatcagctacaagacattcttaccaaaatgtattcgagcaaagatccaagac
tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcaattc
agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt
cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcaaatgaaagccga
gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg
gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccagccgtgcttgaaaatatacaaagcaactgt
catggcccaatttcgatggattttgccattagtaaactgaagaaagcaggtaatcagact
ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttttgacttttgct
gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa
gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt
taccagatggaaactgttcgctcagacaatataattttccagtttactaaatgctgtccc
ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgatgta
ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatatttaatgaaagccttggccaaggcacttttacaaagattttt
aaaggcgtacgaagagaagtaggagactacggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagtatg
atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagac
gagaatattctggttcaggagtttgtaaaatttggatcactagatacatatctgaaaaag
aataaaaattgtataaatatattatggaaacttgaagttgctaaacagttggcatgggcc
atgcattttctagaagaaaacacccttattcatgggaatgtatgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataaacctctaagtgctctggattctcaa
agaaagctacaattttatgaagataggcatcagcttcctgcaccaaagtgggcagaatta
gcaaaccttataaataattgtatggattatgaaccagatttcaggccttctttcagagcc
atcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac
atgttaccaaatatgaggataggtgccctggggttttctggtgcctttgaagaccgggat
cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaatttt
gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtcgct
gtaaaaaagcttcagcatagtactgaagagcacctaagagactttgaaagggaaattgaa
atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat
cttcaaaaacataaagaacggatagatcacataaaacttctgcagtacacatctcagata
tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacgaga
aatatattggtggagaacgagaacagagttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgatcgtgttccatttgatagaa
cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatctatatg
atcatgacagaatgctggaacaataatgtaaatcaacgcccctcctttagggatctagct
cttcgagtggatcaaataagggataacatggctggatga
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integrated database retrieval system