KEGG PATHWAY: hsp00260

PATHWAY: hsp00260

Entry

hsp00260                    Pathway

Name

Glycine, serine and threonine metabolism - Hippoglossus stenolepis (Pacific halibut)

Description

Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].

Class

Metabolism; Amino acid metabolism

Pathway map

hsp00260

Glycine, serine and threonine metabolism

Module

hsp_M00020

Serine biosynthesis, glycerate-3P => serine [PATH:hsp00260]

hsp_M00047

Creatine pathway [PATH:hsp00260]

hsp_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:hsp00260]

hsp_M00555

Betaine biosynthesis, choline => betaine [PATH:hsp00260]

hsp_M00621

Glycine cleavage system [PATH:hsp00260]

hsp_M00974

Betaine metabolism, animals, betaine => glycine [PATH:hsp00260]

Other DBs

GO:	0006544 0006563 0070178 0006566

Organism

Hippoglossus stenolepis (Pacific halibut) [GN:hsp]

Gene

118098095

dmgdh; dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]

118098097

[KO:K00544] [EC:2.1.1.5]

118099573

tdh; L-threonine dehydrogenase isoform X1 [KO:K15789] [EC:1.1.1.103]

118100598

[KO:K01620] [EC:4.1.2.48]

118100636

grhprb; glyoxylate reductase/hydroxypyruvate reductase b [KO:K00049] [EC:1.1.1.79 1.1.1.81]

118100727

[KO:K01620] [EC:4.1.2.48]

118103168

[KO:K01697] [EC:4.2.1.22]

118104597

shmt2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]

118105185

alas1; 5-aminolevulinate synthase, nonspecific, mitochondrial [KO:K00643] [EC:2.3.1.37]

118105432

glyctk; glycerate kinase [KO:K11529] [EC:2.7.1.165]

118106118

psph; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]

118106474

pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]

118109505

[KO:K02437]

118109657

dldh; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]

118110035

bpgm; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]

118110375

[KO:K00600] [EC:2.1.2.1]

118110449

[KO:K00643] [EC:2.3.1.37]

118111295

alas2; 5-aminolevulinate synthase, erythroid-specific, mitochondrial isoform X1 [KO:K00643] [EC:2.3.1.37]

118111330

chdh; choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]

118111633

amt; aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]

118112167

grhpra; glyoxylate reductase/hydroxypyruvate reductase [KO:K00049] [EC:1.1.1.79 1.1.1.81]

118114159

gcshb; glycine cleavage system protein H (aminomethyl carrier), b [KO:K02437]

118114836

[KO:K00544] [EC:2.1.1.5]

118114895

[KO:K00544] [EC:2.1.1.5]

118114896

[KO:K00544] [EC:2.1.1.5]

118114950

[KO:K00273] [EC:1.4.3.3]

118115631

[KO:K17989] [EC:4.3.1.17 4.3.1.19]

118116217

gnmt; glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]

118116551

gatm; glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]

118117031

tdh2; L-threonine dehydrogenase 2 isoform X1 [KO:K15789] [EC:1.1.1.103]

118117084

sdsl; serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]

118117255

zgc:162816; D-threo-3-hydroxyaspartate dehydratase [KO:K20498] [EC:4.3.1.18]

118117916

agxtb; alanine--glyoxylate and serine--pyruvate aminotransferase b [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

118118595

pgam1b; phosphoglycerate mutase 1b [KO:K01834] [EC:5.4.2.11]

118118620

[KO:K01754] [EC:4.3.1.19]

118119264

[KO:K01834] [EC:5.4.2.11]

118120076

mao; amine oxidase [flavin-containing] [KO:K00274] [EC:1.4.3.4]

118120257

phgdh; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

118120656

gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]

118120761

cth; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

118120794

aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]

118120915

agxta; alanine--glyoxylate and serine--pyruvate aminotransferase a [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]

118123512

shmt1; serine hydroxymethyltransferase, cytosolic [KO:K00600] [EC:2.1.2.1]

118123745

aoc2; retina-specific copper amine oxidase [KO:K00276] [EC:1.4.3.21]

118123826

gcat; 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]

118125404

sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]

118125655

agxt2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]

118125703

si:ch211-127i16.2; LOW QUALITY PROTEIN: probable flavin-containing monoamine oxidase A [KO:K00274] [EC:1.4.3.4]

118125764

pgam2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]

124852410

gldc; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]

124852503

psat1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00011

CO2

C00014

Ammonia

C00022

Pyruvate

C00037

Glycine

C00048

Glyoxylate

C00049

L-Aspartate

C00065

L-Serine

C00078

L-Tryptophan

C00097

L-Cysteine

C00101

Tetrahydrofolate

C00109

2-Oxobutanoate

C00114

Choline

C00143

5,10-Methylenetetrahydrofolate

C00168

Hydroxypyruvate

C00188

L-Threonine

C00197

3-Phospho-D-glycerate

C00213

Sarcosine

C00258

D-Glycerate

C00263

L-Homoserine

C00300

Creatine

C00430

5-Aminolevulinate

C00441

L-Aspartate 4-semialdehyde

C00546

Methylglyoxal

C00576

Betaine aldehyde

C00581

Guanidinoacetate

C00631

2-Phospho-D-glycerate

C00719

Betaine

C00740

D-Serine

C00986

1,3-Diaminopropane

C01005

O-Phospho-L-serine

C01026

N,N-Dimethylglycine

C01102

O-Phospho-L-homoserine

C01242

[Protein]-S8-aminomethyldihydrolipoyllysine

C01888

Aminoacetone

C02051

Lipoylprotein

C02291

L-Cystathionine

C02737

Phosphatidylserine

C02972

Dihydrolipoylprotein

C03082

4-Phospho-L-aspartate

C03194

(R)-1-Aminopropan-2-ol

C03232

3-Phosphonooxypyruvate

C03283

L-2,4-Diaminobutanoate

C03508

L-2-Amino-3-oxobutanoic acid

C05519

L-Allothreonine

C06231

Ectoine

C06442

N(gamma)-Acetyldiaminobutyrate

C16432

5-Hydroxyectoine

C19929

N(alpha)-Acetyl-L-2,4-diaminobutyrate

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:11823218

Authors

Kuhlmann AU, Bremer E.

Title

Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.

Journal

Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002

Reference

PMID:10473374

Authors

Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.

Title

Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.

Journal

Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999

Reference

PMID:17636255

Authors

Bursy J, Pierik AJ, Pica N, Bremer E.

Title

Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.

Journal

J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200

Reference

PMID:16707670

Authors

Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.

Title

The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.

Journal

J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06

Reference

PMID:15470257

Authors

Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J

Title

FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.

Journal

Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004

Reference

PMID:7639721