KEGG   PATHWAY: ko00970
Entry
ko00970                     Pathway                                
Name
Aminoacyl-tRNA biosynthesis
Class
Genetic Information Processing; Translation
Pathway map
ko00970  Aminoacyl-tRNA biosynthesis
ko00970

Drug
D01076  Mupirocin (USP/INN)
D02195  Mupirocin calcium (USP)
D04413  Halofuginone hydrobromide (USAN)
D08034  Halofuginone (INN)
D09324  Bederocin (USAN/INN)
Orthology
K00604  MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]
K01042  selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]
K01866  YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
K01867  WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
K01868  TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]
K01869  LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]
K01870  IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
K01872  AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01873  VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]
K01874  MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]
K01875  SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]
K01876  DARS2, aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]
K01878  glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
K01879  glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
K01880  GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14]
K01881  PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]
K01883  CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
K01884  cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]
K01885  EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]
K01886  QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
K01887  RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]
K01889  FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
K01890  FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
K01892  HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]
K01893  NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
K02433  gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
K02434  gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
K02435  gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
K03330  gatE; glutamyl-tRNA(Gln) amidotransferase subunit E [EC:6.3.5.7]
K03341  SEPSECS; O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase [EC:2.9.1.2]
K03865  GTF1; glutamyl-tRNA(Gln) amidotransferase subunit F
K04566  lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]
K04567  KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
K06868  sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]
K07587  sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]
K09482  gatD; glutamyl-tRNA(Gln) amidotransferase subunit D [EC:6.3.5.7]
K09698  gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
K09759  aspC, aspS; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]
K10837  PSTK; O-phosphoseryl-tRNA(Sec) kinase [EC:2.7.1.164]
K11627  pylS; pyrrolysyl-tRNA synthetase [EC:6.1.1.26]
K14163  EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]
K14164  glyQS; glycyl-tRNA synthetase [EC:6.1.1.14]
K14218  tRNA-Ala; tRNA Ala
K14219  tRNA-Arg; tRNA Arg
K14220  tRNA-Asn; tRNA Asn
K14221  tRNA-Asp; tRNA Asp
K14222  tRNA-Cys; tRNA Cys
K14223  tRNA-Gln; tRNA Gln
K14224  tRNA-Glu; tRNA Glu
K14225  tRNA-Gly; tRNA Gly
K14226  tRNA-His; tRNA His
K14227  tRNA-Ile; tRNA Ile
K14228  tRNA-Leu; tRNA Leu
K14229  tRNA-Lys; tRNA Lys
K14230  tRNA-Met; tRNA Met
K14231  tRNA-Phe; tRNA Phe
K14232  tRNA-Pro; tRNA Pro
K14233  tRNA-Ser; tRNA Ser
K14234  tRNA-Thr; tRNA Thr
K14235  tRNA-Trp; tRNA Trp
K14236  tRNA-Tyr; tRNA Tyr
K14237  tRNA-Val; tRNA Val
K14238  tRNA-Sec; tRNA Sec
K14239  tRNA-Pyl; tRNA Pyl
K22503  DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
K24278  ERDS; ergosteryl-3beta-O-L-aspartate synthase
Compound
C00025  L-Glutamate
C00037  Glycine
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00073  L-Methionine
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00123  L-Leucine
C00135  L-Histidine
C00148  L-Proline
C00152  L-Asparagine
C00183  L-Valine
C00188  L-Threonine
C00234  10-Formyltetrahydrofolate
C00407  L-Isoleucine
C00886  L-Alanyl-tRNA
C01005  O-Phospho-L-serine
C01931  L-Lysyl-tRNA
C02047  L-Leucyl-tRNA
C02163  L-Arginyl-tRNA(Arg)
C02282  Glutaminyl-tRNA
C02412  Glycyl-tRNA(Gly)
C02430  L-Methionyl-tRNA
C02553  L-Seryl-tRNA(Ser)
C02554  L-Valyl-tRNA(Val)
C02702  L-Prolyl-tRNA(Pro)
C02839  L-Tyrosyl-tRNA(Tyr)
C02984  L-Aspartyl-tRNA(Asp)
C02987  L-Glutamyl-tRNA(Glu)
C02988  L-Histidyl-tRNA(His)
C02992  L-Threonyl-tRNA(Thr)
C03125  L-Cysteinyl-tRNA(Cys)
C03127  L-Isoleucyl-tRNA(Ile)
C03294  N-Formylmethionyl-tRNA
C03402  L-Asparaginyl-tRNA(Asn)
C03511  L-Phenylalanyl-tRNA(Phe)
C03512  L-Tryptophanyl-tRNA(Trp)
C06112  L-Glutamyl-tRNA(Gln)
C06113  L-Aspartyl-tRNA(Asn)
C06481  L-Seryl-tRNA(Sec)
C06482  L-Selenocysteinyl-tRNA(Sec)
C16138  L-Pyrrolysine
C16638  O-Phosphoseryl-tRNA(Sec)
C17022  O-Phosphoseryl-tRNA(Cys)
C17027  L-Pyrrolysyl-tRNA(Pyl)
Reference
PMID:18252769
  Authors
Sheppard K, Yuan J, Hohn MJ, Jester B, Devine KM, Soll D
  Title
From one amino acid to another: tRNA-dependent amino acid biosynthesis.
  Journal
Nucleic Acids Res 36:1813-25 (2008)
DOI:10.1093/nar/gkn015
Reference
PMID:15314242
  Authors
Polycarpo C, Ambrogelly A, Berube A, Winbush SM, McCloskey JA, Crain PF, Wood JL, Soll D
  Title
An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
  Journal
Proc Natl Acad Sci U S A 101:12450-4 (2004)
DOI:10.1073/pnas.0405362101
Related
pathway
ko00250  Alanine, aspartate and glutamate metabolism
ko00260  Glycine, serine and threonine metabolism
ko00270  Cysteine and methionine metabolism
ko00290  Valine, leucine and isoleucine biosynthesis
ko00300  Lysine biosynthesis
ko00330  Arginine and proline metabolism
ko00340  Histidine metabolism
ko00380  Tryptophan metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis

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