KEGG   PATHWAY: mun04350
Entry
mun04350                    Pathway                                
Name
TGF-beta signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04350  TGF-beta signaling pathway
mun04350

Other DBs
GO: 0007179
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539455  Acvr2a; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
110540728  [KO:K04513]
110541442  Igsf1; immunoglobulin superfamily member 1 isoform X2 [KO:K26168]
110544345  Hjv; hemojuvelin [KO:K23100]
110545014  Nbl1; neuroblastoma suppressor of tumorigenicity 1 isoform X1 [KO:K19558]
110545291  Fbn1; fibrillin-1 isoform X1 [KO:K06825]
110545396  Id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
110545636  E2f4; transcription factor E2F4 isoform X1 [KO:K04682]
110545686  Skil; ski-like protein isoform X1 [KO:K18499]
110545943  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110546344  Bmp6; bone morphogenetic protein 6 [KO:K16620]
110546411  Inhbb; inhibin beta B chain [KO:K22687]
110546531  Rgmb; repulsive guidance molecule B isoform X2 [KO:K06847]
110546541  Tmem53; transmembrane protein 53 isoform X1 [KO:K28359]
110546618  Sin3a; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
110546728  Fmod; fibromodulin [KO:K08121]
110546886  Zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
110547040  Smurf2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
110547249  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110547501  Cul1; cullin-1 [KO:K03347]
110547651  Tfrc; transferrin receptor protein 1 [KO:K06503]
110547833  Smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110548026  Bmpr1a; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
110548328  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110548554  Hdac1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
110549220  Id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
110549244  Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110549400  Chrd; chordin isoform X1 [KO:K04657]
110549515  Acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
110549524  Acvr1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
110549625  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
110549633  Skp1; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
110549803  Ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
110549889  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110549964  [KO:K16622]
110550301  Smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110550302  Smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
110550435  Rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
110550464  Emp3; epithelial membrane protein 3 [KO:K26257]
110550573  Gdf5; growth/differentiation factor 5 [KO:K04664]
110550715  Smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
110550958  Bmp4; bone morphogenetic protein 4 [KO:K04662]
110551136  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110551159  Thsd4; thrombospondin type-1 domain-containing protein 4 isoform X2 [KO:K23377]
110551735  Hamp; hepcidin [KO:K23106]
110552317  Amhr2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
110552322  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
110553092  Hfe; hereditary hemochromatosis protein isoform X1 [KO:K26535]
110553161  Pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
110553288  Nrros; transforming growth factor beta activator LRRC33 isoform X1 [KO:K26317]
110553742  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110554089  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110554385  Cdkn2b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
110554916  Smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
110555057  Acvr2b; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
110555548  Nog; noggin [KO:K04658]
110555580  Amh; muellerian-inhibiting factor [KO:K04665]
110555644  Smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X3 [KO:K04678] [EC:2.3.2.26]
110555901  Nodal; nodal homolog [KO:K04666]
110555961  Grem1; gremlin-1 [KO:K23318]
110556135  Neo1; neogenin isoform X1 [KO:K06766]
110556360  Bmp7; bone morphogenetic protein 7 [KO:K16621]
110556761  Tfr2; transferrin receptor protein 2 isoform X1 [KO:K23910]
110556830  Inhba; inhibin beta A chain [KO:K04667]
110556861  Smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
110556943  Tgif2; homeobox protein TGIF2 [KO:K19553]
110557579  Grem2; gremlin-2 [KO:K23318]
110557683  Lemd3; inner nuclear membrane protein Man1 [KO:K19410]
110557887  Smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
110557925  Gdf6; growth/differentiation factor 6 [KO:K20012]
110557991  Bmp2; bone morphogenetic protein 2 isoform X2 [KO:K21283]
110558065  Gdf7; growth/differentiation factor 7 [KO:K20013]
110558214  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110558230  Tfdp1; transcription factor Dp-1 isoform X1 [KO:K04683]
110558293  Bambi; BMP and activin membrane-bound inhibitor homolog [KO:K10162]
110558488  Tgif1; homeobox protein TGIF1 isoform X2 [KO:K19383]
110559003  Smad6; mothers against decapentaplegic homolog 6 [KO:K04677]
110559103  Bmpr2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
110559138  Acvr1b; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
110559865  Ski; ski oncogene isoform X1 [KO:K26503]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110560136  Tnf; LOW QUALITY PROTEIN: tumor necrosis factor [KO:K03156]
110560360  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110560565  Lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
110560607  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
110561107  [KO:K14736]
110561197  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110561307  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
110561657  Inhbc; inhibin beta C chain [KO:K22688]
110561752  Inhbe; inhibin beta E chain [KO:K22689]
110561827  Ifng; interferon gamma [KO:K04687]
110562162  Dcn; decorin [KO:K04660]
110562662  Ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
110562735  Rgma; repulsive guidance molecule A isoform X1 [KO:K23096]
110563235  E2f5; transcription factor E2F5 [KO:K04682]
110563777  Zfyve9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
110564034  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
110564049  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
110564211  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
110564738  Bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
110565123  Rhoa; transforming protein RhoA isoform X2 [KO:K04513]
110565358  Fst; follistatin isoform X1 [KO:K04661]
110565542  Id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
110565556  [KO:K14736]
110565703  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110566281  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
132653010  [KO:K16622]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
mun04010  MAPK signaling pathway
mun04110  Cell cycle
mun04120  Ubiquitin mediated proteolysis
mun04210  Apoptosis
KO pathway
ko04350   

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