KEGG   PATHWAY: mun04010
Entry
mun04010                    Pathway                                
Name
MAPK signaling pathway - Meriones unguiculatus (Mongolian gerbil)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mun04010  MAPK signaling pathway
mun04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539385  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
110539533  Fgf16; fibroblast growth factor 16 [KO:K04358]
110539539  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
110539611  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
110540260  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
110540558  Stk3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
110540621  Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
110540777  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
110541070  Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
110541273  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110541459  Cacna2d1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
110541705  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110541719  Cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
110542126  Vegfc; vascular endothelial growth factor C [KO:K05449]
110542507  Pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
110543001  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
110543451  Rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
110543863  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
110543906  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110544110  Daxx; death domain-associated protein 6 isoform X2 [KO:K02308]
110544642  [KO:K07828]
110544653  [KO:K04467] [EC:2.7.11.10]
110544765  Nras; GTPase NRas [KO:K07828]
110545010  Cdc42; cell division control protein 42 homolog isoform X2 [KO:K04393]
110545505  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110545551  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
110545561  Ntf3; neurotrophin-3 [KO:K04356]
110545637  Mapt; microtubule-associated protein tau isoform X11 [KO:K04380]
110545661  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
110545680  Mecom; histone-lysine N-methyltransferase MECOM isoform X6 [KO:K04462] [EC:2.1.1.367]
110545779  Braf; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
110545821  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110545836  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110545842  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110545886  Fgf2; fibroblast growth factor 2 [KO:K18497]
110545902  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
110546214  Pspn; persephin [KO:K25416]
110546254  Nrtn; neurturin isoform X2 [KO:K25414]
110546396  Mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
110546441  Fgf3; fibroblast growth factor 3 [KO:K04358]
110546517  Fgf19; fibroblast growth factor 19 [KO:K22603]
110546548  Fgf4; fibroblast growth factor 4 [KO:K04358]
110546562  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110546585  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110546648  Map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X3 [KO:K04416] [EC:2.7.11.25]
110546688  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110546690  Igf2; insulin-like growth factor II isoform X1 [KO:K13769]
110546695  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
110546864  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
110546918  Cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
110546962  Fos; protein c-Fos [KO:K04379]
110546968  Pgf; placenta growth factor [KO:K16859]
110547048  Map3k3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
110547067  Map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
110547073  Sos1; son of sevenless homolog 1 isoform X1 [KO:K03099]
110547163  Tgfa; protransforming growth factor alpha [KO:K08774]
110547249  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110547261  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110547298  Ins; insulin [KO:K04526]
110547315  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110547367  Crk; adapter molecule crk isoform X1 [KO:K04438]
110547372  Flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
110547429  Cacnb3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
110547567  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110547767  Max; protein max isoform X1 [KO:K04453]
110547817  Fgf18; fibroblast growth factor 18 [KO:K04358]
110547818  Dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
110547825  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
110547978  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110548017  Taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
110548224  Stk4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
110548268  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110548400  Mras; ras-related protein M-Ras [KO:K07831]
110548422  Ptpn7; tyrosine-protein phosphatase non-receptor type 7 isoform X2 [KO:K18019] [EC:3.1.3.48]
110548425  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110548442  Cacng2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
110548466  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110548604  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
110548616  Fgf6; fibroblast growth factor 6 [KO:K04358]
110548635  Fgf23; fibroblast growth factor 23 [KO:K22428]
110548671  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
110548686  Mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
110548820  Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
110549151  Jund; transcription factor JunD [KO:K04449]
110549244  Tgfb2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110549306  Map3k11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
110549322  Map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
110549343  Rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110549494  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
110549551  Rap1a; ras-related protein Rap-1A [KO:K04353]
110549673  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
110549680  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110549683  Mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
110549737  Fgf9; fibroblast growth factor 9 [KO:K04358]
110549775  Fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
110549800  Mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
110549871  Mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
110550145  Nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
110550150  Nf1; neurofibromin isoform X1 [KO:K08052]
110550185  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110550273  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110550321  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110550351  Srf; serum response factor isoform X1 [KO:K04378]
110550366  Vegfa; vascular endothelial growth factor A, long form isoform X3 [KO:K05448]
110550381  [KO:K05462]
110550427  Cacna1i; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
110550451  Fgf10; fibroblast growth factor 10 [KO:K04358]
110550501  Fgf21; fibroblast growth factor 21 [KO:K22429]
110550525  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110550528  Map2k5; dual specificity mitogen-activated protein kinase kinase 5 isoform X14 [KO:K04463] [EC:2.7.12.2]
110550654  Cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
110550675  Cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110550814  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
110551005  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110551136  Tgfbr1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110551211  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110551350  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110551374  Efna2; ephrin-A2 [KO:K05462]
110551396  Il1a; interleukin-1 alpha [KO:K04383]
110551400  Il1b; interleukin-1 beta [KO:K04519]
110551541  Relb; transcription factor RelB isoform X2 [KO:K09253]
110551593  Rps6ka4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
110551598  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
110551668  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
110551766  Efna5; ephrin-A5 isoform X1 [KO:K05462]
110551898  Dusp3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
110551938  Taok3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
110551992  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
110552024  Efna1; ephrin-A1 isoform X1 [KO:K05462]
110552032  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
110552065  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
110552128  Dusp6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110552178  Stmn1; stathmin [KO:K04381]
110552225  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
110552285  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110552314  Map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
110552339  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
110552482  Ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
110552483  Map3k6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
110552526  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
110552537  Map4k1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
110552560  Rasgrp4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
110552616  Angpt1; angiopoietin-1 isoform X2 [KO:K05465]
110552652  Ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
110552932  Artn; artemin isoform X1 [KO:K25415]
110552966  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110553196  Egf; pro-epidermal growth factor [KO:K04357]
110553293  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110553443  Map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
110553491  Pla2g4a; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
110553796  Mapk1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
110553931  Hras; GTPase HRas isoform X1 [KO:K02833]
110554278  Cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
110554364  Map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
110554439  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
110554579  Ppm1a; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
110554628  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110554732  Gna12; guanine nucleotide-binding protein subunit alpha-12 isoform X2 [KO:K04346]
110554739  Dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
110554755  Pla2g4b; cytosolic phospholipase A2 beta isoform X2 [KO:K16342] [EC:3.1.1.4]
110554759  Pla2g4e; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
110554765  Pla2g4d; LOW QUALITY PROTEIN: cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
110554773  Pla2g4f; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110554862  Map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
110554946  Fgfr2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
110555016  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110555059  Myd88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
110555127  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110555293  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
110555334  Cacng5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
110555335  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110555590  Mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
110555604  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110555605  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110555822  Angpt4; angiopoietin-4 isoform X1 [KO:K05467]
110555867  Hspb1; heat shock protein beta-1 [KO:K04455]
110555973  Ppp3ca; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
110556003  Cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
110556013  Cacng7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
110556016  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110556017  Cacng8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
110556050  Rras2; ras-related protein R-Ras2 [KO:K07830]
110556458  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
110556579  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110556613  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110556683  Cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X3 [KO:K04861]
110556719  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110556721  Map3k10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
110556776  Fgf8; fibroblast growth factor 8 isoform X4 [KO:K04358]
110556827  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110556913  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110556944  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110557003  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
110557305  Fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110557323  Arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
110557360  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110557386  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110557417  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110557497  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
110557680  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110557813  Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
110557819  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110557998  Taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
110558019  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
110558042  Ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
110558105  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110558214  Tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
110558401  Map3k8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
110558423  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2 [KO:K04402]
110558424  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110558804  Map3k9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
110558913  Kras; GTPase KRas isoform X1 [KO:K07827]
110558957  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
110558966  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110559000  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110559073  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110559141  Nr4a1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X1 [KO:K04465]
110559213  Crkl; crk-like protein [KO:K04438]
110559281  Kitlg; kit ligand isoform X1 [KO:K05461]
110559286  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110559352  Angpt2; angiopoietin-2 [KO:K05466]
110559383  Erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
110559567  Cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
110559612  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110559622  Cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
110559663  Ptpn5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
110559727  Jun; transcription factor Jun [KO:K04448]
110559960  Il1r1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
110560051  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110560130  [KO:K03283]
110560136  Tnf; LOW QUALITY PROTEIN: tumor necrosis factor [KO:K03156]
110560143  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
110560146  Areg; amphiregulin [KO:K09782]
110560157  Fgf7; fibroblast growth factor 7 isoform X1 [KO:K04358]
110560327  Ptprr; receptor-type tyrosine-protein phosphatase R isoform X3 [KO:K04458] [EC:3.1.3.48]
110560411  Arrb1; beta-arrestin-1 isoform X3 [KO:K04439]
110560456  Dusp9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
110560656  Ntf4; neurotrophin-4 [KO:K12457]
110560922  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110561197  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
110561325  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
110561450  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
110561521  Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
110561590  Map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
110561622  Igf1; insulin-like growth factor I isoform X5 [KO:K05459]
110561677  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [KO:K04432] [EC:2.7.12.2]
110561819  Map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
110561910  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110562149  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
110562151  Rap1b; ras-related protein Rap-1b [KO:K07836]
110562528  Ikbkg; NF-kappa-B essential modulator isoform X3 [KO:K07210]
110562530  Flna; filamin-A isoform X1 [KO:K04437]
110562619  Mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
110562664  Rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
110562875  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110562952  Erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110563015  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
110563057  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110563236  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
110563307  Fgfr1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110563636  Irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
110563661  Dusp4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110563773  Cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
110564013  Rapgef2; rap guanine nucleotide exchange factor 2 isoform X7 [KO:K08018]
110564258  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110564316  Fgf20; fibroblast growth factor 20 [KO:K04358]
110564325  Rps6ka5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
110564378  Ngf; beta-nerve growth factor [KO:K02582]
110564462  Rasa1; ras GTPase-activating protein 1 [KO:K04352]
110564553  Mapkapk3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
110564620  Cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X6 [KO:K04859]
110564629  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110564688  Gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
110564837  Rps6ka2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
110564898  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110564977  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110565064  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110565075  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110565085  Rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
110565263  Ereg; proepiregulin [KO:K09784]
110565312  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
110565729  Rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
110565808  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
110566945  Irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
132650544  Map2k7; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
132653623  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mun04070  Phosphatidylinositol signaling system
mun04110  Cell cycle
mun04115  p53 signaling pathway
mun04210  Apoptosis
mun04310  Wnt signaling pathway
mun04668  TNF signaling pathway
KO pathway
ko04010   

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