KEGG   PATHWAY: mze03013
Entry
mze03013                    Pathway                                
Name
Nucleocytoplasmic transport - Maylandia zebra (zebra mbuna)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
mze03013  Nucleocytoplasmic transport
mze03013

Other DBs
GO: 0050658
Organism
Maylandia zebra (zebra mbuna) [GN:mze]
Gene
101463626  [KO:K12812] [EC:5.6.2.7]
101464308  xpo4; exportin-4 [KO:K25203]
101464651  [KO:K12875]
101464657  upf2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
101464671  nxf1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
101465516  nup107; nuclear pore complex protein Nup107 [KO:K14301]
101465729  nup153; nuclear pore complex protein Nup153 [KO:K14296]
101465787  [KO:K14316]
101465842  nup54; nucleoporin p54 isoform X1 [KO:K14308]
101465880  [KO:K14290]
101466118  ipo8; importin-8 isoform X1 [KO:K18755]
101466250  acin1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
101466741  [KO:K14319]
101466821  casc3; protein CASC3 [KO:K14323]
101467061  nup210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
101467133  kpna2; importin subunit alpha-1 isoform X1 [KO:K15043]
101467159  ran; GTP-binding nuclear protein Ran [KO:K07936]
101467559  ipo9; importin-9 [KO:K20224]
101467778  ipo5; importin-5 [KO:K20222]
101467850  rbm8a; RNA-binding protein 8A isoform X1 [KO:K12876]
101468052  [KO:K15042]
101468124  [KO:K18727]
101468128  [KO:K15043]
101468215  thoc6; THO complex subunit 6 homolog isoform X2 [KO:K13175]
101468323  xpo7; exportin-7 [KO:K18460]
101468462  ipo11; importin-11 [KO:K25201]
101468795  thoc3; THO complex subunit 3 [KO:K12880]
101468849  thoc5; THO complex subunit 5 homolog [KO:K13174]
101468860  kpna1; importin subunit alpha-5 [KO:K23940]
101468950  [KO:K12882]
101469039  nup35; nucleoporin NUP35 [KO:K14313]
101469350  snupn; snurportin-1 [KO:K13151]
101469485  ndc1; nucleoporin NDC1 [KO:K14315]
101469873  nup133; nuclear pore complex protein Nup133 [KO:K14300]
101469876  [KO:K03231]
101469959  [KO:K12881]
101470354  [KO:K03345] [EC:3.4.22.68]
101470444  [KO:K18655] [EC:5.6.2.7]
101470621  [KO:K12172] [EC:2.3.2.-]
101470873  kpna4; importin subunit alpha-3 [KO:K23583]
101471323  [KO:K14285]
101471482  tpr; nucleoprotein TPR [KO:K09291]
101472185  [KO:K12160]
101472344  phax; phosphorylated adapter RNA export protein [KO:K14291]
101472608  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
101472733  [KO:K03231]
101472848  [KO:K14325]
101472951  [KO:K18727]
101473188  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
101473952  tnpo3; transportin-3 isoform X2 [KO:K15436]
101474012  [KO:K12877]
101474040  [KO:K10577]
101474207  [KO:K13025] [EC:5.6.2.7]
101474245  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
101474462  ipo4; importin-4 [KO:K20221]
101474483  nup43; nucleoporin Nup43 [KO:K14305]
101474771  [KO:K14297]
101474856  xpo5; exportin-5 [KO:K14289]
101475278  kpnb1; importin subunit beta-1 [KO:K14293]
101475408  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
101475743  rae1; mRNA export factor isoform X1 [KO:K14298]
101476300  nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
101476741  [KO:K25202]
101477304  nup88; nuclear pore complex protein Nup88 [KO:K14318]
101477436  thoc7; THO complex subunit 7 homolog [KO:K13176]
101477546  nup37; LOW QUALITY PROTEIN: nucleoporin Nup37 [KO:K14302]
101477952  tmem33; transmembrane protein 33 [KO:K20724]
101477998  thoc1; THO complex subunit 1 [KO:K12878]
101478010  nup93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
101478157  xpot; exportin-T [KO:K14288]
101478318  gle1; nucleoporin GLE1 isoform X1 [KO:K18723]
101478524  nup155; nuclear pore complex protein Nup155 [KO:K14312]
101478884  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
101479238  kpna3; importin subunit alpha-4 [KO:K23583]
101479371  ahctf1; protein ELYS [KO:K25129]
101479826  [KO:K12160]
101480205  [KO:K14290]
101480245  nup50; nuclear pore complex protein Nup50 [KO:K14295]
101480423  [KO:K15043]
101480690  [KO:K14319]
101480745  ipo7; importin-7 [KO:K20223]
101481223  cse1l; exportin-2 [KO:K18423]
101481461  pym1; partner of Y14 and mago [KO:K14294]
101481587  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101481741  [KO:K09291]
101481970  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
101482309  [KO:K03231]
101482337  nup62; nuclear pore glycoprotein p62 [KO:K14306]
101482643  kpna6; importin subunit alpha-7 [KO:K15042]
101482897  [KO:K03231]
101482994  [KO:K14303]
101483001  xpo6; exportin-6 [KO:K25204]
101483110  rnps1; RNA-binding protein with serine-rich domain 1 [KO:K14325]
101484430  sec13; protein SEC13 homolog [KO:K14004]
101484582  tnpo1; transportin-1 [KO:K18752]
101484743  [KO:K25202]
101485310  [KO:K12160]
101485349  nup188; nucleoporin NUP188 homolog [KO:K14311]
101485381  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
101485522  nup58; nucleoporin p58/p45 isoform X1 [KO:K14307]
101485550  [KO:K03231]
101485607  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
101485755  [KO:K14304]
101486041  [KO:K12160]
101486105  thoc2; THO complex subunit 2 [KO:K12879]
101486344  pnn; pinin [KO:K13114]
101486461  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
101486952  aaas; aladin isoform X1 [KO:K14320]
101487009  ube2i; SUMO-conjugating enzyme UBC9 [KO:K10577]
101487429  [KO:K18655] [EC:5.6.2.7]
101487745  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
101487911  nupl2; nucleoporin-like protein 2 [KO:K14321]
101487920  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
112429996  [KO:K13025] [EC:5.6.2.7]
112430036  [KO:K12882]
112431382  [KO:K14297]
112434176  [KO:K14303]
112434433  [KO:K14302]
112434737  sumo2; small ubiquitin-related modifier 2 isoform X1 [KO:K12160]
112434738  [KO:K14304]
112435392  [KO:K14297]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
mze03015  mRNA surveillance pathway
KO pathway
ko03013   

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