KEGG   PATHWAY: oki00600
Entry
oki00600                    Pathway                                
Name
Sphingolipid metabolism - Oncorhynchus kisutch (coho salmon)
Class
Metabolism; Lipid metabolism
Pathway map
oki00600  Sphingolipid metabolism
oki00600

Module
oki_M00066  Lactosylceramide biosynthesis [PATH:oki00600]
oki_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:oki00600]
oki_M00094  Ceramide biosynthesis [PATH:oki00600]
oki_M00099  Sphingosine biosynthesis [PATH:oki00600]
oki_M00100  Sphingosine degradation [PATH:oki00600]
Other DBs
GO: 0006665
Organism
Oncorhynchus kisutch (coho salmon) [GN:oki]
Gene
109864707  [KO:K04715] [EC:2.7.1.138]
109864894  gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
109865222  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
109865275  [KO:K04718] [EC:2.7.1.91]
109865539  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
109866408  [KO:K23727]
109866469  [KO:K00654] [EC:2.3.1.50]
109866842  [KO:K04715] [EC:2.7.1.138]
109867178  arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
109867369  [KO:K12373] [EC:3.2.1.52]
109867801  [KO:K12352] [EC:3.1.4.12]
109868024  [KO:K12382]
109868222  [KO:K12353] [EC:3.1.4.12]
109868273  [KO:K01080] [EC:3.1.3.4]
109868447  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
109868685  [KO:K12373] [EC:3.2.1.52]
109869053  [KO:K23727]
109869446  [KO:K04715] [EC:2.7.1.138]
109869807  [KO:K09905] [EC:2.4.1.274 2.4.1.-]
109870127  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
109870161  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
109870398  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
109871346  cers6; ceramide synthase 6 isoform X2 [KO:K23727]
109871475  [KO:K01019] [EC:2.8.2.11]
109871617  [KO:K04708] [EC:1.1.1.102]
109872115  [KO:K01080] [EC:3.1.3.4]
109872571  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109873013  [KO:K12357] [EC:3.2.1.18]
109873118  [KO:K04711] [EC:3.5.1.-]
109873528  [KO:K12382]
109873550  [KO:K12353] [EC:3.1.4.12]
109873817  hexb; beta-hexosaminidase subunit beta isoform X2 [KO:K12373] [EC:3.2.1.52]
109873960  [KO:K12353] [EC:3.1.4.12]
109874297  [KO:K12357] [EC:3.2.1.18]
109874679  [KO:K24621]
109874946  kdsr; 3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
109875148  [KO:K01080] [EC:3.1.3.4]
109875968  [KO:K04718] [EC:2.7.1.91]
109876219  [KO:K12354] [EC:3.1.4.12]
109876657  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
109878342  [KO:K12383]
109879088  cers5; ceramide synthase 5 [KO:K23727]
109879737  [KO:K01080] [EC:3.1.3.4]
109880124  [KO:K01080] [EC:3.1.3.4]
109880201  [KO:K12382]
109880396  [KO:K00720] [EC:2.4.1.80]
109880648  smpd1; sphingomyelin phosphodiesterase isoform X1 [KO:K12350] [EC:3.1.4.12]
109880877  [KO:K00720] [EC:2.4.1.80]
109880997  [KO:K01441] [EC:3.5.1.23]
109882055  [KO:K12383]
109882338  gba; lysosomal acid glucosylceramidase isoform X1 [KO:K01201] [EC:3.2.1.45]
109882821  sgpp2; sphingosine-1-phosphate phosphatase 2 [KO:K04717] [EC:3.1.3.-]
109882869  [KO:K01080] [EC:3.1.3.4]
109882892  psap; prosaposin [KO:K12382]
109883204  [KO:K04718] [EC:2.7.1.91]
109884473  [KO:K04718] [EC:2.7.1.91]
109884494  [KO:K12352] [EC:3.1.4.12]
109884519  [KO:K24621]
109884520  [KO:K24621]
109884600  sptlc3; serine palmitoyltransferase 3 [KO:K00654] [EC:2.3.1.50]
109885490  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
109886548  [KO:K24622]
109888630  [KO:K12352] [EC:3.1.4.12]
109889166  [KO:K04710] [EC:2.3.1.299]
109889773  [KO:K01634] [EC:4.1.2.27]
109889910  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109889944  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
109890557  [KO:K01080] [EC:3.1.3.4]
109890836  smpd2; sphingomyelin phosphodiesterase 2 isoform X1 [KO:K12351] [EC:3.1.4.12]
109891138  [KO:K00725] [EC:2.4.1.92]
109892071  [KO:K01019] [EC:2.8.2.11]
109892119  [KO:K04711] [EC:3.5.1.-]
109892277  [KO:K04718] [EC:2.7.1.91]
109892375  plpp1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
109893511  [KO:K01019] [EC:2.8.2.11]
109894166  [KO:K12348] [EC:3.5.1.23]
109894223  sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
109894304  galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
109894442  [KO:K04716] [EC:3.1.3.-]
109894705  degs2; sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109894716  [KO:K12382]
109895655  [KO:K01019] [EC:2.8.2.11]
109896141  [KO:K01080] [EC:3.1.3.4]
109897189  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
109897380  [KO:K04718] [EC:2.7.1.91]
109897393  [KO:K12354] [EC:3.1.4.12]
109897765  cerk; ceramide kinase isoform X1 [KO:K04715] [EC:2.7.1.138]
109897871  [KO:K01080] [EC:3.1.3.4]
109898085  [KO:K07553] [EC:2.4.1.274]
109899151  [KO:K12354] [EC:3.1.4.12]
109899586  [KO:K01634] [EC:4.1.2.27]
109899701  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
109899933  [KO:K23727]
109899943  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
109900430  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
109900841  [KO:K04716] [EC:3.1.3.-]
109900873  [KO:K00654] [EC:2.3.1.50]
109901024  [KO:K01441] [EC:3.5.1.23]
109901126  [KO:K12348] [EC:3.5.1.23]
109901540  [KO:K24621]
109902413  [KO:K04710] [EC:2.3.1.299]
109902527  [KO:K01080] [EC:3.1.3.4]
109902694  [KO:K01080] [EC:3.1.3.4]
109902782  [KO:K07553] [EC:2.4.1.274]
109902974  acer1; alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
109903723  [KO:K01186] [EC:3.2.1.18]
109903754  [KO:K24621]
109904750  [KO:K00725] [EC:2.4.1.92]
109904931  [KO:K12357] [EC:3.2.1.18]
109906419  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
109907071  [KO:K00725] [EC:2.4.1.92]
109907619  [KO:K01186] [EC:3.2.1.18]
109907680  [KO:K24621]
109908674  [KO:K04715] [EC:2.7.1.138]
116359029  [KO:K01080] [EC:3.1.3.4]
116359313  [KO:K12352] [EC:3.1.4.12]
116360046  [KO:K04714] [EC:2.7.8.27 2.7.8.48 3.1.4.62]
116360057  [KO:K04628] [EC:2.4.1.47]
116371651  [KO:K12352] [EC:3.1.4.12]
116372071  [KO:K04628] [EC:2.4.1.47]
116374473  [KO:K01019] [EC:2.8.2.11]
116375934  [KO:K01080] [EC:3.1.3.4]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
oki00260  Glycine, serine and threonine metabolism
oki00601  Glycosphingolipid biosynthesis - lacto and neolacto series
oki00603  Glycosphingolipid biosynthesis - globo and isoglobo series
oki00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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