KEGG   PATHWAY: oor00230
Entry
oor00230                    Pathway                                
Name
Purine metabolism - Orcinus orca (killer whale)
Class
Metabolism; Nucleotide metabolism
Pathway map
oor00230  Purine metabolism
oor00230

Module
oor_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:oor00230]
oor_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:oor00230]
oor_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:oor00230]
oor_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:oor00230]
oor_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:oor00230]
oor_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:oor00230]
oor_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:oor00230]
Other DBs
GO: 0006163 0042278
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101269275  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X4 [KO:K00088] [EC:1.1.1.205]
101269588  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101269594  [KO:K00764] [EC:2.4.2.14]
101269848  [KO:K00760] [EC:2.4.2.8]
101270151  DGUOK; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
101270249  GMPR2; GMP reductase 2 isoform X7 [KO:K00364] [EC:1.7.1.7]
101270258  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
101270317  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
101270463  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
101270735  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X4 [KO:K18283] [EC:3.1.4.17]
101270798  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X4 [KO:K10808] [EC:1.17.4.1]
101271093  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101271368  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
101271586  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
101271601  NME4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
101271746  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101271940  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101271949  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
101272069  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
101272116  GDA; guanine deaminase isoform X2 [KO:K01487] [EC:3.5.4.3]
101272451  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
101272802  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X4 [KO:K01939] [EC:6.3.4.4]
101272837  NUDT9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
101273023  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101273171  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101273275  NPR2; atrial natriuretic peptide receptor 2 isoform X4 [KO:K12324] [EC:4.6.1.2]
101273566  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
101273592  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101273644  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101273742  HDDC2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
101273780  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
101273799  APRT; adenine phosphoribosyltransferase isoform X2 [KO:K00759] [EC:2.4.2.7]
101273934  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X2 [KO:K00760] [EC:2.4.2.8]
101273982  PGM1; phosphoglucomutase-1 isoform X3 [KO:K01835] [EC:5.4.2.2]
101274275  PNP; purine nucleoside phosphorylase isoform X1 [KO:K03783] [EC:2.4.2.1]
101274436  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
101274454  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X2 [KO:K00944] [EC:2.7.4.10]
101274633  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101274830  PDE1C; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X8 [KO:K13755] [EC:3.1.4.17]
101274835  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
101274865  [KO:K12321] [EC:4.6.1.2]
101274910  ADA2; adenosine deaminase 2 isoform X4 [KO:K19572] [EC:3.5.4.4]
101275290  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X2 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101275581  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
101275632  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101275661  ENTPD2; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
101275708  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
101275718  [KO:K00365] [EC:1.7.3.3]
101275900  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101275975  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
101276001  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
101276085  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
101276881  ATIC; bifunctional purine biosynthesis protein ATIC isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101276971  [KO:K13758]
101277401  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
101277869  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
101277956  AMPD2; AMP deaminase 2 isoform X4 [KO:K01490] [EC:3.5.4.6]
101278214  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X2 [KO:K01951] [EC:6.3.5.2]
101278368  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101278417  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
101278521  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X4 [KO:K18436] [EC:3.1.4.53]
101278828  [KO:K13293] [EC:3.1.4.53]
101279031  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
101279035  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
101279277  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
101279296  AK1; adenylate kinase isoenzyme 1 isoform X2 [KO:K00939] [EC:2.7.4.3]
101279332  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' isoform X1 [KO:K13757] [EC:3.1.4.35]
101279340  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 [KO:K01511] [EC:3.6.1.6]
101279369  PGM2; phosphopentomutase isoform X2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101279566  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
101279744  AMPD3; AMP deaminase 3 isoform X2 [KO:K01490] [EC:3.5.4.6]
101280143  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X9 [KO:K00088] [EC:1.1.1.205]
101280190  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
101280327  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
101280331  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
101280616  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101281295  GUK1; guanylate kinase isoform X4 [KO:K00942] [EC:2.7.4.8]
101281567  [KO:K11265] [EC:4.6.1.1]
101281654  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101281878  NT5C2; cytosolic purine 5'-nucleotidase isoform X3 [KO:K01081] [EC:3.1.3.5]
101281945  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101282014  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
101282221  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
101282297  GUCY2D; retinal guanylyl cyclase 1 isoform X4 [KO:K12321] [EC:4.6.1.2]
101282314  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
101282725  [KO:K00760] [EC:2.4.2.8]
101283178  ADCY5; adenylate cyclase type 5 isoform X2 [KO:K08045] [EC:4.6.1.1]
101283195  NME6; nucleoside diphosphate kinase 6 isoform X2 [KO:K00940] [EC:2.7.4.6]
101283266  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101283390  [KO:K00760] [EC:2.4.2.8]
101283481  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101283651  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
101283754  NT5C1B; LOW QUALITY PROTEIN: cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
101284028  GUCY2C; guanylyl cyclase C isoform X3 [KO:K12320] [EC:4.6.1.2]
101284193  AK5; adenylate kinase isoenzyme 5 isoform X3 [KO:K00939] [EC:2.7.4.3]
101284452  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
101284487  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X2 [KO:K01510] [EC:3.6.1.5]
101284510  [KO:K12319] [EC:4.6.1.2]
101284531  NTPCR; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
101284574  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101285084  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X2 [KO:K01511] [EC:3.6.1.6]
101285115  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
101285238  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X2 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101285550  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101285935  NME7; nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
101286059  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101286207  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101286238  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101286401  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
101286409  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101286464  LACC1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101286524  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
101286661  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101286773  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X2 [KO:K00948] [EC:2.7.6.1]
101287276  PRPS1L1; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
101287535  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101287712  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X4 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101288127  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
101288628  NPR1; atrial natriuretic peptide receptor 1 isoform X2 [KO:K12323] [EC:4.6.1.2]
101288772  URAD; LOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
101288813  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
101288931  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
101288967  ITPA; inosine triphosphate pyrophosphatase isoform X2 [KO:K01519] [EC:3.6.1.66]
101289326  ADA; adenosine deaminase isoform X3 [KO:K01488] [EC:3.5.4.4]
101289375  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
101289635  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101289640  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
101289728  [KO:K00088] [EC:1.1.1.205]
101289858  ADCY4; adenylate cyclase type 4 isoform X2 [KO:K08044] [EC:4.6.1.1]
101290055  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
101290409  [KO:K07127] [EC:3.5.2.17]
102314695  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
105747718  [KO:K00940] [EC:2.7.4.6]
105747905  FHIT; bis(5'-adenosyl)-triphosphatase isoform X2 [KO:K01522] [EC:3.6.1.29]
105748332  [KO:K10808] [EC:1.17.4.1]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
oor00030  Pentose phosphate pathway
oor00220  Arginine biosynthesis
oor00250  Alanine, aspartate and glutamate metabolism
oor00260  Glycine, serine and threonine metabolism
oor00340  Histidine metabolism
oor00630  Glyoxylate and dicarboxylate metabolism
oor00730  Thiamine metabolism
oor00740  Riboflavin metabolism
oor00790  Folate biosynthesis
KO pathway
ko00230   

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