KEGG   PATHWAY: osa00030
osa00030                    Pathway                                
Pentose phosphate pathway - Oryza sativa japonica (Japanese rice) (RefSeq)
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Metabolism; Carbohydrate metabolism
Pathway map
osa00030  Pentose phosphate pathway

osa_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:osa00030]
osa_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:osa00030]
osa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:osa00030]
osa_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:osa00030]
Other DBs
GO: 0006098
Oryza sativa japonica (Japanese rice) (RefSeq) [GN:osa]
4347311  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:]
4334290  glucose-6-phosphate isomerase, cytosolic A [KO:K01810] [EC:]
4340677  glucose-6-phosphate isomerase, cytosolic B [KO:K01810] [EC:]
4345842  glucose-6-phosphate isomerase 1, chloroplastic [KO:K01810] [EC:]
4342988  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:]
4336209  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:]
4329889  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:]
4332659  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:]
4333103  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X1 [KO:K00036] [EC:]
4333117  probable 6-phosphogluconolactonase 1 isoform X1 [KO:K01057] [EC:]
4347654  probable 6-phosphogluconolactonase 4, chloroplastic [KO:K01057] [EC:]
4343843  probable 6-phosphogluconolactonase 2 [KO:K01057] [EC:]
4346232  probable 6-phosphogluconolactonase 3, chloroplastic [KO:K01057] [EC:]
4339892  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:]
4350528  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:]
4331761  ribulose-phosphate 3-epimerase, chloroplastic [KO:K01783] [EC:]
4347508  ribulose-phosphate 3-epimerase, cytoplasmic isoform [KO:K01783] [EC:]
4335330  transketolase, chloroplastic [KO:K00615] [EC:]
4340025  transketolase, chloroplastic [KO:K00615] [EC:]
4344683  transaldolase [KO:K00616] [EC:]
4327239  transaldolase [KO:K00616] [EC:]
4342543  probable ribose-5-phosphate isomerase 3, chloroplastic [KO:K01807] [EC:]
4335430  probable ribose-5-phosphate isomerase 1 [KO:K01807] [EC:]
4334316  probable ribose-5-phosphate isomerase 4, chloroplastic [KO:K01807] [EC:]
4326855  ribokinase [KO:K00852] [EC:]
4333895  phosphoglucomutase, cytoplasmic 2 [KO:K01835] [EC:]
4348230  phosphoglucomutase, chloroplastic [KO:K01835] [EC:]
4328168  ribose-phosphate pyrophosphokinase 1, chloroplastic [KO:K00948] [EC:]
4341535  ribose-phosphate pyrophosphokinase 2, chloroplastic isoform X1 [KO:K00948] [EC:]
107276220  ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:]
4345685  NADP-dependent glyceraldehyde-3-phosphate dehydrogenase [KO:K00131] [EC:]
9266365  probable gluconokinase [KO:K00851] [EC:]
4341496  fructose-bisphosphate aldolase, cytoplasmic isozyme 1 [KO:K01623] [EC:]
4326074  probable fructose-bisphosphate aldolase 3, chloroplastic [KO:K01623] [EC:]
4349897  fructose-bisphosphate aldolase, chloroplastic [KO:K01623] [EC:]
4344545  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:]
4338737  fructose-bisphosphate aldolase cytoplasmic isozyme [KO:K01623] [EC:]
4325027  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:]
107277365  fructose-bisphosphate aldolase cytoplasmic isozyme-like [KO:K01623] [EC:]
4338912  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:]
4325071  fructose-1,6-bisphosphatase, cytosolic [KO:K03841] [EC:]
4332364  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:]
4341770  fructose-1,6-bisphosphatase, chloroplastic [KO:K03841] [EC:]
4339369  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:]
4327301  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:]
4348582  ATP-dependent 6-phosphofructokinase 5, chloroplastic [KO:K00850] [EC:]
4347060  ATP-dependent 6-phosphofructokinase 5, chloroplastic isoform X1 [KO:K00850] [EC:]
4347383  ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:]
4336113  LOW QUALITY PROTEIN: ATP-dependent 6-phosphofructokinase 2 [KO:K00850] [EC:]
4338034  ATP-dependent 6-phosphofructokinase 6 [KO:K00850] [EC:]
4340153  ATP-dependent 6-phosphofructokinase 3 [KO:K00850] [EC:]
4327196  ATP-dependent 6-phosphofructokinase 6 isoform X1 [KO:K00850] [EC:]
4345338  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:]
4330512  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:]
4340909  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha [KO:K00895] [EC:]
4340643  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta [KO:K00895] [EC:]
9271821  pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha isoform X1 [KO:K00895] [EC:]
C00022  Pyruvate
C00031  D-Glucose
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05345  beta-D-Fructose 6-phosphate
C05378  beta-D-Fructose 1,6-bisphosphate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Nishizuka Y (ed).
[Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1980)
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
[Cellular Functions and Metabolic Maps] (In Japanese)
Tokyo Kagaku Dojin (1997)
Michal G.
Biochemical Pathways
Wiley (1999)
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
J Bacteriol 185:2793-801 (2003)
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
J Bacteriol 188:4698-704 (2006)
Kato N, Yurimoto H, Thauer RK
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
Biosci Biotechnol Biochem 70:10-21 (2006)
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
FEBS J 280:1126-38 (2013)
Reher M, Schonheit P
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
FEBS Lett 580:1198-204 (2006)
Reher M, Fuhrer T, Bott M, Schonheit P
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
J Bacteriol 192:964-74 (2010)
osa00010  Glycolysis / Gluconeogenesis
osa00040  Pentose and glucuronate interconversions
osa00052  Galactose metabolism
osa00230  Purine metabolism
osa00240  Pyrimidine metabolism
osa00340  Histidine metabolism
osa00750  Vitamin B6 metabolism
KO pathway

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