KEGG   PATHWAY: panu04530
Entry
panu04530                   Pathway                                
Name
Tight junction - Papio anubis (olive baboon)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
panu04530  Tight junction
panu04530

Other DBs
GO: 0005923
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126675  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100137396  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
100137421  CGN; cingulin [KO:K06102]
100137459  CLDN12; claudin-12 [KO:K06087]
100137560  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
100997019  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100997156  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
100997319  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100997521  CLDN25; putative claudin-25 [KO:K06087]
100997671  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.39]
100998712  AFDN; afadin isoform X1 [KO:K05702]
100998840  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100998841  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
100999330  TJP1; tight junction protein ZO-1 isoform X3 [KO:K05701]
100999495  MYL6B; myosin light chain 6B isoform X2 [KO:K12751]
101000065  MYL6; myosin light polypeptide 6 isoform X2 [KO:K12751]
101000314  ACTR2; actin-related protein 2 isoform X2 [KO:K17260]
101000613  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101001072  MYH11; myosin-11 isoform X1 [KO:K10352]
101001204  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
101001432  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules isoform X1 [KO:K20479]
101001622  CLDN20; claudin-20 [KO:K06087]
101002054  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101002070  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X6 [KO:K04851]
101002160  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
101002500  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101002644  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
101002912  [KO:K12751]
101002917  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
101002996  HCLS1; hematopoietic lineage cell-specific protein isoform X2 [KO:K06106]
101003099  ROCK2; rho-associated protein kinase 2 isoform X5 [KO:K17388] [EC:2.7.11.39]
101003483  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101003510  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101003637  DLG3; disks large homolog 3 isoform X6 [KO:K21098]
101003925  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [KO:K03456]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101004196  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
101004197  SYMPK; symplekin isoform X2 [KO:K06100]
101004833  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101004982  MICALL2; MICAL-like protein 2 isoform X2 [KO:K21068]
101004998  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
101005008  CRB3; protein crumbs homolog 3 [KO:K06090]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101005052  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101005235  CLDN10; claudin-10 isoform X1 [KO:K06087]
101005373  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X2 [KO:K08020]
101005585  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X17 [KO:K13305] [EC:2.3.2.26]
101005652  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101005664  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101006030  JAM2; junctional adhesion molecule B [KO:K06735]
101006121  [KO:K07374]
101006674  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101006681  MYH9; myosin-9 [KO:K10352]
101006845  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X8 [KO:K07200]
101007278  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101007578  PARD3; partitioning defective 3 homolog isoform X9 [KO:K04237]
101007773  BVES; blood vessel epicardial substance [KO:K21108]
101009212  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
101009709  AMOTL1; angiomotin-like protein 1 isoform X5 [KO:K06104]
101010758  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
101010894  JUN; transcription factor AP-1 [KO:K04448]
101011004  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101011099  AMOT; angiomotin isoform X1 [KO:K16819]
101011206  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101011219  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101011267  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
101011726  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101011807  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101012121  MARVELD2; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
101012560  [KO:K12751]
101012708  OCLN; occludin isoform X1 [KO:K06088]
101013013  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
101013448  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101013599  MSN; moesin isoform X2 [KO:K05763]
101013854  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
101013882  CLDN18; claudin-18 isoform X1 [KO:K06087]
101013941  CLDN34; claudin-34 [KO:K06087]
101014093  YBX3; Y-box-binding protein 3 isoform X1 [KO:K06099]
101014164  ARHGAP17; rho GTPase-activating protein 17 isoform X5 [KO:K20638]
101014245  CLDN3; claudin-3 [KO:K06087]
101014276  CLDN9; claudin-9 [KO:K06087]
101014289  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
101014322  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
101014356  CLDN14; claudin-14 [KO:K06087]
101014385  RAB8A; ras-related protein Rab-8A [KO:K07901]
101014597  CLDN4; claudin-4 [KO:K06087]
101014992  CLDN6; claudin-6 [KO:K06087]
101015005  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101015341  [KO:K12757]
101015375  CLDN2; claudin-2 [KO:K06087]
101015472  SYNPO; synaptopodin isoform X2 [KO:K21112]
101016175  ARHGEF18; rho guanine nucleotide exchange factor 18 [KO:K21066]
101016432  [KO:K10591] [EC:2.3.2.26]
101016500  CTTN; src substrate cortactin isoform X2 [KO:K06106]
101016590  PCNA; proliferating cell nuclear antigen [KO:K04802]
101016648  [KO:K12757]
101016784  CLDN24; putative claudin-24 [KO:K06087]
101016803  [KO:K12751]
101016804  RAP2C; ras-related protein Rap-2c isoform X1 [KO:K07839]
101016992  EPB41L4B; LOW QUALITY PROTEIN: band 4.1-like protein 4B [KO:K21111]
101017040  [KO:K04354]
101017045  SCRIB; protein scribble homolog isoform X5 [KO:K16175]
101017171  [KO:K07374]
101017325  DLG1; disks large homolog 1 isoform X23 [KO:K12076]
101017542  RAB13; ras-related protein Rab-13 isoform X2 [KO:K06109]
101017576  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X4 [KO:K06094]
101018343  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101018365  [KO:K07374]
101018430  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101018653  MPDZ; multiple PDZ domain protein isoform X3 [KO:K06095]
101018934  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
101018974  PATJ; inaD-like protein isoform X1 [KO:K06092]
101019001  JAM3; LOW QUALITY PROTEIN: junctional adhesion molecule C [KO:K06785]
101019262  EZR; ezrin isoform X1 [KO:K08007]
101019287  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
101019379  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
101019552  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X6 [KO:K05758]
101019772  CLDN5; claudin-5 [KO:K06087]
101019835  TJAP1; tight junction-associated protein 1 isoform X2 [KO:K06105]
101019858  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101020378  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101020551  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101020553  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101020650  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
101020651  CLDN8; claudin-8 [KO:K06087]
101020655  CLDN15; claudin-15 [KO:K06087]
101020796  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X6 [KO:K04354]
101020849  CD1D; antigen-presenting glycoprotein CD1d isoform X2 [KO:K06448]
101020994  CLDN17; claudin-17 [KO:K06087]
101021211  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
101021217  CLDN7; claudin-7 [KO:K06087]
101021546  CD1C; T-cell surface glycoprotein CD1c isoform X1 [KO:K06448]
101021745  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101021750  [KO:K06087]
101021916  CD1A; T-cell surface glycoprotein CD1a isoform X1 [KO:K06448]
101022026  PRKCE; protein kinase C epsilon type isoform X2 [KO:K18050] [EC:2.7.11.13]
101022265  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101022503  CLDN19; claudin-19 isoform X2 [KO:K06087]
101022717  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
101023567  [KO:K06448]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101023816  CLDN11; claudin-11 [KO:K06087]
101024105  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
101024164  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101024387  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
101024601  NF2; merlin isoform X1 [KO:K16684]
101024621  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X10 [KO:K12791]
101024910  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101025097  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101025178  CLDN23; claudin-23 [KO:K06087]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101025592  MYH10; myosin-10 isoform X9 [KO:K10352]
101025806  RDX; radixin isoform X1 [KO:K05762]
101026251  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X15 [KO:K04345] [EC:2.7.11.11]
101026276  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
101026282  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101026397  CLDN1; claudin-1 [KO:K06087]
101026436  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
101026613  F11R; junctional adhesion molecule A [KO:K06089]
101026754  CLDN16; claudin-16 [KO:K06087]
101026869  ACTB; actin, cytoplasmic 1 [KO:K05692]
101026893  TJP3; LOW QUALITY PROTEIN: tight junction protein ZO-3 [KO:K06097]
101027000  TJP2; tight junction protein ZO-2 isoform X2 [KO:K06098]
108580413  [KO:K06087]
110741987  [KO:K05692]
116272592  [KO:K06087]
116272920  [KO:K10591] [EC:2.3.2.26]
116272968  [KO:K04354]
116273011  [KO:K21110]
116273539  [KO:K06448]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
panu04520  Adherens junction
panu04810  Regulation of actin cytoskeleton
KO pathway
ko04530   

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