KEGG   PATHWAY: asn04150
Entry
asn04150                    Pathway                                
Name
mTOR signaling pathway - Alligator sinensis (Chinese alligator)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
asn04150  mTOR signaling pathway
asn04150

Organism
Alligator sinensis (Chinese alligator) [GN:asn]
Gene
102386748  SLC7A5; LOW QUALITY PROTEIN: large neutral amino acids transporter small subunit 1 [KO:K13780]
102372110  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
102381633  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
102375315  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
102375327  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
102370877  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
102370909  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
102367765  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
102379049  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102376689  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102376182  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102368070  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
102381396  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102382423  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102378175  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
102385671  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
102387573  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
102386782  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
102382066  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102381805  FLCN; folliculin [KO:K09594]
102387744  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102381471  FNIP2; folliculin-interacting protein 2 isoform X4 [KO:K20401]
102380773  ras-related GTP-binding protein A [KO:K16185]
102376139  RRAGC; ras-related GTP-binding protein C [KO:K16186]
102377646  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
102368018  SESN2; sestrin-2 isoform X5 [KO:K20394]
102377620  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
102380748  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
102378746  MIOS; GATOR complex protein MIOS isoform X1 [KO:K20407]
102369821  SEH1L; nucleoporin SEH1 [KO:K14299]
102368999  WDR24; GATOR complex protein WDR24 [KO:K20408]
102376857  WDR59; GATOR complex protein WDR59 isoform X2 [KO:K20409]
102378054  SEC13; protein SEC13 homolog [KO:K14004]
102376773  DEPDC5; GATOR complex protein DEPDC5 isoform X2 [KO:K20404]
102379923  NPRL2; GATOR complex protein NPRL2 isoform X2 [KO:K20405]
102385018  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
102367894  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
102380108  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
102388292  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102367984  AKT1S1; LOW QUALITY PROTEIN: proline-rich AKT1 substrate 1 [KO:K16184]
102372197  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102375277  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
102369220  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
102382401  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
102386853  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
102377146  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
102375292  GRB10; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
102369550  LPIN1; phosphatidate phosphatase LPIN1 isoform X3 [KO:K15728] [EC:3.1.3.4]
102370366  LPIN3; phosphatidate phosphatase LPIN3 isoform X2 [KO:K15728] [EC:3.1.3.4]
102376809  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
102372779  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
102371419  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
102385107  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102375341  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102386145  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102387892  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
102370189  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
102375389  EIF4B; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B [KO:K03258]
102382192  RPS6; 40S ribosomal protein S6 [KO:K02991]
102376013  STRADA; LOW QUALITY PROTEIN: STE20-related kinase adapter protein alpha [KO:K08271]
102379348  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
102379013  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
102372989  CAB39; calcium-binding protein 39 [KO:K08272]
102376475  CAB39L; calcium-binding protein 39-like isoform X1 [KO:K08272]
102374152  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102375567  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
102383470  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
102387523  TSC2; tuberin isoform X1 [KO:K07207]
102380742  TBC1D7; TBC1 domain family member 7 isoform X1 [KO:K20396]
102381385  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
102368881  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
102372844  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102388685  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
102377917  WNT2B; protein Wnt-2b [KO:K00182]
102371877  WNT3; proto-oncogene Wnt-3 [KO:K00312]
102368715  WNT3A; protein Wnt-3a [KO:K00312]
102367890  protein Wnt-4-like [KO:K00408]
102376031  WNT4; protein Wnt-4 [KO:K00408]
102382716  WNT5B; protein Wnt-5b [KO:K00444]
102373200  WNT5A; protein Wnt-5a [KO:K00444]
102377243  WNT6; LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
102380960  protein Wnt-7b [KO:K00572]
102383312  protein Wnt-7a [KO:K00572]
102372347  WNT8B; LOW QUALITY PROTEIN: protein Wnt-8b [KO:K00714]
102378786  WNT8A; protein Wnt-8a [KO:K00714]
102369665  WNT9A; protein Wnt-9a [KO:K01064]
102381043  WNT9B; protein Wnt-9b [KO:K01064]
102377468  WNT10A; protein Wnt-10a [KO:K01357]
102370312  WNT11; protein Wnt-11 isoform X1 [KO:K01384]
102371518  WNT16; protein Wnt-16 [KO:K01558]
102379576  FZD7; LOW QUALITY PROTEIN: frizzled-7 [KO:K02432]
102371988  FZD1; LOW QUALITY PROTEIN: frizzled-1 [KO:K02432]
102368618  FZD2; LOW QUALITY PROTEIN: frizzled-2 [KO:K02235]
102377195  FZD3; LOW QUALITY PROTEIN: frizzled-3 [KO:K02329]
102388636  FZD4; frizzled-4 [KO:K02354]
102367885  FZD5; LOW QUALITY PROTEIN: frizzled-5 [KO:K02375]
102380339  FZD6; frizzled-6 [KO:K02376]
102388030  FZD9; LOW QUALITY PROTEIN: frizzled-9 [KO:K02842]
102371525  FZD10; frizzled-10 [KO:K02842]
102368975  LRP6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
102386328  LRP5; low-density lipoprotein receptor-related protein 5 isoform X2 [KO:K03068]
102374968  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
102369873  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
102368492  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
102387985  GSK3B; glycogen synthase kinase-3 beta isoform X3 [KO:K03083] [EC:2.7.11.26]
102378738  tumor necrosis factor [KO:K03156]
102378637  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102377560  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102378642  INS; insulin [KO:K04526]
102372626  IGF1; insulin-like growth factor I [KO:K05459]
102378715  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102387852  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102376596  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102382733  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102387180  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102380807  HRAS; GTPase HRas [KO:K02833]
112547860  GTPase HRas-like [KO:K07827]
102373235  KRAS; GTPase KRas [KO:K07827]
102382019  NRAS; GTPase NRas [KO:K07828]
102380007  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102374398  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102373880  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102375508  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102376690  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102375250  glycogen synthase kinase-3 alpha-like [KO:K04371] [EC:2.7.11.24]
102374386  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X3 [KO:K04373] [EC:2.7.11.1]
102382254  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
102378267  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102368134  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102372136  IRS1; insulin receptor substrate 1 [KO:K16172]
102382060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102377899  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102380057  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102388304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102372482  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102387818  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106721809  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102383992  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102388514  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102388207  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102372104  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102374729  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102370690  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
102380342  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102376110  PRR5; proline-rich protein 5 isoform X2 [KO:K20411]
102368474  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
102377583  RHOA; transforming protein RhoA [KO:K04513]
102383248  transforming protein RhoA-like [KO:K04513]
102377784  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102368878  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102371860  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102371183  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
asn00561  Glycerolipid metabolism
asn04010  MAPK signaling pathway
asn04140  Autophagy - animal
asn04810  Regulation of actin cytoskeleton
asn04910  Insulin signaling pathway
KO pathway
ko04150   
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