KEGG   PATHWAY: biu04514
Entry
biu04514                    Pathway                                
Name
Cell adhesion molecules - Bos indicus (zebu cattle)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
biu04514  Cell adhesion molecules
biu04514

Other DBs
GO: 0050839
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109555875  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
109556769  lymphocyte function-associated antigen 3-like [KO:K06492]
109555873  CD2; T-cell surface antigen CD2 [KO:K06449]
109553685  VSIR; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
109576990  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
109562902  CD274; programmed cell death 1 ligand 1 isoform X1 [KO:K06745]
109569809  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
109554436  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
109569818  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
109561071  ICOSLG; ICOS ligand [KO:K06710]
109569829  ICOS; inducible T-cell costimulator [KO:K06713]
109576545  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109576596  HLA class II histocompatibility antigen, DO alpha chain-like isoform X1 [KO:K06752]
109577038  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109577039  SLA class II histocompatibility antigen, DQ haplotype D alpha chain [KO:K06752]
109577041  LOW QUALITY PROTEIN: DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577042  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
109576666  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
109577307  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
109577316  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
109576780  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
109558922  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
109577067  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577074  BOLA class I histocompatibility antigen, alpha chain BL3-6-like isoform X1 [KO:K06751]
109577076  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577078  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109577080  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109577083  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
109577088  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
109577113  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
109576723  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
109561936  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
109566151  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
109566150  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
109562901  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
109564754  CD276; CD276 antigen [KO:K06746]
109556768  VTCN1; V-set domain-containing T-cell activation inhibitor 1 [KO:K06747]
109556613  PDCD1; programmed cell death protein 1 isoform X1 [KO:K06744]
109567510  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109555532  CD40LG; CD40 ligand [KO:K03161]
109568754  ALCAM; CD166 antigen isoform X1 [KO:K06547]
109554658  CD6; T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
109572759  PVR; poliovirus receptor [KO:K06539]
109577994  CD226; CD226 antigen [KO:K06567]
109572641  NECTIN2; nectin-2 isoform X1 [KO:K06531]
109575725  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
109578145  ITGAL; integrin alpha-L [KO:K05718]
109560786  ITGB2; integrin beta-2 [KO:K06464]
109561581  intercellular adhesion molecule 1 [KO:K06490]
109573936  ICAM2; intercellular adhesion molecule 2 isoform X1 [KO:K06523]
109573938  intercellular adhesion molecule 2-like isoform X1 [KO:K06523]
109561585  ICAM3; intercellular adhesion molecule 3 [KO:K06486]
109572327  CD22; B-cell receptor CD22 isoform X1 [KO:K06467]
109570498  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
109567191  SIGLEC1; sialoadhesin isoform X1 [KO:K06548]
109578803  SPN; leukosialin [KO:K06477]
109554960  CLDN34; claudin-34 [KO:K06087]
109553313  putative claudin-24 [KO:K06087]
109556426  CLDN19; claudin-19 [KO:K06087]
109571458  CLDN5; claudin-5 [KO:K06087]
109573768  CLDN7; claudin-7 [KO:K06087]
109556261  CLDN8; claudin-8 [KO:K06087]
109553577  CLDN23; claudin-23 [KO:K06087]
109558215  CLDN11; claudin-11 [KO:K06087]
109555504  CLDN2; claudin-2 [KO:K06087]
109578644  CLDN6; claudin-6 [KO:K06087]
109578682  CLDN15; claudin-15 isoform X1 [KO:K06087]
109564632  CLDN18; claudin-18 [KO:K06087]
109578827  CLDN4; claudin-4 [KO:K06087]
109578849  CLDN3; claudin-3 [KO:K06087]
109578262  CLDN9; claudin-9 [KO:K06087]
109563836  CLDN17; claudin-17 [KO:K06087]
109566916  CLDN10; claudin-10 isoform X1 [KO:K06087]
109569480  CLDN25; putative claudin-25 [KO:K06087]
109556733  CLDN16; LOW QUALITY PROTEIN: claudin-16 [KO:K06087]
109556744  CLDN1; claudin-1 [KO:K06087]
109553468  claudin-22-like isoform X1 [KO:K06087]
109561521  CLDN14; claudin-14 [KO:K06087]
109564073  CLDN20; claudin-20 [KO:K06087]
109558187  CLDN12; claudin-12 [KO:K06087]
109574987  OCLN; occludin [KO:K06088]
109578437  F11R; junctional adhesion molecule A isoform X1 [KO:K06089]
109559245  JAM2; junctional adhesion molecule B [KO:K06735]
109554463  JAM3; junctional adhesion molecule C [KO:K06785]
109554472  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
109573915  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
109555123  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
109571485  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
109570715  SELP; P-selectin [KO:K06496]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109556011  vascular cell adhesion protein 1-like [KO:K06527]
109556012  vascular cell adhesion protein 1-like isoform X1 [KO:K06527]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109561258  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
109570717  SELL; L-selectin [KO:K06495]
109558673  glycosylation-dependent cell adhesion molecule 1 [KO:K06815]
109570522  CD34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
109571601  GLG1; Golgi apparatus protein 1 [KO:K06816]
109570254  SELE; E-selectin [KO:K06494]
109568807  NECTIN1; LOW QUALITY PROTEIN: nectin-1 [KO:K06081]
109577925  CDH2; cadherin-2 [KO:K06736]
109562148  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
109569890  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
109555392  L1CAM; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
109569654  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
109556165  NEGR1; neuronal growth regulator 1 [KO:K06775]
109570005  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
109566563  NTNG2; netrin-G2 [KO:K16359]
109557835  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
109556400  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
109571901  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
109566354  SDC1; syndecan-1 [KO:K06257]
109568478  SDC2; syndecan-2 [KO:K16336]
109572676  SDC3; syndecan-3 [KO:K16337]
109567481  SDC4; syndecan-4 [KO:K16338]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109554070  NRXN2; neurexin-2-beta [KO:K07377]
109565390  NRXN3; neurexin 3 isoform X1 [KO:K07377]
109562860  NLGN1; neuroligin-1 [KO:K07378]
109555491  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
109573240  NLGN2; neuroligin-2 [KO:K07378]
109561724  PTPRS; receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
109567132  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
109555432  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
109555511  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
109567074  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
109566898  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
109562887  PTPRD; receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
109564400  SLITRK3; LOW QUALITY PROTEIN: SLIT and NTRK-like protein 3 [KO:K25834]
109578901  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
109557394  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
109559214  CNTN1; contactin-1 isoform X1 [KO:K06759]
109577771  PTPRM; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
109570098  NFASC; neurofascin [KO:K06757]
109573310  contactin-associated protein 1-like [KO:K07379]
109574304  contactin-associated protein 1 [KO:K07379]
109558029  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
109578222  myelin protein P0 [KO:K06770]
109578251  LOW QUALITY PROTEIN: myelin protein P0-like [KO:K06770]
109572349  MAG; myelin-associated glycoprotein [KO:K06771]
109572856  cadherin-1 [KO:K05689]
109562307  VCAN; versican core protein isoform X1 [KO:K06793]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109572531  cadherin-3-like isoform X1 [KO:K06796]
109567280  CDH4; cadherin-4 [KO:K06797]
109572774  CDH15; cadherin-15 [KO:K06809]
109564194  NEO1; neogenin [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
biu04520  Adherens junction
biu04530  Tight junction
biu04610  Complement and coagulation cascades
biu04660  T cell receptor signaling pathway
biu04670  Leukocyte transendothelial migration
KO pathway
ko04514   
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