KEGG   PATHWAY: bom00590
Entry
bom00590                    Pathway                                
Name
Arachidonic acid metabolism - Bos mutus (wild yak)
Class
Metabolism; Lipid metabolism
Pathway map
bom00590  Arachidonic acid metabolism
bom00590

Other DBs
GO: 0019369
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102283824  PLA2G12B; phospholipase A2 group XIIB [KO:K01047] [EC:3.1.1.4]
102266640  PLA2G1B; phospholipase A2 group IB [KO:K01047] [EC:3.1.1.4]
102278743  PLA2G2C; phospholipase A2 group IIC [KO:K01047] [EC:3.1.1.4]
102287614  PLA2G12A; phospholipase A2 group XIIA [KO:K01047] [EC:3.1.1.4]
102279020  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102279309  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
102275927  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102275361  group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102276213  phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
102275649  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
102276506  PLA2G2E; phospholipase A2 group IIE [KO:K01047] [EC:3.1.1.4]
102275072  PLA2G2F; phospholipase A2 group IIF [KO:K01047] [EC:3.1.1.4]
102283735  PLA2G3; phospholipase A2 group III [KO:K01047] [EC:3.1.1.4]
102265754  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
102271639  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
102282019  PLA2G4B; phospholipase A2 group IVB [KO:K16342] [EC:3.1.1.4]
102282862  PLA2G4D; phospholipase A2 group IVD [KO:K16342] [EC:3.1.1.4]
102283142  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
102282579  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
102285524  PLA2G6; phospholipase A2 group VI [KO:K16343] [EC:3.1.1.4]
102269942  PLB1; phospholipase B1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
102282352  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102284880  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102283673  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102272818  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102272527  HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
102287995  PTGS1; prostaglandin-endoperoxide synthase 1 [KO:K00509] [EC:1.14.99.1]
102271174  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102267091  PTGES; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
102274141  PTGES2; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
102272807  prostaglandin E synthase 3-like [KO:K15730] [EC:5.3.99.3]
102281563  PTGES3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
102280721  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102280157  carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102279110  DCXR; dicarbonyl and L-xylulose reductase [KO:K00081] [EC:1.1.1.184]
102279872  CBR3; carbonyl reductase [NADPH] 3 [KO:K00084] [EC:1.1.1.184]
102268856  FAM213B; family with sequence similarity 213 member B [KO:K15717] [EC:1.11.1.20]
102269812  HPGD; hydroxyprostaglandin dehydrogenase 15-(NAD) [KO:K00069] [EC:1.1.1.141]
102269002  TBXAS1; thromboxane A synthase 1 [KO:K01832] [EC:5.3.99.5]
102274981  PTGDS; prostaglandin D2 synthase [KO:K01830] [EC:5.3.99.2]
102269024  HPGDS; hematopoietic prostaglandin D synthase [KO:K04097] [EC:5.3.99.2 2.5.1.18]
102269337  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102272882  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102272594  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102273443  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102272308  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102271453  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102271733  prostaglandin F synthase 1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102283454  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102284205  dihydrodiol dehydrogenase 3 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102267155  prostaglandin F synthase 1 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102279286  PTGIS; prostaglandin I2 synthase [KO:K01831] [EC:5.3.99.4]
102270550  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
102275332  LTA4H; leukotriene A4 hydrolase [KO:K01254] [EC:3.3.2.6]
102268913  ZADH2; zinc binding alcohol dehydrogenase domain containing 2 [KO:K07119] [EC:1.3.1.48]
102280112  PTGR2; prostaglandin reductase 2 [KO:K13949] [EC:1.3.1.48]
102271298  PTGR1; prostaglandin reductase 1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
102278603  LTC4S; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
102275636  GGT1; gamma-glutamyltransferase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102274785  GGT5; gamma-glutamyltransferase 5 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
102284111  GPX4; glutathione peroxidase 4 [KO:K05361] [EC:1.11.1.12]
102281471  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
102283844  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102284389  cytochrome P450 2J2 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
102268257  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
102268504  cytochrome P450 4A11-like [KO:K07425] [EC:1.14.14.80]
102270081  cytochrome P450 4A24-like [KO:K07425] [EC:1.14.14.80]
102286095  taurochenodeoxycholic 6 alpha-hydroxylase [KO:K07425] [EC:1.14.14.80]
102284543  ALOX12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]
102276466  ALOXE3; hydroperoxide isomerase ALOXE3 [KO:K18684] [EC:4.2.1.152 5.4.4.7]
102276175  ALOX12B; arachidonate 12-lipoxygenase, 12R type [KO:K08021] [EC:1.13.11.-]
102275513  ALOX15B; arachidonate 15-lipoxygenase B [KO:K08022] [EC:1.13.11.33 1.13.11.-]
102281419  arachidonate 15-lipoxygenase B-like [KO:K08022] [EC:1.13.11.33 1.13.11.-]
102282243  cytochrome P450 2B4 [KO:K07412] [EC:1.14.14.1]
102287777  cytochrome P450 2B4-like [KO:K07412] [EC:1.14.14.1]
102279786  cytochrome P450 2C19 [KO:K07413] [EC:1.14.14.1]
102266046  cytochrome P450 2C31 [KO:K07413] [EC:1.14.14.1]
102282716  cytochrome P450 2C23-like [KO:K07413] [EC:1.14.14.1]
102268262  cytochrome P450 2C31-like [KO:K07413] [EC:1.14.14.1]
102285833  cytochrome P450 2C9 [KO:K07413] [EC:1.14.14.1]
102280731  cytochrome P450 2C42 [KO:K07413] [EC:1.14.14.1]
102267808  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
102285661  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
102285373  arachidonate 12-lipoxygenase, epidermal-type-like [KO:K00460] [EC:1.13.11.33]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
bom00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

DBGET integrated database retrieval system