KEGG   PATHWAY: caua00600
Entry
caua00600                   Pathway                                
Name
Sphingolipid metabolism - Carassius auratus (goldfish)
Class
Metabolism; Lipid metabolism
Pathway map
caua00600  Sphingolipid metabolism
caua00600

Module
caua_M00066  Lactosylceramide biosynthesis [PATH:caua00600]
caua_M00067  Sulfoglycolipids biosynthesis, ceramide/1-alkyl-2-acylglycerol => sulfatide/seminolipid [PATH:caua00600]
caua_M00094  Ceramide biosynthesis [PATH:caua00600]
caua_M00099  Sphingosine biosynthesis [PATH:caua00600]
caua_M00100  Sphingosine degradation [PATH:caua00600]
Other DBs
GO: 0006665
Organism
Carassius auratus (goldfish) [GN:caua]
Gene
113054001  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
113112516  serine palmitoyltransferase 3-like [KO:K00654] [EC:2.3.1.50]
113094528  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
113121262  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
113056741  serine palmitoyltransferase 3-like isoform X1 [KO:K00654] [EC:2.3.1.50]
113109559  serine palmitoyltransferase 1-like [KO:K00654] [EC:2.3.1.50]
113063413  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
113071035  serine palmitoyltransferase 2-like [KO:K00654] [EC:2.3.1.50]
113117416  serine palmitoyltransferase 2-like isoform X1 [KO:K00654] [EC:2.3.1.50]
113038864  3-ketodihydrosphingosine reductase-like isoform X1 [KO:K04708] [EC:1.1.1.102]
113046084  3-ketodihydrosphingosine reductase [KO:K04708] [EC:1.1.1.102]
113100970  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
113039432  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
113040275  ceramide synthase 1-like [KO:K04710] [EC:2.3.1.299]
113060050  ceramide synthase 2-like isoform X1 [KO:K24621] [EC:2.3.1.297]
113119998  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113062229  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113045240  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113099083  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113116567  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113039301  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113074099  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113059700  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113112126  ceramide synthase 2-like [KO:K24621] [EC:2.3.1.297]
113051920  ceramide synthase 2-like isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
113100321  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
113052001  ceramide synthase 2-like isoform X1 [KO:K24622] [EC:2.3.1.297 2.3.1.298]
113105753  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
113118158  ceramide synthase 2-like [KO:K24622] [EC:2.3.1.297 2.3.1.298]
113108267  ceramide synthase 6-like [KO:K23727] [EC:2.3.1.291]
113080556  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
113100953  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
113039395  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
113052943  cers6; ceramide synthase 6 [KO:K23727] [EC:2.3.1.291]
113040386  ceramide synthase 5-like [KO:K23727] [EC:2.3.1.291]
113107462  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113113993  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113114201  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113044164  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113080950  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113057920  acid ceramidase-like [KO:K12348] [EC:3.5.1.23]
113056364  asah2; neutral ceramidase [KO:K12349] [EC:3.5.1.23]
113106411  alkaline ceramidase 2 [KO:K01441] [EC:3.5.1.23]
113107247  alkaline ceramidase 1 [KO:K01441] [EC:3.5.1.23]
113051714  alkaline ceramidase 2-like [KO:K01441] [EC:3.5.1.23]
113054504  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
113069528  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
113110011  alkaline ceramidase 3-like [KO:K04711] [EC:3.5.1.-]
113060590  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
113113113  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
113069079  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
113057445  sphingolipid delta(4)-desaturase DES1-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
113117474  sphingolipid delta(4)-desaturase/C4-monooxygenase DES2-like [KO:K04712] [EC:1.14.19.17 1.14.18.5]
113076133  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113041639  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113041647  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113093188  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113056349  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113044745  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113044750  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113082383  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113117124  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113117404  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113111949  phosphatidylcholine:ceramide cholinephosphotransferase 1-like [KO:K04714] [EC:2.7.8.27]
113065791  phosphatidylcholine:ceramide cholinephosphotransferase 2-like [KO:K04714] [EC:2.7.8.27]
113092440  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
113109800  sphingomyelin phosphodiesterase-like [KO:K12350] [EC:3.1.4.12]
113041027  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
113070260  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
113104356  sphingomyelin phosphodiesterase 2-like [KO:K12351] [EC:3.1.4.12]
113066787  sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
113115775  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
113100272  LOW QUALITY PROTEIN: sphingomyelin phosphodiesterase 3-like [KO:K12352] [EC:3.1.4.12]
113059388  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
113059396  sphingomyelin phosphodiesterase 5-like [KO:K12352] [EC:3.1.4.12]
113064190  sphingomyelin phosphodiesterase 4-like isoform X1 [KO:K12353] [EC:3.1.4.12]
113038720  sphingomyelin phosphodiesterase 4 isoform X1 [KO:K12353] [EC:3.1.4.12]
113056530  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
113062919  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
113063175  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
113112213  ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like [KO:K12354] [EC:3.1.4.12]
113048069  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
113070521  ceramide kinase-like isoform X1 [KO:K04715] [EC:2.7.1.138]
113057940  ceramide kinase-like [KO:K04715] [EC:2.7.1.138]
113054106  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113112734  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113106886  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
113067695  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
113114009  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
113121075  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113079308  plpp2; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
113079365  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
113063292  phospholipid phosphatase 3-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113051515  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
113110416  phospholipid phosphatase 1-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113052639  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
113052668  phospholipid phosphatase 1-like [KO:K01080] [EC:3.1.3.4]
113065005  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
113040038  phospholipid phosphatase 2-like [KO:K01080] [EC:3.1.3.4]
113112461  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
113121036  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
113056817  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
113063371  sphingosine-1-phosphate phosphatase 1-like [KO:K04716] [EC:3.1.3.-]
113058699  sphingosine-1-phosphate phosphatase 2-like [KO:K04717] [EC:3.1.3.-]
113055031  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113067871  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113067876  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113055812  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
113079872  sphingosine kinase 2-like [KO:K04718] [EC:2.7.1.91]
113116044  sphingosine kinase 2-like isoform X1 [KO:K04718] [EC:2.7.1.91]
113112661  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
113056956  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
113083901  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
113072492  sphingosine-1-phosphate lyase 1-like [KO:K01634] [EC:4.1.2.27]
113054060  ceramide glucosyltransferase-like [KO:K00720] [EC:2.4.1.80]
113109641  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
113109669  ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
113116327  gba; glucosylceramidase [KO:K01201] [EC:3.2.1.45]
113052105  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
113105814  non-lysosomal glucosylceramidase-like [KO:K17108] [EC:3.2.1.45]
113121064  beta-1,4-galactosyltransferase 6-like [KO:K07553] [EC:2.4.1.274]
113063269  beta-1,4-galactosyltransferase 6-like isoform X1 [KO:K07553] [EC:2.4.1.274]
113040991  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
113068671  beta-1,4-galactosyltransferase 5-like [KO:K09905] [EC:2.4.1.274 2.4.1.-]
113062583  glb1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
113106881  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
113044224  2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [KO:K04628] [EC:2.4.1.47]
113121250  galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
113117428  galactocerebrosidase-like [KO:K01202] [EC:3.2.1.46]
113055190  galactose-3-O-sulfotransferase 2-like [KO:K01019] [EC:2.8.2.11]
113055198  galactose-3-O-sulfotransferase 4-like [KO:K01019] [EC:2.8.2.11]
113068092  gal3st1; galactosylceramide sulfotransferase isoform X1 [KO:K01019] [EC:2.8.2.11]
113110090  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
113072071  galactosylceramide sulfotransferase-like [KO:K01019] [EC:2.8.2.11]
113073071  arylsulfatase A-like [KO:K01134] [EC:3.1.6.8]
113118177  arylsulfatase A-like isoform X1 [KO:K01134] [EC:3.1.6.8]
113119511  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
113119512  sialidase-1-like isoform X1 [KO:K01186] [EC:3.2.1.18]
113090783  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
113090792  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
113090830  sialidase-1-like [KO:K01186] [EC:3.2.1.18]
113064256  sialidase-4-like [KO:K12357] [EC:3.2.1.18]
113064257  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
113064259  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
113064260  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
113038632  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
113038634  sialidase-3-like [KO:K12357] [EC:3.2.1.18]
113058974  neu4; sialidase-4 isoform X1 [KO:K12357] [EC:3.2.1.18]
113075390  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
113114125  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
113081207  alpha-galactosidase A-like [KO:K01189] [EC:3.2.1.22]
113047614  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
113066542  beta-1,4 N-acetylgalactosaminyltransferase 2-like isoform X1 [KO:K00725] [EC:2.4.1.92]
113094168  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
113050355  beta-1,4 N-acetylgalactosaminyltransferase 1-like [KO:K00725] [EC:2.4.1.92]
113085425  beta-1,4 N-acetylgalactosaminyltransferase 2-like [KO:K00725] [EC:2.4.1.92]
113046700  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
113046702  beta-1,4 N-acetylgalactosaminyltransferase 1-like isoform X1 [KO:K00725] [EC:2.4.1.92]
113075961  beta-hexosaminidase subunit beta-like [KO:K12373] [EC:3.2.1.52]
113067062  beta-hexosaminidase subunit alpha-like [KO:K12373] [EC:3.2.1.52]
113093900  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
113049526  beta-hexosaminidase subunit beta-like isoform X1 [KO:K12373] [EC:3.2.1.52]
113043549  beta-hexosaminidase subunit alpha-like isoform X1 [KO:K12373] [EC:3.2.1.52]
113114261  ganglioside GM2 activator-like [KO:K12383]
113114533  ganglioside GM2 activator-like [KO:K12383]
113113018  prosaposin-like isoform X1 [KO:K12382]
113057280  prosaposin-like isoform X1 [KO:K12382]
113110407  prosaposin-like [KO:K12382]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
caua00260  Glycine, serine and threonine metabolism
caua00601  Glycosphingolipid biosynthesis - lacto and neolacto series
caua00603  Glycosphingolipid biosynthesis - globo and isoglobo series
caua00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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