KEGG   PATHWAY: cbai04914
Entry
cbai04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Camelus bactrianus (Bactrian camel)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
cbai04914  Progesterone-mediated oocyte maturation
cbai04914

Other DBs
GO: 0001556
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105083583  PGR; LOW QUALITY PROTEIN: progesterone receptor [KO:K08556]
105082679  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105064416  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
105065663  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105063312  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105071167  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105066839  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105075609  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105077723  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105062001  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105064175  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105064176  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070806  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070807  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105080234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105062385  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105063651  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105080525  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105081234  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105063873  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105068818  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105081635  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105076187  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105074271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105082946  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
105064797  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105071826  AURKA; aurora kinase A [KO:K11481] [EC:2.7.11.1]
105081902  CPEB3; LOW QUALITY PROTEIN: cytoplasmic polyadenylation element-binding protein 3 [KO:K02602]
105082658  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
105083234  CPEB2; cytoplasmic polyadenylation element-binding protein 2 [KO:K02602]
105069100  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
105077710  speedy protein E4-like [KO:K08694]
105063805  SPDYA; speedy protein A isoform X1 [KO:K08694]
105070673  SPDYC; speedy protein C [KO:K08694]
105075910  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105071301  CDK1; cyclin-dependent kinase 1 isoform X1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
105066208  CCNA1; cyclin-A1 [KO:K06627]
105067120  CCNA2; cyclin-A2 [KO:K06627]
105081482  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
105079942  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
105083823  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105068636  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105063460  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105064748  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105065398  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105064827  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
105064414  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
105080458  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
105076105  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
105082646  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
105073670  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
105083373  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
105083026  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105082163  CDC25C; M-phase inducer phosphatase 3 [KO:K05867] [EC:3.1.3.48]
105075052  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105075161  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105079975  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105083596  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105062855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105076796  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
105062297  KRAS; GTPase KRas [KO:K07827]
105079376  ARAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105063019  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105072154  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 [KO:K02178] [EC:2.7.11.1]
105077957  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
105067128  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
105070969  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
105078189  FZR1; fizzy-related protein homolog [KO:K03364]
105072151  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
105073373  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
105069804  CDC27; cell division cycle protein 27 homolog isoform X1 [KO:K03350]
105075285  ANAPC4; anaphase-promoting complex subunit 4 [KO:K03351]
105080625  ANAPC5; anaphase-promoting complex subunit 5 [KO:K03352]
105066872  CDC16; cell division cycle protein 16 homolog [KO:K03353]
105080615  ANAPC7; anaphase-promoting complex subunit 7 [KO:K03354]
105082162  CDC23; cell division cycle protein 23 homolog [KO:K03355]
105068675  ANAPC10; anaphase-promoting complex subunit 10 [KO:K03357]
105065551  ANAPC11; anaphase-promoting complex subunit 11 [KO:K03358]
105070746  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
105063247  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
105083284  ANAPC15; anaphase-promoting complex subunit 15 [KO:K25228]
105075392  ANAPC16; anaphase-promoting complex subunit 16 [KO:K25229]
105082817  KIF22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
cbai04010  MAPK signaling pathway
cbai04110  Cell cycle
KO pathway
ko04914   
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