KEGG   PATHWAY: cbai04010
Entry
cbai04010                   Pathway                                
Name
MAPK signaling pathway - Camelus bactrianus (Bactrian camel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cbai04010  MAPK signaling pathway
cbai04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Camelus bactrianus (Bactrian camel) [GN:cbai]
Gene
105061624  MAPK7; LOW QUALITY PROTEIN: mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
105061728  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
105061997  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105062001  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105062044  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
105062127  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105062231  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105062297  KRAS; GTPase KRas [KO:K07827]
105062378  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
105062379  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105062388  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
105062544  [KO:K04460] [EC:3.1.3.16]
105062602  FGF21; fibroblast growth factor 21 [KO:K22429]
105062615  NTF4; neurotrophin-4 [KO:K12457]
105062634  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
105062641  RRAS; ras-related protein R-Ras [KO:K07829]
105062716  RELB; transcription factor RelB [KO:K09253]
105062853  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
105062855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105062879  TGFB1; transforming growth factor beta-1 [KO:K13375]
105063019  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105063149  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
105063445  [KO:K04425] [EC:2.7.11.25]
105063460  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105063482  STMN1; stathmin [KO:K04381]
105063662  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
105063692  RAP1A; ras-related protein Rap-1A [KO:K04353]
105063918  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
105063941  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
105063942  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
105063943  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
105063964  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105064109  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
105064175  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105064176  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105064268  DAXX; LOW QUALITY PROTEIN: death domain-associated protein 6 [KO:K02308]
105064334  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
105064378  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105064543  [KO:K16342] [EC:3.1.1.4]
105064616  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105064748  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105064877  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
105065398  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
105065425  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105065479  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105065517  FGF16; fibroblast growth factor 16 [KO:K04358]
105065540  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105065653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105065770  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
105066246  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105066272  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
105066317  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105066402  ARRB2; beta-arrestin-2 [KO:K04439]
105066680  MECOM; LOW QUALITY PROTEIN: MDS1 and EVI1 complex locus protein EVI1 [KO:K04462] [EC:2.1.1.367]
105066734  [KO:K17534] [EC:2.7.11.25]
105066827  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
105066844  MRAS; ras-related protein M-Ras [KO:K07831]
105067000  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105067006  KITLG; kit ligand [KO:K05461]
105067112  FGF2; fibroblast growth factor 2 [KO:K18497]
105067391  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
105067475  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105067589  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105067606  [KO:K04346]
105067633  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105067674  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
105067685  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105067716  ANGPT2; angiopoietin-2 [KO:K05466]
105067732  FGF20; LOW QUALITY PROTEIN: fibroblast growth factor 20 [KO:K04358]
105067742  VEGFC; vascular endothelial growth factor C [KO:K05449]
105067900  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
105067906  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
105067913  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105067960  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105068023  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
105068164  EFNA1; ephrin-A1 [KO:K05462]
105068230  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
105068244  EFNA3; ephrin-A3 [KO:K05462]
105068246  EFNA4; ephrin-A4 [KO:K05462]
105068302  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105068344  [KO:K04347]
105068402  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
105068597  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
105068625  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105068636  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
105068979  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105068993  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105069026  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
105069046  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
105069139  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
105069349  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105069374  PDGFC; platelet-derived growth factor C [KO:K05450]
105069401  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
105069422  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105069495  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
105069608  STK3; serine/threonine-protein kinase 3 [KO:K04412]
105069653  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
105069789  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
105069943  HRAS; GTPase HRas isoform X1 [KO:K02833]
105069992  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
105070011  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105070302  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
105070386  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
105070398  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105070434  FGF19; fibroblast growth factor 19 [KO:K22603]
105070566  CRKL; crk-like protein [KO:K04438]
105070615  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105070629  VEGFB; vascular endothelial growth factor B [KO:K16858]
105070640  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
105070645  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
105070649  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
105070689  RELA; transcription factor p65 [KO:K04735]
105070717  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
105070806  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
105070807  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105070822  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
105070875  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105070931  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
105071112  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105071116  NTF3; neurotrophin-3 [KO:K04356]
105071245  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
105071266  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
105071441  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
105071480  MAPT; microtubule-associated protein tau [KO:K04380]
105071519  CRK; adapter molecule crk [KO:K04438]
105071547  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
105071593  NF1; LOW QUALITY PROTEIN: neurofibromin [KO:K08052]
105071635  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
105071674  JUN; transcription factor AP-1 [KO:K04448]
105071706  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
105071910  STK4; serine/threonine-protein kinase 4 [KO:K04411]
105072052  [KO:K04458] [EC:3.1.3.48]
105072137  IL1B; interleukin-1 beta [KO:K04519]
105072138  IL1A; interleukin-1 alpha [KO:K04383]
105072182  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
105072217  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
105072277  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105072288  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
105072315  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
105072355  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
105072383  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
105072525  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
105072570  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
105072636  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
105072689  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105072941  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
105073101  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
105073104  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
105073106  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
105073153  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105073200  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
105073209  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
105073259  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
105073272  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
105073404  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
105073441  [KO:K04424] [EC:2.7.11.25]
105073454  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105073643  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
105073668  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
105073669  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
105074047  [KO:K03283]
105074048  HSPA1B; LOW QUALITY PROTEIN: heat shock 70 kDa protein 1A/1B [KO:K03283]
105074049  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
105074074  TNF; tumor necrosis factor [KO:K03156]
105074289  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105074292  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
105074322  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105074323  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105074324  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
105074480  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
105074636  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
105074678  MAX; protein max isoform X1 [KO:K04453]
105074721  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
105074785  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105074812  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
105074856  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105074880  RASA1; LOW QUALITY PROTEIN: ras GTPase-activating protein 1 [KO:K04352]
105075052  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
105075161  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105075181  PGF; placenta growth factor isoform X1 [KO:K16859]
105075289  FOS; proto-oncogene c-Fos [KO:K04379]
105075369  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105075375  TGFB3; LOW QUALITY PROTEIN: transforming growth factor beta-3 [KO:K13377]
105075427  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
105075444  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105075498  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105075552  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105075578  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
105075609  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
105075709  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
105075786  TGFA; protransforming growth factor alpha [KO:K08774]
105075826  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
105075904  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105076053  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105076064  FLNA; filamin-A [KO:K04437]
105076069  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
105076100  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
105076188  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
105076251  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
105076289  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
105076396  [KO:K07210]
105076475  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
105076500  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105076521  FGF6; fibroblast growth factor 6 [KO:K04358]
105076551  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
105076573  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
105076612  RRAS2; ras-related protein R-Ras2 [KO:K07830]
105076642  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
105076657  CACNA2D4; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
105076883  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
105076930  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105076933  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
105077011  FGF7; fibroblast growth factor 7 [KO:K04358]
105077055  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105077056  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
105077264  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105077308  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
105077365  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105077460  MAP3K4; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
105077515  TP53; cellular tumor antigen p53 [KO:K04451]
105077599  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
105077672  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105077673  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
105077723  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105077731  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
105077813  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
105077831  FGF10; fibroblast growth factor 10 [KO:K04358]
105077858  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
105078155  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
105078165  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105078209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105078210  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
105078244  NRTN; neurturin [KO:K25414]
105078270  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105078286  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105078315  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
105078345  FGF22; fibroblast growth factor 22 [KO:K04358]
105078356  EFNA2; ephrin-A2 [KO:K05462]
105078393  PSPN; persephin [KO:K25416]
105078489  SOS2; son of sevenless homolog 2 [KO:K03099]
105078638  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
105078857  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
105078955  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
105078987  SOS1; son of sevenless homolog 1 [KO:K03099]
105079014  PPM1B; LOW QUALITY PROTEIN: protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
105079060  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
105079160  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
105079228  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
105079294  FIGF; vascular endothelial growth factor D [KO:K05449]
105079376  ARAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105079378  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
105079415  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105079555  NRAS; GTPase NRas [KO:K07828]
105079582  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
105079596  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
105079861  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
105079965  NGF; beta-nerve growth factor [KO:K02582]
105079975  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105080190  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
105080216  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
105080307  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
105080377  AREG; amphiregulin isoform X1 [KO:K09782]
105080429  EREG; proepiregulin [KO:K09784]
105080598  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
105080789  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
105081341  RAP1B; ras-related protein Rap-1b [KO:K07836]
105081383  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
105081708  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
105081722  FGF8; fibroblast growth factor 8 [KO:K04358]
105081852  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105081887  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105082019  EFNA5; ephrin-A5 [KO:K05462]
105082208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105082571  JUND; transcription factor jun-D [KO:K04449]
105082649  DUSP1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105082696  FGF18; fibroblast growth factor 18 [KO:K04358]
105082705  HSPB1; heat shock protein beta-1 [KO:K04455]
105082827  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
105082839  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105082940  MYC; myc proto-oncogene protein [KO:K04377]
105083026  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
105083323  ARRB1; beta-arrestin-1 [KO:K04439]
105083596  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105083612  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
105083797  SRF; serum response factor [KO:K04378]
105083818  VEGFA; vascular endothelial growth factor A [KO:K05448]
105083961  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
105083972  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
105084000  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105084150  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cbai04070  Phosphatidylinositol signaling system
cbai04110  Cell cycle
cbai04115  p53 signaling pathway
cbai04210  Apoptosis
cbai04310  Wnt signaling pathway
cbai04668  TNF signaling pathway
KO pathway
ko04010   

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