KEGG   PATHWAY: ccw04530
Entry
ccw04530                    Pathway                                
Name
Tight junction - Corvus cornix (hooded crow)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ccw04530  Tight junction
ccw04530

Other DBs
GO: 0005923
Organism
Corvus cornix (hooded crow) [GN:ccw]
Gene
104686332  CLDN34; claudin-34 [KO:K06087]
104685967  CLDN10; claudin-10 isoform X2 [KO:K06087]
104689991  CLDN20; claudin-20 [KO:K06087]
104688043  CLDN11; claudin-11 [KO:K06087]
104687926  CLDN16; claudin-16 [KO:K06087]
104691631  CLDN2; claudin-2 [KO:K06087]
104690566  claudin-22-like [KO:K06087]
104693058  claudin-15-like isoform X2 [KO:K06087]
104698121  LOW QUALITY PROTEIN: claudin-17-like [KO:K06087]
104696706  CLDN18; claudin-18 isoform X2 [KO:K06087]
104695780  claudin-3-like [KO:K06087]
104696756  CLDN14; claudin-14 [KO:K06087]
104697573  claudin-16-like isoform X1 [KO:K06087]
109146370  CLDN19; claudin-19 isoform X1 [KO:K06087]
104687927  CLDN1; claudin-1 [KO:K06087]
104689187  CLDN12; claudin-12 [KO:K06087]
120409923  CLDN23; claudin-23 [KO:K06087]
120410856  CLDN5; claudin-5 [KO:K06087]
120411019  claudin-4-like [KO:K06087]
120411029  CLDN3; LOW QUALITY PROTEIN: claudin-3 [KO:K06087]
120411239  CLDN25; putative claudin-25 [KO:K06087]
104686951  JAM2; junctional adhesion molecule B isoform X1 [KO:K06735]
104692125  JAM3; junctional adhesion molecule C [KO:K06785]
104691783  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
104697540  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104687786  PARD6B; LOW QUALITY PROTEIN: partitioning defective 6 homolog beta [KO:K06093]
104685813  partitioning defective 6 homolog gamma [KO:K06093]
104691885  PARD6A; LOW QUALITY PROTEIN: partitioning defective 6 homolog alpha [KO:K06093]
104683850  PALS1; MAGUK p55 subfamily member 5 [KO:K06091]
104693783  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
104696911  TJP3; tight junction protein ZO-3 [KO:K06097]
104695144  PATJ; inaD-like protein isoform X1 [KO:K06092]
104685190  MPDZ; multiple PDZ domain protein isoform X17 [KO:K06095]
104693294  PRKCZ; protein kinase C zeta type isoform X2 [KO:K18952] [EC:2.7.11.13]
104688046  PRKCI; protein kinase C iota type isoform X3 [KO:K06069] [EC:2.7.11.13]
104691622  AMOT; angiomotin [KO:K16819]
104690080  AMOTL1; angiomotin-like protein 1 isoform X2 [KO:K06104]
104696709  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
104684737  ARHGAP17; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
104684856  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
104691090  merlin-like [KO:K16684]
104694990  NF2; merlin isoform X1 [KO:K16684]
104685016  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
104694316  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
104693473  DLG1; disks large homolog 1 isoform X14 [KO:K12076]
104684212  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
104696831  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
104683725  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
104694825  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
104694957  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
104689468  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
104690747  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X3 [KO:K04354]
104686461  PARD3; partitioning defective 3 homolog isoform X6 [KO:K04237]
104684195  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X3 [KO:K05731]
104683818  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
104684358  TJAP1; tight junction-associated protein 1 isoform X1 [KO:K06105]
104690308  DLG2; disks large homolog 2 isoform X7 [KO:K12075]
104691751  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
104683840  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
104698611  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X9 [KO:K13305] [EC:2.3.2.26]
104683833  CGNL1; cingulin-like protein 1 isoform X1 [KO:K21110]
104683253  RHOA; transforming protein RhoA [KO:K04513]
104696892  GATA4; transcription factor GATA-4 isoform X1 [KO:K09183]
104698162  MARVEL domain-containing protein 3-like [KO:K21099]
120410581  MARVELD3; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
104686679  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
104689594  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104696634  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104697227  MAPK10; mitogen-activated protein kinase 10 isoform X4 [KO:K04440] [EC:2.7.11.24]
104695158  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
104695757  uncharacterized protein LOC104695757 [KO:K06448]
104698445  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
104696476  YBX3; Y-box-binding protein 3 [KO:K06099]
104683760  PCNA; proliferating cell nuclear antigen [KO:K04802]
104697629  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
104697788  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104696772  RUNX1; LOW QUALITY PROTEIN: runt-related transcription factor 1 [KO:K08367]
104689481  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
104694295  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
104689804  EZR; ezrin isoform X2 [KO:K08007]
104690038  RDX; radixin isoform X2 [KO:K05762]
104691269  MSN; moesin [KO:K05763]
104685689  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
104684799  ACTB; actin, cytoplasmic 1 [KO:K05692]
120410965  ACTG1; LOW QUALITY PROTEIN: actin, cytoplasmic 2 [KO:K05692]
104683258  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
104689448  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104687766  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
104697607  CTTN; src substrate cortactin isoform X1 [KO:K06106]
120411962  hematopoietic lineage cell-specific protein-like isoform X1 [KO:K06106]
104696588  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
104686431  ACTR3B; actin-related protein 3B [KO:K18584]
104694213  ACTR3; actin-related protein 3 [KO:K18584]
104684794  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104684795  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104693979  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
104688709  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104683484  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
104693652  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
109144378  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
104683972  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
104695299  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104696981  ARHGEF18; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
104687309  ROCK1; rho-associated protein kinase 1 isoform X4 [KO:K04514] [EC:2.7.11.1]
104685437  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
104688679  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104685913  EPB41L4B; band 4.1-like protein 4B isoform X1 [KO:K21111]
104697015  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
104695510  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
104686759  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
104688531  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
104695440  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
104686512  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
104693965  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
104684897  MYH11; myosin-11 isoform X1 [KO:K10352]
104695627  MYH10; myosin-10 isoform X1 [KO:K10352]
104696276  MYH9; myosin-9 [KO:K10352]
104698028  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
104687298  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
120409655  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
104696769  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
104683351  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
104689692  SYNPO; LOW QUALITY PROTEIN: synaptopodin [KO:K21112]
104683694  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
120412105  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
104685037  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
104697398  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
104684027  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
104697988  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
104692321  RAP1A; ras-related protein Rap-1A [KO:K04353]
104686529  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
104684336  AFDN; afadin isoform X1 [KO:K05702]
104685213  TJP2; tight junction protein ZO-2 isoform X1 [KO:K06098]
104697194  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
104691331  RAP2C; ras-related protein Rap-2c [KO:K07839]
104689774  LOW QUALITY PROTEIN: MARVEL domain-containing protein 2 [KO:K17291]
104688184  tubulin alpha-3 chain [KO:K07374]
104693949  LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
104692253  TUBA8; tubulin alpha-8 chain [KO:K07374]
104692452  tubulin alpha-8 chain [KO:K07374]
104695968  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
120410287  tubulin alpha-5 chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
ccw04520  Adherens junction
ccw04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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