KEGG   PATHWAY: cjc04666
Entry
cjc04666                    Pathway                                
Name
Fc gamma R-mediated phagocytosis - Callithrix jacchus (white-tufted-ear marmoset)
Description
Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes.
Class
Organismal Systems; Immune system
Pathway map
cjc04666  Fc gamma R-mediated phagocytosis
cjc04666

Other DBs
GO: 0006909
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
103793556  immunoglobulin heavy variable 1-18 [KO:K06856]
100393738  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X2 [KO:K06498]
100387574  FCGR2A; low affinity immunoglobulin gamma Fc region receptor II-a isoform X2 [KO:K06472]
100387926  low affinity immunoglobulin gamma Fc region receptor III-A-like isoform X1 [KO:K06463]
100385061  PTPRC; receptor-type tyrosine-protein phosphatase C isoform X3 [KO:K06478] [EC:3.1.3.48]
100389637  HCK; tyrosine-protein kinase HCK isoform X4 [KO:K08893] [EC:2.7.10.2]
100390096  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100394657  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100397180  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
100409247  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X3 [KO:K04688] [EC:2.7.11.1]
100397497  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
100390347  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100395399  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
100388620  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100391709  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100400789  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100401154  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100402439  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
118142760  PLA2G4B; cytosolic phospholipase A2 beta isoform X6 [KO:K16342] [EC:3.1.1.4]
100415535  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
100400860  MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561]
100387829  MARCKS-related protein [KO:K13536]
100896145  MARCKS-related protein-like [KO:K13536]
100410948  MARCKSL1; MARCKS-related protein [KO:K13536]
100397093  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100391217  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100410546  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
100410701  phospholipid phosphatase 2-like isoform X1 [KO:K01080] [EC:3.1.3.4]
100401080  PLPP1; phospholipid phosphatase 1 isoform X4 [KO:K01080] [EC:3.1.3.4]
100395846  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
100387720  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100406587  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100391814  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100410136  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
100404028  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
100402613  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
100401564  GSN; gelsolin isoform X1 [KO:K05768]
100398485  SCIN; scinderin [KO:K05768]
100410236  gelsolin-like [KO:K05768]
100406408  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100388432  VAV1; proto-oncogene vav [KO:K05730]
100390165  VAV3; guanine nucleotide exchange factor VAV3 isoform X4 [KO:K05730]
100404291  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
100412947  WAS; actin nucleation-promoting factor WAS [KO:K05747]
100407817  vasodilator-stimulated phosphoprotein [KO:K06274]
100399553  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100392731  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
100396552  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
100400303  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100410640  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
100391527  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
100402441  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
128932462  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
100386903  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
100398433  actin-related protein 2/3 complex subunit 3 [KO:K05756]
100399830  ARPC3; actin-related protein 2/3 complex subunit 3 isoform X1 [KO:K05756]
100399283  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
100406997  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
100409219  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
128929325  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
100894431  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
100387679  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100398201  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100895294  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100403045  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
100391469  WASF2; actin-binding protein WASF2 [KO:K05748]
100388335  WASF3; actin-binding protein WASF3 isoform X1 [KO:K06083]
100392970  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100395466  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
100396965  LIMK2; LIM domain kinase 2 isoform X2 [KO:K05744] [EC:2.7.11.1]
100397668  CFL2; cofilin-2 isoform X1 [KO:K05765]
103796391  CFL1; cofilin-1 isoform X1 [KO:K05765]
100397115  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
100398292  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
100398080  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X6 [KO:K00889] [EC:2.7.1.68]
100409406  ARF6; ADP-ribosylation factor 6 [KO:K07941]
100390206  CRKL; crk-like protein [KO:K04438]
100399916  CRK; adapter molecule crk isoform X1 [KO:K04438]
100411936  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
100411588  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
100407033  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K12488]
100414051  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
100412558  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X3 [KO:K12560]
100400043  INPP5D; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084] [EC:3.1.3.86]
100396447  INPPL1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform X1 [KO:K15909] [EC:3.1.3.86]
100408076  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
100414442  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
100412229  DNM2; dynamin-2 isoform X4 [KO:K23484] [EC:3.6.5.5]
100392436  myc box-dependent-interacting protein 1-like [KO:K12562]
100407797  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
100391968  AMPH; amphiphysin isoform X3 [KO:K12562]
100389861  MYO10; unconventional myosin-X isoform X2 [KO:K12559]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00416  Phosphatidate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06124  Sphingosine 1-phosphate
Reference
PMID:12488490
  Authors
Garcia-Garcia E, Rosales C
  Title
Signal transduction during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 72:1092-108 (2002)
DOI:10.1189/jlb.72.6.1092
Reference
PMID:11708889
  Authors
Cox D, Greenberg S
  Title
Phagocytic signaling strategies: Fc(gamma)receptor-mediated phagocytosis as a model system.
  Journal
Semin Immunol 13:339-45 (2001)
DOI:10.1006/smim.2001.0330
Reference
PMID:15466916
  Authors
Swanson JA, Hoppe AD
  Title
The coordination of signaling during Fc receptor-mediated phagocytosis.
  Journal
J Leukoc Biol 76:1093-103 (2004)
DOI:10.1189/jlb.0804439
Reference
PMID:11244038
  Authors
Ravetch JV, Bolland S
  Title
IgG Fc receptors.
  Journal
Annu Rev Immunol 19:275-90 (2001)
DOI:10.1146/annurev.immunol.19.1.275
Reference
PMID:18322649
  Authors
Groves E, Dart AE, Covarelli V, Caron E
  Title
Molecular mechanisms of phagocytic uptake in mammalian cells.
  Journal
Cell Mol Life Sci 65:1957-76 (2008)
DOI:10.1007/s00018-008-7578-4
Reference
PMID:10376013
  Authors
Kwiatkowska K, Sobota A
  Title
Signaling pathways in phagocytosis.
  Journal
Bioessays 21:422-31 (1999)
DOI:10.1002/(SICI)1521-1878(199905)21:5<422::AID-BIES9>3.0.CO;2-#
Reference
PMID:10577498
  Authors
Greenberg S
  Title
Modular components of phagocytosis.
  Journal
J Leukoc Biol 66:712-7 (1999)
DOI:10.1002/jlb.66.5.712
Reference
PMID:10224668
  Authors
Lennartz MR
  Title
Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.
  Journal
Int J Biochem Cell Biol 31:415-30 (1999)
DOI:10.1016/S1357-2725(98)00108-3
Reference
PMID:11228151
  Authors
May RC, Machesky LM
  Title
Phagocytosis and the actin cytoskeleton.
  Journal
J Cell Sci 114:1061-77 (2001)
Reference
PMID:17050193
  Authors
Joshi T, Butchar JP, Tridandapani S
  Title
Fcgamma receptor signaling in phagocytes.
  Journal
Int J Hematol 84:210-6 (2006)
DOI:10.1532/IJH97.06140
Reference
PMID:17308335
  Authors
Lee WL, Cosio G, Ireton K, Grinstein S
  Title
Role of CrkII in Fcgamma receptor-mediated phagocytosis.
  Journal
J Biol Chem 282:11135-43 (2007)
DOI:10.1074/jbc.M700823200
Reference
PMID:11304556
  Authors
Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H
  Title
PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages.
  Journal
J Exp Med 193:955-66 (2001)
DOI:10.1084/jem.193.8.955
Reference
PMID:15485887
  Authors
Ganesan LP, Wei G, Pengal RA, Moldovan L, Moldovan N, Ostrowski MC, Tridandapani S
  Title
The serine/threonine kinase Akt Promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase.
  Journal
J Biol Chem 279:54416-25 (2004)
DOI:10.1074/jbc.M408188200
Reference
PMID:9545263
  Authors
Melendez A, Floto RA, Gillooly DJ, Harnett MM, Allen JM
  Title
FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking.
  Journal
J Biol Chem 273:9393-402 (1998)
DOI:10.1074/jbc.273.16.9393
Reference
PMID:12821647
  Authors
Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG
  Title
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis.
  Journal
J Cell Biol 161:1151-61 (2003)
DOI:10.1083/jcb.200212158
Reference
PMID:9417101
  Authors
Dana R, Leto TL, Malech HL, Levy R
  Title
Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase.
  Journal
J Biol Chem 273:441-5 (1998)
DOI:10.1074/jbc.273.1.441
Reference
PMID:10601359
  Authors
Gold ES, Underhill DM, Morrissette NS, Guo J, McNiven MA, Aderem A
  Title
Dynamin 2 is required for phagocytosis in macrophages.
  Journal
J Exp Med 190:1849-56 (1999)
DOI:10.1084/jem.190.12.1849
Reference
PMID:10755615
  Authors
Gold ES, Morrissette NS, Underhill DM, Guo J, Bassetti M, Aderem A
  Title
Amphiphysin IIm, a novel amphiphysin II isoform, is required for macrophage phagocytosis.
  Journal
Immunity 12:285-92 (2000)
DOI:10.1016/S1074-7613(00)80181-8
Reference
PMID:10586078
  Authors
Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Shayman JA, Boxer LA
  Title
Syk activation initiates downstream signaling events during human polymorphonuclear leukocyte phagocytosis.
  Journal
J Immunol 163:6785-93 (1999)
Reference
PMID:9581795
  Authors
Sanchez-Mejorada G, Rosales C
  Title
Signal transduction by immunoglobulin Fc receptors.
  Journal
J Leukoc Biol 63:521-33 (1998)
DOI:10.1002/jlb.63.5.521
Reference
  Authors
Rosales C (ed).
  Title
Molecular Mechanisms of Phagocytosis
  Journal
Springer (2005)
Related
pathway
cjc04020  Calcium signaling pathway
cjc04142  Lysosome
cjc04144  Endocytosis
cjc04810  Regulation of actin cytoskeleton
KO pathway
ko04666   
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